Clinical trials: Hyperuricemia
Hyperuricemia, Healthy
The Relationship Among, Serum Uric Acid, Left Ventricular Hypertrophy and Metabolic Syndrome
Hyperuricemia is associated with the prevalence of metabolic syndrome and cardiovascular risks in diverse of the population. Whether the dose-response effects on the prevalence of metabolic syndrome and cardiometabolic risks is…
- Trial name
- NCT03473951
- Testing
- Hyperuricemia
- Where
- Taiwan
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Primary Gout, Hyperuricemia
Study on the Bioavailability of Three Different Prescription Processes of SHR4640 Tablets in Healthy Volunteers
The primary objective of the study is to evaluate the relative bioavailability of three different prescription processes of SHR4640 tablets in healthy volunteers.
- Trial name
- NCT04586803
- Testing
- SHR4640
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Atrial Fibrillation, Hyperuricemia
Prediction of UA/SOD Ratio as a Biomarker of Oxidative Stress in Atrial Fibrillation
To clarify the predictive effects of uric acid and superoxide dismutase as biomarkers of oxidative stress on atrial fibrillation, and to provide greater value for the diagnosis and prediction of atrial fibrillation.
- Trial name
- NCT06119802
- Testing
- atrial fibrillation
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Yinglong Hou
Hyperuricemia
Possible Pharmacological Effect of Quercetin in the Management of Hyperuricemia - Results From Real-life Clinical Studies
Quercetin, a natural flavonoid found in various fruits and vegetables, has gained attention for its potential role in managing hyperuricemia.
- Trial name
- NCT06652035
- Testing
- Quevir® (Quercetin Phytosome®), Bactoblis®
- Where
- Italy
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
Hyperuricemia
Gender Differences in the Metabolic Effects of Uric Acid
Increased stiffening of the heart and blood vessels is a predictor of heart disease. Stiffening has been found to be greater in women than men, which puts women with poor blood sugar control at a greater risk for heart disease…
- Trial name
- NCT03076684
- Testing
- low-fructose diet, Allopurinol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
CKD Progression
Hyperuricemia as Early Indication of CKD Progressing in Prediabetic
Chronic kidney disease (CKD) is a major global health problem, and hyperuricemia has emerged as both a consequence and a potential driver of its progression.
- Trial name
- NCT07199205
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assiut University
Subjects With Hyperuricemia
Prebiotics and the Management of Hyperuricemia
Hyperuricemia is a major risk factor for many chronic diesease. Recently, gut mcirobiota has been identified as a novel theraputic target for hyperuricemia.
- Trial name
- NCT06420401
- Testing
- araboxylan, inulin, inulin and araboxylan
- Where
- 2 sites in China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Hyperuricemia
Pharmacokinetic/Pharmacokinetic and Safety Studies of SHR4640 in Subjects With Moderate Renal Insufficiency and Healthy Subjects
This study aimed to evaluate the pharmacokinetics, pharmacodynamics, and safety of SHR4640 tablets in subjects with moderate renal insufficiency and healthy subjects, and to explore the relationship between renal function (e.g.…
- Trial name
- NCT05954169
- Testing
- SHR4640
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Chronic Kidney Diseases, Hypertension
Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic Diseases
With the development of China's economy, people's living standard have improved, and the dietary structure have changed. Metabolic diseases, such as hypertension, diabetes, hyperuricemia and obesity have gradually become an…
- Conditions
- Chronic Kidney Diseases, Hypertension, Diabetes Mellitus, Hyperuricemia
- Trial name
- NCT05476627
- Testing
- Biomarkers
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Gout; Hyperuricemia
Multiple Dose Study of SHR4640 in Healthy Subjects
The objective of the study is to assess the tolerance, pharmacokinetic and pharmacodynamic properties of multiple dose adminstration of SHR4640 in healthy volunteers.
- Trial name
- NCT02890966
- Testing
- SHR4640
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Hypertension, Hyperuricemia
Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women.
The aim was to assess the effect of estrogen-progestin therapy (EPT) on serum levels of uric acid (SUA) and its precursors: xanthine (X) and hypoxanthine (HX) and on uric acid (UA) renal excretion in hypertensive postmenopausal…
- Conditions
- Hypertension, Hyperuricemia, Menopause
- Trial name
- NCT03921736
- Testing
- Perindopril, Hydrochlorothiazide, Estracomb TTS
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Anna Posadzy-Małaczyńska
Healthy Volunteers, Hyperuricemia
A Research Study to Evaluate the Safety of NNC4004-0002 When Given to Participants With Asymptomatic Hyperuricemia
This study will evaluate an investigational drug called NNC4004-0002. "Investigational" means NNC4004-0002 has not been approved for sale/ for clinical use or for the use described in this study/ by any regulatory authority.
- Trial name
- NCT06859073
- Testing
- NNC4004-0002
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Gout
Pharmacogenetics of SGLT2 Inhibitors
Sodium-dependent glucose transporter-2 (SGLT2) inhibitors are a new class of anti-diabetic drugs, which increase urinary glucose excretion thereby promoting weight loss and decreasing plasma glucose levels.
- Conditions
- Diabetes Mellitus, Gout, Hyperuricemia
- Trial name
- SGLT2iPGx (NCT02462421)
- Testing
- Canagliflozin
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Gout, Hyperuricemia
SAD,MAD and Food Effect Study of SAP-001 Tablets in Chinese Subjects
To evaluate the pharmacokinetics (PK) profile of single or multiple oral doses of SAP-001 tablets in healthy Chinese subjects and gout patients with hyperuricemia.
- Trial name
- NCT06678581
- Testing
- SAP-001
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shanton Pharma Co., Ltd.
Hyperuricemia, Prediabetes
Effect of Allopurinol Treatment on Insulin Resistance
Several studies showed that hyperuricemia is an independent risk factor for development of diabetes mellitus. However none of the previous studies have investigated the effect of lowering serum uric acid levels on insulin…
- Conditions
- Hyperuricemia, Prediabetes, Insulin Resistance
- Trial name
- NCT02008968
- Testing
- allopurinol 300 mg./day, No intervention, Normouricemic
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Gout, Hyperuricemia
Research and Development of a New Technology for Detection of Abnormal Excretion of Intestinal Uric Acid Involved in the Incidence of Gout
To evaluate differences in specific SNPs and intestinal microflora between patients with gout and hyperuricemia and healthy controls.
- Conditions
- Gout, Hyperuricemia, Gut Microbiota, Uric Acid
- Trial name
- NCT04953533
- Testing
- no intervention
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Obesity
Clinical Efficacy and Safety of a Laparoscopic Sleeve Gastrectomy in Obese Patients
This study aim to evaluate the clinical efficacy and safety after laparoscopic sleeve gastrectomy in patients with obesity. 300 patients with obesity and 49 healthy individuals with normal BMI were enrolled.
- Trial name
- NCT04548232
- Testing
- Laparoscopic sleeve gastrectomy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Hyperuricemia
Quercetin as Possible Supportive Therapy for Mild to Moderate Hyperuricemia
Uric acid, a metabolic byproduct of purine degradation in humans, is a known risk factor for conditions such as gout and type 2 diabetes.
- Trial name
- NCT06591767
- Testing
- Quercetin, Berberol K®
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
Hyperuricemia, NAFLD (Nonalcoholic Fatty Liver Disease)
Is There a Relationship Between Uric Acid Level and Liver Fibrosis in Obese Patients
1. Identifying the association between hyperuricemia and NAFLD can lead to early detection and prevention of liver fibrosis in adult obese patients. 2.
- Conditions
- Hyperuricemia, NAFLD (Nonalcoholic Fatty Liver Disease), Liver Fibrosis
- Trial name
- NCT07168551
- Testing
- *Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level ., *Imaging Studies:* 1- Ultrasound 2 - FibroScan, Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Assiut University
Gout
Effect of Aquatic Exercise and Traditional Physical Therapy on Gout in Hypertensive Menopausal Women With Hyperuricemia
Aquatic Exercise and traditional physical therapy are effective methods of treatment for gout and hypertension in menopausal women.
- Trial name
- NCT05454423
- Testing
- the Aquatic exercises +Traditional physical therapy programs +anti-hyperuricemia medication, traditional physical therapy + anti-hyperuricemia medication
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Merit University