Clinical trials: Hypertonic Disorder
Heart Failure
Hypertonic Saline Therapy in Ambulatory Heart Failure Unit.
The purpose of this study is to compare intravenous furosemide (125 to 250 mg), isolated or in combination with hypertonic saline solution (2.6% to 3.4%) in the outpatient heart failure patient.
- Trial name
- NCT04533997
- Testing
- Hypertonic saline solution plus intravenous furosemide, Intravenous furosemide
- Where
- 14 sites in Spain
- Volunteers
- 167 people
- Sponsor
- Puerta de Hierro University Hospital
Heart Failure Acute, Diabetes Type 2
SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF
The purpose of the current investigation is to demonstrate the efficacy of high-dose furosemide plus small-volume hypertonic saline solution and a Sodium-Glucose cotransporter-2 (SGLT-2) inhibitor among patients admitted for…
- Conditions
- Heart Failure Acute, Diabetes Type 2, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
- Trial name
- DAPA-TONIC (NCT06442280)
- Testing
- Dapagliflozin tablet, Hypertonic Saline Solution, 1 Ml, Furosemide Injection
- Volunteers
- 544 people
- Sponsor
- University of Palermo
Gastric Varices
N-butyl-2-cyanoacrylate, Iso-amyl-2-cyanoacrylate and Hypertonic Glucose With 72% Chromated Glycerin in Gastric Varices
AIM: To compare between n-butyl-2-cyanoacrylate, iso-amyl-2-cyanoacrylate and mixture of 72% chromated glycerin with hypertonic glucose solution in management of gastric varices.
- Trial name
- NCT02330731
- Testing
- injection sclerotherapy for gastric varices
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Subarachnoid Hemorrhage, Acute Kidney Injury
A Low ChloridE hyperTonic Solution for Brain Edema
This pilot study will compare the two hypertonic solutions currently used for subarachnoid hemorrhage (SAH) - related complications and to determine if the reduction of chloride load is safer, and as efficacious as the classic…
- Trial name
- ACETATE (NCT03204955)
- Testing
- Sodium chloride /sodium acetate (16.4%), Sodium chloride (23.4%), PlasmaLyte
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Emory University
Cystic Fibrosis
Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Cystic Fibrosis (CF) Subjects
Cystic fibrosis (CF) lung disease is characterized by chronic bacterial colonization and recurrent infection of the airways. Lowering the airway surface liquid (ASL) salt concentration has been shown to increase activity of salt…
- Trial name
- NCT00928135
- Testing
- Xylitol, Hypertonic saline
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Joseph Zabner
Transurethral Resection of Prostate Syndrome
Prophylaxis Versus Treatment for TURP Syndrome.
This study is designed to investigate the usage \& effects of prophylactic HS preloading, with two different concentrations, to combat the expected dilutional hyponatremia induced by irrigating fluid absorption and to prevent the…
- Trial name
- NCT03428451
- Testing
- NaCl 3% HS, NaCl 0.9% NS
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ahmed Mohamed ELbadawy
Bronchiolitis
A Study of Hypertonic Saline for Infants Hospitalized With Bronchiolitis
The purpose of this study is to determine if nebulized hypertonic saline (or extra salty water mist) helps infants less than 12 months old hospitalized with bronchiolitis (or bad chest colds) get better enough to be discharged…
- Trial name
- NCT01488448
- Testing
- 3% sodium chloride, 0.9% sodium chloride
- Where
- United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Acute Bronchiolitis
Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis
This is a randomized, double-blind, controlled trial in the Pediatric Emergency Department. The primary objective is to determine whether nebulized 3% hypertonic saline is more effective than nebulized 0.9% saline in the…
- Trial name
- NCT02029040
- Testing
- 3% Hypertonic Saline, 0.9 % normal saline
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Texas Southwestern Medical Center
Temporomandibular Joint Disorders, Temporomandibular Disorder
Role of Liquid Phase Concentrated Growth Factors vs. Hypertonic Dextrose Prolotherapy for Management of Patients With Disc Displacement Without Reduction
Purpose of the study is to compare clinically, radiographically and biochemically the effect of intra- articular injection of hypertonic dextrose with a stabilization appliance and the intra- articular injection of 2 ml of liquid…
- Trial name
- NCT04557878
- Testing
- Hypertonic Dextrose Solution, Liquid Phase Concentrated Growth Factor (LPCGFs)
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Nourhan M.Aly
Acute Bronchiolitis
Nebulised 3% Hypertonic Saline in Infants With Acute Bronchiolitis
This study aims to determine the efficacy of nebulising 3% hypertonic saline in improving clinical symptoms and reducing the length of hospital stay in infants with acute bronchiolitis.
- Trial name
- NCT06558461
- Testing
- 3% Sodium Chloride, Standard care
- Where
- Vietnam
- Volunteers
- 140 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
Bronchiectasis, Airway Clearance Impairment
Is a Single Daily Session Combining HS + Physio Sufficient to Obtain Long-term Clinical Benefits in Bronchiectasis?
The present study will aim to find out whether a home treatment in people with bronchiectasis consisting of a single daily session to facilitate expectoration (combining nebulization of hypertonic saline (HS) at 6% followed by…
- Trial name
- NCT04905992
- Testing
- Hypertonic saline at 6%, Airway clearance techniques (oscillating positive expiratory pressure therapy)
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Clínico Universitario Lozano Blesa
Cystic Fibrosis
Comparison of the Tolerability of Two Formulations of Hypertonic Saline in Cystic Fibrosis Patients
The purpose of this study is to compare the tolerability and acceptability of a formulation containing Hypertonic saline 7% (HS) alone and a formulation containing HS and Hyaluronic acid 0.1% in a population of Cystic Fibrosis…
- Trial name
- NCT01658449
- Testing
- Inhalable Hypertonic saline 7% + Hyaluronan 0.1%, Inhalable Hypertonic saline 7%
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale Civile Ca' Foncello
Heart Failure, Renal Failure
Hypertonic Saline Solution in Heart Failure
Patients with decompensated heart failure have high rates of mortality and morbidity despite recent improvements in diagnosis and treatment.
- Conditions
- Heart Failure, Renal Failure, Hyponatremia
- Trial name
- NCT00555685
- Testing
- NaCl 7,5% (Hypertonic Saline Solution), NaCl 0,9%
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo
Heart Failure
Sodium Management in Acute and Chronic Heart Failure
The study was aimed to verify the effects of Hypertonic saline solution (HSS) and a moderate sodium (Na) restriction plus high furosemide dose in the short term (hospitalization time) and a moderate Na restriction in the long…
- Trial name
- SMAC-HF (NCT01156337)
- Where
- Italy
- Sponsor
- Ospedale G. F. Ingrassia
Intracranial Hypertension, Cerebral Edema
Coagulation Activation by Hyperosmolar Agents in Intracranial Hypertension
Osmotherapy consists in the therapeutic use of osmotically active substances with the aim of reducing the volume and therefore the intracranial pressure.
- Trial name
- NCT03409237
- Testing
- Mannitol, Hypertonic saline solution
- Where
- Italy
- Sponsor
- Neuromed IRCCS
Bronchiolitis
The Effectiveness of Nebulized Hypertonic Saline Solution for Acute Bronchiolitis
This study evaluates the effectiveness of nebulized 3% hypertonic saline solution with salbutamol in the treatment of children under 2 years, hospitalised for acute viral bronchiolitis.
- Trial name
- NHSAB (NCT02760719)
- Testing
- nebulized 3% hypertonic solution
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Bronchiolitis
Epinephrine, Dexamethasone and Hypertonic Saline in Bronchiolitis
Bronchiolitis is one of the main reasons for consultation in primary care and emergency services, as well as the leading cause of hospitalization for lower respiratory tract infection in children under two years.
- Trial name
- NCT02585531
- Testing
- Hypertonic Saline 3%, Epinephrine and Dexamethasone
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Hospital General Naval de Alta Especialidad - Escuela Medico Naval
Traumatic Brain Injury, Intracranial Hypertension
Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients
This is a clinical study comparing the physiologic effects of two hypertonic solutions (mannitol, hypertonic saline) with a particular emphasis on changes in cerebral blood flow in patients with intracranial hypertension…
- Trial name
- NCT00125229
- Testing
- Mannitol, Hypertonic Saline
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Nephropathy
Effect of Hypertonic Sodium Chloride on Urinary Biomarkers in Healthy Subjects and Patients With Chronic Kidney Disease
Patients with chronic kidney disease (CKD) have a defect in the tubular reabsorption of sodium, and therefore the ability to excrete a sodium load is diminished compared to healthy subjects.
- Trial name
- CASE (NCT01623661)
- Testing
- hypertonic saline
- Where
- Denmark
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Varicose Veins
Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins
It will be done a randomized triple-blind study comparing 0,2% polidocanol versus 75% hypertonic glucose of sclerotherapy in lower limbs´ reticular veins.
- Trial name
- NCT02054325
- Testing
- Polidocanol with Glucose, Glucose
- Where
- Brazil
- Volunteers
- 106 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp