Clinical trials: Hypoglycemic Syndrome
COVID 19, Coronavirus
Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19
The coronavirus disease 2019 (COVID-19) is an emerging pandemic in 2020 caused by a novel coronavirus named SARS-CoV2. Diabetes confers a significant additional risk for COVID-19 patients.
- Conditions
- COVID 19, Coronavirus, Diabetes Mellitus, Type 2, Diabetes Mellitus
- Trial name
- NCT04371978
- Testing
- Linagliptin 5 MG
- Where
- 3 sites in Israel
- Volunteers
- 64 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes Mellitus
Safety, Tolerability, and Efficacy of Immunomodulation With A Monoclonal Antibody Against CD40L in Combination With Transplanted Islet Cells in Adults With Brittle Type 1 Diabetes Mellitus (T1D)
Tegoprubart (AT-1501) is a monoclonal antibody. Antibodies are Y-shaped proteins that are produced naturally by the subject's immune system to attack and fight foreign substances that cause illness.
- Trial name
- Tegoprubart (NCT06305286)
- Testing
- Islet transplantation with Tegoprubart (AT-1501) immunosupression-based therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Chicago
Post-Bariatric Hypoglycemia
Pasireotide s.c. in Patients With Post-Bariatric Hypoglycaemia
The Total duration of trial participation for each participant with post-bariatric hypoglycemia will be a maximum of 59 weeks, with the following duration of trial periods 19 weeks for the Core Phase.
- Trial name
- PASIPHY (NCT05928390)
- Testing
- Pasireotide Diaspartate
- Where
- 29 sites in United States, Belgium and 4 more
- Volunteers
- 93 people
- Sponsor
- RECORDATI GROUP
Type 1 Diabetes
The Effect of Prolonged Pramlintide Infusion in Pediatric Diabetes
The purpose of this study is to see if reducing the dose of insulin before a meal and giving both pramlintide and insulin as dual wave infusions will lower the chance of low blood sugars after a meal.
- Trial name
- NCT00206297
- Testing
- Pramlintide
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Diabetes Mellitus, Type 1
Dapagliflozin During Exercise for the PrevenTion of Hypoglycaemia
There are approximately 400,000 people in the UK who are living with type 1 diabetes (T1DM), of whom 29,000 are children. People with T1DM experience on average 2 episodes of symptomatic hypoglycaemia per week , and exercise…
- Trial name
- DEPTH (NCT03537131)
- Testing
- Dapagliflozin 10 MG Oral Tablet
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Oxford
Anesthesia, Sedation
The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes
Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful.
- Conditions
- Anesthesia, Sedation, Monitored Anesthesia Care, Procedure
- Trial name
- MACS (NCT07022951)
- Testing
- Preoperative fasting
- Where
- United States
- Volunteers
- 1,200,000 people
- Sponsor
- Massachusetts General Hospital
Critical Illness
Individualized Blood Glucose Control in ICU. The CONTROLING Study. A Double Blinded Multicentric Randomized Study.
During the last 2 decades, the management of hyperglycemia in critically ill patients has become one of the most discussed topics in the intensive-care field.
- Trial name
- CONTROLING (NCT02244073)
- Testing
- Human insulin - Insulin administration to control blood glucose level.
- Where
- 12 sites in France
- Volunteers
- 2,069 people
- Sponsor
- Hospices Civils de Lyon
Diabetes Insulin Dependent
Evaluation of Interests of FIT Therapy on Diabetics Children Insulin-dependent
Evaluation of interests of the functional insulin therapy (FIT Therapy) on metabolic control, hypoglycemia prevention and life quality of diabetics children insulin-dependent treated with insulin pump.
- Trial name
- DIABFIT (NCT01443741)
- Testing
- Therapeutic education
- Where
- 6 sites in France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Angers
Critical Illness, Hyperglycemia
Multicentre LOGIC-Insulin Algorithm-guided Versus Nurse-directed Blood Glucose Control During Critical Illness (LOGIC-2)
Most critically ill patients are confronted with hyperglycaemia, which is associated with an increased mortality and morbidity risk.
- Conditions
- Critical Illness, Hyperglycemia, Hypoglycemia
- Trial name
- LOGIC-2 (NCT02056353)
- Testing
- LOGIC-Insulin algorithm, Paper protocol
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 1,550 people
- Sponsor
- KU Leuven
Type 1 Diabetes Mellitus
Impact of Optimized Titration and Delivery of Bedtime Insulin on Prevention of Nocturnal Hypoglycemia
The purpose of this study is to determine whether or not bedtime snacks are necessary to prevent overnight low blood glucose reactions (nocturnal hypoglycemia) in adults with type 1 diabetes who are using intensive insulin…
- Trial name
- NCT00475345
- Testing
- Bedtime snacks
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- McGill University
Congenital Hyperinsulinism, Neuroblastoma
18F-DOPA II - PET Imaging Optimization
A single centre non-randomized, non-blinded phase III prospective cohort study of 18F-DOPA PET/CT imaging in specific patient populations: 1. Pediatric patients (less than 18 years old) with congenital hyperinsulinism. 2.
- Conditions
- Congenital Hyperinsulinism, Neuroblastoma, Parkinson Disease, Lewy Body Disease
- Trial name
- NCT04706910
- Testing
- 18F-DOPA, Furosemide Injection
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- University of Alberta
Congenital Hyperinsulinism, Insulinoma
Pasireotide in Hyperinsulinemic Hypoglycemia
This is a small controlled pilot study to assess the effect of subcutaneous pasireotide on preventing hypoglycemia due to hyperinsulinism, including congenital hyperinsulinism and insulinoma.
- Conditions
- Congenital Hyperinsulinism, Insulinoma, Hyperinsulinism
- Trial name
- NCT03053284
- Testing
- Pasireotide 0.6Mg Solution for Injection, Saline Solution
- Sponsor
- Montefiore Medical Center
Hyperinsulinism
Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism
The purpose of the study is to provide access to 18F-DOPA PET to patients at Washington University and assess the utility of 18F-DOPA PET/MRI as a preoperative tool to detect and localize focal lesions in the pancreas that are…
- Trial name
- 18FDOPA HI (NCT05088798)
- Testing
- 18F-Fluoro Dopa PET/MRI Imaging
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Washington University School of Medicine
Type 1 Diabetes Mellitus, Hypoglycemia
Skittles(TM) Effective for Treating Hypoglycemia in Children With Type 1 Diabetes
The purpose of this study is to determine the most effective treatment option for managing naturally occurring hypoglycemia in children with type 1 diabetes. Hypotheses: 1.
- Trial name
- NCT00706693
- Testing
- Ingestion of BD glucose tablets (TM), Ingestion of Skittles (TM), Ingestion of Fruit to Go (TM)
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- University of Calgary
Severe Hypoglycemia, Type1diabetes
Longitudinal Study of the GLUcagon REsponse to Hypoglycemia in Children and Adolescents With New-onset Type 1 DIAbetes
The GLUREDIA study investigates the counter-regulatory response (CRR) during hypoglycemia in children with type 1 diabetes (T1D).
- Trial name
- GLUREDIA (NCT06770621)
- Testing
- Insulin-induced hypoglycemia test, Glucagon profile, Biological sample once
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hypoglycemia
Safety and Efficacy Study of Mini-Dose Glucagon (G-Pen Mini) in Patients With Type 1 Diabetes
The purpose of the study is to demonstrate that mini-doses of stable liquid glucagon (G-Pen Mini) produced by Xeris Pharmaceuticals are safe and effective as a treatment for mild to moderate hypoglycemia, a complication of…
- Trial name
- NCT02081014
- Testing
- G-Pen Mini™ (glucagon injection)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Xeris Pharmaceuticals
Type 1 Diabetes Mellitus
Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose
The main purpose of the study is to investigate the reason for the reduced number of hypoglycaemic attacks in type 1 diabetic patients when, for a period of time, using Insulin Aspart at meals together with NPH insulin mornings…
- Trial name
- NCT00145353
- Testing
- Insulin NovoRapid versus Actrapid
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Odense University Hospital
Diabetes Mellitus in Pregnancy, Type 2 Diabetes Mellitus (T2DM)
RCT Glargine vs NPH for Treatment of DM in Pregnancy
We are asking you to take part in this research study because you are diagnosed with pregestational Type 2 Diabetes Mellitus or Gestational Diabetes Mellitus requiring insulin therapy in pregnancy.
- Conditions
- Diabetes Mellitus in Pregnancy, Type 2 Diabetes Mellitus (T2DM), Gestational Diabetes Mellitus, Class A2
- Trial name
- NCT06619301
- Testing
- Insulin glargine, insulin NPH
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Loyola University
Type 1 Diabetes
Effect of Fiber Supplementation in Children With Type 1 Diabetes
High fiber foods are recommended as a preferential source of carbohydrate by the Nutrition Study Group of the European Association for the Study of Diabetes.
- Trial name
- NCT01399892
- Testing
- soluble fiber in the form of benefiber
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Hypoglycemia
Post Bariatric Closed Loop Glucagon Trial
This study is to test our automated hypoglycemia prevention and treatment device (glucagon-only bionic pancreas) in subjects that have undergone post-bariatric surgery that are experiencing symptoms of hypoglycemia.
- Trial name
- NCT02966275
- Testing
- Glucagon-only bionic pancreas - glucagon
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital