Clinical trials: Hyposalivation
Keratoconjunctivitis Sicca, Dry Eye Syndromes
Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye
To investigate and compare the burden of dry eye in Sjögren's syndrome dry eye vs non-Sjögren's syndrome dry eye, as well as investigate the diagnostic potential of tear film mucins and various inflammatory cytokines evaluated by…
- Conditions
- Keratoconjunctivitis Sicca, Dry Eye Syndromes, Ocular Surface Disease, Sjogren's Syndrome
- Trial name
- NCT04493658
- Testing
- Questionnaires, Tear fluid sampling, Impression Cytology
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Oral Health Related Quality of Life (OHRQoL)
New Functional Ingredient for Oral Care
The goal of this clinical trial is to find new ingredients for oral care products that can improve gum health. We want to learn if new botanical blends can help reduce gum inflammation, strengthen the gum's natural barrier, and…
- Trial name
- NCT07771907
- Testing
- Botanical A, Botanical B
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Access Business Group
Xerostomia
Mesenchymal Stemcells for Radiation Induced Xerostomia
The current study aims to assess the safety and feasibility of the injection of autologous adipost tissue derived MSCs on radiation-induced salivary gland hypofunction and xerostomia in head and neck cancer participants.
- Trial name
- MESRIX (NCT02513238)
- Testing
- Mesenchymal stem cell, Isotonic NaCl
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Systemic Lupus, Rheumatoid Arthritis
Yellow Fever Vaccine in Patients With Rheumatic Diseases
According to World Health Organization (WHO), since December 2016, Brazil is showing a significant increase in cases of yellow fever in humans.
- Conditions
- Systemic Lupus, Rheumatoid Arthritis, Spondyloarthritis, Inflammatory Myopathy
- Trial name
- NCT03430388
- Testing
- Yellow Fever vaccine (17D)
- Where
- Brazil
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Edentulous Jaw, Edentulous Mouth
Use of Two Dissolvable Therapeutics Under Removable Partial Dentures
Older removable denture wearing adults suffer from a complex set of oral health challenges, with relatively few solutions identified at this time.
- Trial name
- NCT05441527
- Testing
- MI Paste, then, Biotene Dry Mouth Gel, Biotene Dry Mouth Gel, then, MI Paste
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Sjögren's Syndrome, Systemic Lupus Erythematosus
Objective Measurement With TCM Pattern for AIDDES
To explore the association with TCM pattern and TCM tongue diagnosis for Autoimmune disease and Dry eye syndrome.
- Conditions
- Sjögren's Syndrome, Systemic Lupus Erythematosus, Dry Eye Syndrome
- Trial name
- NCT04747288
- Testing
- Traditional Chinese Medicine pattern, Traditional Chinese Medicine tongue diagnosis, Heart rate variability
- Where
- Taiwan
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Meibomian Gland Dysfunction, Sjögren's Syndrome
Sjögren's Syndrome Is Associated With Meibomian Gland Dysfunction
The investigators hypothesize that the dry eye caused by SS may include the evaporative type, resulting from the MGD. Furthermore, the investigators hypothesize that both pSS and sSS are associated with MGD.To test our…
- Trial name
- NCT03434106
- Testing
- liposic, Tears Naturale Forte
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- LanZhou University
Dry Mouth
Bioequivalency Study of 5 mg Pilocarpine Tablets Under Fasting Conditions
The objective of this study was the bioequivalence of a Roxane Laboratories' Pilocarpine Tablets, 5 mg, to SALAGEN® Tablets, 5 mg (MGI Pharma) under fasting conditions using a single-dose, 2-treatment, 2-period, crossover design.
- Trial name
- NCT00601874
- Testing
- Pilocarpine
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Food Comminution, Jaw Movements
Salivary Flow Rate and Oral Function
The purpose of this study was to investigate if salivary flow rate is important to maintain adequate oral functions.
- Trial name
- SOF (NCT01020084)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Xerostomia
A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water
This study assessed the efficacy of three dry mouth products (including an experimental Oralbalance gel, oral rinse, and moisturizing spray) to relieve the feeling of dry mouth compared to water, in dry mouth population over a…
- Trial name
- NCT03494985
- Testing
- Experimental Oralbalance Moisturizing Gel, Biotene Original Oral Rinse, Biotene Moisturizing Mouth Spray
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Xerostomia
Validation of the French Version of the Xerostomia Inventory
The main objective of this study is to achieve cross-cultural and psychometric validation of the Xerostomia Inventory initially developed in English language into French Language.
- Trial name
- XIvf (NCT03009786)
- Testing
- Measurement of salivary flow
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Oral Dryness and Saliva Altered, Oral Manifestations
The Effects of Using Augmented Reality (AR) System to Train Foreign Care Workers.
The aim of this study was to evaluate the effect of augmented reality (AR) system training intervention of foreign care workers on the salivary biomarker and oral function of older people.
- Conditions
- Oral Dryness and Saliva Altered, Oral Manifestations, Swallowing Disorder
- Trial name
- NCT05938166
- Testing
- oral care augmented reality (AR), video-based oral hygiene education course
- Where
- Taiwan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Rhinoplasty
The Effect of Ice Cold Mentholated Water Spray After Rhinoplasty
This clinical trial aims to evaluate the effects of a menthol-infused cold water spray on thirst perception, dry mouth, nausea, and physiological parameters in patients after rhinoplasty.
- Trial name
- NCT07233057
- Testing
- Menthol Cool Water Spray, Ice water spray
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Firat University
Dry Eye Syndromes, Sjogren's Syndrome
TrueTear in Sjogren's Disease Patients
The purpose of this study is to evaluate acute tear production produced by the intranasal tear neurostimulator in participants with Sjögrens syndrome and aqueous tear deficiency.
- Trial name
- NCT03719885
- Testing
- TrueTear Intranasal Tear Neurostimulator
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pregnancy, Systemic Lupus Erythematosus
Duke Autoimmunity in Pregnancy Registry
It is difficult to predict how a women with an autoimmune disease will do during pregnancy. Some women will improve, others will worsen. Some pregnancies progress normally and others become very complicated.
- Conditions
- Pregnancy, Systemic Lupus Erythematosus, Cutaneous Lupus, Rheumatoid Arthritis
- Trial name
- DAP Registry (NCT00513591)
- Where
- United States
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- Duke University
Primary Sjögren's Syndrome, Xerostomia
Effect of B-cell Depletion in Patients With Primary Sjögren's Syndrome
The primary purpose of the study is to determine whether B-cell depletion with Rituximab has an effect on the oral, ocular and general disease manifestations in patients with primary Sjögren´s syndrome, that is, an effect on the…
- Conditions
- Primary Sjögren's Syndrome, Xerostomia, Hyposalivation, Keratoconjunctivitis Sicca
- Trial name
- NCT00426543
- Testing
- MabThera (rituximab), Rituximab, Mabthera
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Sjogren's Syndrome
Comprehensive Evaluation of Clinical and Biopsychosocial Characteristics in Primary Sjögren's Disease
Following the guidance of individuals with primary Sjögren's Syndrome who receive diagnosis, routine medical care, and treatment management, the evaluations will be performed once by the researchers and will take approximately…
- Trial name
- NCT06410742
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Burning Mouth Syndrome, Quality of Life
Effect to the Photobiomodulation in the Burning Mouth Syndrome
Introduction: Burning mouth syndrome (BMS) is a pathology with a low prevalence, affecting between 0.1% and 3.7% of the general population, the ratio between women and men is between 3 and 7:1.
- Conditions
- Burning Mouth Syndrome, Quality of Life, Anxiety Depression, Dry Mouth
- Trial name
- PBM-BMS (NCT05871580)
- Testing
- Low frequency laser activated photobiomodulation, Low frequency laser photobiomodulation inactive
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Xerostomia, Hyposalivation
The Effect of Biotene® on the Symptoms of Xerostomia and Mastication and Swallowing
This study will compare the effects of Biotene® Oral Balance Moisturizing Gel (Biotene), an over-the-counter artificial saliva, that the effects of a sham condition on oral health-related quality of life, mastication, and…
- Trial name
- NCT04323384
- Testing
- Biotene® Oralbalance Moisturizing Gel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Xerostomia, Dry Mouth
Efficacy of Natural Enzymes Mouthwash: a Randomised Controlled Trial
The goal of this clinical is to assess the efficacy of natural enzymes mouthwash in the treatment of xerostomia (dry mouth). The main questions it aims to answer are: (1) the efficacy of natural enzymes mouthwash in the…
- Trial name
- NCT05640362
- Testing
- Natural enzymes mouthwash, Benzydamine mouthwash
- Where
- Malaysia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia