Clinical trials: Hypertonic Disorder
Bronchiectasis
Randomised Open Label Trial of Hypertonic Saline and Carbocisteine in Bronchiectasis (CLEAR)
Patients with bronchiectasis (BE) suffer from a persistent cough, daily sputum expectoration, recurrent chest infections, and a poor health-related quality of life.
- Trial name
- CLEAR (NCT04140214)
- Testing
- Hypertonic saline, Carbocysteine 750 MG
- Where
- 20 sites in United Kingdom
- Volunteers
- 288 people
- Sponsor
- Belfast Health and Social Care Trust
Bronchiectasis
Trial on The Efficacy of Hypertonic Saline on Non-CF CSLD.
To determine the efficacy of nebulized 5% hypertonic saline on cough severity and quality of life, in children with non-CF CSLD. Secondary Aims: To determine the: 1.
- Trial name
- NCT04765033
- Testing
- Nebulized 5% Hypertonic saline
- Where
- Malaysia
- Volunteers
- 46 people
- Sponsor
- University of Malaya
Septic Shock, Adult Respiratory Distress Syndrome
Hyperoxia and Hypertonic Saline in Septic Shock
Assessment of the effect of hyperoxia and hypertonic saline on survival in patients with septic shock Hyperoxia and hypertonic saline may have beneficial effects on organ perfusion and oxygenation and may reduce the organ failure…
- Trial name
- Hyper2S (NCT01722422)
- Testing
- oxygen and saline
- Where
- France
- Volunteers
- 441 people
- Sponsor
- University Hospital, Angers
Acute Lung Injury, Adult Respiratory Distress Syndrome
Clinical Trial of Nebulized Hypertonic Saline to Attenuate Post-Traumatic Acute Lung Injury
This study evaluates the use of nebulized hypertonic saline (aerosolized salt water) as a preventive treatment for post-traumatic acute lung injury (ALI).
- Trial name
- NCT01667666
- Testing
- Nebulized hypertonic saline
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Denver Health and Hospital Authority
Dengue Shock Syndrome
Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS)
Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are among the leading causes of pediatric hospitalization in Asia.Mortality rates range from 1% at centres experienced in fluid resuscitation, to upto 44% in…
- Trial name
- NCT00966628
- Testing
- Hypertonic sodium lactate, Ringer's lactate
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Innogene Kalbiotech Pte. Ltd
Cystic Fibrosis
A Randomized-Controlled Trial of Inhaled Hypertonic Saline (7%) to Evaluate the Lung Clearance Index
The Lung Clearance Index (LCI) is a non invasive measure of lung function that is more sensitive than FEV1. It can be used to measure lung function in children younger than 6 years of age.
- Trial name
- NCT02276898
- Testing
- Hypertonic Saline 7%
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- The Hospital for Sick Children
Asthma (Diagnosis), Airway Inflammation
Can Astaxanthin Help Manage Asthma in POlluted Areas?
This study will test whether astaxanthin, a naturally occurring antioxidant supplement, can improve lung function, reduce airway inflammation, and improve asthma control in adults with mild-to-moderate asthma.
- Conditions
- Asthma (Diagnosis), Airway Inflammation, Airway Hyperresponsiveness
- Trial name
- NCT07507682
- Testing
- Astaxanthin Oral Capsule
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Middlesex University
Moderate to Severe Bronchiolitis
Moderate to Severe Bronchiolitis: Standard Therapy Versus Therapy With NaCl 3% Inhalations
Our study will investigate inhalation therapy of NaCl 3% compared to standard therapy with no inhalation in the treatment of moderate to severe bronchiolitis. The impact on length of hospital stay will be analyzed.
- Trial name
- NCT01812525
- Testing
- NaCl 3%, Standard therapy
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Raphaelle Jaquet-Pilloud
Brain Injuries, Disorder of Consciousness
Long Term Effects of Soft Splints on Stroke Patients and Patients With Disorders of Consciousness
The purpose of this study is to assess the effects on upper limb spasticity of soft splints worn during three weeks three hours a day by patients with stroke or disorders of consciousness.
- Conditions
- Brain Injuries, Disorder of Consciousness, Stroke, Spasticity as Sequela of Stroke
- Trial name
- NCT03008486
- Testing
- Real soft splint (6 cm)
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Géraldine Martens
Acute Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
The Feasibility of Pulmonary Perfusion Assessment Using Sodium Bicarbonate Contrast With Electrical Impedance Tomography: A Prospective Pilot Study
The goal of this observational pilot study is to learn if sodium bicarbonate can be used safely and effectively as a contrast agent to map lung blood flow using electrical impedance tomography (EIT) in adults on mechanical…
- Conditions
- Acute Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Pneumonia, Critical Illness
- Trial name
- NCT07542366
- Where
- China
- Volunteers
- 41 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Bronchiolitis
Nebulised 3% Hypertonic Saline Versus 0.9% Saline for Treating Patients Hospitalized With Acute Bronchiolitis
Bronchiolitis is an acute viral infection of the lower respiratory tract. It is most commonly caused by respiratory syncytial virus (RSV).
- Trial name
- NCT06069336
- Testing
- Hypertonic saline, Normal saline
- Where
- 3 sites in Poland
- Volunteers
- 180 people
- Sponsor
- Szpital im. Św. Jadwigi Śląskiej
Allergic Rhinitis, URTI
PMCF to Assess Real-life Usage Effectiveness, Safety and Patient Satisfaction of a Range of Hypertonic Seawater-based Decongestant Nasal Sprays
The brief of this observational study is to evaluate usage, efficacy, safety and patient satisfaction of a range of hypertonic seawater-based decongestant nasal sprays in general population.
- Trial name
- NCT06104332
- Testing
- ProRhinel Naturel spray nasal/ Allergic rhinitis, ProRhinel EXTRA Eucalyptus spray nasal, RESPIMER Enfant
- Where
- 2 sites in France
- Volunteers
- 534 people
- Sponsor
- Laboratoire de la Mer
Low Cardiac Output
The Efficacy of Hypertonic Lactate Solution in CABG(Coronary Artery Bypass Grafting) Patients
Previous clinical trials with 11.2% Hypertonic Ringer's Lactate in post-operative CABG subjects have shown an increase in several cardiac performance parameters, with lesser volume of resuscitation fluid required to reach…
- Trial name
- NCT00529711
- Testing
- Hypertonic lactate, Ringer's lactate
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Innogene Kalbiotech Pte. Ltd
Bronchiolitis, Wheezing
Nebulized 3% Hypertonic Saline Solution Treatment of Bronchiolitis in Infants
Determine the efficacy of nebulized salbutamol/hypertonic saline combination in moderate to severe bronchiolitis.
- Trial name
- NCT02233985
- Testing
- 0.9% Sodium Chloride, 3% Sodium Chloride
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Otorhinolaryngologic Diseases, Rhinosinusitis
Type and Frequency of Nasal Irrigation in Rhinosinusitis Patients
Rhinosinusitis is a common clinical problem with significant morbidity which alters patients' quality of life that has its effect on 1 out of 7 adults.
- Trial name
- NCT04213508
- Testing
- Isotonic Saline ( 0.9% Sodium Chloride Saline), Hypertonic Saline ( 3% Sodium Chloride Saline)
- Where
- Saudi Arabia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Bronchiolitis
Efficacy of Nebulized Hypertonic Saline in the Treatment of Acute Bronchiolitis
The purpose of this study is to evaluate the efficacy of hypertonic saline vs. normal saline in the treatment of infants hospitalized for bronchiolitis, regarding length of hospital stay, oxygen requirements and clinical outcome.
- Trial name
- Hypertonic (NCT01238848)
- Testing
- Hypertonic saline, Normal saline
- Where
- Argentina
- Volunteers
- 82 people
- Sponsor
- Hospital General de Niños Pedro de Elizalde
Acute Decompensated Heart Failure
Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure
Acute decompensated heart failure (HF) is one of the most common cardiologic issues in emergency departments. Loop diuretics have long been recognized as the key for the treatment of Acute Decompensated Heart Failure…
- Trial name
- HSS (NCT05298098)
- Testing
- Hypertonic Saline Solution
- Where
- Tunisia
- Volunteers
- 600 people
- Sponsor
- University of Monastir
Cystic Fibrosis
Tolerability of Hypertonic Saline in Infants With Cystic Fibrosis
The objective of the study is to determine whether or not inhalation of hypertonic saline will be tolerated by infants with cystic fibrosis and the effect of inhalation on their lung function.
- Trial name
- NCT00753987
- Testing
- Hypertonic Saline
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- The Hospital for Sick Children
Bronchiolitis
Safety of Airway Clearance in Non-hospitalized Infants With Acute Viral Bronchiolitis
Bronchiolitis is a disease that can occur in a mild form and moderate, and often does not require hospitalization. The technique of prolonged slow expiration followed by cough caused in children not hospitalized with mild and…
- Trial name
- NCT03835858
- Testing
- Respiratory physiotherapy
- Where
- Spain
- Volunteers
- 265 people
- Sponsor
- Guadarrama Hospital
Endotracheal Tube, Tracheostomy
Safety of Mechanical Insufflation-exsufflation and Hypertonic Saline
Conventional catheter suctioning of respiratory tract secretions is a mandatory procedure in intubated patients. Poor tolerance, pain and other, sometimes severe, lung and cardiovascular complications may occur during suctioning.
- Trial name
- SMASH (NCT03940118)
- Testing
- Catheter secretion suctioning, Secretion suctioning + hypertonic saline, Ins-exsufflation
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital San Carlos, Madrid