Clinical trials: Hypoglycemia, Reactive
Hypoglycemia, Reactive
Pasireotide in the Treatment of Hypoglycemia Following Gastric Bypass Surgery
Postprandial hyperinsulinemic hypoglycemia is a well-known and potentially severe complication of Roux-en-Y gastric bypass (RYGB), and the treatment options are limited.
- Trial name
- NCT03514576
- Testing
- Pasireotide 0.3 MG/ML, Meal tolerance test (MTT)
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- Zealand University Hospital
Hypoglycemia, Hypoglycemia, Reactive
Glucagon Dose-Response in Patients With Post-Bariatric Hypoglycemia
The purpose of the study is to determine how blood sugar levels in individuals with and without hypoglycemia after bariatric surgery respond to different doses of glucagon, a hormone that is usually present in your body that…
- Conditions
- Hypoglycemia, Hypoglycemia, Reactive, Bariatric Surgery
- Trial name
- NCT06986603
- Testing
- Glucagon for Injection (Fresenius Kabi USA)
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Joslin Diabetes Center
Post-bariatric Hypoglycemia
An Expanded Access Protocol to Provide Avexitide in Patients With Post-Bariatric Hypoglycemia
The Expanded Access Program will provide access to avexitide for people with post-bariatric hypoglycemia (PBH) following Roux-en-Y gastric bypass (RYGB) who meet the eligibility criteria for this program.
- Trial name
- NCT07582874
- Testing
- Avexitide
- Where
- 4 sites in United States
- Sponsor
- Amylyx Pharmaceuticals Inc.
Postprandial Hypoglycemia, Bariatric Surgery
Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study
The purpose of the study is to investigate whether hypoglycaemia observed after food intake in bariatric patients can be either influenced by an SGLT2 inhibitor, empagliflozin, or via inhibition of inflammation with an human…
- Conditions
- Postprandial Hypoglycemia, Bariatric Surgery, Late Dumping Syndrome
- Trial name
- Hypo-BEAR (NCT03200782)
- Testing
- Empagliflozin, Anakinra
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University Hospital, Basel, Switzerland
Postprandial Hypoglycemia, Age-Related Memory Disorders
The Scottish Fruit Study
The purpose of this study is to determine if new varieties of fruits grown in Scotland which can adapt better to climate change namely, honeyberries and cherries, have the same health benefits as established fruits such as…
- Trial name
- NCT05513404
- Testing
- Honeyberry, Cherry, Raspberry
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Postprandial Hypoglycemia
Canakinumab for the Treatment of Postprandial Hypoglycemia
The primary objective of this randomized trial is to test whether a treatment with canakinumab is superior to placebo in patients with postprandial hypoglycemia after bariatric surgery, that is if it improves health related…
- Trial name
- CanpHy (NCT05401578)
- Testing
- Canakinumab
- Where
- 2 sites in Switzerland
- Volunteers
- 56 people
- Sponsor
- University Hospital, Basel, Switzerland
Dumping Syndrome, Hypoglycemia, Reactive
Investigating the Impact of the SGLT2 Inhibitor Empagliflozin on Postprandial Hypoglycaemia After Gastric Bypass
Bariatric surgery is an effective anti-obesity treatment providing durable weight loss and profound beneficial effects on glucose metabolism.
- Trial name
- NCT05057819
- Testing
- Empagliflozin 25 MG
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hyperinsulinemic Hypoglycemia, Postprandial Hypoglycemia
Dasiglucagon in the Treatment of Postprandial Hypoglycaemia After Roux-en-Y Gastric Bypass
The aim of this study is investigating the effect of a novel glucagon analogue administration in gastric bypass operated individuals, who are reactive hypoglycemic.
- Trial name
- NCT03984370
- Testing
- ZP4207
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Hypoglycemia, Cerebral Blood Flow
External Carotid Blood Flow in Individuals With Post-Bariatric Hypoglycemia
This is a pilot study (small-scale study) that aims to understand more about how blood flow changes in people who have low blood sugar after bariatric surgery (post-bariatric hypoglycemia) compared to those who have had surgery…
- Trial name
- NCT07082478
- Testing
- in-ear device measuring blood flow
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Postprandial Hypoglycemia, End-stage Renal Disease (ESRD)
Anakinra for the Treatment of Postprandial Hypoglycemia in a Patient With Total Gastrectomy and End-Stage Renal Disease
Post-meal low blood sugar (postprandial hypoglycemia) is a common problem after certain stomach surgeries like gastric bypass or stomach removal.
- Conditions
- Postprandial Hypoglycemia, End-stage Renal Disease (ESRD), Gastrectomy, Glucose Metabolism Disorders
- Trial name
- AnPHy-ReD (NCT07580079)
- Testing
- Anakinra (interleukin-1 receptor antagonist)
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Marc Donath
Healthy
Effects of Reactive Hypoglycaemia on Cognition in Earlier or Later Chronotypes
Studies suggest a link between lower postprandial glycaemic response and better cognitive performance in children, adolescents, and young adults, though evidence remains inconclusive.
- Trial name
- GlyCoBrainI2 (NCT06941740)
- Testing
- immediate verbal memory after low glycemic index breakfast inducing no reactive hypoglycaemia, immediate verbal memory after low glycemic index breakfast causing reactive hypoglycaemia
- Where
- Germany
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Anette Buyken
Hypoglycemia, Reactive, Hypoglycaemia Night
CGM (Continuous Glucose Monitoring) Use in Diagnosis of Spontaneous and Reactive Hypoglycaemia
Use of CGM to determine diagnosis in possible spontaneous or reactive hypoglycaemia. Use of CGM to aid treatment optimisation in spontaneous or reactive hypoglycaemia
- Conditions
- Hypoglycemia, Reactive, Hypoglycaemia Night, Hypoglycemia Non-Diabetic, Hypoglycemia Unawareness
- Trial name
- NCT04452396
- Testing
- use of continuous glucose monitoring
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Barts & The London NHS Trust
Roux-en-Y Gastric Bypass, Postprandial Hypoglycemia
Effect of Postprandial Hyperinsulinaemic Hypoglycaemia on Driving Performance.
The primary objective of this study is to assess the effect of the natural course of postprandial hypoglycemia vs. a postprandial euglycaemic condition on driving performance in individuals with confirmed postprandial…
- Conditions
- Roux-en-Y Gastric Bypass, Postprandial Hypoglycemia, Driving Impaired
- Trial name
- DEEP1C (NCT04330196)
- Testing
- Oral glucose tolerance test
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Lia Bally
Post-Prandial Hyperglycemia, Post-Prandial Hypoglycemia
Improving Post-Prandial Blood Glucose Control With Afrezza During Closed-Loop Therapy
The study will be conducted in two phases; an in-patient meal study phase (Phase I) and an outpatient home study (Phase II). The two phase study design is chosen to enhance safety by testing the Afrezza Closed-Loop (CL) system in…
- Trial name
- NCT03234491
- Testing
- DiAS, Afrezza low dose, Afrezza high dose
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Polycystic Ovarian Syndrome
Compare Effects of Flax Seed Oil, and Fish Oil on Blood Sugar Levels
Flax seed oil, fish oil, and soy bean oil, are commonly recommended supplements for Polycystic Ovarian Syndrome (PCOS). These oils have different chemical structures and biological actions.
- Trial name
- PCOS (NCT00579540)
- Testing
- Flax Seed Oil, Fish Oil, Soybean Oil
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, Davis