Clinical trials: Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism, Endothelial Dysfunction
Bone Mineral Markers in Hypogonadism
The aim of this study is to investigate the markers of bone mineral metabolism in an unconfounded group of patients with hypogonadism and to search for a relationship between endothelial dysfunction and insulin resistance.
- Conditions
- Hypogonadotropic Hypogonadism, Endothelial Dysfunction, Insulin Resistance
- Trial name
- NCT02062307
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Kallmann Syndrome, Hypogonadotropic Hypogonadism
Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism
Observe the therapeutic efficacy of human menopausal gonadotropin combining with human chorionic gonadotropin in adolescent boys with congenital hypogonadotropic hypogonadism.
- Trial name
- NCT02880280
- Testing
- Human Menopausal Gonadotropin, Human Chorionic Gonadotropin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Children's Hospital
Hypogonadotropic Hypogonadism
Effect of Intranasal Insulin on LH Concentrations in Man
Over the last few years, studies have shown that men with type 2 diabetes sometimes develop a condition called hypogonadotrophic hypogonadism (HH). People with this condition produce little or no sex hormones.
- Trial name
- NCT02154477
- Testing
- intranasal insulin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Texas Tech University Health Sciences Center
Hypogonadism
Testosterone Replacement Therapy Decreases Plasma Paraoxonase 1 Enzyme Activity In Male Patients With Hypogonadism
The purpose of this study is investigating the effect of testosterone treatment on paraoxonase level in male patients with hypogonadotrophic hypogonadism
- Trial name
- NCT01107067
- Testing
- Sustanon
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Gulhane School of Medicine
Diabete Mellitus, Hypogonadism
Hypothalamic-pituitary Dysfunction in Diabetes
Type 2 Diabetes mellitus (T2DM) is a chronic disease with a high prevalence and several comorbidities impacting on public health and society.
- Conditions
- Diabete Mellitus, Hypogonadism, Hypogonadotropic Hypogonadism, Hypergonadotropic Hypogonadism
- Trial name
- DIAPO (NCT05752591)
- Testing
- Diagnostic testing
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Auxologico Italiano
Delayed Puberty, Kallmann Syndrome
Kisspeptin in the Evaluation of Delayed Puberty
The goal of this study is to test whether the hormone kisspeptin has the potential to prospectively diagnose adolescents with self-resolving or permanent delayed puberty.
- Conditions
- Delayed Puberty, Kallmann Syndrome, Hypogonadotropic Hypogonadism, GnRH Deficiency
- Trial name
- NCT01438034
- Testing
- kisspeptin 112-121, GnRH
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Hypogonadotropic Hypogonadism, Kallmann Syndrome
Sequential Therapy for Hypogonadotropic Hypogonadism
The traditional therapy for induction of spermatogenesis in male hypogonadotropic hypogonadism requires both HCG and human menopausal gonadotropin (HMG) or FSH until pregnancy occurs.
- Trial name
- NCT01403532
- Testing
- Traditional intervention for HH using HCG and FSH, Sequential intervention for HH using HCG and FSH, Sequential intervention for HH using HCG and FSH plus zinc
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Secondary Hypogonadism
Study to Evaluate the Safety and Efficacy of Androxal™ Treatment in Men With Secondary Hypogonadism
Approximately 4 to 5 million men in the U.S. are testosterone-deficient. Enclomiphene (trans-clomiphene) citrate (Androxal) was evaluated to determine if Androxal increased serum testosterone levels in men with secondary…
- Trial name
- NCT00962637
- Testing
- Androxal, AndroGel
- Where
- 18 sites in United States
- Volunteers
- 194 people
- Sponsor
- Repros Therapeutics Inc.
Obesity, Infertility
Reprometabolic Syndrome Mediates Subfertility in Obesity
Obesity plays an adverse role at every stage of conception and pregnancy and mounting evidence implicates relative hypogonadotropic hypogonadism, and reduced menstrual cycle hormone secretion as likely contributors to the…
- Conditions
- Obesity, Infertility, Hypogonadotropic Hypogonadotropism, Hyperinsulinemia
- Trial name
- NCT02653092
- Testing
- Insulin, Intralipid, Dextrose
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypogonadism, Male
52 Week Study + 24-Month Long-Term Extension of Safety, PK, & Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents With Hypogonadism
This is a 52-week open label single arm study + 24-Month long-term safety extension to investigate the effects of XYOSTED, as testosterone replacement therapy, on adolescent males with either primary or secondary hypogonadism.
- Trial name
- NCT06689085
- Testing
- Testosterone enanthate
- Where
- 20 sites in United States
- Volunteers
- 100 people
- Sponsor
- Halozyme Therapeutics
Hypogonadism
Testosterone Replacement in Men With Diabetes and Obesity
The purpose of this study is to examine the effect of having testosterone deficiency in men with diabetes and with obesity. The study will also evaluate the effect of testosterone therapy.
- Trial name
- NCT01127659
- Testing
- testosterone
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- University at Buffalo
AMH, Hypogonadism, Hypogonadotropic
Hormones in Hypogonadotropic Hypogonadism
Therefore, the main objective of this prospective pilot study is to evaluate a complete hormonal profile in women with hypogonadotropic hypogonadism, including anti-mullerian hormone (AMH) and antral follicle count.
- Conditions
- AMH, Hypogonadism, Hypogonadotropic, Follicle Cyst
- Trial name
- NCT04927676
- Testing
- Blood sample
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Secondary Hypogonadism
Evaluation of the Pharmacokinetics and Safety of Androxal in Male Subjects With Impaired Hepatic Function
To determine and compare the pharmacokinetics (PK) of a single dose of 25 mg Androxal in overweight male subjects with hepatic impairment and in volunteers with normal hepatic function.
- Trial name
- NCT01923870
- Testing
- Androxal 25 mg
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Repros Therapeutics Inc.
Pubertal Delay, Hypogonadism, Hypogonadotropic
Triptorelin for Early Diagnosis of Hypogonadotrophic Hypogonadism
The goal of this clinical trial is to learn if Triptorelin test works to early diagnose hypogonadotrophic hypogonadism in adolescents.
- Conditions
- Pubertal Delay, Hypogonadism, Hypogonadotropic, Constitutional Delay in Growth and Puberty (CDGP)
- Trial name
- NCT06691815
- Testing
- Triptorelin (GnRH agonists)
- Where
- Argentina
- Volunteers
- 48 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Secondary Hypogonadism
Safety Study of Enclomiphene Citrate in the Treatment of Men With Secondary Hypogonadism
ZA-300 is meant to determine the safety profile of Androxal (enclomiphene citrate) in men with secondary hypogonadism.
- Trial name
- NCT01534208
- Testing
- Androxal
- Where
- 31 sites in United States
- Volunteers
- 499 people
- Sponsor
- Repros Therapeutics Inc.
Hypogonadotropic Hypogonadism
Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism
The purpose of this study is to evaluate the safety and efficacy of BGS649 in male obese subjects with hypogonadotropic hypogonadism. All subjects will be treated for a maximum of 24 weeks.
- Trial name
- NCT02730169
- Testing
- BGS649
- Where
- 63 sites in United States, Italy and 2 more
- Volunteers
- 271 people
- Sponsor
- Mereo BioPharma
Amenorrhea, Hypogonadotropic Hypogonadism
Baselines in Reproductive Disorders
The purpose of the study is to explore the way in which gonadotropins (pituitary hormones) are released into the body. The knowledge acquired in this study will be used for the diagnosis and treatment of reproductive endocrine…
- Conditions
- Amenorrhea, Hypogonadotropic Hypogonadism, Kallmann's Syndrome
- Trial name
- NCT00456274
- Testing
- Frequent baseline blood sampling
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Massachusetts General Hospital
Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism
Growing up With the Young Endocrine Support System (YESS!)
Transition from paediatric to adult endocrinology is a challenge for adolescents, families and doctors. Up to 25% of young adults with chronic endocrine disorders are lost to follow-up ('drop-out') once the young adult moves out…
- Conditions
- Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism, Growth Hormone Deficiency, Combined Pituitary Hormone Deficiency
- Trial name
- YESS (NCT04252001)
- Testing
- YESS! game, Snake '97, Transition-toolkit
- Where
- 7 sites in Belgium, Netherlands and 2 more
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- dr. Laura C. G. de Graaff-Herder
Hypogonadotropic Hypogonadism
Kisspeptin Administration Subcutaneously to Patients With IHH
The goal of this study is to see whether kisspeptin, a naturally occurring hormone, can stimulate the release of other reproductive hormones in men and women with idiopathic hypogonadotropic hypogonadism (IHH).
- Trial name
- NCT05896293
- Testing
- kisspeptin 112-121, leuprolide acetate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Stephanie B. Seminara, MD
Obese Hypogonadotropic Hypogonadism
Safety and Efficacy of BGS649 in Obese, Hypogonadotropic Hypogonadal Men
This study is designed as a 2-part study, with Part 1 being open-label to best determine the appropriate dose levels to use in Part 2, which has a randomized, double-blind, placebo controlled design.
- Trial name
- OHH (NCT01200862)
- Testing
- Investigational new drug company code: BGS649
- Where
- 5 sites in United States, Canada
- Volunteers
- 29 people
- Sponsor
- Mereo BioPharma