Clinical trials: Hyponatremic
Cirrhosis, Hepatic Encephalopathy
Effect of Tolvaptan on Cognitive Function in Cirrhosis
Hypothesis: Tolvaptan will improve cognitive function, brain edema and health-related quality of life in cirrhotic patients with hyponatremia
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Hyponatremia
- Trial name
- NCT01556646
- Testing
- Tolvaptan
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Hyponatremia
Analysis of Factors Determining Increase of Serum Sodium in Hyponatremic Patients
The aim of this study is to further analyse the dataset of the Hyponatremia Registry, a multicenter, prospective, observational study conducted between September 2020 and February 2013 in the United States of America and the…
- Trial name
- NCT05277584
- Where
- Germany
- Volunteers
- 3,460 people
- Sponsor
- University of Cologne
Advanced Cancers
Tolvaptan in Hyponatremic Cancer Patients
The goal of this clinical research study is to learn if tolvaptan can help raise salt (sodium) levels in the cancer patients' blood by removing extra body water as urine.
- Trial name
- NCT01199198
- Testing
- Tolvaptan
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- M.D. Anderson Cancer Center
Hyponatremia
Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic Patients
Demonstrate an improvement in the composite scores of validated neurocognitive tests in elderly subjects with chronic sub-clinical (i.e., asymptomatic) hyponatremia.
- Trial name
- INSIGHT (NCT00550459)
- Testing
- Tolvaptan
- Where
- 12 sites in United States
- Volunteers
- 57 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Hyponatremia, Hyponatremic
Hyponatremia Study (Delayed Hyponatremia After Pituitary Surgery)
Hyponatremia is defined as sodium below the normal range of 135-145. Symptomatically, it can cause patients to experience a wide range of symptoms including lethargy, headache, nausea, vomiting and in severe cases coma and even…
- Conditions
- Hyponatremia, Hyponatremic, Pituitary Tumor, Pituitary
- Trial name
- DHAPS (NCT03636568)
- Testing
- Fluid Restricted Group
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Ascites, Liver Cirrhosis
Satavaptan Dose-Ranging Study in Hyponatraemic Patients With Cirrhotic Ascites
The primary objective is to determine the optimal dose or range of doses of SR121463B for the treatment of ascites and the correction of hyponatraemia when used concomitantly with a standard dose regimen of spironolactone.
- Trial name
- Hypo~CAT (NCT00501722)
- Testing
- satavaptan (SR121463B)
- Where
- 13 sites in United States, Argentina and 11 more
- Volunteers
- 110 people
- Sponsor
- Sanofi
Hyponatremia, Acute Decompensated Heart Failure
Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated Heart Failure (ADHF)
This study will evaluate the safety and effectiveness of Conivaptan, a vasopressin antagonist, in the treatment of hyponatremic subjects having symptomatic acute decompensated heart failure (ADHF).
- Trial name
- CONVERT-H (NCT00843986)
- Testing
- conivaptan
- Where
- 4 sites in India
- Volunteers
- 9 people
- Sponsor
- Cumberland Pharmaceuticals
Hyponatremia
Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients
Conivaptan (Vaprisol) is FDA-Approved for the treatment of low serum sodium (hyponatremia), but there are few data in patients with neurologic disease.
- Trial name
- NCT00727090
- Testing
- Conivaptan
- Volunteers
- 6 people
- Sponsor
- Northwestern University
Heart Failure
Aquaresis Utility for Hyponatremic Acute Heart Failure Study
Hyponatremia is a common finding in acute heart failure (HF) patients and is associated with worse prognosis. In addition to its prognostic value, hyponatremia may have importance during the acute management of HF.
- Trial name
- AQUA-AHF (NCT02183792)
- Testing
- Tolvaptan, Furosemide
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Southern California
Heart Failure, Heart Assist Device
Postoperative Tolvaptan Use in Left Ventricular Assist Device Implantation Patients
This research study will compare two standard of care approaches for managing low sodium levels in heart failure patients with Left Ventricular Assist Device (LVAD).
- Conditions
- Heart Failure, Heart Assist Device, Hyponatremic
- Trial name
- TOLVAD (NCT05408104)
- Testing
- tolvaptan
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Chicago