Clinical trials: Hyperthyroidism/Thyrotoxicosis
Thyrotoxicosis
Therapeutic Plasma Exchange in Thyrotoxicosis
Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of…
- Trial name
- NCT04485975
- Testing
- Therapeutic plasma exchange
- Volunteers
- 27 people
- Sponsor
- Baskent University
Thyrotoxicosis, Hypothyroidism
Biosignals by Wearables in Thyroid Dysfunction
This study is a single center observational study to investigate the association between biosignals from wearables and thyroid dysfunction.
- Trial name
- NCT04806269
- Testing
- Fitbit and Glandy
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
THYROTOXICOSIS
The Association Between Autoimmune or Inflammation and Thyroid Disease
This study aims to evaluate the effects of thyroid functions on energy homeostasis and inflammation.
- Trial name
- NCT02886949
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Taichung Veterans General Hospital
Hyperthyroidism, Graves Disease
AI-Based Wearable Monitoring (Glandy HYPER) for Antithyroid Drug Dose Adjustment in Graves' Disease
Graves' disease is the most common cause of hyperthyroidism and is usually treated with antithyroid drugs such as methimazole (MMI).
- Conditions
- Hyperthyroidism, Graves Disease, Thyrotoxicosis
- Trial name
- NCT07857421
- Testing
- Glandy HYPER (AI-based monitoring software), Methimazole
- Where
- 2 sites in Germany
- Volunteers
- 30 people
- Sponsor
- THYROSCOPE INC.
Thyrotoxicosis
Thiamine Supplement in Patients With Severe Hyperthyroidism
Thyrotoxicosis is a hypermetabolic state in which there is increased utilization of thiamine. Thiamine deficiency has been observed in association with hyperthyroidism.
- Trial name
- NCT02767245
- Testing
- Thiamine
- Where
- Thailand
- Volunteers
- 12 people
- Sponsor
- Ramathibodi Hospital
Hyperthyroidism/Thyrotoxicosis
Clinical Value of Microvascular Ultrasonography in Real-time Differential Diagnosis of Thyrotoxic Patients
This study aims to verify the clinical value of thyroid ultrasound with microvascular flow imaging in thyrotoxic patients for differential diagnosis between hyperthyroidism and thyroiditis.
- Trial name
- NCT04879173
- Testing
- RS85 Ultrasound device
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Dong Jun Lim
Toxic; Thyroid
Preoperative Administration of Lugols Solution in Toxic Thyroid Diseases (TD): A Prospective Study
Lugol's solution and other preparations containing iodide have been used as an adjuvant treatment in patients with toxic disease planned for thyroidectomy.
- Trial name
- NCT06176976
- Testing
- Lugol's iodine solution 5%
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Hyperthyroidism/Thyrotoxicosis
LIthium as Bridging thErapy Prior to Radioactiveiodine in hyperThYroidism
A prospective randomised controlled open label, single centre study. subjects will be randomised into lithium or carbimazole arms in a 1:1 ratio.
- Trial name
- LIBERTY (NCT05512715)
- Testing
- radioactive iodine
- Where
- Malaysia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Thyrotoxic Periodic Paralysis
Genetic Analysis of Thyrotoxic Periodic Paralysis
Thyrotoxic periodic paralysis (TPP) is characterized by episodes of reversible hypokalemia and weakness in thyrotoxic patients. It is commonly found in males of Asian descent and is also seen in individuals having Native American…
- Trial name
- NCT00443833
- Volunteers
- 80 people
- Sponsor
- Ramathibodi Hospital
Graves Disease, Hyperthyroidism/Thyrotoxicosis
Evaluating an AI Tool for Detecting Thyrotoxic States
This observational study aims to evaluate the performance of a software-based medical device, Glandy HYPER, in detecting the thyrotoxic state in patients with hyperthyroidism.
- Trial name
- NCT07017907
- Testing
- Heart rate-based AI software for detecting thyrotoxicosis
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- THYROSCOPE INC.
Thyrotoxicosis
Trial to Evaluate the Efficacy of a Zinc, Selenium, and L-Tyrosine Supplement in the Prevention of Thyrotoxicosis in Subjects With r25191G/A SEPP1 Polymorphism
This randomized, double-blind, placebo-controlled trial evaluates the efficacy of a zinc, selenium, and L-tyrosine supplement in preventing thyrotoxicosis among adults aged 18-85 with elevated TPOAb levels and the r25191G/A SEPP1…
- Trial name
- ZEST-PREP (NCT06264544)
- Testing
- zinc, selenium, and L-tyrosine in SEPP1
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- S.LAB (SOLOWAYS)
Amiodarone-Induced Thyrotoxicosis
Radiofrequency Ablation for Amiodarone-induced Thyrotoxicosis
Investigators intend to study the changes in thyroid hormone storage and production in amiodarone-induced thyrotoxicosis patients after RFA therapy.
- Trial name
- NCT03720210
- Testing
- RFA
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Thyrotoxicosis, Graves Disease
Clinical Application of Pulse Rate-monitoring Activity Trackers in Thyrotoxicosis
The study is a single-center prospective cohort study of clinical application of continuously monitored data by wearable activity trackers in the patients with thyrotoxicosis.
- Conditions
- Thyrotoxicosis, Graves Disease, Thyroiditis
- Trial name
- AT-thyro (NCT03009357)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Bundang Hospital
Hyperthyroidism/Thyrotoxicosis
Clinical Study of Ultrasound-guided Radiofrequency Ablation in the Treatment of Refractory Hyperthyroidism
Hyperthyroidism is an endocrine disease with a high incidence rate, and some patients are difficult to effectively control the condition after long-term drug treatment, and the disease recurs, forming refractory hyperthyroidism.
- Trial name
- NCT06305871
- Testing
- Ablation therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhang Bo
Paediatric Thyrotoxicosis
Antithyroid Drug Treatment of Thyrotoxicosis in Young People
The investigators aim to establish whether biochemical control during anti-thyroid drug therapy in young people with thyrotoxicosis varies depending upon whether a 'block and replace' or 'dose titration' regimen is used.
- Trial name
- NCT01436994
- Testing
- Block and Replace, Dose Titration, carbimazole
- Where
- 18 sites in United Kingdom
- Volunteers
- 81 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Graves Disease, Amiodarone-Induced Thyrotoxicosis
Thyroidectomy for Graves' Disease or Amiodarone-induced Thyrotoxicosis
The goal of this observational study is to learn about the potential differences in morbidity of thyroidectomy (removal of the thyroid gland) depending on the preoperative hormonal status.
- Conditions
- Graves Disease, Amiodarone-Induced Thyrotoxicosis, Thyroidectomy
- Trial name
- GRATES (NCT06963203)
- Where
- 15 sites in Belgium, France and 3 more
- Volunteers
- 486 people
- Sponsor
- Andrea Goldmann
Malignant Neoplasm of Thyroid, Heart Diseases
Thyrotropin Over-suppression and Heart
The investigators evaluated the cardiac effects of Thyroid-stimulating hormone (TSH) over-suppression in women with differentiated thyroid cancer (DTC) frequently encountered during suppression therapy.
- Conditions
- Malignant Neoplasm of Thyroid, Heart Diseases, Thyrotoxicosis on Thyroxine Therapy
- Trial name
- NCT02645786
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Subacute Thyroiditis, SARS CoV 2 Infection
Subacute Thyroiditis in the SARS-CoV-2 Era
Many cases of subacute thyroiditis (SAT) have been described related to SARS-CoV-2 infection, but no prospective data about follow-up is known.
- Conditions
- Subacute Thyroiditis, SARS CoV 2 Infection, Thyrotoxicosis
- Trial name
- SAT-COVID-19 (NCT06391515)
- Testing
- Blood sample, CRF, thyroid ultrasound
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- University of Modena and Reggio Emilia
Hypothyroidism, Hyperthyroidism/Thyrotoxicosis
Evaluation of Different Diagnostic Therapeutic Strategies in Patients with Thyroid Pathology
Observational single-center prospective and retrospective, nonpharmacological, spontaneous cohort study.
- Conditions
- Hypothyroidism, Hyperthyroidism/Thyrotoxicosis, Thyroid Nodule (Benign), Thyroid Carcinoma
- Trial name
- NCT06779747
- Where
- Italy
- Volunteers
- 5,850 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Thyrotoxicosis, Peak Systolic Velocity of Superior Thyroid Artery
Differential Diagnosis of STA-PSV in Thyrotoxicosis
Aim: Graves's disease and thyroiditis can both characterized with thyrotoxicosis, but their clinical outcome and therapy is quiet different.
- Conditions
- Thyrotoxicosis, Peak Systolic Velocity of Superior Thyroid Artery, Thyroiditis, Graves Disease
- Trial name
- NCT01227499
- Where
- China
- Volunteers
- 169 people
- Sponsor
- xiaolong zhao