Clinical trials: Hyperthyroidism
Hypothyroidism, Hyperthyroidism
Brown Adipose Tissue Activity and Thyroid Hormone
Rationale: During the last decades, research in possible therapies for existing obesity and developmental factors causing obesity has explosively increased.
- Conditions
- Hypothyroidism, Hyperthyroidism, Obesity
- Trial name
- NCT02499471
- Testing
- Levothyroxine therapy (137.75 ± 23.75 μg/day)
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Maastricht University Medical Center
Thyroid Eye Disease
Treatment of Graves' Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in an Open-Label Clinical Extension Study
The overall objective is to evaluate the safety and efficacy of teprotumumab in the treatment of thyroid eye disease (TED) in participants who participated in the lead-in study HZNP-TEP-301 (NCT03298867; OPTIC) and who were…
- Trial name
- OPTIC-X (NCT03461211)
- Testing
- Teprotumumab
- Where
- 13 sites in United States, Germany and 1 more
- Volunteers
- 51 people
- Sponsor
- Amgen
Thyroid Associated Ophthalmopathy
Study of Therapeutic Value of Periorbital Injection of Glucocorticoid in Mild TAO
The purpose of this study is to determine whether periorbital injection of glucocorticoid is effective and necessary in the treatment of mild TAO.
- Trial name
- NCT04548284
- Testing
- Glucocorticoids
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Sun Yat-sen University
Hyperthyroidism
Exercise Capacity, Physical Activity Levels in Patients With Hyperthyroid
The primary aim of the study is to evaluate physical activity level and functional exercise capacity in patients with hyperthyroid.
- Trial name
- NCT04825964
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gazi University
Hyperthyroidism, Tomography
Comparison of SUV Using SPECT/CT Between Grave's Disease Patients and Normal Humans
The purpose of this study is to find out the capacity of standardized uptake value (SUV) using single-photo emission computed tomography and computed tomography (SPECT/CT) in diagnosing Grave's Disease (hyperthyroidism).
- Conditions
- Hyperthyroidism, Tomography, Emission-Computed, Single-Photon
- Trial name
- NCT02772705
- Where
- 9 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Thyroid Eye Disease, Thyroid Eye Disease, TED
Comparison of the Efficacy and Safety of 4 vs. 8 Treatments With Tepezza (Teprotumumab) for Thyroid Eye Disease
The goal of this interventional study is to compare the clinical outcomes of shortened 4-infusion course versus the standard 8-infusion course of Teprotumumab (Tepezza) in patients with active Thyroid Eye Disease (TED).
- Conditions
- Thyroid Eye Disease, Thyroid Eye Disease, TED, Thyroid Eye Disease (TED)
- Trial name
- NCT07308964
- Testing
- Teprotumumab Injection [Tepezza]
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Graves Disease, Amiodarone-Induced Thyrotoxicosis
Thyroidectomy for Graves' Disease or Amiodarone-induced Thyrotoxicosis
The goal of this observational study is to learn about the potential differences in morbidity of thyroidectomy (removal of the thyroid gland) depending on the preoperative hormonal status.
- Conditions
- Graves Disease, Amiodarone-Induced Thyrotoxicosis, Thyroidectomy
- Trial name
- GRATES (NCT06963203)
- Where
- 15 sites in Belgium, France and 3 more
- Volunteers
- 486 people
- Sponsor
- Andrea Goldmann
Thyroid Eye Disease, TED
A Multicenter, Open-label Extension Study Evaluating the Efficacy and Safety of IBI311 in Subjects With Thyroid Eye Disease
A multicenter, open-label extension study evaluating the efficacy and safety of IBI311 in subjects with thyroid eye disease
- Trial name
- NCT06126783
- Testing
- IBI311
- Where
- China
- Volunteers
- 91 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Hyperthyroidism
Optimization With a Gamma Camera of the Individualized Patient Dosimetry in Radioiodine Therapy of Thyroid Diseases
This is a pilot, single-center, prospective, open-label clinical investigation of a medical device (ambulatory gamma camera " MoTI " (Mobile Therapy Imager)) for patients with hyperthyroidism (Graves' disease, toxic nodule and…
- Trial name
- THIDOS (NCT06371339)
- Testing
- Additional acquisitions with the investigational gamma-camera " MoTI ".
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Institut Claudius Regaud
Thyroid-associated Ophthalmopathy
Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections
Thyroid-associated ophthalmopathy (TAO) is an autoimmune process that can affect the orbital and periorbital tissues and the thyroid gland.
- Trial name
- NCT01599273
- Testing
- subconjunctival triamcinolone injection
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Hyperthyroidism
Treatment of M.Graves With Radioactive Iodine: Follow-up Study
Hypothesis: What is the natural course after treatment with radioactive iodine in patients with hyperthyroidism? What are the determinants for the development of acute hypo- or hyperthyroidism after treatment with radioactive…
- Trial name
- NCT00525122
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Medisch Centrum Rijnmond-Zuid, Netherlands
Graves' Disease
In Vivo CAR-T for Refractory Graves' Disease
Graves' disease is an autoimmune thyroid disorder characterized by the production of autoantibodies against the thyroid-stimulating hormone receptor (TRAb), leading to excessive thyroid hormone secretion and systemic…
- Trial name
- NCT07333677
- Testing
- In Vivo CAR-T Therapy
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai Zhongshan Hospital
Dysthyroid Orbitopathy
Morphometric Analysis of Orbital Structures in Graves´ Orbitopathy
The purpose of this protocol is to study orbital structures in Graves´ Disease using multidetector computed tomography and color doppler imaging.
- Trial name
- NCT00665795
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo
Hyperthyroidism/Thyrotoxicosis
Clinical Value of Microvascular Ultrasonography in Real-time Differential Diagnosis of Thyrotoxic Patients
This study aims to verify the clinical value of thyroid ultrasound with microvascular flow imaging in thyrotoxic patients for differential diagnosis between hyperthyroidism and thyroiditis.
- Trial name
- NCT04879173
- Testing
- RS85 Ultrasound device
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Dong Jun Lim
Graves´ Disease, Thyroid Associated Ophthalmopathy
Rituximab in the Treatment of Graves' Disease
Aim: In a phase II pilot study encompassing 20 patients with Graves' disease to evaluate the effect of rituximab: 1. Biochemically as assessed by markers of disease activity ( free T4, free T3, TSH, TSH-receptor antibodies…
- Trial name
- NCT00150111
- Testing
- Methimazole, Rituximab, Immunization with various vaccines
- Where
- 2 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- Odense University Hospital
Thyroid Neoplasms, Thyroid Nodules
Is the Routine Pressure Dressing After Thyroidectomy Necessary?
Thyroidectomy is an operation that is commonly performed. After an operation a pressure dressing by Hypafix is usually used due to the belief that it will help to reduce complications such as post-operative bleeding or haematoma.
- Conditions
- Thyroid Neoplasms, Thyroid Nodules, Graves Disease, Goiter
- Trial name
- NCT00400465
- Testing
- Normal dressing, Pressure dressing
- Where
- Thailand
- Volunteers
- 116 people
- Sponsor
- Khon Kaen University
Thyroid Eye Disease (TED)
A Study to Assess the Efficacy and Safety of ZL-1109 in Chinese Participants With Active Thyroid Eye Disease
A Multicenter, Double-blinded, Randomized, Placebo-controlled Phase 3 Study of ZL-1109 in Chinese Participants with Thyroid Eye Disease (TED)
- Trial name
- NCT07211776
- Testing
- ZL-1109 (VRDN-003)
- Where
- 26 sites in China
- Volunteers
- 108 people
- Sponsor
- Zai Lab (Shanghai) Co., Ltd.
Graves' Disease
Assessment of Thyroid Doppler Ultrasound in Followup of Pediatric Graves' Disease
All cases of the study will be diagnosed as Graves' by History, examination, laboratory (FT3, FT4, TSH \& TRAbs), X-ray on left wrist for bone age, neck grey scale ultrasonography for thyroid gland size, shape, echotexture…
- Trial name
- NCT06357494
- Volunteers
- 32 people
- Sponsor
- Assiut University
Hyperthyroidism
The Role of Thyroid Status in Regulating Brown Adipose Tissue Activity, White Adipose Tissue Partitioning and Resting Energy Expenditure
To determine how thyroid status regulates the relationship between brown adipose tissue (BAT) volume/activity, white adipose tissue (WAT) partitioning and basal metabolic rate (BMR) in hyperthyroid patients transitioning to…
- Trial name
- TRIBUTE (NCT03064542)
- Testing
- carbimazole (CMZ) or thiamazole (TMZ)
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation