Clinical trials: Hypoglycemic Syndrome
Caffeine and Carbohydrate, Carbohydrate Only
Caffeine Ingestion to Counter the Exercise-mediated Fall in Glycaemia in Type 1 Diabetes
This project will aim to investigate the clinical efficacy and metabolic effects of a pre-exercise dose of caffeine with a low (10g) dose of carbohydrate (CAF+lowCHO) without modification of insulin degludec on exercise…
- Conditions
- Caffeine and Carbohydrate, Carbohydrate Only, Placebo
- Trial name
- DE-CAF (NCT04671043)
- Testing
- Caffeine and glucose, Glucose alone
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes Mellitus, Type 1
High-intensity Interval Exercise Compared With Continuous Moderate Exercise on Glycemia in Postabsorptive vs. Postprandial State in Adults With Type 1 Diabetes
This randomized crossover trial examined whether exercise modality (high-intensity interval exercise vs. moderate-intensity continuous exercise) and timing relative to meals (postprandial vs.
- Trial name
- Interdiab 1 (NCT07365176)
- Testing
- High-intensity interval exercise performed in postprandial phase, High-intensity interval exercise performed in postabsorptive phase, Moderate-intensity continuous exercise performed in postprandial phase
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Universite du Littoral Cote d'Opale
Type 1 Diabetes, Hypoglycemia Unawareness
Hypoglycemia Awareness Study in Diabetes Type 1
The goal of this observational study is to assess clinical factors associated with the occurrence of impaired hypoglycemia awareness in adult patients with type 1 diabetes The main questions it aims to answer are: 1.
- Conditions
- Type 1 Diabetes, Hypoglycemia Unawareness, Cardiac Autonomic Neuropathy
- Trial name
- HAD-1 (NCT05620927)
- Where
- Poland
- Volunteers
- 245 people
- Sponsor
- Poznan University of Medical Sciences
Type 1 Diabetes, Hypoglycemia
Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes
The objectives of this study are to examine how sex hormones (use of hormonal birth control, menstrual cycle phase) impact glycemic control among women with type 1 diabetes (T1D), and to test adjustments to insulin dosing and…
- Conditions
- Type 1 Diabetes, Hypoglycemia, Hyperglycaemia Due to Type 1 Diabetes Mellitus, Menstruation Disturbances
- Trial name
- MERIT (NCT06297980)
- Testing
- Personalized modifications to treatment to address menstrual cycle effects on glycemia
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Neonatal Hypoglycemia, Neurodevelopmental Disorders
Neurodevelopment of Hypoglycemic Neonates
The investigators propose to prospectively conduct a neurodevelopmental evaluation of SGA and late preterm neonates who underwent risk-based screening for hypoglycemia at newborn nursery during the first 24 hours of life based on…
- Trial name
- NCT04875624
- Testing
- Bayley Scales of Infant and Toddler Development, Fourth Edition (Bayley-4)
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Montefiore Medical Center
Cirrhosis
Study of the Impact of HYPOglycaemia on Sarcopenia in CIRrhosis
Fasting blood glucose is maintained by hepatic production of glucose from glycogenolysis or gluconeogenesis. In cirrhosis, glycogen storage capacity is reduced, with a consequent increase in gluconeogenesis to maintain blood…
- Trial name
- HYPOCIR (NCT06948656)
- Testing
- fitting a blood glucose sensor, food collection, tests and questionnaires
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Diabetes, Diabetes Mellitus, Type 1
An International Survey on Hypoglycaemia Among Insulin-treated Patients With Diabetes
This study is conducted in Europe. The aim of the study is to gather information about hypoglycaemia (low blood glucose) among patients with Type 1 or Type 2 diabetes mellitus. The study is both retrospective and prospective.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01696266
- Testing
- No treatment given
- Where
- 24 sites in Argentina, Austria and 22 more
- Volunteers
- 29,304 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes Mellitus
Comparison of Neutral Protamine Hagedorn (NPH) and Lantus Based Insulin Regimen in the Management of Hypoglycemia in the Hospitalized Patients in Noncritical Care Setting
The goal of the current study is to determine difference in glycemic control between traditional split mix regimen with Neutral Protamine Hagedorn (NPH) and regular insulin vs basal bolus regimen with glargine and humalog in a…
- Trial name
- NCT02189395
- Testing
- NPH and regular insulin, glargine and humalog
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Riverside University Health System Medical Center
Diabetes, Hypoglycaemia
Predicting Hypoglycaemia and Arrhythmias in the Patient With Diabetes and CKD - Validation Study
Patients with insulin-dependent diabetes mellitus (DM) and chronic kidney disease (CKD) exhibit an excessive risk for cardiac arrhythmias, in particular sudden cardiac death (SCD).
- Conditions
- Diabetes, Hypoglycaemia, Chronic Kidney Disease
- Trial name
- HypoArrhythmia (NCT02778269)
- Testing
- 12-lead ECG T-shirt, Dexcom G4-System
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- RWTH Aachen University
Diabetes Mellitus, Type 1
The Use of Mini-dose Glucagon to Prevent Exercise-induced Hypoglycemia in Type 1 Diabetes
This project focuses on development of new strategy for the prevention of exercise-associated hypoglycemia using mini-dose glucagon.
- Trial name
- NCT02660242
- Testing
- G-Pen Mini™ (glucagon injection), Glucose Tabs, Basal Insulin Reduction
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Jaeb Center for Health Research
Primary Adrenal Insufficiency, Intermittent Fasting
Risks of Intermittent Fasting in Patients With Primary Adrenal Insufficiency
In primary adrenal insufficiency, there is an increased risk of hypoglycaemia and dehydration. These risks have been little studied particularly during intermittent fasting.
- Trial name
- NCT06299020
- Testing
- intermittent fasting
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- Hopital La Rabta
Postbariatric Hypoglycemia
Effect of Mizagliflozin Repeat Dosing on Adverse Events and Postprandial Glucose Excursions
This is a phase 2 crossover, randomized, placebo-controlled, single-blind, repeat dose study in PBH subjects to determine the effect of mizagliflozin on adverse events and postprandial glucose excursions.
- Trial name
- NCT05721729
- Testing
- Mizagliflozin
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Vogenx, Inc.
Diabetes Mellitus, Type 2, Arrhythmia, Cardiac
Hypoglycaemia and Cardiac Arrhythmias in Type 2 Diabetes
Twenty-one patients with insulin-treated type 2 diabetes with diabetic complications will be recruited to Part 1 of the study, a three-hour combined hyper- and hypoglycaemic clamp, along with a control group of twenty-one…
- Trial name
- HYPO-HEART (NCT03150030)
- Testing
- Combined hyper- and hypoglycaemic clamp, Loop recorder (Reveal LINQ, Medtronic, Minneapolis, MN, USA), Continuous glucose monitoring (iPro2, Medtronic, Minneapolis, MN, USA)
- Where
- Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Insulin Treated Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 1
Control:Diabetes Pilot Study I
This is a single arm open label pilot clinical trial that will assess patient-reported blood glucose levels before and after using the Control:Diabetes mobile app, while collecting user feedback and recommendations for further…
- Trial name
- NCT04158921
- Testing
- Control:Diabetes mobile app
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Brigham and Women's Hospital
Long QT Syndrome, Hypoglycemia
Frequency of Hypoglycemia in Children With Beta-blocker Treated Long QT-syndrome
The goal of this observational study is to investigate the frequency and characteristics of hypoglycemic episodes in children with long QT syndrome (LQTS) and beta-blocker treatment, specifically those receiving propranolol…
- Trial name
- LQThypo (NCT07233421)
- Testing
- Continuous Glucose Monitoring
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Congenital Hyperinsulinism
Effect of Exendin (9-39) on Glucose Requirements to Maintain Euglycemia
The primary aim of this study is to evaluate the effect of Exendin (9-39) on glucose requirements to maintain euglycemia in pediatric patients with congenital hyperinsulinism (CHI) who have failed medical therapy.
- Trial name
- NCT00835328
- Testing
- Exendin (9-39), Vehicle
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Diva De Leon
Type1diabetes
The Current Health Status of Patients Living With Type 1 Diabetes From the LMC Diabetes Patient Registry
This retrospective study uses the Canadian LMC Diabetes Registry to describe the current health status of Canadians with type 1 diabetes.
- Trial name
- NCT04162067
- Where
- Canada
- Volunteers
- 3,600 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Type 1 Diabetes
Study Comparing Effectiveness of Intraperitoneal Insulin Administration to Subcutaneous Insulin Administration
The purpose of this study is to evaluate the effectiveness of insulin delivered in the peritoneum (abdomen)by an implantable pump in Type 1 diabetics.
- Trial name
- MIP310 (NCT00211536)
- Testing
- Medtronic MiniMed Implantable Pump Human Recombinant Insulin, Medtronic MiniMed Implantable Pump System, Aventis HOE21PH U400
- Where
- 5 sites in United States
- Volunteers
- 107 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetes Mellitus With Hypoglycemia, Diabetes Mellitus, Type 2
Impact of Hypoglycaemia in Patients With Diabetes Mellitus Type 2 on Platelet Activation
This experimental study is planned to investigate the impact of hypoglycaemia on platelet activation parameters (PAP) during a hyperinsulinaemic hypoglycaemic clamp study.
- Conditions
- Diabetes Mellitus With Hypoglycemia, Diabetes Mellitus, Type 2, Hypoglycemia, Hypoglycemic Episode
- Trial name
- Diaplate (NCT03460899)
- Testing
- Euglycaemic Clamp, Hyperinsulinaemic/Hypoglycaemic Clamp
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Graz
Diabetes Mellitus
Pilot Study of Clinician-supported Patient Self-management of Hospital Insulin Therapy
This study will examine the feasibility of implementing a clinician-supported patient self-managed inpatient insulin intervention.
- Trial name
- NCT02144441
- Testing
- glargine and aspart
- Where
- United States
- Sponsor
- University of Pennsylvania