Clinical trials: Hypoadrenalism
Adrenal Insufficiency
Updated Diagnostic Cortisol Values for Adrenal Insufficiency
The purpose of this study is to determine the cortisol levels that most accurately diagnose a patient with adrenal insufficiency, a condition in which cortisol levels are too low for daily living.
- Trial name
- NCT05149638
- Testing
- Cosyntropin stimulation test
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Adrenal Insufficiency
Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency
30 adolescent girls and young women between 13 and 26 years with central adrenal insufficiency and a grand shortage of DHEA are recruit.
- Trial name
- DHEA2000 (NCT00575341)
- Testing
- Dehydroepiandrosterone
- Where
- 4 sites in Germany
- Volunteers
- 23 people
- Sponsor
- University Hospital Tuebingen
Sepsis, Adrenal Insufficiency
Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis
The purpose of this study is to determine if the combination of hydrocortisone plus fludrocortisone is more efficacious than hydrocortisone alone in treating adrenal insufficiency in severe sepsis.
- Trial name
- NCT00368381
- Testing
- Hydrocortisone, Fludrocortisone
- Sponsor
- CAMC Health System
Adrenal Insufficiency
Predisposing Factors for the Incidence of Adrenal Crisis
Within this clinical study patients with chronic adrenal insufficiency will be investigated by clinical and biochemical examination as well as questionnaire to identify predisposing factors for adrenal crisis.
- Trial name
- PIA (NCT03410160)
- Testing
- Clinical and biochemical examination.
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- Wuerzburg University Hospital
Neurodegenerative Diseases, Leukodystrophy
Home Exercise for Individuals With Neurodegenerative Disease
The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative diseases.
- Conditions
- Neurodegenerative Diseases, Leukodystrophy, Ataxia, LBSL
- Trial name
- NCT05443906
- Testing
- Home exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Adrenal Insufficiency
A Study of Infacort® Versus Cortef® in Healthy Adult Male and Female Subjects
This was a two-part, single centre, open-label, randomised, single dose, two-period, crossover study to evaluate the bioavailability of Infacort® versus Cortef® immediate release hydrocortisone tablets in dexamethasone-suppressed…
- Trial name
- NCT03311932
- Testing
- Infacort®, Cortef®
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Primary Adrenal Insufficiency
Pharmacokinetics of Hydrocortisone After Subcutaneous Administration in Chronic Adrenal Insufficiency
Patients with chronic adrenal insufficiency need to adapt their hydrocortisone replacement dose in conditions of physical or psychological stress to prevent life threatening adrenal crisis.
- Trial name
- PHYSCA (NCT01450930)
- Testing
- Hydrocortisone intramuscular first, Hydrocortisone subcutaneously first
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Bruno Allolio
Adrenal Insufficiency
Bioavailability of Infacort When Administered Onto Food Compared to Direct Oral Administration
This is a single centre, open-label, randomised, single dose, three-period, crossover study to evaluate the bioavailability of Infacort® administered as 'sprinkles' with soft food and yoghurt compared with direct administration…
- Trial name
- NCT03178214
- Testing
- Infacort
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Adrenal Insufficiency
Prospective Study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency
Prospective study to evaluate incidence, causes and potential risk factors for adrenal crisis in patients with chronic adrenal insufficiency.
- Trial name
- NCT01184209
- Where
- 2 sites in Germany
- Volunteers
- 444 people
- Sponsor
- University of Wuerzburg
Adrenal Insufficiency
Hydrocortisone Versus Methylprednisolone for the Treatment of Glucocorticoid-Induced Adrenal Insufficiency
This study aims to compare the use of methylprednisolone and hydrocortisone as replacement therapies in patients with glucocorticoid-induced adrenal insufficiency.
- Trial name
- NCT07703098
- Testing
- Patients will receive 3 mg of methylprednisolone once daily. The dose is administered in the morning (1 ½ tablets of 2 mg Medrol after breakfast)., Patients will receive 15 mg of hydrocortisone daily. The dose is split into 10 mg in the morning after breakfast and 5 mg after 6-7 hours.
- Where
- Slovenia
- Volunteers
- 66 people
- Sponsor
- University Medical Centre Ljubljana
Adrenal Insufficiency
Effects of Steroid Replacement Therapy on Metabolic, Cardiovascular and Bone Outcomes in Adrenal Insufficiency
The current study is a randomized, open study aimed to compare the effects of conventional glucocorticoid replacement treatment and dual-release hydrocortisone on anthropometric, metabolic, cardiovascular and bone outcomes in…
- Trial name
- NCT06260462
- Testing
- dual-release hydrocortisone, Conventional glucocortidois
- Volunteers
- 88 people
- Sponsor
- University of Palermo
Adrenal Gland Hypofunction
Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment
Suppression of the adrenal function is a common, potentially dangerous and unpredictable consequence of short term high dose glucocorticoid treatment. Identification of patients at risk would be of high clinical importance.
- Trial name
- NCT00975078
- Testing
- adrenal insufficiency testing, prednisone
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cirrhosis With Ascites
Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function
Relative adrenal insufficiency (RAI) is an well known condition in patients with septic shock. Liver failure (including chronic liver failure)and sepsis are both characterized by hyperdynamic circulatory failure (with low…
- Trial name
- AILD (NCT00657306)
- Testing
- hydrocortisone, dextrose solution 5%
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Turin, Italy
Adrenal Insufficiency
National Education Programme for Patients With Chronic Adrenal Insufficiency
Even under established replacement therapy, patients with adrenal insufficiency still suffer from impaired quality of life and experience adrenal crises. Patient education is regarded as important preventive measure.
- Trial name
- NCT02694926
- Testing
- Education
- Where
- Germany
- Volunteers
- 528 people
- Sponsor
- Wuerzburg University Hospital
Healthy
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of OP-101 After Intravenous Administration in Healthy Volunteers
A clinical study to measure the effect of OP-101 after being administered intravenously in healthy volunteers.
- Trial name
- NCT03500627
- Testing
- OP-101
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Orpheris, Inc.
Cushing Disease Due to Increased ACTH Secretion
Combination Osilodrostat and Cabergoline in Cushing's Disease
Cushing disease remains a challenging endocrine disorder in which persistent or recurrent hypercortisolism often requires medical therapy after surgery or when surgery is not feasible.
- Trial name
- COSCA-ECD (NCT07603466)
- Testing
- osilodrostat, osilodrostat and cabergoline
- Where
- 5 sites in Iraq
- Volunteers
- 50 people
- Sponsor
- University of Basrah
Digestive Diseases, Adrenal Insufficiency
Adrenal Insufficiency in Critical Emergencies in Digestive Diseases
Observational study about the incidence of relative adrenal insufficiency in patients with cirrhosis and acute variceal bleeding; in patients with acute peptic gastrointestinal bleeding and without liver disease; and in patients…
- Conditions
- Digestive Diseases, Adrenal Insufficiency, Gastrointestinal Bleeding, Variceal Bleeding
- Trial name
- NCT00562445
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
X-linked Adrenoleukodystrophy
Validation of a Prognostic Biomarker Using Brain Diffusion MRI in X-linked Adrenoleukodystrophy
CALD is an inflammatory demyelinating disease that causes severe motor and cognitive deficit leading to rapid death. Hematopoietic stem cell transplantation (HSCT) can halt neuroinflammation in CALD through the replacement of…
- Trial name
- CALDIFF (NCT05911919)
- Testing
- brainQuant module of brainTale-care platform
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatoid Arthritis (RA)
Comparison of Glucocorticoid Tapering Schedules in Rheumatoid Arthritis
This multicenter, randomized, controlled, single-blind prospective study aims to establish an evidence-based protocol for discontinuing long-term low-dose glucocorticoids in patients with rheumatoid arthritis (RA).
- Trial name
- NCT07227428
- Testing
- Prednisolone
- Volunteers
- 206 people
- Sponsor
- Seoul National University Hospital
Acute Respiratory Distress Syndrome, Adrenal Insufficiency
Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS)
The purpose of this study is to see if stress doses of hydrocortisone improve early outcome in patients who are in early stage of ARDS and with relative adrenal insufficiency.
- Trial name
- NCT00773058
- Testing
- hydrocortisone
- Volunteers
- 100 people
- Sponsor
- Southeast University, China