Clinical trials: Hypoparathyroidism
Hypoparathyroidism
A Clinical Study Investigating the Safety, Tolerability, PK and PD of PCO371 in Patients With Hypoparathyroidism
This is a multi-center, placebo-controlled, randomized, double-blind, multiple-ascending dose study in patients with hypoparathyroidism.
- Trial name
- NCT04209179
- Testing
- PCO371
- Where
- 11 sites in United States, Canada and 1 more
- Volunteers
- 5 people
- Sponsor
- Chugai Pharmaceutical
Postoperative Hypoparathyroidism, Postsurgical Hypoparathyroidism
PRESS -PAR: Early Detection and PREvention of Symptomatic postSurgical hypoPARathyroidism After Thyroid Surgery"
This study aims to investigate whether an earlier measurement of parathyroid hormone can reduce the number of patients who develop symptomatic hypoparathyroidism.
- Conditions
- Postoperative Hypoparathyroidism, Postsurgical Hypoparathyroidism, Hypoparathyroidism Post-surgical
- Trial name
- PRESSPAR (NCT07491601)
- Testing
- Active vitamin D, Calcium
- Where
- Germany
- Volunteers
- 336 people
- Sponsor
- Nicolas Schlegel
Hypoparathyroidism
Study of Safety and Efficacy of a rhPTH[1-84] of Fixed Doses of 25 and 50 mcg in Adults With Hypoparathyroidism (RELAY)
Use of PTH (1-84) a recombinant hormone in 25 µg or 50 µg doses for the treatment of adults with hypoparathyroidism. The use of PTH (1-84) should result in a decrease of calcium and vitamin D supplements.
- Trial name
- NCT01268098
- Testing
- NPSP558
- Where
- 12 sites in United States
- Volunteers
- 42 people
- Sponsor
- Shire
Hypoparathyroidism
Oral PTH(1-34) PK and PD Study in Patients With Hypoparathyroidism
A Randomized, active comparator, two-part, partial crossover design. The study is designed to assess the pharmacokinetics and pharmacodynamics of EnteraBio's Oral PTH(1-34) [EB612 (EBP05)] in adult patients with…
- Trial name
- NCT03516773
- Testing
- EB612 (EBP05), NATPARA/NATPAR
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Entera Bio Ltd.
Thyroid Surgery, Parathyroid Dysfunction
PTeye vs Surgeons Eyes in Intraoperative Identification and Functional Preservation of Parathyroid Glands During Thyroid Surgery: A Parallel Randomized Controlled Clinical Trial.
The goal of this randomized clinical trial is to learn if there are any added benefits of using near-infrared autofluorescence (NIRAF) probe-based imaging system (the PTeye) for intraoperative identification of parathyroid glands…
- Conditions
- Thyroid Surgery, Parathyroid Dysfunction, Hypoparathyroidism Post-surgical
- Trial name
- PTSURGEYE (NCT06765941)
- Testing
- Probe-based near-infrared parathyroid autofluorescence detection system, Surgeons naked eyes for parathyroid glands identification
- Where
- Poland
- Volunteers
- 154 people
- Sponsor
- Marcin Barczynski
Hypoparathyroidism
A Global Pregnancy Registry to Assess Maternal, Fetal, and Infant Outcomes Following Exposure to YORVIPATH® (Palopegteriparatide) During Pregnancy and Breastfeeding
The purpose of this registry study is to collect both prospective and retrospective data in women exposed to palopegteriparatide during pregnancy to assess risk of pregnancy and maternal complications, and adverse effects on the…
- Trial name
- NCT07345494
- Testing
- Palopegteriparatide
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ascendis Pharma A/S
DiGeorge Syndrome, Complete Typical DiGeorge Anomaly
Thymus Transplantation in DiGeorge Syndrome #668
The study purpose is to determine whether cultured thymus tissue implantation (CTTI) is effective in treating typical complete DiGeorge syndrome.
- Trial name
- NCT00576407
- Testing
- Cultured Thymus Tissue for Implantation (CTTI)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Secondary Hyperparathyroidism, Chronic Kidney Disease-Mineral and Bone Disorder
Injection of Teriparatide to Prevent Hypocalcemia After Parathyroidectomy in Dialysis Patients (TeriCa).
This is a pilot randomized controlled trial aimed to evaluate the effect of teriparatide on the clinical course of hypocalcemia after parathyroidectomy for secondary hyperparathyroidism in dialysis-dependent patients.
- Conditions
- Secondary Hyperparathyroidism, Chronic Kidney Disease-Mineral and Bone Disorder, Dialysis, Hypocalcemia
- Trial name
- TeriCa (NCT04750460)
- Testing
- Teriparatide
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Saint Petersburg State University, Russia
Idiopathic Hypoparathyroidism, Autosomal Dominant Hypocalcaemia
Characterization of Patients With Non-surgical Hypoparathyroidism and Pseudohypoparathyroidism
Hypoparathyroidism (hypoPT) and pseudohypoparathyroidism (Ps-hypoPT) are rare diseases, characterized by low levels of parathyroid hormone [PTH] and plasma calcium or high plasma PTH and low plasma calcium, respectively.
- Conditions
- Idiopathic Hypoparathyroidism, Autosomal Dominant Hypocalcaemia, Pseudohypoparathyroidism
- Trial name
- NCT02551120
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Hypoparathyroidism Postprocedural
Study on the Effects of Hypoparathyroidism on Post-thyroidectomy Health-related Quality of Life (QoL-hPTP)
Our study will evaluate the health related quality of life (HRQoL) after a thyroidectomy and the relevance of postoperative hypoparathyroidism.
- Trial name
- QoL-hPTP (NCT04604808)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Comorbidities and Coexisting Conditions, Morality
Registry for Hypoparathyroidism Wuerzburg
Long-term conventional treatment of chronic hypoparathyroidism does not fully restore calcium homeostasis leading to increased morbidity, emergency events and reduced subjective health status.
- Conditions
- Comorbidities and Coexisting Conditions, Morality, Hypocalcemia, Hypercalcemia
- Trial name
- NCT05585593
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University of Wuerzburg
Goiter
Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter
The aim of this three-arm randomized study was to evaluate results of different thyroid resection modes among patients with bilateral multinodular non-toxic goiter, with special emphasis put on recurrence rate and morbidity rate…
- Trial name
- NCT00946894
- Testing
- Total thyroidectomy, Dunhill operation, Bilateral subtotal thyroidectomy
- Where
- Poland
- Volunteers
- 600 people
- Sponsor
- Jagiellonian University
Hypoparathyroidism
Palopegteriparatide in Chronic Hypoparathyroidism
This is a multicenter, prospective cohort study conducted across 9 tertiary and university hospitals in the rural area of Athens, which investigates the clinical and biochemical effects of palopegteriparatide (TransCon PTH) in…
- Trial name
- PaTHreal (NCT07299838)
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- National and Kapodistrian University of Athens
Hypoparathyroidism
Predicting Risk Factors of Postoperative Hypocalcemia After Total Thyroidectomy
With increasing economic pressures to shorten the length of hospital stay, there has been much recent interest in studying risk factors for the development of postoperative hypocalcemia.
- Trial name
- NCT04372225
- Testing
- analysis of hypocalcemia
- Where
- France
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- Aix Marseille Université
Vitamin D Deficiency, Osteoporosis
Vitamin D Deficiency in Elderly African American Women in Central Texas
In order to make bone health a reality for older adults, we need to consider the prevalence of Vitamin D deficiency in relation to environment latitude as well as vitamin D supplementation.
- Conditions
- Vitamin D Deficiency, Osteoporosis, Osteopenia
- Trial name
- NCT01971411
- Testing
- Calcium 500mg with 200 IU Vitamin D - 2 tablets daily, Blood levels of Vitamin D, Serum CTX, Mg, Ca++ and iPTH, Usual sun exposure documentation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McLennan County Medical Education and Research Foundation
Neurodevelopmental Disorders, Autism
Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
There are currently no approved medications for the treatment of anxiety in children and youth with neurodevelopmental disorders (NDDs), both common and rare.
- Conditions
- Neurodevelopmental Disorders, Autism, Autism Spectrum Disorder, Fragile X Syndrome
- Trial name
- CALM (NCT06081348)
- Testing
- Sertraline
- Where
- 7 sites in Canada
- Volunteers
- 130 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Hypoparathyroidism
Magnesium Treatment in Hypoparathyroidism
Study hypothesis: supplementary magnesium may influence the blood calcium level in treated hypoparathyroid patients. Patients will be treated with supplementary magnesium (350 mg/day) for 3 weeks.
- Trial name
- NCT00824226
- Testing
- magnesium
- Where
- Estonia
- Volunteers
- 10 people
- Sponsor
- University of Tartu
Autofluorescence, Thyroidectomy
Near-infrared Autofluorescence (NIRAF)-Guided Total Thyroidectomy: Impact in Low-volume, Non-parathyroid Institutions
Hypoparathyroidism is the most frequent complication in total thyroidectomy. The use of near-infrared autofluorescence (NIRAF) intraoperatively, seems to reduce the rate of transient hypoparathyroidism.
- Conditions
- Autofluorescence, Thyroidectomy, Hypoparathyroidism, Hypocalcemia
- Trial name
- NCT05043584
- Testing
- Fluobeam LX, Fluoptics, Grenoble, France
- Where
- 2 sites in Denmark
- Volunteers
- 78 people
- Sponsor
- Regional Hospital West Jutland
Down Syndrome, Edwards Syndrome
Whole Blood Specimen Collection From Pregnant Subjects
To obtain whole blood specimens from pregnant subjects to be used for research and development and clinical validation studies of prenatal assays.
- Conditions
- Down Syndrome, Edwards Syndrome, Patau Syndrome, Klinefelter Syndrome
- Trial name
- NCT02430584
- Testing
- Observational - no intervention
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Progenity, Inc.
Hypoparathyroidism
A Study to Test the Effects and Safety of Palopegteriparatide in Adolescents With Long-term Hypoparathyroidism
This trial will enroll adolescents between ages of ≥12 and <18 years with clinically diagnosed hypoparathyroidism . The purpose of the study is to see how well treatment with once-daily palopegteriparatide works and how safe it…
- Trial name
- NCT07706764
- Testing
- Palopegteriparatide
- Where
- 3 sites in France, Poland
- Volunteers
- 12 people
- Sponsor
- Ascendis Pharma A/S