Clinical trials: Hypoglycaemia
End-Stage Renal Disease, Type 2 Diabetes
Study to Determine the Efficacy of Real-time CGM in Preventing Hypoglycemia Among Insulin-treated Patients With DM2 on Hemodialysis, Compared to Standard of Care (POC BG)
The study is conducted to assess the efficacy of real-time CGM data in preventing hypoglycemia in patients with type 2 diabetes and end-stage kidney disease (ESKD), treated with insulin therapy and receiving hemodialysis.
- Trial name
- NCT04473430
- Testing
- Dexcom Real-time G6 Continuous Glucose Monitoring System (CGM), POC Glucose Testing
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Emory University
Type 1 Diabetes
Measurement of Glucose/Glycogen Metabolism in Humans Using Magnetic Resonance at 4 or 7 Tesla
The long-range goal of this project is to determine the effects of diabetes and the hypoglycemic consequences of intensive therapy on in vivo brain glucose metabolism in humans.
- Trial name
- Glycogen (NCT00786825)
- Testing
- somatostatin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Postbariatric Hypoglycemia
Safety and Efficacy of Exendin 9-39 in Patients With Postbariatric Hypoglycemia
This clinical study will evaluate whether taking an investigational drug called exendin 9-39 is safe, well-tolerated, and helps to prevent low blood sugar in people who have had bariatric surgery and later develop a rare…
- Trial name
- PREVENT (NCT03373435)
- Testing
- exendin 9-39
- Where
- 5 sites in United States
- Volunteers
- 18 people
- Sponsor
- Eiger BioPharmaceuticals
Type1diabetes
The Monitoring Study
To conduct an outpatient study testing two configurations of the bionic pancreas (bi-hormonal and insulin-only) with and without remote monitoring of hypoglycemia in 25 adult (≥ 18 years of age) subjects with type 1 diabetes in a…
- Trial name
- NCT02969863
- Testing
- Bihormonal Bionic Pancreas, Insulin Only Bionic Pancreas, Monitored for Hypoglycemia
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type II, Hypoglycemia
Effects of Mild Hypoglycaemia on Cognitive Function in Type 2 Diabetes
Hypoglycaemia in subjects suffering from type 2 diabetes may have substantial consequences including a significant negative impact on quality of life.
- Conditions
- Diabetes Mellitus, Type II, Hypoglycemia, Cognitive Change
- Trial name
- NCT03014011
- Testing
- Hypoglycaemic clamp, Euglycaemic clamp
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Bispebjerg Hospital
Type 1 Diabetes Mellitus
An Evaluation of Novel Glucose Sensing Technology on Hypoglycaemia in Type 1 Diabetes (IMPACT)
The purpose of this study is to evaluate the impact of the Abbott Sensor Based Glucose Monitoring System on hypoglycaemia compared to Self Monitoring Blood Glucose (SMBG) testing using a randomised controlled study design in…
- Trial name
- IMPACT (NCT02232698)
- Testing
- Sensor Based Glucose Monitoring System, Standard Blood Glucose Monitoring
- Where
- 23 sites in Austria, Germany and 3 more
- Volunteers
- 328 people
- Sponsor
- Abbott Diabetes Care
Nosocomial Infection, External Causes of Morbidity and Mortality
Tight Glycaemic Control During Cardiac Surgery
To determine whether intraoperative tight glycaemic control can reduce postoperative infection, morbidity and mortality
- Conditions
- Nosocomial Infection, External Causes of Morbidity and Mortality, Hypoglycemia
- Trial name
- TGC (NCT01225159)
- Testing
- TGC, Conventional glycaemic control
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Prince of Songkla University
Diabetes
Continuous Glucose Monitoring in Critically Ill
The goal of this clinical research study is to learn if The Guardian® blood-sugar monitoring device can be used reliably in patients with high blood sugar who are receiving care in the ICU.
- Trial name
- NCT00707434
- Testing
- Guardian® blood-sugar monitoring device
- Where
- 6 sites in United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Type 1 Diabetes, Hypoglycemia Unawareness
A Randomized Double Blinded Study to Examine the Use of N-acetyl Cysteine for the Prevention and Treatment of HAAF in Patients With Type 1 Diabetes
This is a single center, double blind randomized cross over design trial that will compare the impact of N-acetyl cysteine (200 mg) vs.
- Trial name
- NAC for HAAF (NCT02206152)
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Minnesota
Acquired Hyperinsulinemic Hypoglycemia
Avexitide Safety and Efficacy to Treat Acquired Hyperinsulinemic Hypoglycemia
The primary goal of this study is to evaluate the safety and efficacy of two different dosing regimens of an investigational drug called Avexitide in treating low blood sugar in patients with Acquired Hyperinsulinemic…
- Trial name
- NCT04652479
- Testing
- Avexitide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Dr. Tracey McLaughlin, MD
Neonatal Hypoglycemia
Detecting Neonatal Hypoglycemia Using Real-Time Continuous Glucose Monitoring (CGM)
Hypoglycemia is the most common metabolic problem faced after birth. The investigators will be studying the utility of using a continuous glucose monitoring(CGM) system to more closely monitor low blood sugars in newborns.
- Trial name
- NCT03032523
- Testing
- Standard of care glucose test
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Stanford University
Hypoglycemia, Cognitive Impairment
The Impact of Renin-angiotensin System on Brain Activation During Hypoglycaemia in Healthy Men, a PET Study
The purpose of this study is to evaluate the cerebral blood flow in subjects with high and low activity in the renin-angiotensin system (RAS).The renin-angiotensin system is a hormone system which is involved in the regulation of…
- Trial name
- NCT00264641
- Testing
- Human insulin
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hypoglycaemia Research Group
Hypoglycemia, Evidence of Previous Gastric Surgery
Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery
The purpose of this study is to determine whether pramlintide (Symlin) will help to reduce the frequency and severity of hypoglycemia in individuals who have had gastric bypass surgery.
- Trial name
- NCT01841359
- Testing
- Pramlintide
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Joslin Diabetes Center
Type 2 Diabetes Mellitus
Evaluation of Low Blood Sugar Events in Participants With Diabetes (MK-0431-401)
This is a multi-center, observational, retrospective and cross-sectional study to be conducted in a cohort of consecutively selected participants with Type 2 diabetes mellitus (DM) who have been treated with sulphonylurea (SU)…
- Trial name
- NEEDS (NCT01285076)
- Testing
- Other: Retrospective chart review; one participant encounter visit.
- Where
- Taiwan
- Volunteers
- 834 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes
Sitagliptin and Glucagon Counterregulation
To evaluate the effect of DPP-4 inhibition on glucagon counter-regulatory mechanisms at moderate hypoglycemia in metformin-treated subjects with T2DM
- Trial name
- SITACLAMP (NCT02256189)
- Testing
- Sitagliptin
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Lund University
Diabetes Mellitus, Type 1
Feasibility Trial Testing the Bionic Pancreas With ZP4207
The purpose of this study was to determine whether the Bionic Pancreas with ZP4207 (dasiglucagon*) was feasible to improve glycemic control in adults with type 1 diabetes mellitus.
- Trial name
- dasiglucagon (NCT02971228)
- Testing
- Insulin Lispro, ZP4207 (dasiglucagon), Glucagon
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Zealand Pharma
Hypoglycemia Unawareness, Type 1 Diabetes
Intra-nasal Naloxone for Treatment of Impaired Awareness of Hypoglycemia
This is a single center, single-blind randomized cross over design trial that will compare the impact of intra-nasal naloxone vs.
- Trial name
- NCT02700048
- Testing
- intra-nasal naloxone, Intra-nasal saline
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Type 1 Diabetes, Hypoglycemia
CGM Use in Poorly Controlled Youth With Type 1 Diabetes
The purpose of this prospective study is to determine if trial use of a Dexcom G6 CGM system for a 10 day wear period in high risk, poorly controlled pediatric Type 1 diabetes patients increases uptake of personal CGM use, and…
- Conditions
- Type 1 Diabetes, Hypoglycemia, High Blood Sugar
- Trial name
- IMPaCT (NCT04721145)
- Testing
- Dexcom G6 Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Johns Hopkins University
Diabetes Mellitus With Hypoglycemia, Diabetes Mellitus, Type 2
Impact of Hypoglycaemia in Patients With Diabetes Mellitus Type 2 on Platelet Activation
This experimental study is planned to investigate the impact of hypoglycaemia on platelet activation parameters (PAP) during a hyperinsulinaemic hypoglycaemic clamp study.
- Conditions
- Diabetes Mellitus With Hypoglycemia, Diabetes Mellitus, Type 2, Hypoglycemia, Hypoglycemic Episode
- Trial name
- Diaplate (NCT03460899)
- Testing
- Euglycaemic Clamp, Hyperinsulinaemic/Hypoglycaemic Clamp
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Graz
Type 2 Diabetes Mellitus
Evaluation of Low Blood Sugar Events in Participants With Diabetes (MK-0431-402)
This is a multicenter, observational, retrospective and cross-sectional study to be conducted in a cohort of consecutively selected participants with type 2 diabetes mellitus (T2DM) who have been treated with sulphonylurea (SU)…
- Trial name
- NEEDS (NCT01278485)
- Testing
- Sulphonylurea, Metformn
- Volunteers
- 726 people
- Sponsor
- Merck Sharp & Dohme LLC