Clinical trials: Hypertriglyceridaemia
Hypertriglyceridemia
Effect of Consuming n-3 Polyunsaturated Fatty Acids Rich Foods on Triglyceride Concentration and Lipoprotein Composition
Hypertriglyceridemia is one of the most prevalent lipid profile disorders and is linked to a large proportion of mortality in Mexico and around the world.
- Trial name
- SALVIMEX (NCT07004777)
- Testing
- Isocaloric diet including chia and pumpkin seeds, Isocaloric diet
- Where
- Mexico
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Hypertriglyceridemia
The Effect of Multiple Doses of Epanova® on the Multiple-Dose Pharmacokinetics of Simvastatin in Healthy Normal Subjects
The primary objective is to determine the effect of multiple doses of Epanova® (omega fatty acids) on the pharmacokinetics (PK) of multiple 40 mg doses of simvastatin.
- Trial name
- NCT01486433
- Testing
- Simvastatin, acetylsalicylic acid (ASA), omefas
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hypertriglyceridemia
Bioavailability of EPA and DHA From Two Dietary Supplements
The primary objective of this study is to test the effects of two different fish oil products containing DHA and EPA by comparing the omega-3 fatty acid levels in the blood.
- Trial name
- NCT01908374
- Testing
- DHA-rich fish oil versus Phospholipid-rich fish oil
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Arctic Nutrition AS
Hypertriglyceridemia
Regulation of Sterol Homeostasis
The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol.
- Trial name
- NCT00018720
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Hyperlipemia, Carbohydrate Inducible
Milk as a Recovery Beverage After Exercise for Improving Metabolic Health
Fasting blood fat levels (triglycerides) are often used to assess risk of heart disease but the level of fats in the blood after a meal is actually a stronger risk factor.
- Trial name
- NCT03154216
- Testing
- Exercise, Drink
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Gut Microbiota, Hyperglycemia
Sustainable-psycho-nutritional Intervention Program and Its Effects on Health Outcomes and the Environment
Mexico is going through a major environmental and nutritional crisis, which is related to unsustainable dietary behaviors. Sustainable diets could solve both problems together.
- Conditions
- Gut Microbiota, Hyperglycemia, Hypercholesterolemia, HDLC
- Trial name
- NCT05457439
- Testing
- Sustainable diet promotion through behavioral change intervention
- Where
- Mexico
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Waist, Hypertriglyceridemic
Dietary Incorporation of Lentils to Improve Metabolic Health
Approximately 40% of Americans are pre-diabetic or diabetic, mostly in the form of type 2 diabetes (T2D), which is heavily influenced by diet.
- Trial name
- NCT04448067
- Testing
- Dietary Lentil Intake, No Dietary Lentil CONTROL
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Montana State University
Hypertriglyceridemia
Effects Of Consumption Of A Highly Mineralized Sodium Bicarbonated Water On Blood Lipid Profile
The aim of the study is to assess the beneficial effect of the short term consumption of the highly mineralized bicarbonated sodium water on blood lipid parameters compared to a low mineralized water.
- Trial name
- NCT01819636
- Testing
- sparkling highly mineral bicarbonated sodium water
- Where
- 3 sites in France
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Neptune
Hypertriglyceridemia
A Study of LY3875383 in Healthy Participants and Participants With Hypertriglyceridemia
The main purpose of this study is to determine the tolerability and side effects related to LY3875383 given as a single injection under the skin to healthy participants and participants with elevated triglyceride (TG) levels.The…
- Trial name
- NCT05609825
- Testing
- LY3875383
- Where
- Singapore
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Hypertriglyceridemia
Postprandial Lipid Metabolism in Patients With Hypertriglyceridemia and Normo-lipidemic Controls: Medium Chain Fatty Acids (MCT) in Comparison to Long-chain, Saturated Fatty Acids (SFA) and Mono-unsaturated Fatty Acids (MUFA)
Postprandial lipid metabolism will be evaluated in patients with hypertriglyceridemia and normo-lipidemic controls; different fats will be used (saturated fatty acids, mon-unsaturated fatty acids and medium chain fatty acids) for…
- Trial name
- NCT03846908
- Testing
- MCT, SFA, MUFA
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Hyperlipemia
Effect of Consumption of Bagel Without Palm Oil on Postprandial Lipidemia
Postprandial lipemia produced by fat intake is a major risk factor for the development of cardiovascular diseases (CVD), the most important cause of disease and death in the Western world.
- Trial name
- PALMFREE (NCT03950752)
- Testing
- Optimized Bagel, Conventional Bagel
- Where
- Spain
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Metabolic Syndrome, Familial Hypertriglyceridemia
Effects of FXR Activation on Hepatic Lipid and Glucose Metabolism
The purpose of this study is to determine whether chenodeoxycholic acid decreases de novo hepatic lipogenesis, hepatic fat content, hepatic triglyceride production and plasma triglyceride concentrations and improves hepatic…
- Conditions
- Metabolic Syndrome, Familial Hypertriglyceridemia, Familial Combined Hyperlipidemia
- Trial name
- NCT00465751
- Testing
- chenodeoxycholic acid
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Metabolic Syndrome x
The Fenofibrate and Metformin for Atherogenic Dyslipidemia (FAMA) Study
Patients with metabolic syndrome, insulin resistance, and elevated triglycerides of 150 mg/dl or higher will be randomized to one of four groups: 1) placebo; 2) metformin; 3) fenofibrate; or 4) combined metformin and fenofibrate…
- Trial name
- NCT00400231
- Testing
- Study drugs: Metformin and fenofibrate, Study Drug: Metformin, Study Drug: fenofibrate
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Diabetes Mellitus, Type 2, Obesity
Culturally-Adapted Diet for Puerto Rican Adults
This pilot project will determine whether a diet culturally-adapted to Puerto Ricans can effectively decrease cardiometabolic risk for diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Hypertension, Dyslipidemias
- Trial name
- NCT03975556
- Testing
- Culturally tailored food and diet advice, Standard healthy eating advice
- Where
- Puerto Rico
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Hypertriglyceridemia, Familial Chylomicronemia
Study of ARO-APOC3 in Healthy Volunteers, Hypertriglyceridemic Patients and Patients With Familial Chylomicronemia Syndrome (FCS)
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single- and multiple doses of ARO-APOC3 in healthy adult volunteers and in patients with severe hypertriglyceridemia and…
- Trial name
- NCT03783377
- Testing
- ARO-APOC3, sterile normal saline (0.9% NaCl)
- Where
- 10 sites in Australia, Canada and 1 more
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Arrowhead Pharmaceuticals
Hypertriglyceridemia
Single-ascending Dose Study of Kylo-12 in Healthy Subjects
This is a first-in-human, randomized, double-blind, placebo-controlled, single ascending dose study in healthy volunteers. Kylo-12 will be evaluated in approximately 50 subjects to assess safety, tolerability, pharmacokinetics…
- Trial name
- NCT06783881
- Testing
- Kylo-12
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kylonova (Xiamen) Biopharma co., LTD.
Elevated Triglycerides (TG)
Safety, Tolerability, PK, and Pharmacodynamics(PD) of IONIS APOCIII-LRx in Healthy Volunteers With Elevated Triglycerides
The purpose is to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of IONIS APOC-III-LRx given to healthy volunteer subjects.
- Trial name
- NCT02900027
- Testing
- APOC-III-L-Rx
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ionis Pharmaceuticals, Inc.
Dyslipidemia
Effect of Plant Sterols Esterified to Fish Oil Fatty Acids on Plasma Lipid Levels
The purpose of this study is to determine whether plant sterols esterified to fish oil fatty acids in a fish oil matrix improve the lipid profile, predominantly LDL-cholesterol and TG concentrations in healthy hyperlipidemic…
- Trial name
- NCT00441480
- Testing
- Plant sterols esters
- Where
- Israel
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Enzymotec
Hypertriglyceridemia, Gout
Apolipoprotein CIII Reduction Via Colchicine
The aim of this trial will be to determine an effect-size for the administration of chronic low-dose colchicine in the reduction of serum levels of triglycerides (TG), very-low density lipoproteins (VLDL), and apolipoprotein CIII…
- Conditions
- Hypertriglyceridemia, Gout, Pericarditis
- Trial name
- NCT02083510
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Overweight and Obesity, Elevated Triglycerides
A Trial to Assess Full-fat or Low-fat Dairy Foods on Insulin Sensitivity, RBC FA's and Other Markers of Metabolic Health
The objectives of this trial are to assess the effects of adding 2 servings/d of either full-fat or low-fat fermented dairy products to the diet, as a replacement for non-dairy foods with macronutrient composition similar to the…
- Trial name
- NCT04999462
- Testing
- Full-fat fermented dairy, Low-fat fermented dairy, Non-dairy, non-fermented foods
- Where
- 4 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research