Clinical trials: Hypotension, Controlled
Ephedrine, Intramuscular
Intramuscular Ephedrine in the Prevention of Hypotension in Patients Undergoing Spinal Anesthesia
Subarachnoid anesthesia is an alternative and usually the first choice for many surgical procedures. It is a simple and safe procedure, however it can present complications such as hypotension and bradycardia.
- Conditions
- Ephedrine, Intramuscular, Hypotension, Spinal Anesthesia
- Trial name
- NCT05498857
- Testing
- Intramuscular ephedrine
- Where
- Brazil
- Volunteers
- 202 people
- Sponsor
- Hospital de Base
Adverse Effect
Ondansetron for Postspinal Anesthesia Hypotension
The purpose of this study is to investigate the effectiveness of ondansetron for postspinal anesthesia hypotension in patients undergoing cesarean section.
- Trial name
- NCT05475873
- Testing
- normal saline, Ondansetron 4 mg, Ondansetron 8 mg
- Where
- China
- Volunteers
- 120 people
- Sponsor
- General Hospital of Ningxia Medical University
Haemodynamic Instability
Internal Jugular Vein and Spinal-induced Hypotension
The study aims to assess internal jugular vein ultrasound derived measurements and indices prior to spinal anesthesia in elderly population who fulfills predetermined inclusion criteria and might greatly benefit from an…
- Trial name
- NCT05015218
- Testing
- Vacular Ultrasound
- Where
- 2 sites in Greece
- Volunteers
- 50 people
- Sponsor
- Attikon Hospital
Hypotension, Tachycardia
Passive Leg Raising Attenuates and Delays Tourniquet Deflation-induced Hypotension and Tachycardia
Background: The pneumatic tourniquet is frequently used in total knee arthroplasty. Tourniquet deflation may result in hypotension and tachycardia caused by the rapid shift of blood volume back to the ischemic limb and a decrease…
- Trial name
- NCT01592669
- Testing
- passive leg raising
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Hypotension, Anesthesia
Intramuscular Phenylephrine HCL for Prevention of Spinal Anesthesia Induced Hypotension
Background: Spinal anesthesia (SA) is preferred over general anesthesia in Cesarean section (CS) due to its better safety profile but SA induced hypotension remains a big challenge for the clinical Anesthetist.
- Trial name
- NCT05348980
- Testing
- Phenylephrine Hydrochloride 4 mg, Phenylephrine Hydrochloride 8 mg
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Shock, Sepsis
Single Dose Enteral Tranexamic Acid in Critically Ill Patients
The premise of this study is that enteral tranexamic acid will help to maintain small bowel integrity, which is often compromised by critical illness due to inadequate cardiovascular perfusion (i.e., shock), and that maintenance…
- Conditions
- Shock, Sepsis, Hypotension, Critical Illness
- Trial name
- NCT01683747
- Testing
- Tranexamic Acid, Control Intervention (Carrier fluid only)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- San Diego Veterans Healthcare System
Dialysis Membranes and Hemodynamic Tolerance
Dialysis Membranes and Hemodynamic Tolerance
Background: High- and low-flux dialysis membranes made of different materials may correlate with various hemodynamic tolerance profiles.
- Trial name
- NCT01898234
- Testing
- Revaclear, Helixone high flux, Xevonta
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- Ospedale Regionale di Locarno
Rhinoplasty, Depth of Anesthesia
Processed EEG Monitoring During Controlled Hypotension in Patients Undergoing Rhinoplasty
This prospective observational study evaluates intraoperative processed electroencephalography parameters in adult patients undergoing elective rhinoplasty under total intravenous anesthesia with controlled hypotension.
- Conditions
- Rhinoplasty, Depth of Anesthesia, Surgical Bleeding, Postoperative Recovery
- Trial name
- NCT07671781
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Gazi University
Anesthesia, General, Hypotension
Haemodynamic Effects of Four Sevoflurane Wash-In Strategies After Tracheal Intubation
The goal of this clinical trial is to compare how four different ways of starting sevoflurane anaesthesia (the "wash-in" phase) affect the heart and circulation during the first 10 minutes after endotracheal intubation in adults…
- Trial name
- WASH-PRAM (NCT07894393)
- Testing
- End-tidal-controlled sevoflurane wash-in, Low-flow high-concentration wash-in (0.5 L/min, 8% sevoflurane), Low-flow wash-in (1 L/min, 4% sevoflurane)
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Ataturk University
Intradialytic Hypotension, Hemodialysis
Effect of Breathing Exercise on Intradialytic Hypotension in Hemodialysis Patients
Intradialytic hypotension is a common complication of hemodialysis that may adversely affect patient safety and treatment tolerance.
