Clinical trials: Hypospadias
Regional Anesthesia, Hypospadias
Ultrasound-guided PNB and DPNB for Pediatric Distal Hypospadias Surgery
Hypospadias repair is a urological surgical operation that is very painful in the postoperative period and requires long-term analgesia.
- Trial name
- NCT04668183
- Testing
- Pudendal nerve block group, Dorsal penile nerve block group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Caudal Block
Caudal Combination of Dexamethasone and/or Dexmedetomidine to Bupivacaine in Pediatric Hypospadias Surgery
One of the most commonly used regional anesthetic techniques in pediatric surgeries is the caudal epidural block. Its main disadvantage remains the short duration of action. Hence, different additives have been used.
- Trial name
- NCT03261921
- Testing
- Dexamethasone, Dexmedetomidine, Bupivacaine
- Volunteers
- 63 people
- Sponsor
- Cairo University
Distal Penile Hypospadias (Disorder)
Distal Hypospadias Repair Outcome
Aim is : To define the preoperative parameters that may influence the results of distal hypospadias repair
- Trial name
- NCT06700629
- Testing
- Distal Penile Hypospadias (Disorder)
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Armia Ezzat Thabet Azer
Postoperative Pain
Comparison Sacral Erector Spinae Block Versus Caudal Block
The purpose of this research study is to find the best way to decrease pain in children whom have had hypospadias surgery. Investigators will perform two technique; Caudal block or Sacral erector spinae block.
- Trial name
- NCT04106687
- Testing
- Ultrasound Guided Caudal Block, Sacral Erector Spinae Block
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Proximal Penile Hypospadias
Graft Versus Flap in Management of Proximal Penile Hypospadias
Proximal hypospadias (penoscrotal, scrotal, and perineal types) account for approximately 20% of all cases . The management of hypospadias has greatly improved over the past two decades since the introduction of tubularized…
- Trial name
- NCT06565286
- Testing
- inner preputial graft versus transverse preputial island flap in two-stage repair of proximal penile hypospadias
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Hypospadias
Efficacy of PRF in Hypospadias Repair
Hypospadias is an anomaly characterized by an ectopic ventral urethral meatus, and an incomplete or hooded prepuce. Its incidence is estimated at 1 in 200-300 live male births, with variations across populations and severity…
- Trial name
- NCT07757828
- Testing
- Tubularized Incised Plate urethroplasty with intraoperative placement of autologous PRF onto the urethral plate., standard Tubularized Incised Plate urethroplasty
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Hypospadias
Reconstructing Forked Corpus Spongiosum in Hypospadias Repair
Hypospadias is one of the most common genital malformations in children. The high incidence of hypospadias, which occurs in 1 in 200 to 300 live births, means that it affects a large number of patients.
- Trial name
- NCT04533477
- Testing
- Reconstructing forked corpus spongiosum (FCS), Routine standardized surgery
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Dexmedetomidine Infusion, Pediatric
Comparison of Caudal Block Versus Dexmedetomidine Infusion in Pediatric Patients Undergoing Hypospadias Repair Surgery
Pain is one of the most misunderstood, underdiagnosed, and untreated medical problems, particularly in children. New Joint Commission on Accreditation of Health Care Organization regards pain as fifth vital sign and requires…
- Conditions
- Dexmedetomidine Infusion, Pediatric, Hypospadias Repair Surgery
- Trial name
- NCT04331418
- Testing
- Dexmedetomidine, caudal block
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Tanta University
Hypospadias
Clinical Trial to Assess the Safety and Efficacy of Investigational Product in Patients Due to Hypospadias Treatment Failure
The purpose of this trial is to assess the safety and efficacy of Holour in patients suffering from hypospadias treatment failure.
- Trial name
- HOLOUR (NCT05093166)
- Testing
- "Ex vivo" expanded autologous human oral epithelium containing stem cells
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Holostem s.r.l.
Disorders of Sex Development, Hypospadias
Genetics of Differences of Sex Development and Hypospadias
This study seeks to identify genetic causes of conditions that affect the gonads and genitals, and to study the impact on families of receiving genetic results.
- Trial name
- NCT03102554
- Testing
- Return of Genetic Results
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Boston Children's Hospital
Hydrocele, Inguinal Hernia
The Caudal Space in Children: Ultrasound Evaluation
Caudal anesthesia is commonly employed in pediatrics to produce postoperative analgesia in low abdominal or urologic surgery. An exact understanding of the anatomy of the sacral area including sacral hiatus and surrounding…
- Conditions
- Hydrocele, Inguinal Hernia, Hypospadia, Cryptorchidism
- Trial name
- NCT01896076
- Testing
- ultrasound evaluation of caudal space
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Caudal Block
Methylprednisolone Versus Dexamethasone in Pediatric Caudal Block
This randomized, double-blind, controlled bi-center study was designed to compare the postoperative analgesic efficacy of dexamethasone and methylprednisolone in caudal block for children undergoing hypospadias surgical repair…
- Trial name
- NCT05717374
- Testing
- caudal block using dexamethasone, caudal block using methylprednisolone
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Postoperative Pain
Effect of Caudal Nalbuphine on Postoperative Analgesia in Children
Nalbuphine as an adjuvant to bupivacaine caudal anesthesia for postoperative analgesia in children undergoing Hypospadias repair. 2 groups, 30 patients each
- Trial name
- NCT02618876
- Testing
- Nalbuphine plus Bupivacaine, Bupivacaine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Hypospadias
The Role of "Hypospadias Objective Scoring Evaluation" (HOSE) and Uroflowmetry in Evaluation of Successful Hypospadias Repair
Hypospadias is a common anomaly of the male genitalia affecting 0.4-8.2 of 1000 live male babies and varies considerably in severity.
- Trial name
- NCT05032222
- Testing
- Uroflowmetry
- Where
- Egypt
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Mohammad Alaa Ezzat
Hypospadias
Comparison Of Outcome Of Different Layers in Hypospadias Surgery
To compare the outcome of applying autologous platelet-rich plasma membrane layer and dartos fascial flap versus only dartos fascial flap in mid and distal penile hypospadias surgery.
- Trial name
- NCT06275646
- Testing
- PRP layer, dartos flap
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Children Hospital and Institute of Child Health, Lahore
Emergence Delirium
Effect of Intravenous Nalbuphine and Magnesium Sulfate on Emergence Agitation in Pediatric
Primary outcome: Measure The incidence of EA in children undergoing to hypospadias repair under general anesthesia is considered using Pediatric Anesthesia Emergence Delirium (PAED) scales.
- Trial name
- NCT06306040
- Testing
- Nalbuphine Versus Magnesium Sulfate
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hypospadias
Local Oestrogen Versus Placebo as Preoperative Treatment in Patients With Severe Hypospadias: Effects on Post-operative Complications
Hypospadias is a congenital abnormality of the penis that is caused by incomplete development of the anterior urethra. This pathology is one of the most common genital anomalies in paediatric urology .The incidence is reported to…
- Trial name
- HYPOSPADES (NCT01370798)
- Testing
- promestriene, Urethroplasty, Wrist X ray
- Where
- 4 sites in France
- Volunteers
- 244 people
- Sponsor
- Hospices Civils de Lyon
Hypospadias
Worldwide Yearly Screening for Hypospadias
The purpose of this study is to recruit approximately 20 male participants who have a history of repaired hypospadias to test the feasibility and acceptability of the Care Planning Tool within the Worldwide Yearly Screening for…
- Trial name
- WYSH (NCT06966375)
- Testing
- WYSH Web Application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Residual Severe Ventral Curvature, Transection of the Urethral Plate
Urethral Plate Flap vs. Tunica Vaginalis Flap for Residual Severe Ventral Curvature in Hypospadias
The correction of ventral curvature in hypospadias follows a stepwise principle. Clinically, in some cases of hypospadias, residual severe ventral curvature (VC ≥ 30°) persists even after thorough skin degloving and transection…
- Conditions
- Residual Severe Ventral Curvature, Transection of the Urethral Plate, Corporoplasty, Pedicled Tunica Vaginalis Flap (TVF)
- Trial name
- NCT07404722
- Testing
- Urethral Plate Flap Corporoplasty, Tunica Vaginalis Flap Corporoplasty
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Postoperative Pain, Hypospadias
Comparison of Sacral ESP Block and Dorsal Penile Nerve Block in Pediatric Hypospadias Surgery
This randomized controlled trial aims to compare the postoperative analgesic efficacy of ultrasound-guided Sacral Erector Spinae Plane (ESP) block versus Dorsal Penile Nerve Block (DPNB) in pediatric patients aged 1-7 years…
- Trial name
- NCT07426731
- Testing
- Sacral ESP Block Group, Dorsal Penile Nerve Block Group
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Medipol University