Clinical trials: Hypoglycemia
Motivational Interviewing, Type 1 Diabetes
The Effect of Motivational Interviewing in Children With Type 1 Diabetes
This research was conducted in a randomized controlled experimental way to determine the effect of motivational interviewing on hypoglycemia fear, caregiving, fatigue and self-compassion in parents of children with Type 1…
- Conditions
- Motivational Interviewing, Type 1 Diabetes, Hypoglycemia, Fatigue
- Trial name
- NCT06424574
- Testing
- motivational interview
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Neonatal Hypoglycemia
Immediate Skin-To-Skin Contact and Early Breastfeeding During Caesarean Section
Background: Neonatal hypoglycemia is a prevalent and serious condition among late preterm and term infants, which can lead to severe neurodevelopmental consequences if not managed properly.
- Trial name
- NCT06543160
- Testing
- Immediate SSC and early breastfeeding during CS, Delayed SSC and breastfeeding after CS, Routine newborn care
- Where
- China
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Qingdao Municipal Hospital
Bariatric Surgery
Glycemic Patterns After Bariatric Surgery and High Glycemic Variability and Hypoglycemia Unawareness Risk Factors
To study the glycemic patterns of patients undergoing bariatric surgery and what are the risk factors capable of predicting episodes of unnoticed hypoglycemia and high glycemic variability, evaluating patients who underwent…
- Trial name
- NCT05728320
- Testing
- Glucose monitoring with flash glucose monitor
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Type 1 Diabetes Mellitus
Automated Insulin Delivery in Elderly With Type 1 Diabetes (AIDE T1D)
A multi-center, randomized, crossover trial consisting of three sequential 12-week periods, with the HCL feature used during one period, the PLGS feature used during one period and SAP therapy (control) during one period.
- Trial name
- AIDE T1D (NCT04016662)
- Testing
- Tandem t:slim X2 with HCL or PLGS
- Where
- 4 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes
Measurement of Glucose/Glycogen Metabolism in Humans Using Magnetic Resonance at 4 or 7 Tesla
The long-range goal of this project is to determine the effects of diabetes and the hypoglycemic consequences of intensive therapy on in vivo brain glucose metabolism in humans.
- Trial name
- Glycogen (NCT00786825)
- Testing
- somatostatin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hypoglycemia
Disorders of Systemic Glucose Balance
We wish to identify people with hypoglycemia (low blood sugar) and ultimately determine why the blood sugar levels are so low. To do so, we will contrast the responses of patients suspected to have hypoglycemia with those of…
- Trial name
- NCT00006508
- Testing
- Controlled hypoglycemia using insulin, formula meal
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Diabetes Mellitus, Hypoglycemia
Mechanisms of Hypoglycemia Associated Autonomic Failure
Intensive glucose control in type 1 diabetes mellitus (T1DM) is associated with clear health benefits. However, despite development of insulin analogs, pump/multi-dose treatment and continuous glucose monitoring, maintaining…
- Conditions
- Diabetes Mellitus, Hypoglycemia, Autonomic Failure
- Trial name
- NCT00678145
- Testing
- naloxone, fructose, exercise
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Type 1 Diabetes, Hypoglycemia
hOKT3γ1 (Ala-Ala) Combined With Sirolimus and Delayed Tacrolimus in Type 1 Diabetic Islet Allograft Recipients
The collective effects of two-layer pancreas preservation, pretransplant islet culture, day -2 pretransplant immunosuppression, and induction immunosuppression with the FcR-nonbinding anti-CD3 monoclonal antibody hOKT3γ1…
- Trial name
- NCT00285194
- Testing
- Allogeneic Islets of Langerhans, hOKT3γ1 (Ala-Ala)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Diabetes Mellitus, Type 2, Arrhythmia, Cardiac
Hypoglycaemia and Cardiac Arrhythmias in Type 2 Diabetes
Twenty-one patients with insulin-treated type 2 diabetes with diabetic complications will be recruited to Part 1 of the study, a three-hour combined hyper- and hypoglycaemic clamp, along with a control group of twenty-one…
- Trial name
- HYPO-HEART (NCT03150030)
- Testing
- Combined hyper- and hypoglycaemic clamp, Loop recorder (Reveal LINQ, Medtronic, Minneapolis, MN, USA), Continuous glucose monitoring (iPro2, Medtronic, Minneapolis, MN, USA)
- Where
- Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Hypoglycemia, Type 1 Diabetes
Effect of C-peptide on Hypoglycemic Counterregulation
Iatrogenic hypoglycemia is the most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes due to periodic over-insulinization.
- Trial name
- NCT06470295
- Testing
- Saline, C-peptide
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Diabetes, Hypoglycemia
Acute Changes in Plasma Glucose and Cardiovascular Disease in Diabetes
Patients with diabetes have an increased risk of sudden cardiac death compared to the general population. Severe hypoglycemia is associated with an increased risk of cardiovascular (CV) disease (CVD) and events, including cardiac…
- Conditions
- Diabetes, Hypoglycemia, Hyperglycemia, Cardiovascular Diseases
- Trial name
- NCT05500352
- Testing
- Hyperglycemia with slow decline in plasma glucose in type 1 diabetes, Hyperglycemia with rapid decline in plasma glucose in type 1 diabetes, Rebound hyperglycemia in type 1 diabetes
- Where
- Denmark
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Hypoglycemia, Diabetes Mellitus, Type 1
Comparison Between Hypoglycemic Counter Regulatory Responses in Type 1 Diabetics vs Control Subjects
This study compares the hypoglycemic counter regulatory response in type 1 diabetics and in healthy control subjects with and without antecedent hypoglycemia
- Trial name
- NCT03034226
- Testing
- Glucose clamp technique
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypoglycemia Non-Diabetic, Gastric Bypass Status Complicating Pregnancy, Birth, or Puerperium
Bariatric Surgery and Consequences for Mother and Baby in Pregnancy
Background Roux-en-Y gastric bypass (RYGB) is a well-established treatment of obesity, most often performed in women during their reproductive years. Adverse events related to RYGB include hypoglycemia.
- Trial name
- BAMBI (NCT03713060)
- Testing
- Mixed meal test
- Where
- 2 sites in Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Diabetes Mellitus
Does Islet Transplantation Eliminate Hypoglycemia?
Low blood sugar (hypoglycemia) is a recurrent problem for many people with diabetes. Successful transplantation of clusters (islets) of normal cells, that include those which produce the sugar-lowering hormone insulin, from the…
- Trial name
- NCT00006068
- Testing
- Pancreatic Islet Transplantation
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Type 1 Diabetes, Hypoglycemia Unawareness
Naltrexone and Hypoglycemia in Type 1 Diabetes
Low blood sugar is also called hypoglycemia. Usually, it is mild and can be treated quickly and easily by eating or drinking a small amount of a sugar-rich food.
- Trial name
- Naltrexone (NCT01053078)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hypoglycemia
Effect of Fasting on Insulin-induced Hypoglycemia Counterregulation in Healthy Humans
Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D).
- Trial name
- NCT04392843
- Testing
- Fasting, Feeding
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus with Hypoglycemia
A Pilot Study to Assess the Feasibility of a Novel Non-invasive Technology to Measure Changing Blood Glucose Levels in Adults with Type-1 Diabetes Mellitus
The primary aim of this study is to assess the feasibility of the Lab demo 1.0 and associated computational models to detect and track glucose changes noninvasively and transcutaneously in defined and dynamic states of glycemia.
- Conditions
- Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus with Hypoglycemia, Type 1 Diabetes Mellitus with Hyperglycemia
- Trial name
- NCT06097689
- Testing
- Lab Demo 1.0
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Liom Health AG
Type 1 Diabetes
The Effect of Prolonged Pramlintide Infusion in Pediatric Diabetes
The purpose of this study is to see if reducing the dose of insulin before a meal and giving both pramlintide and insulin as dual wave infusions will lower the chance of low blood sugars after a meal.
- Trial name
- NCT00206297
- Testing
- Pramlintide
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Diabetes Mellitus, Hyperglycaemia (Diabetic)
Validation of Remote Photoplethysmography for Non-Invasive Estimation of Blood Glucose and HbA1c
The goal of this observational study is to evaluate whether a non-invasive facial scan technology using remote photoplethysmography (rPPG) can accurately estimate blood glucose and HbA1c levels in adults living in the community…
- Conditions
- Diabetes Mellitus, Hyperglycaemia (Diabetic), Hyperglycaemia (Non Diabetic), Hypoglycaemia
- Trial name
- NCT07502690
- Where
- Indonesia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International