Clinical trials: Hypertonic Disorder
Low Cardiac Output
Efficacy, Safety of Hypertonic Lactate Soln. as Fluid Resuscitation Compared With Ringer's Lactate in Post-CABG Pats
Prospective, randomized, open-label study to assess the efficacy and safety of hypertonic lactate solution, compared to Ringer's Lactate as fluid resuscitation to maintain hemodynamic stability in post-coronary artery bypass…
- Trial name
- NCT00529490
- Testing
- Hypertonic lactate, Ringer's lactate
- Where
- Indonesia
- Volunteers
- 230 people
- Sponsor
- Innogene Kalbiotech Pte. Ltd
Bronchiectasis, Non-cystic Fibrosis Bronchiectasis
Hypertonic Saline in NCFB
The purpose of this single arm clinical trial is to evaluate the effects of 7% hypertonic saline (HS) delivered by nebulizer on clearance of mucus from the lungs in people with bronchiectasis (dilated airways) not due to cystic…
- Trial name
- NCT06242795
- Testing
- 7% Hypertonic Saline via nebulization
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
Hemorrhagic Shock, Traumatic Brain Injury
Hypertonic Modulation of Inflammation Following Injury
This project seeks to determine the effect of prehospital resuscitation with hypertonic saline vs. conventional crystalloids on the inflammatory response after injury.
- Trial name
- NCT00750997
- Testing
- hypertonic saline
- Where
- 2 sites in United States, Canada
- Volunteers
- 119 people
- Sponsor
- University of Washington
Cardiovascular Diseases, Valvular Heart Disease
Hypertonic Saline for Fluid Resuscitation After Cardiac Surgery
Background: Volume replacement strategies and type of fluid used in patients undergoing cardiac surgery have changed during the last years.
- Trial name
- HERACLES (NCT03280745)
- Testing
- Hypertonic saline, 0.9% saline
- Where
- Switzerland
- Volunteers
- 165 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cystic Fibrosis
Utility of Induced Sputum Using Hypertonic Saline to Evaluate Infection and Inflammation in Cystic Fibrosis
The objective of the study is to evaluate the clinical utility and the feasibility, in an outpatient setting, of sputum induction using hypertonic saline.
- Trial name
- NCT00721071
- Testing
- Hypertonic Saline
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- The Hospital for Sick Children
Heart Failure，Congestive
Effects of Furosemide Plus Small HSS in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF)
The investigators sought to evaluate the effectiveness of treatment with furosemide + HSS in terms of reduction of serum levels of some chosen markers of heart failure and the response in terms of these markers at a compensated…
- Trial name
- NCT04628325
- Testing
- Furosemide
- Where
- 2 sites in Italy
- Volunteers
- 136 people
- Sponsor
- University of Palermo
Head Injury, Minor, Pediatric
Hypertonic Saline for Mild TBI in Pediatric Patients
The purpose of this study is to compare two different treatments (normal saline and hypertonic saline) for concussions to see if one makes more of a difference in symptoms that can occur following concussions.
- Conditions
- Head Injury, Minor, Pediatric, Emergency Department Patient
- Trial name
- NCT07060105
- Testing
- Hypertonic Saline ( 3% Sodium Chloride Saline), Normal Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Texas at Austin
Bronchiolitis
The Use of an Inhaled Salt Solution to Treat Viral Lung Infections in Infants.
Bronchiolitis is a common viral lung infection in infants. Standard treatment often includes the use of inhaled medications which are usually first mixed with a standard salt solution.
- Trial name
- NCT00151905
- Testing
- 3 % hypertonic saline
- Where
- 3 sites in Canada, United Arab Emirates
- Sponsor
- Sheikh Khalifa Medical City
Gastro Intestinal Bleeding
The Role of Hypertonic Dextrose Spray as Endoscopic Topical Hemostatic Agent for Acute Non-Variceal Upper GI Bleeding
This study is conducted to evaluate the effectivity of hypertonic dextrose spray as an endoscopic topical hemostatic agent, compared to conventional agent (adrenaline injection, followed by hemoclip or thermocoagulation), in…
- Trial name
- NCT04979273
- Testing
- Dextrose 40 % in Water, Adrenaline 1 Mg/mL Solution for Injection, argon plasma coagulation
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Essential Hypertension and Healthy Controls
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Essential Hypertension
The aim of the study is to test the following hypotheses: that the function and/or regulation of AQP2 and/or ENaC in the principal cells is abnormal in essential hypertension.
- Trial name
- NCT00345124
- Testing
- high sodium diet, Low Sodium Diet
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Postoperative Cardiorespiratory Failure
Hypertonic Saline-hetastarch in Cardiac Surgery
Cardiopulmonary bypass(CPB) is associated with increased fluid extravasation and edema formation. A continuous infusion of a mixture of hypertonic saline/hydroxyethyl starch (HSH)during CPB reduced fluid extravasation and total…
- Trial name
- HH (NCT00469716)
- Testing
- Hypertonic saline (7.2%) hetastarch (6 %)(200/0.5)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Obesity
Water Deprivation Protocol
Background: One area in which obese and lean individuals may be different is how their bodies handle water balance and thirst. Studies done in animals suggest that individuals with greater body fat may tolerate periods without…
- Trial name
- NCT01224704
- Testing
- Hypertonic saline infusion, Water deprivation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Allergic Rhinitis
Effects of Hypertonic Saline Solution (NACL 3%+NAHCO3) on Nasal Inflammation in Children With AR. RinASol- Pilot Study
The main objective of RinASol project is to assess in patients with seasonal Allergic Rhinitis the effect of hypertonic saline solution NACL 3%+NAHCO3 vs the effect of standard saline solution on nasal inflammation by means of…
- Trial name
- RinASol (NCT02729012)
- Testing
- hypertonic saline solution (NACL 3%+NAHCO3), Saline Solution (NACL 0,9%)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Stefania La Grutta, MD
Hypoosmolality, Hyperosmolality
Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion
The are 2 principal goals in this study: 1. To measure plasma copeptin levels in healthy subjects and to correlate them with plasma AVP concentrations and urine osmolalities in iso-, hypo-, and hyperosmolar states. 2.
- Conditions
- Hypoosmolality, Hyperosmolality, Renal Failure
- Trial name
- NCT00696605
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Centre Biel/Bienne
Kidney Stones
Acoustic Impedance Matching in ESWL Coupling
The purpose of this study is to investigate the effect of different salt concentrations (tonicity) in the coupling fluid used during Extracorporeal Shock Wave Lithotripsy (ESWL).
- Trial name
- NCT07585435
- Testing
- Hypotonic degassed water coupling, Isotonic (0.9% NaCl) coupling, Hypertonic (3% NaCl) coupling
- Where
- Turkey (Türkiye)
- Volunteers
- 294 people
- Sponsor
- Konya City Hospital
Sinusitis
Effect of Squeezable Bottle Nasal Irrigation Device in Children With Sinusitis
The purpose of this study is to the effect of squeezable bottle nasal irrigation device with syringe in children with sinusitis in symptom score and satisfaction to nasal irrigation
- Trial name
- NCT02191046
- Testing
- squeezable bottle, syringe 20 ml
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Bronchiectasis
Hypertonic Saline (6%) Versus Isotonic Saline (0.9%) in Bronchiectasis
The investigators hypothesise that nebulised hypertonic saline (6%) will increase the volume of sputum expectorated over a 24 hour period compared to nebulised isotonic saline (0.9%) in patients with mild to severe stable…
- Trial name
- NCT01112410
- Testing
- Hypertonic saline, Isotonic saline
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Belfast Health and Social Care Trust
Brain Concussion, Post-Concussion Symptoms
Use of Salt-Water Solution to Improve Symptoms in Concussion
The purpose of this study is to find out if 3% hypertonic saline (salt-water solution) given in a vein improves the headache that may be caused by a concussion.
- Trial name
- NCT00142090
- Testing
- 3% Hypertonic saline
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rady Children's Hospital, San Diego
Chronic Obstructive Pulmonary Disease, COPD
Sustained Effects of Hypertonic Saline on Mucociliary Clearance in Subjects With Chronic Bronchitis
The purpose of this research study is to examine the effects of two weeks of daily dosing of inhaled salt water mist (hypertonic saline - HS) on actual measurements of mucociliary and cough clearance in patients with the chronic…
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Chronic Bronchitis
- Trial name
- NCT01792271
- Testing
- Inhaled 7% HS (NaCl) home treatment
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Cerebral Edema, Saline Solution, Hypertonic
Small-Volume, Patient-Specific, Balanced Hypertonic Fluid Protocol Validation
Many patients with traumatic brain injuries (including strokes, blood clots, or other brain injuries) are given concentrated salt water solutions (hypertonic saline) in order to treat brain swelling (cerebral edema).
- Trial name
- NCT03330704
- Testing
- 3% Sodium Chloride, 23.4% Sodium Chloride, 8.4% Sodium Bicarbonate
- Where
- United States
- Sponsor
- Stanford University