Clinical trials: Hyposalivation
Sjogren Syndrome, Malignant Tumors
The Feasibility of Multispectral Optoacoustic Tomography in Different Diseases
Optoacoustic imaging is a new and innovative imaging technique that combines the high contrast of optical imaging with the penetration depth and high spatial resolution of ultrasonography using the optoacoustic effect.
- Conditions
- Sjogren Syndrome, Malignant Tumors, Arterial Disease
- Trial name
- FOMO (NCT06740175)
- Testing
- Multispectral optoacoustic tomography
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Keratoconus, Ocular Surface Disease
Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting
EYEdeal Scanning Technology enables rapid measurement of corneal and scleral topography. By accurately measuring the ocular surface with this imaging technology, the current iterative fitting method required to fit PROSE…
- Conditions
- Keratoconus, Ocular Surface Disease, Pellucid Marginal Corneal Degeneration, Ectasia
- Trial name
- NCT04649177
- Testing
- Ocular surface optical coherence tomography
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boston Sight
Sjogren's Syndrome
The Functioning of Immune and Hormonal Systems in Patients With Sjogren's Syndrome and in Healthy Volunteers
This study aims to learn more about how the immune and hormonal systems function in patients with Sjogren's syndrome, a disease in which the immune system does not function properly.
- Trial name
- NCT00001953
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Xerostomia
Malic Acid in Treatment of Xerostomia
Background: xerostomia is a subjective sensation of dry mouth resulting from quantitative and /or qualitative changes of saliva.
- Trial name
- NCT04756986
- Testing
- malic acid
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hams Hamed Abdelrahman
Hyposalivation
Fluoride Retention in the Mouth of Older Adults
Individuals with dry mouth (a reduction in the production of saliva) suffer from high rates of oral diseases. Dry mouth is a common problem among older individuals, because many medications to control chronic conditions (such as…
- Trial name
- NCT04239872
- Testing
- Fluoride mouthwash, Calcium and fluoride mouthwash
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sjogren's Syndrome
Sjogrens Syndrome Measured by Ultrasound
Ultrasound study focused on salivary gland outcomes in Sjogren's subjects
- Trial name
- NCT03411850
- Testing
- Orencia
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Arthritis & Rheumatism Associates, P.C.
Sjogren's Syndrome, Dry Eye Syndromes
Salivary Conductivity Screening for Dry Eye Disease and Sjögren's Syndrome
Dry eye disease, or keratoconjunctivitis sicca, is one of the most common diseases encountered at ophthalmologic clinics. Patient with dry eye disease commonly presented foreign body sensation, red eye, blurred vision, etc.
- Trial name
- NCT06406933
- Testing
- Carbomer Gel/Jelly
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Xerostomia
SaliPen Human Factors Study for OTC Labeling
This Human Factors Validation Testing will assess user interactions to verify the capability of potential users to assess if the study product fits their needs and if they can use it correctly based on the provided Information…
- Trial name
- SaliPen (NCT05058430)
- Testing
- Electrical salivary stimulator system assigned to subjects with xerostomia, No Electrical salivary stimulator system assigned to subjects without xerostomia
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Saliwell Ltd.
Saliva Altered
Application of Neuro-electrostimulation as a Treatment for Patients With Dry Mouth
Hyposalivation is a condition that has increased in frequency, primarily due to the degeneration of salivary glands caused by aging, polypharmacy, chronic or autoimmune diseases, or radiation treatments.
- Trial name
- NCT07593495
- Testing
- electrotherapy and physical therapy device
- Where
- Mexico
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma del Estado de Mexico
Dry Eye, Sjogren's Disease
Multi-Colored Placido Disk Viability
The purpose of this study is to show that the multi-colored Placido Disk set-up can get reliable data over long time periods.
- Conditions
- Dry Eye, Sjogren's Disease, Healthy
- Trial name
- NCT02148497
- Testing
- Multi-colored Placido disk imaging
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Dry Eye Syndrome (DES), Sjogren's Syndrome
Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome
By analyzing the differential proteins in exosomes, this study aims to understand the pathological mechanisms of SJS and DES, identify potential diagnostic and therapeutic methods, and advance the diagnosis and treatment of these…
- Conditions
- Dry Eye Syndrome (DES), Sjogren's Syndrome, Xerophthalmia
- Trial name
- NCT06771427
- Testing
- acupuncture GB20 or GB20 plus BL2, Chinese herbal tea TBDESJS
- Where
- Taiwan
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Dry Mouth, Halitosis
Questionnaire Regarding the Effect of Wearing Face Masks on Oral Health
During the current COVID-19 pandemic, the use of face masks is recommended / mandatory to prevent infection. Patients and students have reported to experience limitations in their oral health-related quality of life, especially…
- Trial name
- NCT04632004
- Testing
- Invitation to participate
- Where
- Germany
- Volunteers
- 3,750 people, healthy volunteers welcome
- Sponsor
- University of Göttingen
Rheumatoid Arthritis, Spondylitis, Ankylosing
Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases
Introduction: Patients with autoimmune rheumatic diseases (ARDs), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PAs), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), primary…
- Conditions
- Rheumatoid Arthritis, Spondylitis, Ankylosing, Spondyloarthritis, Systemic Lupus Erythematosus
- Trial name
- RZVRheum (NCT05879419)
- Testing
- Recombinant Herpes Zoster Vaccine (RZV), MTX Discontinuation, MMF Discontinuation
- Where
- Brazil
- Volunteers
- 2,005 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Keratoconjunctivitis Sicca, Dry Eye Syndromes
Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye
To investigate and compare the burden of dry eye in Sjögren's syndrome dry eye vs non-Sjögren's syndrome dry eye, as well as investigate the diagnostic potential of tear film mucins and various inflammatory cytokines evaluated by…
- Conditions
- Keratoconjunctivitis Sicca, Dry Eye Syndromes, Ocular Surface Disease, Sjogren's Syndrome
- Trial name
- NCT04493658
- Testing
- Questionnaires, Tear fluid sampling, Impression Cytology
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Mutans Streptococci, Xerostomia
Xylitol Disk Use in Adults With Dry Mouth
The purpose of this study is to demonstrate whether decay causing bacteria are reduced when adhesive xylitol disks are used intraorally three times a day for two weeks in adults with dry mouth.
- Trial name
- NCT01823445
- Testing
- Xylitol disk
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Washington
Meibomian Gland Dysfunction, Sjögren's Syndrome
Sjögren's Syndrome Is Associated With Meibomian Gland Dysfunction
The investigators hypothesize that the dry eye caused by SS may include the evaporative type, resulting from the MGD. Furthermore, the investigators hypothesize that both pSS and sSS are associated with MGD.To test our…
- Trial name
- NCT03434106
- Testing
- liposic, Tears Naturale Forte
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- LanZhou University
Inflammation, Sjogren's Syndrome
Superb Microvascular Imaging Ultrasonography of Lacrimal Gland in Patients With Sjögren Syndrome
A prospective study will be conducted to evaluate inflammatory activity in lacrimal glands due to Sjögren's syndrome on Superb Microvascular Imaging (SMI), gray scale ultrasound (US), color Doppler US and Power Doppler US.
- Conditions
- Inflammation, Sjogren's Syndrome, Gland; Inflammation
- Trial name
- SMI (NCT05689749)
- Testing
- Superb Microvascular Imaging (SMI) (Toshiba)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Sjögren's Syndrome
Modulation of Immunity-related Gene Expression Under the Chinese Herbal Formula SS-1 Treatment for Sjögren's Syndrome
To evaluate the modulation of immunity-related gene expression for the Sjögren's syndrome under Chinese herbal medicine (SS-1) treatment.
- Trial name
- NCT02855658
- Testing
- SS-1
- Where
- 2 sites in Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital