Clinical trials: Hypoadrenalism
Addison Disease
Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's Disease
Addison's disease is a rare disease, wherein the adrenals can not produce sufficient steroid hormones (cortisol and aldosterone).
- Trial name
- NCT01271296
- Testing
- Liquorice, Grapefruit Juice
- Where
- Norway
- Volunteers
- 17 people
- Sponsor
- Haukeland University Hospital
Reumatoid Arthritis, Corticosteroids Adverse Reaction
Prevalence of Adrenal Insufficiency and Associated Factors in Rheumatoid Arthritis Patients Using Low-dose Corticosteroids.
This study aims to investigate the prevalence of adrenal insufficiency in rheumatoid arthritis (RA) patients receiving low-dose corticosteroid therapy and to identify the factors influencing adrenal insufficiency.
- Conditions
- Reumatoid Arthritis, Corticosteroids Adverse Reaction, Adrenal Insufficiency
- Trial name
- NCT07866326
- Testing
- ACTH stimulation test, Cortisol
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Partial Mineralocorticoid Deficiency
Impact of the Administration of Fludrocortisone in Very Premature Infants
Water and electrolytic homeostasis is remarkably controlled by the mineralocorticoid pathway (renin-angiotensin-aldosterone system acting on the renal tubule).
- Trial name
- MINIPREM (NCT03001089)
- Testing
- Oral Fludrocortisone (enteral)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congenital Adrenal Hyperplasia, Adrenal Insufficiency
An Open Label Study in Healthy Volunteers to Compare Chronocort® to Hydrocortisone
This was an open label, randomized, single dose, three period crossover pharmacokinetic study of Chronocort® in 30 healthy male volunteers. The study was conducted in smaller sub groups (Group 1, n=18 and Group 2, n=12).
- Trial name
- NCT03019614
- Testing
- Hydrocortisone, Chronocort
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Lysosomal Storage Disease, Peroxisomal Disorder
Reduced-Intensity Hematopoietic Stem Cell Transplant for High Risk Lysosomal and Peroxisomal Disorders
This study is designed to test the ability to achieve donor hematopoietic engraftment while maintaining low rates of transplant-related mortality (TRM) in patients with high-risk lysosomal and peroxisomal disorders using a novel…
- Trial name
- NCT01626092
- Testing
- Campath-1H, Clofarabine, Melphalan
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Cerebral Adrenoleukodystrophy (CALD)
A Clinical Study to Assess the Efficacy and Safety of Gene Therapy for the Treatment of Cerebral Adrenoleukodystrophy (CALD)
The purpose of this study is to evaluate the efficacy and safety of Lenti-D Drug Product (also known as elivaldogene autotemcel or Skysona, hereafter referred to as eli-cel) after myeloablative conditioning with busulfan and…
- Trial name
- NCT03852498
- Testing
- Lenti-D
- Where
- 8 sites in United States, France and 4 more
- Volunteers
- 35 people
- Sponsor
- Genetix Biotherapeutics Inc.
Adrenal Insufficiency
Optimising Steroid Replacement in Patients With Adrenal Insufficiency
Adrenal insufficiency is a condition where the adrenal glands do not produce an adequate amount of steroid hormones. The aetiology of adrenal insufficiency can be primary or secondary.
- Trial name
- NCT03282487
- Testing
- Modified release hydrocortisone
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Adelaide and Meath Hospital, incorporating The National Children's Hospital
Adrenal Insufficiency
Circadian Function and Cardio-metabolic Risk in Adrenal Insufficiency
The purpose of this study is to compare cardio-metabolic risk, glucose tolerance, and night time blood pressure between healthy control subjects and patients with adrenal insufficiency.
- Trial name
- NCT03000231
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Sepsis, Relative Adrenal Insufficiency
Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis
The purpose of this pilot study is to (1) examine the changes in gene expression in patients who suffer from severe sepsis and whose shock (inadequate oxygen delivery to vital organs) state does not respond to fluid and…
- Trial name
- NCT00185783
- Testing
- Hydrocortisone Administration (Standard of Care Therapy)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Adrenomyeloneuropathy, Adrenoleukodystrophy
MD1003-AMN MD1003 in Adrenomyeloneuropathy
The primary objective of the trial is to demonstrate the superiority of biotin at 300 mg/day over placebo in the clinical improvement (walking tests) of patients with adrenomyeloneuropathy
- Conditions
- Adrenomyeloneuropathy, Adrenoleukodystrophy, AMN
- Trial name
- NCT02961803
- Testing
- MD1003 100 mg capsule
- Where
- 4 sites in France, Germany and 1 more
- Volunteers
- 67 people
- Sponsor
- MedDay Pharmaceuticals SA
Adrenal Insufficiency
Adrenal Function in Critical Illness
An appropriate hypothalamic-pituitary-adrenal (HPA) axis response is required to survive critical illness. Primary adrenal insufficiency, relative adrenal insufficiency, tissue resistance to glucocorticoids, ACTH deficiency and…
- Trial name
- NCT00156767
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
X-linked Adrenoleukodystrophy
Exercise Study of Function and Pathology for Women With X-linked Adrenoleukodystrophy
The purpose is to see how X-linked adrenoleukodystrophy (X-ALD) is associated with strength and sensation using MRI, in women with X-ALD.
- Trial name
- NCT01594853
- Testing
- exercise training
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Inflammatory Disorder, Autoimmune
Taper Or Abrupt Steroid Stop: TOASSTtrial
This study is an Investigator-initiated, placebo-controlled, multicenter noninferiority trial, comparing rapid termination of systemic glucocorticoid treatment with a tapering regime over 4 weeks.
- Trial name
- TOASST (NCT03153527)
- Testing
- Prednisone
- Where
- 16 sites in Germany, Switzerland
- Volunteers
- 530 people
- Sponsor
- University Hospital, Basel, Switzerland
Adrenal Insufficiency
A Study of Chronocort® Versus Cortef ® in Healthy Adult Male Subjects
This was a single centre, open label, randomised, two period, crossover study to evaluate the bioavailability of Chronocort® versus Cortef® immediate release hydrocortisone tablets in dexamethasone-suppressed healthy adult male…
- Trial name
- NCT03343327
- Testing
- Chronocort®, Cortef®
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Adrenomyeloneuropathy
A Clinical Trial for AMN: Validation of Biomarkers of Oxidative Stress, Efficacy and Safety of a Mixture of Antioxidants
X-linked adrenoleukodystrophy is a rare, demyelinating and neurodegenerative disorder, due to a loss of function of a fatty acid transporter, the peroxisomal ABCD1protein.
- Trial name
- NCT01495260
- Testing
- N-acetylcysteine, lipoic acid, vitamin E
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Pujol, Aurora, M.D.
Adrenal Insufficiency
Residual Adrenal Function in Addison's Disease
The main aim of this study is to assess the role of 11-deoxycortisol as surrogate marker of Residual adrenal function. 11-deoxycortisol levels will be assessed in all recruited patients
- Trial name
- ADD-RES (NCT06309498)
- Testing
- blood test
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Auxologico Italiano
Chronic Adrenal Insufficiency
A European Post-Authorisation Observational Study (Registry) of Patients With Chronic Adrenal Insufficiency (AI)
As a post-approval requirement of the European Medicines Agency, this European patient post authorization safety study is an observational study being conducted to monitor the safety of long-term treatment with Plenadren and…
- Trial name
- NCT01661387
- Where
- 24 sites in Germany, Italy and 3 more
- Volunteers
- 3,258 people
- Sponsor
- Shire
Adrenal Insufficiency
Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT)
The aim of this study is to investigate whether a physiologically low hydrocortisone (HC) dose is better for cognition as compared to a physiologically high HC dose.
- Trial name
- SUPREME CORT (NCT01546922)
- Testing
- Hydrocortisone
- Where
- Netherlands
- Volunteers
- 63 people
- Sponsor
- University Medical Center Groningen
Adrenal Insufficiency, Congenital Adrenal Hyperplasia
A Two-part, Study to Compare the Pharmacokinetics and Dose Proportionality of up to 6 Chronocort Formulations
This was an open label, randomised, single dose study, comprising Part A (undertaken in two separate three-period crossover cohorts denoted as A1 and A2) and Part B (undertaken in one four-period crossover cohort), to evaluate…
- Trial name
- NCT03051893
- Testing
- Chronocort
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Sepsis
The Effect of Moderate-Dose Steroid Therapy in Sepsis
Despite the new developments in sepsis treatment, mortality rate is still high. Discussions on steroid treatment in sepsis are going on.
- Trial name
- NCT01275638
- Testing
- Prednisolone
- Volunteers
- 55 people
- Sponsor
- TC Erciyes University