Clinical trials: Hypospadias Repair
Perioperative Bleeding During Recurrent Hypospadias Repair
Evaluating the Efficacy and Safety of Tranexamic Acid in Reducing Perioperative Bleeding During Recurrent Hypospadias Repair.
This study aims to fill that gap by evaluating the efficacy and safety of intravenous TXA in children undergoing redo hypospadias surgery, potentially establishing a new standard of care
- Trial name
- NCT07778992
- Testing
- single intravenous (IV) bolus dose of tranexamic acid (TXA) at 15 mg/kg (maximum dose 1000 mg), Control (Normal saline)
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Aswan University Hospital
Preemptive Analgesia, Dexmedetomidine
Dexmedetomidine, Ketamine and Magnesium Sulphate in Caudal Block for Hypospadias Repair
Caudal epidural block is a rapid, reliable, and safe technique that can be used with general anesthesia for intraoperative and postoperative analgesia in pediatric patients Ketamine is a selective antagonist of…
- Conditions
- Preemptive Analgesia, Dexmedetomidine, Ketamine, Magnesium Sulphate
- Trial name
- NCT05837000
- Testing
- Dexmedetomidine, Ketamine, Magnesium sulphate
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Kafrelsheikh University
Hypospadias
Redo Repair in Disrupted Hypospadias
Redo hypospadias repair is a challenging situation and its success depends on many factors. Several procedures could be used in such situations with variable outcomes.
- Trial name
- NCT06187363
- Testing
- Tubularized incised plate procedure, Other procedures
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Egyptian Biomedical Research Network
Postoperative Pain
Intravenous Dexmedetomidin on Postoperative Pain After Hypospadias Repair in Children
This study aimed to evaluate the efficacy of intravenous ketorolac versus dexmedetomidine as analgesia after Hypospadias repair surgery to determine the optimal procedure for pain control and postoperative reduction of analgesic…
- Trial name
- NCT05194904
- Testing
- Dexmedetomidine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Pain, Hypospadias
Effect of Intravenous Dexamethasone With Pudendal Nerve Block on Postoperative Pain in Pediatric Hypospadias Repair
This study aims to determine if intravenous Dexamethasone combined with a pudendal nerve block is able to prolong postoperative analgesia in children undergoing hypospadias repair.
- Trial name
- NCT03902249
- Testing
- Dexamethasone
- Volunteers
- 70 people
- Sponsor
- Dr Sonia ben khalifa (PhD)
Complication of Anesthesia
Effect of Caudal vs. Penile Block on the Incidence of Hypospadias Complications
Hypospadias is one of the most common congenital malformations in male babies, affecting approximately 1 in every 200-300 live male births.
- Trial name
- NCT06667947
- Testing
- caudal block
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Glandular Urethral Disassembly, Tubularized Incised Plate
Comparison Between Glandular Urethral Disassembly Versus Tubularized Incised Plate for Primary Distal Hypospadius Repair
To compare Glandular Urethral Disassembly technique versus Tubularized Incised Plate technique for Primary Distal Hypospadius Repair
- Conditions
- Glandular Urethral Disassembly, Tubularized Incised Plate, Distal Hypospadius Repair
- Trial name
- NCT05913128
- Testing
- Glandular Urethral Disassembly technique
- Where
- Egypt
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Benha University
Hypospadias
The Effect of Caudal Block on the Postoperative Complications in Pediatric Patients After Hypospadias Repair
Hypospadias refers to a disease represented by a congenital defect in the urethra meatus (urinary opening) in male children. Due to the postoperative pain, symptoms such as discomfort, agitation, and restlessness are generally…
- Trial name
- NCT02164682
- Testing
- IV PCA group, IV PCA+ caudal block group
- Where
- South Korea
- Volunteers
- 404 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Hypospadias
Snodgrass Versus Grafted Snodgrass Repair in Narrow Urethral Plate in Distal Penile Hypospadias
We aime to compare between Snodgrass and grafted Snodgrass repair in the outcome in distal penile hypospadias with urethral plate less than 8mm
- Trial name
- NCT06405763
- Testing
- Snodgrass repair, Snodgrass repair with graft
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Residual Severe Ventral Curvature, Transection of the Urethral Plate
Urethral Plate Flap vs. Tunica Vaginalis Flap for Residual Severe Ventral Curvature in Hypospadias
The correction of ventral curvature in hypospadias follows a stepwise principle. Clinically, in some cases of hypospadias, residual severe ventral curvature (VC ≥ 30°) persists even after thorough skin degloving and transection…
- Conditions
- Residual Severe Ventral Curvature, Transection of the Urethral Plate, Corporoplasty, Pedicled Tunica Vaginalis Flap (TVF)
- Trial name
- NCT07404722
- Testing
- Urethral Plate Flap Corporoplasty, Tunica Vaginalis Flap Corporoplasty
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Caudal Block
Methylprednisolone Versus Dexamethasone in Pediatric Caudal Block
This randomized, double-blind, controlled bi-center study was designed to compare the postoperative analgesic efficacy of dexamethasone and methylprednisolone in caudal block for children undergoing hypospadias surgical repair…
- Trial name
- NCT05717374
- Testing
- caudal block using dexamethasone, caudal block using methylprednisolone
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Anesthesia, General
The Effect of Anesthetics on Oxidative Stress and Apoptosis Status in Children
The purpose of this study is to determine whether Propofol and Sevoflurane affect the oxidative stress and apoptosis status in children undergoing hypospadias repair surgery.
- Trial name
- NCT02711280
- Testing
- Sevoflurane, Propofol
- Where
- China
- Volunteers
- 47 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hypospadias
Antibiotic Use in Distal Hypospadias Repair
Hypospadias is a common condition where the opening of the penis is not located at the tip, but along the underside of the penis. It is estimated to occur in 1/300 live male births, making it one of the most common birth defects.
- Trial name
- NCT03275519
- Testing
- Randomization to not receive prophylactic antibiotics after surgery., Randomization to receive prophylactic antibiotics after surgery
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Postoperative Pain
Effect of Caudal Nalbuphine on Postoperative Analgesia in Children
Nalbuphine as an adjuvant to bupivacaine caudal anesthesia for postoperative analgesia in children undergoing Hypospadias repair. 2 groups, 30 patients each
- Trial name
- NCT02618876
- Testing
- Nalbuphine plus Bupivacaine, Bupivacaine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Hypospadias Repair
TIP Repair of Distal Penile Hypospadias Using Rapidly Absorbable Braided Vs Slowly Absorbable Monofilament Sutures
Objective: To study the effect of tubularizing the urethral plate in DPH in children using 2 different absorbable suture materials, rapidly absorbable, braided 6/0 Vicryl and slowly absorbable monofilament 6/0 Polydioxanone, on…
- Trial name
- NCT06413901
- Testing
- TIP
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Cairo University
Distal Hypospadias Repair
Topography Guided Repair Versus TIP for Distal Hypospadias
This study compares two surgical techniques used to repair distal hypospadias in children: topography-guided repair (TGR), a newer approach, and tubularized incised plate (TIP) repair, a commonly used standard technique.
- Trial name
- DPH repair (NCT07832760)
- Testing
- Topography Guided Repair, Tubularized Incised Plate Repair
- Where
- Egypt
- Volunteers
- 101 people
- Sponsor
- Alexandria University
Narrow Urethral Plate Hypospadias
Evaluation of Slit-like Adjusted Mathieu Versus Onlay Island Flap for Hypospadias Repair in Pediatrics
Purpose** To compare the Slit-like Adjusted Mathieu (SLAM) technique versus the inner transverse preputial onlay island flap for repair of anterior and mid-penile hypospadias with narrow urethral plate, evaluating complication…
- Trial name
- NCT07592026
- Testing
- Slit-like Adjusted Mathieu, onlay island flap
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Elective Penile Surgeries, Hypospadias
Effects of Dexmedetomidine as Adjunct to Pudendal Block for Pediatric Penile Surgery
Caudal block is often performed to relieve postoperative pain in pediatric urological surgery. Recently, pudendal block is also used in penile surgery and it has advantage because of less side effects such as transient weakness…
- Conditions
- Elective Penile Surgeries, Hypospadias, Urethral Fistula or Stricture After Hypospadias Repair, Penile Curvature
- Trial name
- NCT02848157
- Testing
- Dexmedetomidine, plain ropivacaine, Ropivacaine
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Hypospadias
The Change of the Detrusor Thickness After Hypospadias Repair - Comparison With the Normal Control Group
Even successfully managed hypospadias without any complication, voiding problem could be developed due to the increased urethral resistance.
- Trial name
- NCT01762007
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yonsei University
Hypospadias, Pediatric Urology
Can a Platelet-Rich Plasma Covering Layer Reduce Urethrocutaneous Fistula Rate After Distal Penile Hypospadias Repair Using the STAR Technique: A Randomized Controlled Trial
Methods We conducted a prospective randomized controlled study at the Pediatric Urology Department of Cairo University Specialized Pediatric Hospital between July 2024 and January 2025 .
- Trial name
- NCT07006922
- Testing
- hypospadias repair using the STAR technique with PRP as protective layer, hypospadias repair using the STAR technique
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Cairo University