Clinical trials: Hypoglycemia (Diabetic)
Type 1 Diabetes Mellitus
Islet Cell Transplant for Type 1 Diabetes
City of Hope National Medical Center, located in Duarte, CA, is hosting a clinical study on islet cell transplantation, an experimental procedure being evaluated as a treatment for patients with type 1 diabetes.
- Trial name
- TCD (NCT01909245)
- Testing
- Allogenic Human Islet Cells, Immunosuppressive Agents, Gastrin 17
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- City of Hope Medical Center
Type 1 Diabetes
Washed Microbiota Transplantation for Type 1 Diabetes Mellitus
This is a real-world study to explore the safety and the efficacy of washed microbiota transplantation (WMT) for patients with Type 1 Diabetes Mellitus (T1DM).
- Trial name
- NCT06256614
- Testing
- WMT
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Diabetes (DM), Diabetes Mellitus
Changes in Person-reported Outcomes and Behavior Using the Accu-Chek SmartGuide CGM and Predict App
The goal of this controlled pre-post-trial is to test the Accu-Chek SmartGuide continuous glucose monitoring (CGM) system and whether its predictive features provide additional benefits for adults with type 1 diabetes or insulin…
- Conditions
- Diabetes (DM), Diabetes Mellitus, Diabetes Mellitus Type 2, Diabetes Mellitus Type 1
- Trial name
- NCT07814508
- Testing
- SmartGuide CGM with Predictive Features
- Where
- Germany
- Volunteers
- 89 people
- Sponsor
- FIDAM RDC
Type 2 Diabetes Mellitus, Hypoglycemia
Hypoglycemia Risk Assessment in Elderly and Senile Female Patients With Type 2 Diabetes Mellitus
Hypoglycemia poses a particular danger for elderly patients with type 2 diabetes mellitus (T2DM). According to data, more than 30% of patients aged 60-69 years experience hypoglycemic episodes, and among persons over 85 years…
- Conditions
- Type 2 Diabetes Mellitus, Hypoglycemia, Frailty, Sarcopenia
- Trial name
- HYPOGLYCEMIA16 (NCT07887334)
- Testing
- Comprehensive Geriatric Assessment, Sarcopenia assessment, Laboratory assessment
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Samara State Medical University
Type 2 Diabetes Mellitus With Hypoglycemia, Aging
Prepare for Your Diabetes Care
As adults with type 2 diabetes age, they are increasingly vulnerable to treatment-related hypoglycemia and its related complications (including hospitalization and death).
- Conditions
- Type 2 Diabetes Mellitus With Hypoglycemia, Aging, Patient Activation
- Trial name
- NCT05263310
- Testing
- Prepare for Your Diabetes Care, Usual Care
- Where
- United States
- Volunteers
- 672 people
- Sponsor
- Kaiser Permanente
Diabete Mellitus, Diabete Type 1
Study of the Safety and Efficacy of Pancreatic Endocrine Cells in Adult Patients With Type 1 Diabetes
This study will evaluate the safety, efficacy and durability of SR-02 administered to the omentum of patients of Type 1 diabetes with severe recurrent hypoglycemia. The study will also help establish the optimal treatment dose.
- Trial name
- NCT07581197
- Testing
- Allogeneic pancreatic endocrine cell clusters
- Volunteers
- 9 people
- Sponsor
- Seraxis
Type 1 Diabetes, Hypoglycemia
Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing in Children and Young Adolescents
Objective: to gain experience in children and younger adolescents with in-home use of an algorithm that will dose insulin to minimize projected hyperglycemia overnight in addition to suspending the pump if hypoglycemia is…
- Conditions
- Type 1 Diabetes, Hypoglycemia, Hyperglycemia, Artificial Pancreas
- Trial name
- PHM3 (NCT02714972)
- Testing
- Hyperglycemia Minimization Algorithm
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Type 1
Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
This clinical study will evaluate the safety and effectiveness of Gastrin treatment with islet transplantation to help patients with difficult to control type 1 diabetes make insulin again and improve blood sugar control.
- Trial name
- NCT03746769
- Testing
- Allogenic Human Islet Cells, Gastrin 17
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Diabetes
Hypoglycemia Prevention in High-Risk Type 2 Diabetes Patients
Severe low blood sugar (hypoglycemia) is a serious problem for people with diabetes. It can lead to dangerous falls, heart problems, memory issues, and even death.
- Trial name
- NCT06746714
- Testing
- Proactive population care (active application of HOAP principles in patients flagged as high risk for hypoglycemia), Usual care, after system-side dissemination of HOAP
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Kaiser Permanente
Diabetes Mellitus, Type 1
The Real-World Control-IQ Glycemic Control and Quality of Life Study in Type 1 Diabetes in France
This post-market surveillance study is primarily designed to demonstrate the ongoing safety of the Control-IQ system, the ongoing performance of glycemic control and quality of life with Control-IQ system use, and the rate of use…
- Trial name
- RECORD-IQ (NCT07211126)
- Testing
- t:slim X2 insulin pump with Control-IQ technology (Control-IQ System)
- Where
- 25 sites in France
- Volunteers
- 350 people
- Sponsor
- Tandem Diabetes Care, Inc.
Diabetes, Alzheimer's Disease (Incl Subtypes)
Enhancing Shared Decision-making to Guide Care for People With Dementia and Diabetes
The goal of this study is to test CGM ASSIST. This is a digital tool that uses an interactive information display-an easy-to-read screen designed to help people with dementia (or memory loss) and diabetes, as well as their…
- Conditions
- Diabetes, Alzheimer's Disease (Incl Subtypes), Dementia, Hypoglycemia
- Trial name
- CGM ASSIST (NCT05643144)
- Testing
- Continuous Glucose Monitoring
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Indiana University
Diabetes Mellitus
Continuous Glucose Monitoring in the Intensive Care Unit
The aim of the proposed clinical trial is to study the use of the Dexcom G7 continuous glucose monitor (CGM) within the intensive care unit (ICU) environment.
- Trial name
- NCT06190808
- Testing
- Dexcom G7 Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Massachusetts, Worcester
Diabetes, Hypoglycemia
Evaluating Glial Acetate Metabolism as a Biomarker of Hypoglycemic Counterregulation
Hypoglycemic complications are a major impediment to the maintenance of healthy glucose levels in persons with diabetes. The investigators recently completed a clinical pilot and feasibility study (GLIMPSE, NCT02690168), which…
- Trial name
- E-VAL (NCT04207619)
- Testing
- hyperinsulinemic-hypoglycemic clamp, 13C-MRS procedure/Acetate infusion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Diabetes Mellitus (DM), Hypoglycaemia
Evaluation of the Psychometric Properties of the Turkish Version of the Hypoglycaemia Self-Care Behaviour Scale
The aim of this study is to validate the validity and reliability of the Hypoglycaemia Self-Care Behaviour Scale, developed to assess hypoglycaemia self-care behaviours in patients with type 2 diabetes, through a prospective…
- Conditions
- Diabetes Mellitus (DM), Hypoglycaemia, Self Care
- Trial name
- NCT07316699
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
Diabetes Mellitus, Diet, Healthy
FEAR of HYPOGLYCEMIA in PATIENTS WITH DIABETES
Fear of hypoglycemia has a significant impact on both medication and dietary adherence in individuals with diabetes. Through avoidance behaviors, it can disrupt metabolic control, prevent the achievement of glycemic targets, and…
- Conditions
- Diabetes Mellitus, Diet, Healthy, Medication Adherence, Hypoglycemia
- Trial name
- NCT07329985
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
Type II Diabetes Mellitus
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
This study is testing whether a new medication called CX11 works and is safe for participants with type 2 diabetes who have not reached good blood sugar control while taking a steady dose of metformin, with or without a steady…
- Trial name
- NCT07340320
- Testing
- CX11
- Where
- 48 sites in United States, Poland
- Volunteers
- 240 people
- Sponsor
- Corxel Pharmaceuticals
Diabetes Mellitus, Type 2
Time in Glucose Hospital Target
Inpatient management of glycemia in people with diabetes has been inadequately studied. Previous randomized trials of intensive insulin therapy in the hospital setting resulted in excessive hypoglycemia.
- Trial name
- TIGHT (NCT05135676)
- Testing
- Blinded CGM, real-time CGM
- Where
- 6 sites in United States
- Volunteers
- 166 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Type 2 on Insulin, Hypoglycemia (Diabetic)
Comparing Glycemic Outcomes of Carbohydrate Counting vs. Fixed Mealtime Insulin Dosing in Hospitalized Patients With Hyperglycemia
The study compares two current practices for calculating insulin dose for admitted patients: flexible fixed mealtime dosing based on percent of meal eaten and carbohydrate counting based on amount of carbohydrates eaten.
- Conditions
- Diabetes Type 2 on Insulin, Hypoglycemia (Diabetic), Hyperglycemia Due to Type 2 Diabetes Mellitus
- Trial name
- MEND (NCT07808398)
- Testing
- Carbohydrate-counting-based prandial rapid-acting insulin dosing, Flexible fixed mealtime rapid-acting insulin dosing based on percentage of meal consumed
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Diabetes Mellitus Type 2
Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes.
The goal of this clinical trial is to assess the efficacy of a pharmacogenetics-guided treatment, compared to standard optimized treatment, in patients with inadequately controlled type 2 diabetes.
- Trial name
- EPHIC-DIA2 (NCT06851962)
- Testing
- Metformin, Dulaglutide, Semaglutide 1.0 mg
- Where
- 3 sites in Spain
- Volunteers
- 92 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Diabetes Mellitus, Type 1, Impaired Hypoglycemic Awareness
A Safety, Tolerability, and Efficacy Study of VX-880 and VX-017 in Participants With Type 1 Diabetes
This study will evaluate the safety, tolerability and efficacy of VX-880 infusion and VX-017 infusion in participants with type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.
- Conditions
- Diabetes Mellitus, Type 1, Impaired Hypoglycemic Awareness, Severe Hypoglycemia
- Trial name
- NCT04786262
- Testing
- VX-880, VX-017
- Where
- 29 sites in United States, Canada and 8 more
- Volunteers
- 57 people
- Sponsor
- Vertex Pharmaceuticals Incorporated