- Trial name
- NCT07773311
- Testing
- Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Yasemin Çelik
Anesthesia, Hypotension
Preoperative Ultrasound-based Protocol for Optimization of Fluid Therapy to Prevent Early Intraoperative Hypotension
Background: Intraoperative hypotension increases 30-day mortality and the risks of myocardial injury and acute renal failure. Patients with inadequate volume reserve before the induction of anesthesia are highly exposed.
- Conditions
- Anesthesia, Hypotension, Lung Ultrasound, Echocardiography
- Trial name
- NCT05171608
- Testing
- Ultrasound-based protocol based fluid therapy
- Where
- Hungary
- Volunteers
- 80 people
- Sponsor
- Semmelweis University
Anesthesia, Spinal, Cesarean Section
Post Spinal Anesthesia Hypotension and Preoperative Hydration
Study of the impact of preoperative oral rehydration on the incidence of spinal anesthesia-induced hypotension for scheduled cesarean section.
- Trial name
- NCT04450667
- Testing
- Nutricia PreOp
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brugmann University Hospital
Hemodialysis Complication, Hypotension of Hemodialysis
Hemodialysis.-Induced Hypotension Therapy for End Stage Kidney Disease
Bradykinin is a potent vasodilator that is formed by the activation of the kallikrein-kinin system. We and others have shown that bradykinin increased during hemodialysis; however, the role of bradykinin in dialysis-induced…
- Trial name
- Hinder (NCT05297786)
- Testing
- Lanadelumab Injection [Takhzyro]
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center
End Stage Renal Disease on Dialysis, Intradialytic Hypotension
A Pilot Trial of Chinese Medicine for Patients With Dialytic Hypotension
To evaluate the epidemiological status of traditional Chinese Medicine (TCM) constitution in patients with dialytic hypotension, and design a clinical study based on a Zheng-based herbal formulation to evaluate the clinical…
- Trial name
- NCT07425262
- Testing
- CHM intervention group, No CHM treatment
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Orthostatic Hypotension
Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension
The purpose of this study is to determine whether midodrine works against the symptoms of orthostatic hypotension caused by being on a tilt table.
- Trial name
- NCT01518946
- Testing
- Midodrine HCl
- Where
- 13 sites in United States
- Volunteers
- 24 people
- Sponsor
- Shire
Parkinson Disease, Multiple System Atrophy, Parkinson Variant
Abdominal Binders to Treat Orthostatic Hypotension in Parkinsonian Syndromes
The purpose of the present clinical trial is to determine whether the use of an elastic abdominal binder is effective in the non-pharmacological management of symptomatic, neurogenic orthostatic hypotension (OH) in individuals…
- Conditions
- Parkinson Disease, Multiple System Atrophy, Parkinson Variant, Orthostatic; Hypotension, Neurogenic
- Trial name
- ABOH-PS (NCT04920552)
- Testing
- Elastic abdominal binder
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Universitätsklinik für Neurologie, Innsbruck
Hypotension, Cesarean Section Complications
Maternal Care Bundle to Attenuate Hypotension in Cesarean Section
Cesarean Section (CS) is a common obstetric surgery that can be performed by both general or regional anaesthetic techniques. Hypotension is the most common complication of spinal anaesthesia, its incidence varying from 70% to 80…
- Trial name
- NCT05468125
- Testing
- guidance
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Suez Canal University
Myocardial Infarction Postoperative, Myocardial Injury
Intraoperative Hypotension and Perioperative Myocardial Injury
Acute myocardial infarction (MI) is a significant complication following non-cardiac surgery. We sought to evaluate incidence of perioperative MI, its preoperative - and intraoperative - risk factors and outcomes after this…
- Conditions
- Myocardial Infarction Postoperative, Myocardial Injury, Intraoperative Complications, Intraoperative Hypotension
- Trial name
- NCT03974321
- Where
- Sweden
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Intraoperative Hypotension, Ciprofol
Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors
The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors.
- Conditions
- Intraoperative Hypotension, Ciprofol, Renin-angiotensin System Inhibitors
- Trial name
- NCT06952608
- Testing
- Ciprofol group, Propofol group
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Fetus or Neonate Affected by Maternal Epidural Anesthesia During Labor and Delivery
Pulse Pressure and Post-epidural Fetal Heart Rate Changes
Epidural anesthesia, the most common method of pain control in labor, can contribute to alterations in maternal blood pressure and/or fetal heart rate changes.
- Trial name
- NCT02565485
- Testing
- Lactated Ringer's
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- MetroHealth Medical Center