Clinical trials: Hypertonic Disorder
Asthma
Predicting the Response to Montelukast by Genetic Variation in Asthmatics
The purpose of this study is to examine a specific variation in the genetic code for an enzyme (LTC4 synthase) which plays an important role in the airway inflammation associated with asthma.
- Trial name
- NCT00116324
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Brigham and Women's Hospital
Coronary Heart Disease
Efficacy and Safety of Hypertonic Sodium Lactate Solution Compared With 6% HES Solution in CABG Patients
The choice of fluid therapy is controversial in cardiac surgery. Numerous studies have shown that colloid is better as compared to crystalloids.
- Trial name
- NCT01654653
- Testing
- Hypertonic sodium lactate, 6% Hydroxy Ethyl Starch
- Where
- Indonesia
- Volunteers
- 100 people
- Sponsor
- Innogene Kalbiotech Pte. Ltd
Heart Failure, Renal Disease, Chronic
Outpatient Hypertonic Saline and Loop Diuretic Combination Therapy in Cardiorenal
Congestive heart failure (CHF) remains a major cause of morbidity, rehospitalization, and mortality worldwide, particularly among elderly and polymorbid patients.
- Trial name
- SALT-HF (NCT07596329)
- Testing
- Hypertonic sodium chloride 10%, Sodium Chloride 0.9%, Furosemide intravenous solution
- Volunteers
- 60 people
- Sponsor
- University of Monastir
Cystic Fibrosis Lung Disease
Preventive Inhalation of Hypertonic Saline in Infants With Cystic Fibrosis
The purpose of this study is to assess whether 6% hypertonic saline (HS) is a safe and effective preventive therapy in newborns and infants with cystic fibrosis (CF).
- Trial name
- PRESIS (NCT01619657)
- Testing
- 6% Hypertonic Saline (HS), 4mL, 0.9% Isotonic Saline (IS), 4mL
- Where
- 4 sites in Germany
- Volunteers
- 42 people
- Sponsor
- Heidelberg University
Knee Osteoarthritis
Effects of Short Wave Diathermy Added on Dextrose Prolotherapy Injections in Osteoarthritis of the Knee
Goal: To show the effects of short wave diathermy added on prolotherapy injections in osteoarthritis of the knee on pain, physical functioning and quality of life.
- Trial name
- NCT03931811
- Testing
- Short wave diathermy, Prolotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Ege University
Bronchiolitis
Saline vs Hypertonic Serum With Respiratory Physiotherapy in a Recurrent Wheezing Patient
Bronchiolitis (BQ) is an acute viral infection of the lower respiratory tract that affects the bronchioles of babies younger than 24 months of age.
- Trial name
- NCT04331496
- Testing
- Hypertonic solution, Physiological solution
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Guadarrama Hospital
Cystic Fibrosis
A Study of Lung Clearance After Hypertonic Saline Delivery Using the tPAD Device
The primary objective of this study is to determine whether a single overnight, eight-hour administration of a 7% NaCl solution delivered by the Parion Sciences transnasal Pulmonary Aerosol Delivery (tPAD) device has a…
- Trial name
- NCT02141191
- Testing
- inhaled hypertonic saline (7%)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury, Elevated Intracranial Pressure
Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure
This study examines the role of osmotic agents in controlling brain swelling in brain injured individuals. Two osmotic agents -- mannitol and hypertonic saline -- are in common use, and they will be compared in the context of a…
- Trial name
- NCT01111682
- Testing
- Mannitol, Hypertonic Saline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Cincinnati
Frozen Shoulder
Hypertonic Dextrose Injection and Physical Therapy for Frozen Shoulder
The aim of our study is to investigate whether the combination of hypertonic dextrose injection and shoulder joint hydrodilation, in conjunction with physical therapy, can effectively enhance shoulder joint pain relief, improve…
- Trial name
- NCT06165926
- Testing
- 15% hypertonic dextrose, Normal saline, physical therapy
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Intracranial Hypertension
Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure
The purpose of this study is to determine whether mannitol is as effective as hypertonic saline solution in the treatment of elevated intracranial pressure in patients with brain injury.
- Trial name
- NCT00447018
- Testing
- 20% mannitol, 7.45% hypertonic saline solution
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Grenoble
Bronchiectasis
Sputum Clearance Effects of Hypertonic Saline in Non-cystic Fibrosis Bronchiectasis
This study aims to analyze whether the hypertonic saline nebulization enhances sputum clearance effects, reduces the impact on cough severity and their level of safety and tolerability in a population with non-cystic fibrosis…
- Trial name
- NCT02392663
- Testing
- Hypertonic saline solution, Hyaneb solution, Isotonic saline solution
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Hospital Clinic of Barcelona
Bronchiolitis
Inhaled Hypertonic Saline Use in the Emergency Department to Treat Acute Viral Bronchiolitis
Acute viral bronchiolitis is an extremely common childhood disease, responsible for approximately 17% of childhood admissions to hospital per year, with an annually cost that reaches U$ 500 million.
- Trial name
- NCT02045238
- Testing
- Hypertonic Saline, Chest X-Ray, Respiratory virus screening test
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- University of Sao Paulo
Cystic Fibrosis
Durability of Hypertonic Saline for Enhancing Mucociliary Clearance in Cystic Fibrosis
Direct measurement of mucociliary and cough clearance (MCC/CC) has been used as a biomarker in cystic fibrosis (CF). Additional knowledge of the performance of this biomarker is needed to inform exploratory clinical trial design…
- Trial name
- NCT01094704
- Testing
- sodium chloride (7%)
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of North Carolina, Chapel Hill
Stage IB Melanoma, Stage IIA Melanoma
Sargramostim or Hypertonic Saline Before Sentinel Lymph Node Biopsy in Treating Patients With Stage IB-II Melanoma
This randomized phase III trial studies sargramostim before sentinel lymph node biopsy to see how well it works compared to hypertonic saline before sentinel lymph node biopsy in treating patients with melanoma.
- Conditions
- Stage IB Melanoma, Stage IIA Melanoma, Stage IIB Melanoma, Stage IIC Melanoma
- Trial name
- NCT01826864
- Testing
- sargramostim, sentinel lymph node biopsy, laboratory biomarker analysis
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
TBI Traumatic Brain Injury
Efficacy of Early Continuous Infusion of HSS on the Neurological Outcome at 6 Months in TBI Patients.
The purpose of this study is to demonstrate the efficacy of early continuous intravenous infusion of hypertonic saline solution (HSS) to improve survival and independence in daily life activities (at 6 months) of patients with…
- Trial name
- COSMOS-TBI (NCT07319208)
- Testing
- Hypertonic saline solution
- Where
- 23 sites in France
- Volunteers
- 760 people
- Sponsor
- Nantes University Hospital
Asthma, Cough
Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol
The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal…
- Conditions
- Asthma, Cough, Cough Variant Asthma
- Trial name
- NCT03105843
- Testing
- Methacholine (MCh) Challenge Testing, Eucapneic Voluntary Hyperventilation (EVH), Mannitol Inhalation Kit
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Dr. Diane Lougheed
Cystic Fibrosis
Hypertonic Saline and Mucociliary Clearance in Children
Previously, the investigators and others have shown that mucociliary clearance (MCC) is defective in patients with cystic fibrosis (CF) and it is now thought that alterations in airway mucus rheology figure prominently in the…
- Trial name
- NCT01293084
- Testing
- 0.12% saline, 7% saline
- Volunteers
- 17 people
- Sponsor
- Johns Hopkins University
Corneal Edema
Efficacy and Tolerance of Hypertonic Sodium Chloride (NaCl 5%) Eye Drops Without Preservatives in Corneal Edema
Corneal edema is frequently found in clinical practice as a common sign of acute corneal disease due to different etiologies that cause an accumulation of extracellular fluid in the cornea.
- Trial name
- NCT04125394
- Testing
- hypertonic Sodium chloride (NaCl 5%) eye drops solution in single-dose
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Tiedra Farmacéutica SL
Hyponatremia Symptomatic
Efficacy and Safety of Rapid Intermittent Compared With Slow Continuous Correction in Severe Hyponatremia Patients
This study will investigate efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patient with moderately severe or severe symptomatic severe hyponatremia
- Trial name
- NCT02887469
- Testing
- 3% hypertonic saline
- Where
- 3 sites in South Korea
- Volunteers
- 178 people
- Sponsor
- Seoul National University Hospital
Bronchiolitis
Efficacy and Safety of 3% Hypertonic Saline Inhalation (24h vs 72h) to Treat Acute Bronchiolitis in Hospitalized Infants
Efficacy/Safety of 3% hypertonic saline inhalation (24H vs 72H) to treat acute bronchiolitis in infants.
- Trial name
- BRONDUSAL (NCT02538458)
- Testing
- 3 % hypertonic saline up to 72H, 3 % hypertonic saline up to 24H
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble