Clinical trials: Hypoalbuminemia
Hepatic Ascites
Phase II/III of Recombinant Human Albumin Injection
This study was a Phase II/III multicenter, blinded, and positiveactive-controlled clinical study with seamless adaptive design to evaluate the dose-response relationship, safety, and immunogenicity of recombinant human…
- Trial name
- NCT06411743
- Testing
- Recombinant Human Albumin Injection, Human Albumin
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Hospital of Jilin University
Hypoalbuminemia in Cirrhotic Ascites
A Phase I Clinical Study on the Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Characteristics of GLR1075 Injection in Healthy Trial Participants and Cirrhotic Trial Participants With Ascites and Hypoalbuminemia
This trial is conducted in China. This study plans to include 3 parts,Part A, a single ascending dose (SAD) study in healthy trial participants; Part B, a multiple dose (MD) study in healthy trial participants; and Part C, a…
- Trial name
- NCT07851688
- Testing
- Human Serum Albumin(HSA), GLR1075 Injection
- Where
- China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Gan & Lee Pharmaceuticals.
End-Stage Renal Disease
Fosrenol for Enhancing Dietary Protein Intake in Hypoalbuminemic Dialysis Patients (FrEDI) Study
Protein-energy wasting, as reflected by a serum albumin <4.0 g/dL, is very common in maintenance hemodialysis (MHD) patients and associated with poor clinical outcomes including high death rates.
- Trial name
- FrEDI (NCT01116947)
- Testing
- Meals during hemodialysis accompanied by lanthanum carbonate to control phosphorus
- Volunteers
- 108 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Heart Failure
Effect of W-3 Polyunsaturated Fatty Acids on Serum Albumin Concentration in Patients With Acute Heart Failure, Hypoalbuminemia, and High Inflammatory Activity
Assess whether high doses of ?-3 fatty acids added to standard treatment of patients with acute hearta failure, hypoalbuminemia and high inflammatory activity, promotes an increase in serum albumin
- Trial name
- PROTEICA (NCT02708771)
- Testing
- Polyunsaturated fatty acids omega-3
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Hospital San Juan de la Cruz
Nephrotic Syndrome, Thromboembolic Disease
Causes and Prevention of Thromboembolic Disease in Nephrotic Syndrome
The study aims to describe the biochemical coagulation profile and investigate the effect of Low molecular weight heparin and Apixaban on this profile in patients with nephrotic syndrome.
- Trial name
- CAPTAIN (NCT04850378)
- Testing
- Dalteparin, Apixaban
- Where
- Denmark
- Volunteers
- 57 people
- Sponsor
- University of Aarhus
Shock, Systemic Inflammatory Response Syndrome (SIRS)
Optimization of Therapeutic Human Serum Albumin Infusion in Selected Critically Ill Patients
Primary purpose : mortality at Day 28 Secondary purposes : Daily SOFA (Sequential Organ Failure Assessment) score lessening within Intensive Care Unit (ICU) Duration of increasing doses of norepinephrine infusion to maintain…
- Conditions
- Shock, Systemic Inflammatory Response Syndrome (SIRS), Hypoalbuminaemia
- Trial name
- AlbAlsace (NCT02755155)
- Testing
- Human serum albumin infusion 4%, Human serum albumin infusion 20%
- Where
- France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Strasbourg, France
Peritoneal Dialysis Complication, Hyperphosphatemia
Effect of Velphoro on Serum Phosphate and Albumin in Peritoneal Dialysis Patients
Prospective pilot study to determine if changing the phosphate binder to sucroferric oxyhydroxide for for 6 months improves disordered mineral metabolism and nutrition status in peritoneal dialysis patients.
- Conditions
- Peritoneal Dialysis Complication, Hyperphosphatemia, Hypoalbuminemia
- Trial name
- NCT04046263
- Testing
- Sucroferric Oxyhydroxide Chewable Tablet
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Colorado, Denver
Pharmacokinetics, Critical Illness
Optimization of PK/PD Target Attainment for Ceftriaxone in Critically Ill Patients With Community-acquired Pneumonia.
WP2.1. PK/PD target attainment Plasma exposure ELF exposure WP2.2. Predictive dosing algorithm WP2.3. ECMO subset
- Trial name
- NCT03438981
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ataxia-oculomotor Apraxia 1
Evolution of Albumin on AOA1 Patients Supplemented With Coenzyme Q10
We propose a study on Ataxia with oculomotor apraxia type 1 (AOA1) in which Coenzyme Q10 (CoQ10) deficit has been observed. Main objectives of the study are : To monitor evolution of albumin in patients affected with AOA1 while…
- Trial name
- AOA1 (NCT02333305)
- Testing
- CoQ10
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carcinoma, Hepatocellular
90Y Transarterial Radioembolization Versus Microwave Ablation in Small Hepatocellular Carcinoma With Hypoalbuminemia
This clinical trial will compare 1-year outcomes in patients with hypoalbuminemia and a new diagnosis of small, early-stage hepatocellular carcinoma (HCC) who are candidates for both 90-Yittrium Therasphere transarterial…
- Trial name
- REALM (NCT05953961)
- Testing
- Therasphere 90Y, Microwave Ablation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ochsner Health System
Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant
Biomarkers and Outcome Predictors of Pediatric Nephrotic Syndrome: A Genetic, Transcriptomic, and Secretome Multiomics Study
Idiopathic Nephrotic Syndrome is a rare disease of the kidneys, which typically affects children. For most affected children there is the need of a prolonged treatment with drugs reducing the activity of the immune system, also…
- Conditions
- Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant, Nephrotic Syndrome in Children, Glomerulonephritis
- Trial name
- PRECISE (NCT06792448)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Lumbar Disc Disease
SPI-directed Analgesia for Lumbar Discectomy
The aim of this randomized trial is to assess the efficacy of analgesia for lumbar discectomy and compare Numerical Rating Scale (NRS) with Surgical Pleth Index (SPI) for monitoring pain perception postoperatively.
- Trial name
- SPI (NCT02971540)
- Testing
- Metamizol, Tramadol, Bupivacaine
- Where
- Poland
- Volunteers
- 132 people
- Sponsor
- Medical University of Silesia
Hepatic Ascites
A Study of Recombinant Human Albumin Injection to Treat Hypoalbuminemia in Cirrhotic Patients With Ascites
This study was a Phase III multicenter, blinded, and positive active-controlled clinical study to evaluate the efficacy, safety, and immunogenicity of recombinant human albumin(rHA) injection for the treatment of hypoalbuminemia…
- Trial name
- NCT06911554
- Testing
- Recombinant Human Albumin Injection, Human Albumin
- Where
- China
- Volunteers
- 416 people
- Sponsor
- Tonghua Anrate Biopharmaceutical Co., Ltd.
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Edema, Perioperative/Postoperative Complications
Body Composition and Serum Biochemistry After Intravenous Infusion or Oral Intake of Saline in Healthy Volunteers
The investigators conducted a cross-over study to compare the response of healthy young volunteers to a rapid oral intake or intravenous infusion of 0.9% saline solution on the body composition, serum electrolytes, albumin, and…
- Trial name
- NCT01539798
- Testing
- Oral saline, Intravenous saline
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Federal University of Mato Grosso
Acute Respiratory Distress Syndrome, Sepsis
Effect of Albumin Therapy in Mechanically Ventilated Patients With Sepsis-Associated ARDS
Sepsis-associated acute respiratory distress syndrome (ARDS) is a severe condition where severe infection causes fluid accumulation in the lungs, often requiring invasive mechanical ventilation.
- Conditions
- Acute Respiratory Distress Syndrome, Sepsis, Hypoalbuminemia
- Trial name
- ALB-SARDS (NCT07857928)
- Where
- China
- Volunteers
- 260 people
- Sponsor
- The Second Affiliated Hospital of Hainan Medical University
Hypoalbuminemia, Hepatic Cirrhosis
A Study to Evaluate the Efficacy and Safety of OsrHSA in Patients of Hepatic Cirrhosis With Hypoalbuminemia
The goal of this clinical trial is to evaluate the efficacy of OsrHSA works to treat hypoalbuminemia in hepatic cirrhosis patients. It will also learn about the safety and immunogenicity of OsrHSA.
- Trial name
- NCT06355479
- Testing
- OsrHSA, Plasbumin®-20
- Where
- 37 sites in China
- Volunteers
- 328 people
- Sponsor
- Healthgen Biotechnology Corp.
Pleural Effusions Post Coronary Artery Bypass Graft, Hypoxia
Efficacy of 20% Human Albumin in Reducing Pleural Effusion After Cardiopulmonary Bypass
Human albumin is a widely used additive in cardiopulmonary bypass all around the world, but its effect on various outcomes has been debated.
- Conditions
- Pleural Effusions Post Coronary Artery Bypass Graft, Hypoxia, Hypoalbuminemia
- Trial name
- NCT06681415
- Testing
- Adding 100ml of 20% human albumin to cardiopulmonary bypass priming solution
- Where
- Latvia
- Volunteers
- 70 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Hypoalbuminemia, Acute Kidney Failure
The Relationship Between Hypoalbuminemia and Development of Acute Kidney Failure (AKI) According to KDIGO Criteria
This study was designed to determine the association between preoperative and postoperative hypoalbuminemia and AKI in older age hip fracture surgeons, to determine which period of hypoalbuminemia contributes more to AKI…
- Trial name
- NCT03675906
- Testing
- hypoalbuminemia
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Erzincan University
Coronary Artery Disease, Hyponatremia
Hyponatremia and Hypoalbuminemia is Morbimortality Predictors in Coronary Artery Bypass Graft Surgery
Coronary artery disease is a common medical disease in many populations. The pathogenesis of this disease is very complex. Surgery is one of the treatment choices. Assessing the risk factors will improve the surgical outcome.
- Conditions
- Coronary Artery Disease, Hyponatremia, Hypoalbuminemia
- Trial name
- NCT02765061
- Volunteers
- 1,157 people
- Sponsor
- Ankara University