Clinical trials: Hypotension, Controlled
Hypotension on Induction, Hypnotic Intoxication
Mean Arterial Pressure Reduction Anesthesia Induction Using Propofol Bolus or Tritiated Target-infusion
To compare haemodynamics and bispectral index values between conventional bolus propofol induction and target-controlled propofol infusion.
- Trial name
- NCT04291794
- Testing
- Propofol, Propofol Injection [Diprivan]
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Brasilia University Hospital
Hypotension, Orthostasis
Clinical Trial of Digital Therapeutics (One.Dr) for Suspected Orthostatic Hypotension Patients
Participants who meet the inclusion/exclusion criteria in the Screening visit are randomly assigned 1:1 to the treatment group or the sham control group.
- Trial name
- NCT07348445
- Testing
- Digital therapeutics (One.Dr Application)
- Volunteers
- 86 people
- Sponsor
- Yonsei University
Postural Orthostatic Tachycardia Syndrome
A Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe POTS
POTS is a relatively common condition that affects millions of patients around the globe. It has an estimated prevalence of 170/100,000 with approximately 80% of patients being women of childbearing age.
- Trial name
- NCT03365414
- Testing
- Albumin (Human) 5%, USP, Normal Saline 0.9% Infusion Solution Bag
- Sponsor
- University of Alberta
Vasoplegic Syndrome
Vitamin B12a Vasoplegic Syndrome
The study team will evaluate the medication Hydroxocobalamin (B12a) for treatment of low blood pressure after cardiac surgery.
- Trial name
- NCT03735316
- Testing
- Hydroxocobalamin, Cardiopulmonary Bypass
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Postoperative Orthostatic Hypotension, Postoperative Orthostatic Intolerance
Efficacy of Midodrine for the Prevention of Orthostatic Hypotension During Early Mobilization After Fast-track Hip Arthroplasty
The aim of this study is to examine the efficacy of 5 mg Midodrine (Gutron) vs. placebo on reducing the incidence of orthostatic hypotension during mobilization 6 h after a total hip arthroplasty.
- Trial name
- NCT01707953
- Testing
- Midodrine
- Where
- 3 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Nasal Polyps
Comparison of Metoprolol and Tramadol With Remifentanil in Endoscopic Sinus Surgery
Functional endoscopic sinus surgery (FESS) is indicated in diseases such as chronic sinusitis refractory to medical treatment, nasal polyposis, mass lesions in the nasal cavity.
- Trial name
- NCT02484859
- Testing
- Remifentanil, Tramadol, Metoprolol
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Adverse Effect
Prophylactic Norepinephrine Infusion for Spinal Hypotension and Inferior Vena Cava Collapsibility Index
The purpose of this study is to investigate the preventive effect of norepinephrine on post-spinal hypotension and the effect of norepinephrine on inferior vena cava collapsibility index (IVC-CI).
- Trial name
- NCT03997500
- Testing
- normal saline, Norepinephrine
- Where
- China
- Volunteers
- 195 people
- Sponsor
- General Hospital of Ningxia Medical University
Hypotension
Dexamethasone Blunts the Hypotensive Effect of Spinal Anesthesia in Geriatric Patients Undergoing Lower Limb Orthopedic Surgeries
Based on the data that DEX increases the TPR and may decrease the expression of serotonin the investigator conducted this study to test the hypothesis that the prophylactic intravenous infusion (IVI) of DEX can attenuate the…
- Trial name
- NCT03664037
- Testing
- Dexamethasone phosphate
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hypotension, Orthostatic
A Study for Patients With Neurogenic Orthostatic Hypotension
We are seeking male and female patients to voluntarily take part in a clinical research study. Patients must be aged 18 or older and diagnosed with symptomatic orthostatic hypotension (low blood pressure while in the upright…
- Trial name
- NCT00046475
- Testing
- Midodrine Hydrochloride
- Where
- 15 sites in United States
- Volunteers
- 140 people
- Sponsor
- Shire
Anesthesia, Hypotension
Preoperative Ultrasound-based Protocol for Optimization of Fluid Therapy to Prevent Early Intraoperative Hypotension
Background: Intraoperative hypotension increases 30-day mortality and the risks of myocardial injury and acute renal failure. Patients with inadequate volume reserve before the induction of anesthesia are highly exposed.
