Clinical trials: Hypoglycaemia
Hypoglycemia Unawareness, Type 1 Diabetes
Glucose Counterregulation in Long Standing Type 1 Diabetes
Enrollment for this study is complete. This study is designed to determine if use of a real-time continuous glucose monitor (RT-CGM) can reverse defective Glucose counter regulation and hypoglycemia unawareness in long standing…
- Conditions
- Hypoglycemia Unawareness, Type 1 Diabetes, Healthy
- Trial name
- NCT01474889
- Testing
- RT-CGM
- Where
- 3 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Pennsylvania
Hypoglycemia, Evidence of Previous Gastric Surgery
Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery
The purpose of this study is to determine whether pramlintide (Symlin) will help to reduce the frequency and severity of hypoglycemia in individuals who have had gastric bypass surgery.
- Trial name
- NCT01841359
- Testing
- Pramlintide
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Joslin Diabetes Center
Type 1 Diabetes Mellitus
Home Video-based Telemedicine to Reduce Hypoglycemia Fear in Parents of Young Children
Investigators developed REDCHiP (Reducing Emotional Distress for Childhood Hypoglycemia in Parents), an innovative video-based telemedicine intervention.
- Trial name
- REDCHiP (NCT03914547)
- Testing
- REDCHiP, ATTN
- Where
- 2 sites in United States
- Volunteers
- 394 people
- Sponsor
- Nemours Children's Clinic
Diabetes Mellitus, Type 1
Feasibility Trial Testing the Bionic Pancreas With ZP4207
The purpose of this study was to determine whether the Bionic Pancreas with ZP4207 (dasiglucagon*) was feasible to improve glycemic control in adults with type 1 diabetes mellitus.
- Trial name
- dasiglucagon (NCT02971228)
- Testing
- Insulin Lispro, ZP4207 (dasiglucagon), Glucagon
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Zealand Pharma
Type 2 Diabetes Mellitus
Evaluation of Low Blood Sugar Events in Participants With Diabetes (MK-0431-401)
This is a multi-center, observational, retrospective and cross-sectional study to be conducted in a cohort of consecutively selected participants with Type 2 diabetes mellitus (DM) who have been treated with sulphonylurea (SU)…
- Trial name
- NEEDS (NCT01285076)
- Testing
- Other: Retrospective chart review; one participant encounter visit.
- Where
- Taiwan
- Volunteers
- 834 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 1
The Use of Mini-dose Glucagon to Prevent Exercise-induced Hypoglycemia in Type 1 Diabetes
This project focuses on development of new strategy for the prevention of exercise-associated hypoglycemia using mini-dose glucagon.
- Trial name
- NCT02660242
- Testing
- G-Pen Mini™ (glucagon injection), Glucose Tabs, Basal Insulin Reduction
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Jaeb Center for Health Research
Congenital Hyperinsulinism
Effect of Exendin (9-39) on Glucose Requirements to Maintain Euglycemia
The primary aim of this study is to evaluate the effect of Exendin (9-39) on glucose requirements to maintain euglycemia in pediatric patients with congenital hyperinsulinism (CHI) who have failed medical therapy.
- Trial name
- NCT00835328
- Testing
- Exendin (9-39), Vehicle
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Diva De Leon
Type 1 Diabetes
Study Comparing Effectiveness of Intraperitoneal Insulin Administration to Subcutaneous Insulin Administration
The purpose of this study is to evaluate the effectiveness of insulin delivered in the peritoneum (abdomen)by an implantable pump in Type 1 diabetics.
- Trial name
- MIP310 (NCT00211536)
- Testing
- Medtronic MiniMed Implantable Pump Human Recombinant Insulin, Medtronic MiniMed Implantable Pump System, Aventis HOE21PH U400
- Where
- 5 sites in United States
- Volunteers
- 107 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetes Mellitus With Hypoglycemia, Diabetes Mellitus, Type 2
Impact of Hypoglycaemia in Patients With Diabetes Mellitus Type 2 on Platelet Activation
This experimental study is planned to investigate the impact of hypoglycaemia on platelet activation parameters (PAP) during a hyperinsulinaemic hypoglycaemic clamp study.
- Conditions
- Diabetes Mellitus With Hypoglycemia, Diabetes Mellitus, Type 2, Hypoglycemia, Hypoglycemic Episode
- Trial name
- Diaplate (NCT03460899)
- Testing
- Euglycaemic Clamp, Hyperinsulinaemic/Hypoglycaemic Clamp
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Graz
Hypoglycemia, Type 1 Diabetes
A Study to Inv. Safety, Efficacy & PD of Dasiglucagon as Hypoglycemia Rescue Therapy in Children <6 Years With T1D
This research study will investigate whether dasiglucagon as a rescue therapy for participants under 6 years of age works and is safe to use.
- Trial name
- NCT05378672
- Testing
- Dasiglucagon
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Zealand Pharma
Diabetes Mellitus, Type 1
Effect of Medium Chain Fatty Acids on Cognitive Function During Acute Hypoglycemia in Patients With Type 1 Diabetes
At present, there are no therapeutic agents that can minimize severe hypoglycemia (low blood sugar) and its effects on long-term brain function.
- Trial name
- NCT00592072
- Testing
- Medium chain fatty acid (Octanoic and Decanoic acid)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Diabetes Mellitus Type 2
Vildagliptin vs Sitagliptin add-on to Insulin - Impact on Glycemic Profile and Correlation of Hypoglycemic Episodes and Heart Function
Vildagliptin and Sitagliptin both belong to the class of DPP-4 inhibitors, but differ in their pharmacokinetic profile as well as in their approved application (Vildagliptin, 2x 50 mg daily, Sitagliptin, 1x 100 mg daily).
- Trial name
- CGM-VISIT (NCT01686932)
- Testing
- Vildagliptin, Sitagliptin
- Where
- 11 sites in Germany
- Volunteers
- 51 people
- Sponsor
- Novartis Pharmaceuticals
End-Stage Renal Disease, Type 2 Diabetes
Study to Determine the Efficacy of Real-time CGM in Preventing Hypoglycemia Among Insulin-treated Patients With DM2 on Hemodialysis, Compared to Standard of Care (POC BG)
The study is conducted to assess the efficacy of real-time CGM data in preventing hypoglycemia in patients with type 2 diabetes and end-stage kidney disease (ESKD), treated with insulin therapy and receiving hemodialysis.
- Trial name
- NCT04473430
- Testing
- Dexcom Real-time G6 Continuous Glucose Monitoring System (CGM), POC Glucose Testing
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Emory University
Type 1 Diabetes Mellitus, Hypoglycemia
MGA031, Sirolimus and Tacrolimus in Islet Transplantation
This clinical trial is designed to extend the observations made in our pilot clinical trial (IND 8971, Study #1) on the safety and efficacy of immunotherapy with the anti-CD3 monoclonal antibody hOKT3γ1 (Ala-Ala), (currently…
- Trial name
- NCT00265473
- Testing
- Allogeneic Islets of Langerhans
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Minnesota
Gestational Diabetes Mellitus
The Effect of Continuous Glucose Monitoring on Glycemic Control in Insulin-requiring Gestational Diabetes Mellitus
The purpose of this study is to determine if professional Continuous glucose monitoring improves glycemic control with less hypoglycaemia in insulin-requiring Gestational Diabetes Mellitus
- Trial name
- NCT02204657
- Testing
- Continuous Glucose Monitoring System
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- University of Malaya
Hyperparathyroidism, Hypercalcemia
Studies of Elevated Parathyroid Activity
Observational Phase: Patients whose parathyroid activity is elevated above normal are referred to as having hyperparathyroidism.
- Conditions
- Hyperparathyroidism, Hypercalcemia, Parathyroid Neoplasm, Multiple Endocrine Neoplasia
- Trial name
- NCT00001277
- Testing
- 68Ga-Dotatate, 18F-DOPA
- Where
- United States
- Volunteers
- 1,553 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Critical Illness
Continuous Glucose Monitoring With a Subcutaneous Sensor During Critical Illness and Surgery
We hypothesize that measurements of interstitial fluid (ISF) glucose by the FreeStyle Navigator (Abbot Diabetes Care), a continuous glucose monitoring system, will correlate with blood glucose (BG) values in surgical and ICU…
- Trial name
- NCT00694473
- Testing
- Freestyle Navigator
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Massachusetts General Hospital
Type 2 Diabetes
Sitagliptin and Glucagon Counterregulation
To evaluate the effect of DPP-4 inhibition on glucagon counter-regulatory mechanisms at moderate hypoglycemia in metformin-treated subjects with T2DM
- Trial name
- SITACLAMP (NCT02256189)
- Testing
- Sitagliptin
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Lund University
Diabetes Mellitus, Type 2
Benefits of Insulin Supplementation for Correction of Hyperglycemia in Patients With Type 2 Diabetes
The purpose of this study is to test whether using extra doses of aspart insulin to correct blood sugars before meals improves the care of patients with type 2 diabetes in the hospital who are already receiving the standard of…
- Trial name
- NCT02408120
- Testing
- Insulin glargine, Insulin aspart, Supplemental insulin aspart
- Where
- 2 sites in United States
- Volunteers
- 226 people
- Sponsor
- Emory University
Type 1 Diabetes
Outpatient Pump Shutoff Pilot Feasibility and Efficacy Study
The purpose of this study is to see whether low blood sugar at night can be reduced by using a system that turns off the insulin pump automatically.
- Trial name
- NCT01591681
- Testing
- Pump suspension
- Where
- 3 sites in United States, Canada
- Volunteers
- 49 people
- Sponsor
- Jaeb Center for Health Research