Clinical trials: Hypoperfusion
Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction
CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State
The goal of this observational study is to learn the how to determine the mean arterial pressure(MAP) or blood pressure level to be maintained during non-cardiac surgery for optimal brain health in patients above the age of 60…
- Conditions
- Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction, Postoperative Delirium, EEG With Periodic Abnormalities
- Trial name
- CERBERUS (NCT06133842)
- Testing
- Intra-op EEG and CO data collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Critical Illness, Diabetes Mellitus
Central Venous vs Arterial Blood Gas and CO2 Gap in Critically Ill Patients With and Without Diabetes
Frequent monitoring of acid-base status, ventilation, and tissue oxygenation is essential for managing critically ill patients in the intensive care unit (ICU).
- Conditions
- Critical Illness, Diabetes Mellitus, Acid-Base Imbalance, Tissue Hypoperfusion
- Trial name
- NCT07799727
- Volunteers
- 100 people
- Sponsor
- Assiut University
Tissue Hypoperfusion, Critical Illness
Fecal Lactate and Resuscitation Outcomes in Critical Illness
This study evaluates the prognostic value of fecal lactate and the fecal-to-serum lactate gradient as early biomarkers of tissue hypoperfusion in critically ill patients.
- Conditions
- Tissue Hypoperfusion, Critical Illness, Shock, Sepsis
- Trial name
- DELTA-LAC (NCT07658001)
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital H+ Queretaro
Velocity-time Integral Measurement, Critically Ill Patients
Reliability of Minimally Trained Operator's Velocity-Time Integral Measurement Guided by Artificial Intelligence VTI
Stroke volume is a major determinant of tissue perfusion and therefore a key parameter to monitor in patients with hemodynamic instability and hypoperfusion.
- Conditions
- Velocity-time Integral Measurement, Critically Ill Patients, Tissue Hypoperfusion
- Trial name
- MiniTrainedVTI (NCT06486467)
- Testing
- Fluid challenge (cristalloids) OR passive leg raising
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock, Hypoperfusion
Early Methylene Blue in the Microhemodynamics of Septic Patients
The aim of the study is to evaluate the viability and feasibility of its protocol in order to conduct a larger clinical trial to assess whether methylene blue can improve patient-centered clinical outcomes such as mortality or…
- Trial name
- NCT07264543
- Testing
- Methylene blue infusion
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva
Microcirculatory Dysfunction, Tissue Hypoperfusion
Submental Tissue Oxygenation and Arterial Lactate in Major Surgery
During major surgical procedures performed under general anesthesia, changes in blood flow and oxygen delivery to tissues may occur due to blood loss, hemodynamic fluctuations, and anesthesia-related physiological effects.
- Conditions
- Microcirculatory Dysfunction, Tissue Hypoperfusion, Microcirculatory Status, Microvascular Circulation
- Trial name
- NCT07399275
- Testing
- No intervention. This is a prospective observational study. Near-infrared spectroscopy measurements are performed for monitoring purposes only and do not influence clinical management.
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Carotid Artery Stenosis Symptomatic, Carotid Endarterectomy (CEA) Surgical Patients
Correlation Between Carotid Stump Pressure and Interhemispheric rSO₂ Asymmetry During Awake Carotid Endarterectomy
This study aims to better understand how well the brain is perfused (supplied with blood and oxygen) during a specific type of surgery called carotid endarterectomy (CEA), which is performed to prevent strokes in people with…
- Conditions
- Carotid Artery Stenosis Symptomatic, Carotid Endarterectomy (CEA) Surgical Patients, Cerebral Hypoperfusion
- Trial name
- NCT07150260
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Izmir Katip Celebi University
Sepsis, Cardiomyopathies
Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion
Sepsis induces both a systolic and diastolic cardiac dysfunction. The prevalence of this septic cardiomyopathy ranges between 30 and 60% according to the timing of assessment and definition used.
- Conditions
- Sepsis, Cardiomyopathies, Hypoperfusion, Left Ventricular Systolic Dysfunction
- Trial name
- ADAPT (NCT04166331)
- Testing
- Dobutamine
- Where
- 21 sites in France
- Volunteers
- 136 people
- Sponsor
- University Hospital, Limoges
Triage, Emergency Medical Services
Clinical Predictors of Capillary Refill Time and Their Association With Triage Categories
This observational study aims to determine the correlation between capillary refill time (CRT) and vital parameters in patients presenting to the emergency department.
- Conditions
- Triage, Emergency Medical Services, Vital Signs Monitoring, Hypoperfusion
- Trial name
- CRT_TriageER (NCT07054151)
- Testing
- No clinical intervention (observational study only)
- Where
- Turkey (Türkiye)
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Spinal Hypotension, Hypoperfusion
The Influence of Leg Elevation on Noradrenaline Requirements During Cesarean Delivery
Spinal anesthesia is a widely chosen technique in obstetric theaters due to several advantages, however sympathetic block results in hypotension that carry several consequences on maternal and fetal health, thus early prediction…
- Trial name
- NCT06822699
- Testing
- Leg elevation
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Cerebral Hypoperfusion, Hypotension
The Effect of Controlled Hypotension
Controlled hypotension is currently used in spinal surgery to reduce bleeding at the surgical site, improve the surgeon's visibility, and decrease intraoperative blood loss.
