Clinical trials: Hypotension, Orthostatic
Spinal Cord Injury Cervical, Hypotension, Orthostatic
Controlling Orthostatic Hypotension in People with Cervical Spinal Cord Injury
A common therapeutic intervention after spinal cord injury (SCI) is prolonged standing in a standing frame. For people with SCI, standing for 40 minutes or more, three to four times weekly improves several health-related issues…
- Trial name
- NCT04369131
- Testing
- Functional electrical stimulation
- Where
- United States
- Sponsor
- Quality Living, Inc.
Hypertension, Frailty
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
Rationale: Systolic hypertension represents the leading risk for burden of disease among older adults (age >70 years), with an increasing prevalence due to the increase in lifespan.
- Conditions
- Hypertension, Frailty, Old Age; Dementia, Orthostatic Intolerance
- Trial name
- BLUEBERRY (NCT05529147)
- Testing
- Antihypertensive Agents
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Orthostatic Hypotension, Parkinson's Disease
A Two Part Study (306A/306B) to Assess Droxidopa in Treatment of NOH in Patients With Parkinson's Disease
This is a study to evaluate the effects of an investigational drug, Droxidopa, in participants with neurogenic orthostatic hypotension (NOH), associated with Parkinson's disease.
- Trial name
- 306A/306B (NCT01176240)
- Testing
- Droxidopa
- Where
- 60 sites in United States
- Volunteers
- 225 people
- Sponsor
- Chelsea Therapeutics
Orthostatic Hypotension
Spinal Cord Stimulation for Orthostatic Hypotension
This is a prospective single-center randomized crossover control study that aims to evaluate the effects of non-invasive transcutaneous spinal cord stimulation in patients with known or suspected orthostatic hypotension.
- Trial name
- NCT05230147
- Testing
- Spinal cord stimulation
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Orthostatic Hypotension
Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury
The goal of this interventional crossover study is to determine the effects of transcutaneous spinal cord stimulation (TSCS) on the ability to perform moderate exercise and regulate core body temperature in the chronic spinal…
- Trial name
- NCT05960448
- Testing
- Transcutaneous Spinal Cord Stimulation (TSCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Hypotension
Treatment of Orthostatic Hypotension in SCI
The purpose of this study is to identify the effects of non-pharmacological and pharmacological anti-hypotensive treatment interventions on orthostatic hemodynamic responses, symptoms of autonomic dysreflexia and orthostatic…
- Trial name
- SCI (NCT05839652)
- Testing
- Midodrine Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury
The purpose of this study is to stimulate the circuits in the spinal cord that are directly responsible for hemodynamic control to restore hemodynamic stability in participants with chronic cervical or high-thoracic spinal cord…
- Trial name
- HEMO (NCT05044923)
- Testing
- Targeted Epidural Spinal Stimulation
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Aaron Phillips
Hypotension, Spinal Cord Injury
Prevention of Low Blood Pressure in Persons With Tetraplegia
The aim of this investigation is to determine the blood pressure response to NOS inhibition, with L-NAME, in persons with tetraplegia compared to non-SCI control subjects and to establish if blood pressure can be increased while…
- Trial name
- NCT00237770
- Testing
- N-Nitro L-arginine-methylester (L-NAME), Head-up Tilt maneuver
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Neurogenic Orthostatic Hypotension, Non-Diabetic Autonomic Neuropathy
Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)
The purpose of this study is to assess the durability of effect of Droxidopa in treating symptoms of neurogenic orthostatic hypotension in patients with Primary Autonomic Failure (Pure Autonomic Failure, Multiple System Atrophy…
- Conditions
- Neurogenic Orthostatic Hypotension, Non-Diabetic Autonomic Neuropathy, Multiple System Atrophy, Dopamine Beta Hydroxylase Deficiency
- Trial name
- NOH303 (NCT00738062)
- Testing
- Droxidopa
- Where
- 54 sites in United States, Australia and 2 more
- Volunteers
- 103 people
- Sponsor
- Chelsea Therapeutics
Cardiovascular Diseases, Post-Exercise Hypotension
The Influence of Cardiorespiratory Fitness on Firefighter Cardiovascular Health Under Exercise Conditions
Sudden cardiac death (SCD) is the number one cause of on-duty firefighter death. It is most likely to occur in adults who are not physically fit that engage in sudden vigorous exercise.
- Trial name
- FIT & FIRED UP (NCT04514354)
- Testing
- GEST
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Connecticut
Hypertension, Post-Exercise Hypotension
Set Volume of Optimal Resistance Exercise to Generate Hypotension
This study evaluates the volume of optimal resistance exercise to generate postexercise hypotension after performing a single exercise in hypertensive elderly subjects.
- Conditions
- Hypertension, Post-Exercise Hypotension, Resistance Training
- Trial name
- NCT03957746
- Testing
- Resistance training
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- University of Valencia
Falls, Orthostatic Hypotension
The Value of Near-infrared Spectroscopy and Blood Pressure Measurements in Estimating Future Fall Risk in Older Adults
The investigators aim to study which measurements/definitions from continuous blood pressures measurements (using a Finometer) and from cerebral oxygenation measurements (using near-infrared spectroscopy (NIRS)) are associated…
- Conditions
- Falls, Orthostatic Hypotension, Older Adults (65 Years and Older)
- Trial name
- NIRS-Fall (NCT06714565)
- Where
- Netherlands
- Volunteers
- 141 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Spinal Cord Injuries, Orthostatic Hypotension
Heart Rate Variability and Its Association With Symptom of Orthostatic Hypotension in Spinal Cord Injury
In this study, the SCI patients were sub-grouped on the basis of symptoms into symptomatic and asymptomatic groups and measured HRV during resting and tilt up tests to compare their cardiovascular autonomic functions.
- Conditions
- Spinal Cord Injuries, Orthostatic Hypotension, Heart Rate Variability
- Trial name
- NCT05982652
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Pusan National University Yangsan Hospital
Spinal Cord Injuries, Spinal Cord Diseases
Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)
The goal of this clinical trial is to evaluate the effect of transcutaneous spinal cord stimulation on blood pressure in individuals with an acute spinal cord injury (within 30 days of injury).
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Trauma, Nervous System, Nervous System Diseases
- Trial name
- SCI (NCT05731986)
- Testing
- Orthostatic challenge, Biostim-5 transcutaneous spinal stimulation - Mapping, Biostim-5 transcutaneous spinal stimulation - "Optimal" testing
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Hypotension, Orthostatic, Parkinson Disease
Improved Orthostatic Tolerance = Better Cognitive Function in Parkinson's Disease
Study on orthostatic Hypotension in Parkinson's disease
- Conditions
- Hypotension, Orthostatic, Parkinson Disease, Autonomic Failure, Cognitive Impairment
- Trial name
- PaKogOH (NCT03900000)
- Testing
- Physiotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- RWTH Aachen University
Postural Orthostatic Tachycardia Syndrome
Dietary Sodium's Effect on Urinary Sodium and Dopamine Excretion in Patients With Postural Tachycardia Syndrome
Patients with Postural Tachycardia Syndrome (POTS) may not adequately expand their plasma volume in response to a high sodium diet.
- Trial name
- NCT01563107
- Testing
- Plasma Volume, Exercise Capacity Test - Bicycle, Posture Study
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Neurogenic Orthostatic Hypotension
Spinal Cord Stimulation for Neurogenic Orthostatic Hypotension
Neurogenic orthostatic hypotension is a disabling manifestation of synucleinopathies including Parkinson's disease, multiple system atrophy, dementia with Lewy bodies, and pure autonomic failure.
- Trial name
- NCT07879391
- Testing
- Lower thoracic epidural spinal cord stimulation
- Volunteers
- 20 people
- Sponsor
- Aerospace Center Hospital
Orthostatic; Hypotension, Neurogenic, Autonomic Failure
Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms
The objective of this study is to find a more objective and accurate way to assess the efficacy of the treatment for neurogenic orthostatic hypotension.
- Conditions
- Orthostatic; Hypotension, Neurogenic, Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy
- Trial name
- NCT04782830
- Testing
- Accelerometer, Midodrine or atomoxetine pill
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Vanderbilt University Medical Center
PSP, PSP - Progressive Supranuclear Palsy
The CurePSP Genetics Program
This study is an observational, prospective genetic study. It aims to obtain DNA for research and testing from patients with PSP, CBS, MSA, and related neurological conditions and their families.
- Conditions
- PSP, PSP - Progressive Supranuclear Palsy, Corticobasal Syndrome, Corticobasal Syndrome(CBS)
- Trial name
- NCT06647641
- Testing
- Whole genome sequencing will be performed at the NIH
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Orthostatic Hypotension, Neurogenic Orthostatic Hypotension
Hypercapnia in Orthostatic Hypotension
The Autonomic (or "automatic") Nervous System (ANS) regulates internal processes, including control of heart rate and blood pressure (BP).
- Trial name
- NCT05295810
- Testing
- Sequential Gas Delivery
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Calgary