Clinical trials: Hypotension, Controlled
Hypotension
PeRsonalized Blood prEssure Management on Postoperative Complications and Mortality in hIgh-risk Patients Undergoing Major Non-cardiac Surgery
High-risk populations, particularly elderly individuals and patients with cardiovascular comorbidities, exhibit markedly elevated incidences of postoperative myocardial injury (MINS), acute kidney injury (AKI), and mortality.
- Trial name
- PREMIUM (NCT06952387)
- Testing
- Personalized blood pressure management, Routine blood pressure management
- Where
- 7 sites in China
- Volunteers
- 1,624 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Kidney Transplant, Delayed Graft Function
Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantation
Prospective double blind randomized controlled trial. By randomizing patients undergoing kidney transplantation into a conventional catecholamine drug (dobutamine) blood pressure maintenance group and a terlipressin-complexed…
- Conditions
- Kidney Transplant, Delayed Graft Function, Intraoperative Hypotension
- Trial name
- NCT06855758
- Testing
- terlipressin
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Friendship Hospital
Protamine Adverse Reaction
Effect of Anti-histamine in Prevention Systolic Hypotension After Protamine
Protamine remains the anticoagulant of choice for cardiopulmonary bypass (CPB). The process of protamine neutralization of heparin came with the side effects sometimes; it can be life threatening or fetal reaction.
- Trial name
- NCT03583567
- Testing
- Chlorpheniramine and ranitidine, 0.9% Normal Saline
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Spinal Anesthesia, Hypotension
Prediction of Spinal Anesthesia-Induced Hypotension in Cesarian Section: Carotid Artery-Corrected Flow Time Versus Cardiometry
This research aimed to evaluate and compare the role of carotid corrected flow time (FTc) and electrical cardiometry (EC) in the prediction and prevention of post-spinal hypotension in elective cesarian section.
- Conditions
- Spinal Anesthesia, Hypotension, Cesarian Section, Carotid Artery
- Trial name
- NCT06236217
- Testing
- Carotid Ultrasound, Electrical cardiometry
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Tanta University
Acute Kidney Injury, Hypotension, Controlled
Evaluation of Renal Resistive Index in Patients with Controlled Hypotension
In recent studies, it has been reported that the renal resistive index is effective in detecting postoperative acute kidney injury in the early period.
- Conditions
- Acute Kidney Injury, Hypotension, Controlled, Renal Failure, Ultrasonography, Doppler
- Trial name
- NCT05945706
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Ankara Diskapi Training and Research Hospital
Spinal Anesthetic Toxicity
Echocardiography and Spinal Induced Hypotension.
Modern guidelines have combined both the maximum diameter of IVC at expiration (dIVC max) and the IVCCI to appreciate right atrial pressure (RAP) measurements and consequently to assess intravascular volume status.
- Trial name
- NCT04001881
- Testing
- Transthoracic echocardiography, Spinal anesthesia
- Where
- Greece
- Volunteers
- 61 people
- Sponsor
- Attikon Hospital
Spinal Anaesthesia Induced Hypotension
Role of Ondansetron in Spinal Anaesthesia Induced Hypotension
The objective of this study is to determine the effect of ondansetron on the total consumption of norepinephrine infusion needed to prevent spinal anaesthesia induced hypotension in cesarean section.
- Trial name
- NCT06727201
- Testing
- Ondansetron (Zofran)
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assiut University
Colonoscopy
A Low Dose Dexmedetomidine in Sedation Colonoscopy
104 patients who undergo painless colonoscopy from January 20,2024 to February 29,2024 will be randomized to two groups: propofol group and dexmedetomidine group.
- Trial name
- NCT06208956
- Testing
- Dexmedetomidine, Propofol
- Volunteers
- 104 people
- Sponsor
- West China Hospital
Fetus or Neonate Affected by Maternal Epidural Anesthesia During Labor and Delivery
Pulse Pressure and Post-epidural Fetal Heart Rate Changes
Epidural anesthesia, the most common method of pain control in labor, can contribute to alterations in maternal blood pressure and/or fetal heart rate changes.
- Trial name
- NCT02565485
- Testing
- Lactated Ringer's
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- MetroHealth Medical Center
Hypotension, Postoperative Complications
Effectiveness of Hypotension Prediction Index (HPI) in Preventing Hypotension in the Post-Anesthesia Care Unit (PACU)
Postoperative hypotension in the post-anesthesia care unit (PACU) is common and linked to adverse outcomes. The Hypotension Prediction Index (HPI) predicts hypotensive events intraoperatively, but its PACU application is…
- Trial name
- NCT07097454
- Testing
- Hypotension Prediction Index Monitoring, Standard PACU Monitoring
- Where
- South Korea
- Volunteers
- 210 people
- Sponsor
- Wonkwang University Hospital
Pregnancy Related, Anesthesia
Undetectable Hypotension Episodes in Cesarean Section
In order to evaluate the efficacy and necessity of continuous non-invasive arterial pressure (CNAP) by comparing it with non-invasive blood pressure (NIBP) in order to understand whether it has advantages over oscillometric…
- Conditions
- Pregnancy Related, Anesthesia, Blood Pressure
- Trial name
- NCT05440695
- Testing
- Continuous non-invasive arterial pressure (Infinity® CNAPTM, Dräger)
- Volunteers
- 53 people
- Sponsor
- Asude AYHANt
Multiple System Atrophy
Study of ATH434 in Participants with Multiple System Atrophy
This study will assess the safety and efficacy of ATH434 in participants with Multiple System Atrophy
- Trial name
- NCT05109091
- Testing
- ATH434 dose level 1, ATH434 dose level 2
- Where
- 23 sites in United States, Australia and 4 more
- Volunteers
- 77 people
- Sponsor
- Alterity Therapeutics
Preeclampsia, Cesarean Birth
Norepinephrine Infusion vs Bolus vs Ephedrine for Blood Pressure Stability During Cesarean Delivery in Women With Preeclampsia
This randomized controlled trial will compare norepinephrine infusion, norepinephrine bolus, and ephedrine bolus for maintaining hemodynamic stability during spinal anesthesia for scheduled cesarean delivery in women with…
- Conditions
- Preeclampsia, Cesarean Birth, Hypotension During Surgery
- Trial name
- NCT07842783
- Testing
- Norepinephrine (0.05 μg/kg/min), Norepinephrine 4mcg, Ephedrine Bolus 6 mg
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Benha University
Hypotension Drug-Induced
Is Labetalol More Effective Than Metoprolol for Controlled Hypotensive Anesthesia During Endoscopic Nasal Surgeries?
Background: Mucosal bleeding is the most frequent complication with endoscopic nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, leading to increased complications, operation duration…
- Trial name
- NCT05368376
- Testing
- Labetalol Hydrochloride Oral Tablet, Metoprolol Tartrate Oral Tablet
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Controlled Hypotension for Nasal Surgeries
Comparison of Two Sedative Agents in Terms of Controlled Hypotension
Propofol and Isoflurane are commonly used sedative agents in general anaesthesia.Both these drugs have a side effect of decreasing blood pressure which when used optimally can be used to acheive controlled hypotention.
- Trial name
- NCT07460050
- Testing
- Propofol, Isoflurane
- Where
- Pakistan
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Hayatabad Medical Complex
Otolaryngological Surgery, Anesthesia
Remifentanil Monotherapy vs. Remifentanil-Nicardipine for Controlled Hypotension in Otolaryngological Surgery
Controlled hypotension is a widely employed technique in otolaryngological (ear, nose, and throat) surgery, primarily aimed at improving surgical field visibility and minimizing intraoperative blood loss.
- Trial name
- NCT07659496
- Testing
- Remifentanil / Nicardipine, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dicle University
Hypotension, Pain
The Prevention of Hypotension After Epidural Analgesia After Major Surgery
Epidural analgesia via continuous epidurally infused local anesthetic agent (LA) is widely and very successfully used routinely for perioperative pain control in patients undergoing major orthopedic and abdominal surgery since…
- Trial name
- NCT02722746
- Testing
- Ropivacaine, Epinephrine
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Florida
Remimazolam, Propofol
Comparison in Frequency of Hypotension Between Remimazolam and Propofol in Hip Surgery
The purpose of this study is to compare the incidence of hypotension between remimazolam and propofol for intraoperative sedation in patients undergoing hip surgery with spinal anesthesia.
- Conditions
- Remimazolam, Propofol, Orthopedic Procedures, Sedatives
- Trial name
- NCT05651399
- Testing
- Remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Asan Medical Center
Symptomatic Orthostatic Hypotension
Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension
To study the effect of midodrine against the symptoms of orthostatic hypotension
- Trial name
- NCT01515865
- Testing
- Midodrine HCl
- Where
- 32 sites in United States, Czechia and 2 more
- Volunteers
- 98 people
- Sponsor
- Shire
Symptomatic Neurogenic Orthostatic Hypotension
Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
A Phase 3 study to evaluate efficacy, safety, and tolerability of ampreloxetine (TD-9855) in subjects with primary autonomic failures (MSA, PD, or PAF) and symptomatic nOH with up to 4 weeks of treatment.
- Trial name
- SEQUOIA (NCT03750552)
- Testing
- ampreloxetine
- Where
- 125 sites in United States, Australia and 17 more
- Volunteers
- 195 people
- Sponsor
- Theravance Biopharma