- Trial name
- NIRS (NCT06928870)
- Testing
- MAP 55-65 mmHg, MAP 66-75 mmHg
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Microvascular Disease, Microvascular Complications
Test of Reproducibility of [15O]H20-PET Assessment of Brain Perfusion
In the aging population, ischemic heart disease, stroke and dementia are increasingly prevalent. Diagnosis and treatment of the former two i.e., large-vessel coronary heart disease and endovascular thrombectomy of the brain in…
- Conditions
- Microvascular Disease, Microvascular Complications, Diabetes Mellitus Type 2, Cerebral Hypoperfusion
- Trial name
- SVAT (NCT06624267)
- Testing
- PET
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Microvascular Disease, Microvascular Complications
Comparison of Differencens in VO2-max, Perfusion of the Heart and Brain and Cognitive Performance Between Patients with Type 2 Diabetes and Healthy Age Matched Controls.
In the aging population, ischemic heart disease, stroke and dementia are increasingly prevalent. Diagnosis and treatment of the former two i.e., large-vessel coronary heart disease and endovascular thrombectomy of the brain in…
- Conditions
- Microvascular Disease, Microvascular Complications, Dementia, Diabetes Mellitus Type 2
- Trial name
- SVAT (NCT06628297)
- Testing
- PET
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Hypertension, Frailty
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
Rationale: Systolic hypertension represents the leading risk for burden of disease among older adults (age >70 years), with an increasing prevalence due to the increase in lifespan.
- Conditions
- Hypertension, Frailty, Old Age; Dementia, Orthostatic Intolerance
- Trial name
- BLUEBERRY (NCT05529147)
- Testing
- Antihypertensive Agents
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Intracranial Neoplasm, Hyperlactatemia
The Relationship of Anesthesia Method With Serum Lactate Level in Craniotomies
The investigators aimed to research the incidence of hyperlactatemia in craniotomy cases, the relationship of lactate elevation with tumor type and other factors that may be related, and whether the general anesthesia method…
- Conditions
- Intracranial Neoplasm, Hyperlactatemia, Brain Tumor, Hypoperfusion
- Trial name
- NCT05145049
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ankara Diskapi Training and Research Hospital
Hypoperfusion in Newborn With Congenital Heart Disease
Cerebral Blood Flow in Neonates During Major Cardiac Surgery.
Rationale: During cardiac surgery, neonates are at high risk of cerebral damage: 36-78% will have new cerebral lesions after surgery.
- Trial name
- FLOWER (NCT04713605)
- Testing
- Critical closing pressure detection
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht
Sepsis, Hypoperfusion
Use of Dobutamine in Patients With Sepsis and Maintained Hypoperfusion After Initial Volemic Resuscitation.
This phase 2 study aim to investigate the effect of dobutamine in patients with sepsis/ septic shock after fluid resuscitation and with hypoperfusion (lactate and central venous oxygen saturation or prolonged capillary refill…
- Conditions
- Sepsis, Hypoperfusion, Hyperlactatemia
- Trial name
- DEEP (NCT05953142)
- Testing
- Dobutamine
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Federal University of São Paulo
Cerebral Hypoperfusion, Cerebral Occlusion
Evaluation of Cerebral Blood Flow and Cerebral Oxygenation With Transcranial Doppler and NIRS in Laparoscopic Cholecystectomy Cases
The goal of this clinical trial is to test intracranial blood flow and cerebral oxygenisation changes in patients who have pneumoperitoneum in laparoscopic cholecystectomy procedure.
- Conditions
- Cerebral Hypoperfusion, Cerebral Occlusion, Cholecystitis; Gallstone, Cholecystitis/Cholelithiasis
- Trial name
- NIRS L/C (NCT06036498)
- Testing
- Near Infrared Spectrophotometry Device, Transcranial Doppler Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Uludag University
Chronic Cerebral Hypoperfusion
Exploratory Study of Intermittent Hypoxia Treatment in Chronic Cerebral Hypoperfusion
This study aims to investigate the safety and efficacy of intermittent hypoxia treatment in patients with chronic cerebral hypoperfusion.
- Trial name
- NCT05824104
- Testing
- Intermittent Hypoxia
- Volunteers
- 20 people
- Sponsor
- Capital Medical University
Hypoperfusion
POMCO2 Clinical Study MicroTrend System pCO2 Sensor
The objective of this non-significant risk (NSR) study is to evaluate the safety and efficacy of the MicroTrend System by correlating POMCO2 data with relevant clinical metrics including arterial pressure and heart rate.
- Trial name
- NCT05499624
- Testing
- MicroTrend System
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- ExoStat Medical, Inc.