- Conditions
- Anesthesia, Hypotension, Lung Ultrasound, Echocardiography
- Trial name
- NCT05171608
- Testing
- Ultrasound-based protocol based fluid therapy
- Where
- Hungary
- Volunteers
- 80 people
- Sponsor
- Semmelweis University
Endoscopic Sinus Surgery
Propofol and Magnesium Sulfate Intravenous Infusion During Endoscopic Sinus Surgery
Endoscopic Sinus surgery usually associated by bleeding, despite using of local vasopressor injection, head up position- controlled hypotension is generally used for control of this purpose.
- Trial name
- NCT04078659
- Testing
- Propofol infusion, Magnesium Sulfate infusion, Lidocaine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Hypotension
Interest of Intravenous Ondansetron in the Prevention of Spinal Anaesthesia-induced Hypotension in Caesarean Section
The intravenous injection of 8mg of ondansetron (a serotonin type 3 receptor antagonist) before spinal anaesthesia for caesarean section, leads to a smaller reduction in systolic arterial pressure (SAP).
- Trial name
- ZORA (NCT02862873)
- Testing
- Spinal anaesthesia, Ondansetron, saline solution
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Post-induction Hypotension (PIH), Geriatric Patient
Incidence and Risk Factors of Post-Induction Hypotension in Geriatric Cancer Patients
This observational clinical study aims to investigate the incidence and risk factors of post-induction hypotension (PIH) in geriatric cancer patients undergoing surgery under general anesthesia.
- Conditions
- Post-induction Hypotension (PIH), Geriatric Patient, Oncologic Disease, Hemodynamic Effects of General Anesthesia
- Trial name
- NCT07294040
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Dolunay ARIK
Prostate Cancer
Pneumatic Compression and Post-induction Hypotension
The purpose of this study is to evaluate the effect of pneumatic compression on post-induction hypotension in elderly patients undergoing robot assisted laparoscopic prostatectomy.
- Trial name
- NCT05343689
- Testing
- Pneumatic compression
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Paracetamol, Hypotension Drug-Induced
Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy
Emergency laparotomy is a high-risk procedure often performed in patients with severe physiological derangements due to sepsis, making perioperative management challenging.
- Conditions
- Paracetamol, Hypotension Drug-Induced, Emergency Surgery
- Trial name
- NCT07466108
- Testing
- Paracetamol (acetaminophen)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Intra-operative Hypotension
Preoperative Point of Care Ultrasound Guided Fluid Optimization and Intravenous Ondansetron to Prevent General Anesthesia-Induced Hypotension
Hypotension is a common side-effect of general anesthesia induction and is related to adverse outcomes including significantly increasing risk of one-year mortality.
- Trial name
- NCT05784350
- Testing
- fluid boluses guided by IVC diameter via US/administration of pre-operative IV Odansetrone
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Meir Medical Center
Hypotension, Acute Renal Failure
N-acetylcysteine Plus Deferoxamine for Patients With Hypotension
Oxidative stress is associated with kidney damage in several different situations, including hypotension. In animal models it has been shown that the combination of n-acetylcysteine plus deferoxamine is superior to its isolate…
- Trial name
- NCT00870883
- Testing
- N-acetylcysteine and deferoxamine
- Where
- Brazil
- Volunteers
- 81 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Preeclampsia, Hypotension
Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Hypotension remains a common clinical problem after induction of spinal anesthesia for cesarean delivery. Maternal hypotension has been associated with considerable morbidity (maternal nausea and vomiting and fetal/neonatal…
- Trial name
- NCT00458003
- Testing
- Ephedrine, Phenylephrine
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Atrial Fibrillation With Rapid Ventricular Response, Hypotension Drug-Induced
Diltiazem in the Treatment of Atrial Fibrillation or Atrial Flutter With Rapid Ventricular Rate
The purpose of this study is to see how well calcium pre-treatment works for decreasing incidence of drug-induced hypotension after diltiazem administration for treatment of atrial flutter with rapid ventricular rate.
- Trial name
- AFFRVR (NCT05661942)
- Testing
- Calcium pre-treatment
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Wake Forest University Health Sciences
Hypotension
Echocardiography Based Algorithm for Spinal Anaesthesia
The main aim of the study is to compare the proposed algorithm for preventing and treating spinal hypotension with normal anesthesia management of a spinal anesthesia.
- Trial name
- NCT03106649
- Testing
- Echocardiography, Treatment of spinal hypotension
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh