Clinical trials: Hypobaric Hypoxia
Baro-reflex Sensitivity, Heart Rate Variability
Low Intensity Exercise in Different Normobaric/Hypobaric Normoxic/Hypoxic Conditions.
The main goal of this project is to investigate how low intensity cycling exercise (1.5W/kg, for 6 minutes) influences cerebral functions, such as: Cerebral blood flow, oxygenation, and other physiological variables in different…
- Conditions
- Baro-reflex Sensitivity, Heart Rate Variability, EEG, Microstates, Cerebral Blood Flow Regulation
- Trial name
- Hypoxia (NCT03439202)
- Testing
- Hypoxia
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fliegerärztliches Institut
Hypoxia, Altitude, Exercise
Oxygen Transport in Normobaric vs. Hypobaric Hypoxia
1) Oxygen Transport in Normobaric versus Hypobaric Hypoxia. 2) The purpose of this study is to examine acute responses in arterial and muscle tissue oxygenation during incremental exercise in normobaric versus hypobaric hypoxia.
- Trial name
- NCT03335917
- Testing
- Hypoxia, Exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Major Depressive Disorder
Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females
The investigators propose to determine if 8 weeks of dietary augmentation with oral 5g creatine monohydrate daily and 100 mg of 5-hydroxytryptophan (5-HTP) twice daily reduces hypoxia-related depressive symptoms measured by the…
- Trial name
- NCT02922725
- Testing
- 5-hydroxytryptophan and Creatine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brent Michael Kious, MD, PhD
Sleep-related Respiratory Disturbance
Effects of Mild Hypobaric Hypoxia on Oxygen Saturation During Sleep
Ascent to altitude lowers oxygen saturation. In addition, sleep lowers oxygen saturation at any altitude. In a prior study, we observed that sleep at 8000 feet resulted in pronounced reduction in oxygen saturation, but did not…
- Trial name
- NCT00659009
- Testing
- Reduced barometric pressure, Sea level equivalent barometric pressure
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Boeing Company
Glucose Metabolism, High Altitude
High Altitude and Exogenous Carbohydrate Oxidation
Recent studies have reported that oxidation of exogenous carbohydrate is reduced under acute hypobaric hypoxic (high altitude; HA) conditions compared to normoxia (sea level; SL) in native lowlanders.
- Trial name
- NCT03851744
- Testing
- Sea Level, High Altitude
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Gastrointestinal Injury, Acute Mountain Sickness
Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
The aim of this randomized, crossover clinical trial is to determine the efficacy of a gut microbiota-targeted nutritional intervention containing a blend of fermentable fibers and polyphenols (FP) for mitigating increases in GI…
- Trial name
- NCT04111263
- Testing
- FP, High altitude, Sea level
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Traumatic Brain Injury
Exercise, Hypoxia and CPC in TBI Patients
Circulating progenitor cells (CPC) treatments may have great potential for the recovery of neurons and brain function. Our group has reported how exposure to intermittent hypobaric hypoxia with superficial muscle…
- Trial name
- TCECAM (NCT02083445)
- Testing
- cognitive activities, Exercise program, Muscle electro-stimulation
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- University of Barcelona
Hypoxia, Brain
CO2 (Carbon Dioxide) - Cerebral Oxygenation
Several projects in high altitude research in environments with a low oxygen partial pressure (hypobaric hypoxia) leading to hypoxemia showed, that cerebral perfusion and cerebral performance could be improved by adding C02…
- Trial name
- NCT03338907
- Testing
- Oxycarbon (5% CO2+ 95% O2)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
COPD, Hypoxia
Hypobaric Flight Simulation in COPD Patients
Aim of this study was to evaluate the hypoxic response during hypobaric flight simulation in normal individuals as well as in normocapnic and hypercapnic COPD patients as well as to evaluate the impact of a flight simulation on…
- Conditions
- COPD, Hypoxia, Aviation
- Trial name
- NCT02848391
- Testing
- Environmental
- Where
- Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Krankenhaus Kloster Grafschaft
Hypobaric Hypoxia, Hypobaric Normoxia
Cognition at Altitude in HEMS - Part II
The aim of the current study is to evaluate under blinded conditions, both in a simulated environment and during helicopter flight, the effect of a rapid (within 20 minutes) exposure to altitude (4000 m asl) on physiological…
- Conditions
- Hypobaric Hypoxia, Hypobaric Normoxia, Cognitive Performance, Emergency Medicine
- Trial name
- HEMS II (NCT05073406)
- Testing
- Altitude exposure in hypobaric normoxic condition, Altitude exposure in hypobaric hypoxic condition
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Hypobaric Hypoxemia
Enhancing Operability in a Hypobaric Hypoxic Environment With a Small Oxygen Storage System
This is a study to validate the efficacy of using a small portable oxygen source to mitigate altitude-induced hypoxia.
- Trial name
- NCT03365128
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Cincinnati
Normobaric Hypoxia, Hypoventilation
Influence of Hypoxic, Normobaric and Hypobaric Training on the Immunometabolism of Post-covid-19 Athletes
COVID-19 has significantly impacted sports globally, with event postponements, training disruptions, and wide-ranging concerns. SARS-CoV-2 infection can result in hyperinflammation and cardiopulmonary changes, with hypoxia as an…
- Conditions
- Normobaric Hypoxia, Hypoventilation, Normoxia
- Trial name
- NCT06128941
- Testing
- Repeated sprint
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Acute Mountain Sickness
Effects of Aircraft Cabin Altitude on Passenger Comfort and Discomfort
Commercial aircraft passengers are exposed to atmospheric pressures ranging from the pressure found at ground level to that encountered in the external environment at 8,000 feet.
- Trial name
- NCT00326703
- Testing
- Hypobaric hypoxia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Boeing Company
Altitude, Hypoxia
Effects of Mild Hypobaric Hypoxia on Sleep and Post-sleep Performance
Hypobaric hypoxia (decreased oxygen supply to body tissues due to low atmospheric pressure) caused by exposure to high altitude disrupts sleep.
- Conditions
- Altitude, Hypoxia, Environmental Sleep Disorder
- Trial name
- NCT00498563
- Testing
- altitude exposure in hypobaric chamber
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Changes in the Intestinal Microbiota Under Hypobaric Hypoxia Conditions, Changes in Blood Glucose Under Hypobaric Hypoxia Conditions
Program Protocol for a Population That Works in Conditions of Hypobaric Hypoxia
The objective of this randomized, longitudinal, single-blind, two-group parallel clinical trial is to evaluate the effect of a physical exercise and nutritional protocol on the health determinants of workers performing their work…
- Conditions
- Changes in the Intestinal Microbiota Under Hypobaric Hypoxia Conditions, Changes in Blood Glucose Under Hypobaric Hypoxia Conditions, Changes in Body Composition Under Hypobaric Hypoxia Conditions, Determination of Physiological Stress in Hypobaric Hypoxia
- Trial name
- NCT07624409
- Testing
- Probiotic Nutritional Intervention, Overload Exercise Protocol, Bioimpedanciometry
- Where
- Chile
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Jorge Torres Mejías
High Altitude, Hypobaric Hypoxia
The Effect of Acute High Altitude Exposure on Rescuer Performance and Patient Care
Rescue services in mountainous regions are frequently called to missions at altitudes >3000 m. Under the difficult conditions of acute exposure to altitude, the crews then have to undertake demanding medical and rescue measures.
- Conditions
- High Altitude, Hypobaric Hypoxia, Risk Reduction
- Trial name
- NCT06446427
- Testing
- Acute high altitude exposure, Acute high altitude exposure, with supplementary oxygen, Subacute high altitude exposure, after having spent a night at high altitude
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Obstructive Pulmonary Disease
Early Signs of Altitude Illness in Patients With COPD
This study evaluates whether structured self-monitoring (SSM) by a symptom checklist in combination with a pulse oximeter worn at the wrist allows lowlanders with COPD to accurately identify whether or not they will experience an…
- Trial name
- NCT03957759
- Testing
- Structured self-monitoring during an altitude ascent and stay at high altitude
- Where
- Kyrgyzstan
- Volunteers
- 153 people
- Sponsor
- University of Zurich
Hypertension, High Altitude
HIGH Altitude CArdiovascular REsearch in the ANDES
This study is aimed to assess the efficacy of combined treatment with two antihypertensive agents (telmisartan and nifedipine) in subjects with mild hypertension exposed to high altitude.
- Trial name
- HIGHCARE-A (NCT01830530)
- Testing
- Telmisartan, Nifedipine
- Where
- Peru
- Volunteers
- 100 people
- Sponsor
- Istituto Auxologico Italiano
Hypoxia, Exercise Performance
Acetazolamide and Exercise Performance at Altitude
The goals of the present study are to evaluate whether the most common, and effective, treatment for acute mountain sickness (AMS), acetazolamide (AZ), has a negative, positive, or no influence on exercise performance, cognitive…
- Conditions
- Hypoxia, Exercise Performance, Cognitive Function, Dexterity
- Trial name
- NCT03525561
- Testing
- Acetazolamide Pill
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Hypoxia
High Altitude Medical Research Expedition Himlung 2013 - a Study of Human Adaption to Hypoxia
The aim of the project "High Altitude Medical Research Expedition Himlung 2013" (HiReach2013) is to comprehensively investigate the cerebral, cardiovascular and pulmonary adaptation and the reactions of the human immune system…
- Trial name
- HiReach 2013 (NCT01953198)
- Testing
- Hypobaric hypoxia
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern