Clinical trials: Hypotension, Orthostatic
Orthostatic Intolerance, Syncope
Lower Body Muscle Pre-activation in Initial Orthostatic Hypotension
This study is aimed primarily at providing a simple and effective form of treatment to reduce the symptoms of Initial Orthostatic Hypotension (IOH) and prevent syncope.
- Conditions
- Orthostatic Intolerance, Syncope, Fainting, Presyncope
- Trial name
- IOH (NCT03970551)
- Testing
- Physical Counter-maneuver, Stress Test, Functional Electrical Stimulation
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Fever, Orthostatic Hypotension
Orthostatic Hypotension in Children With Acute Febrile Illness
Objective:to determent if children suffering from acute febrile illness has higher rate of orthostatic hypotension compared with children with no febrile illness. Design: a prospective cohort study.
- Trial name
- NCT00452712
- Testing
- All subjects will have their blood pressure measured in supine position (after 5 minute of rest) and after 3 minute of standing.
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Hypotension, Orthostatic, Hypertension
Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension
Neurogenic Orthostatic Hypotension (NOH) is clinically defined as a consistent drop in systolic blood pressure (SBP) ≥30mmHg upon standing from a seated or lying position.
- Conditions
- Hypotension, Orthostatic, Hypertension, Autonomic Nervous System Diseases
- Trial name
- NCT02963181
- Testing
- Yohimbine, Melatonin
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS
POLish Registry of CArdioneuroablation and CArdioneuromodulation
The multicentre observational study POL-CA involves a wide spectrum of patients with a history of syncopy. The study recruits patients with diagnosed vasovagal syndrome, cardioinhibitory carotid sinus syndrome, symptomatic sinus…
- Conditions
- Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS, Symptomatic Sinus Bradycardia SB or Atrioventricular Block AV, Postural Orthostatic Tachycardia Syndrome POTS
- Trial name
- POL-CA (NCT07196397)
- Testing
- cardioneuroablation, SN sparing hybrid ablation, Cardiac sympathetic denervation
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- SABAMED Medical Center Ltd.
Hypertension
Impact of Citrulline and Arginine Supplementation on the Post-exercise Hypotension (PEH)
Post-exercise hypotension (PEH) is a established phenomenon as one of the non-pharmacological ways of reducing blood pressure, producing important impacts, particularly in hypertensive individuals.
- Trial name
- PEH (NCT03378596)
- Testing
- L-citrulline + L-arginine, L-arginine, L-citrulline
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Juliano Casonatto
Spinal Cord Injury
Transcutaneous Stimulation in Spinal Cord Injury
Cardiovascular disease has become the leading cause of death in the spinal cord injury population. Increased reliance on the renin-angiotensin-aldosterone system (RAAS) is believed to decrease falls in blood pressure when moving…
- Trial name
- SCI (NCT05180227)
- Testing
- DS8R
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Multiple System Atrophy, Orthostatic Hypotension
Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic
The purpose of this study is to learn more about the regulation of the veins of the abdomen by the autonomic (involuntary) nervous system, and how this may affect high blood pressure.
- Conditions
- Multiple System Atrophy, Orthostatic Hypotension, Supine Hypertension
- Trial name
- NCT02726711
- Testing
- Trimethaphan
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Vanderbilt University
Orthostatic Hypotension
Assessment of Hand-grip in the Prevention of Postural Orthostatic Hypotension
The study is aimed to assess the efficacy of hand-grip in preventing orthostatic hypotension in 20 patients diagnosed with autonomic failure. Five healthy subjects will be studied for comparison.
- Trial name
- NCT01521221
- Testing
- Hand grip maneuver
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Orthostatic Hypotension
Phase 3 Study to Evaluate the Efficacy and Safety of Droxidopa on Orthostatic Hypotension Treatment in Hemodialysis Patients
Orthostatic hypotension is a major complication of hemodialysis and interferes with everyday activities in hemodialysis patients.
- Trial name
- OH (NCT01612078)
- Testing
- Droxidopa
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- TSH Biopharm Corporation Limited
Orthostatic Hypotension
Vitamin K Status and Markers of Vascular Function in Patients With and Without Postural Hypotension
Postural hypotension is common in older people, leading to falls, decline in function, and dependence. Available treatments have limited efficacy and tolerability; novel approaches to treatment are therefore needed.
- Trial name
- VITKOH (NCT02505282)
- Testing
- Vitamin K status
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Autonomic Nervous System Diseases, Orthostatic Hypotension
The Pathophysiology of Orthostatic Hypotension
The purpose of this study is to determine the cause of low blood pressure in selective patients who have problems with their involuntary (autonomic) nervous system.
- Conditions
- Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency, Orthostatic Intolerance
- Trial name
- NCT00748059
- Testing
- Standing or upright tilt, Microneurography, QSweat
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Symptomatic Neurogenic Orthostatic Hypotension, MSA - Multiple System Atrophy
Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants With Multiple System Atrophy
This is a Phase 3, multi-center, randomized withdrawal study to evaluate the efficacy and durability of ampreloxetine in participants with MSA and symptomatic nOH after 20 weeks of treatment.
- Trial name
- CYPRESS (NCT05696717)
- Testing
- Ampreloxetine
- Where
- 79 sites in United States, Argentina and 18 more
- Volunteers
- 102 people
- Sponsor
- Theravance Biopharma
Hypotension, Orthostatic
Orthostatic Hypotension in Rehabilitation Patients
The purpose of this study is to determine the prevalence and clinical course of orthostatic hypotension (OH) on a rehabilitation and nursing home unit during their inpatient stay and to initiate a standardized, interdisciplinary…
- Trial name
- NCT00117585
- Testing
- Treatment Phase 1, Treatment Phase 2, Treatment Phase 3
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury, Orthostatic Hypotension
ARC Therapy to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury
The goal of this interventional study is to evaluate the safety and preliminary effectiveness of the ARC-IM Therapy to improve hemodynamic management in people with sub-acute or chronic spinal cord injury.
- Trial name
- HemON-NL (NCT05941819)
- Testing
- ARC-IM Thoracic System implantation
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- ONWARD Medical, Inc.
Parkinson Disease (PD), REM Sleep Behavior Disorder (iRBD)
Artificial Intelligence-based Parkinson's Disease Risk Assessment (AI-PRA) Study
The study aims to provide initial proof-of-concept validation data of an artificial intelligence-based model to estimate individual Parkinson's disease risk using demographic, clinical, genetic information and digital biomarker…
- Conditions
- Parkinson Disease (PD), REM Sleep Behavior Disorder (iRBD), Neurogenic Orthostatic Hypotension, Hyposmia
- Trial name
- AI-PRA (NCT07706829)
- Testing
- Smartwatch and phone app
- Where
- 3 sites in France, Spain and 1 more
- Volunteers
- 60 people
- Sponsor
- Queen Mary University of London
Post-Exercise Hypotension, Ambulatory Blood Pressure Monitoring
Exercise Timing on the Morning Blood Pressure Surge
The goal of this clinical trial was to assess the effects of morning vs. evening high-intensity interval exercise on the magnitude of the morning blood pressure surge in young healthy adults.
- Conditions
- Post-Exercise Hypotension, Ambulatory Blood Pressure Monitoring, High-intensity Interval Exercise
- Trial name
- NCT06702930
- Testing
- Morning high-intensity interval exercise, Evening high-intensity interval exercise
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction
RaGuS Trial by Postoperative Patients
Vasoplegic syndrome is characterized clinically by reduced systemic vascular resistance and normal or increased cardiac output. It is principally observed in cardiovascular and orthopedic interventions and is characterized by a…
- Conditions
- Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction, Orthostatic Hypotension
- Trial name
- RaGuS (NCT04440085)
- Testing
- Midodrine Hydrochloride
- Volunteers
- 50 people
- Sponsor
- Bürgerspital Solothurn
Circulatory Collapse, Circulatory Failure
Suspension Syndrome
Suspension syndrome refers to a potentially life-threatening condition that can occur in unconscious persons after prolonged suspension in a harness.
- Conditions
- Circulatory Collapse, Circulatory Failure, Syncope, Vasovagal, Neurally-Mediated, Orthostatic Hypotension
- Trial name
- NCT02726776
- Testing
- Suspension in a harness, Climbing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Orthostatic Hypotension
Dawn Simulation and Postural Hypotension
One of the most physiologically demanding things that older people do every day is to get up in the morning. After spending a night laying flat, where the blood distributes evenly across the body, when they stand in the morning…
- Trial name
- NCT02632318
- Testing
- Light
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Orthostatic Hypotension
Phase II Study of Midodrine for Neurogenic Orthostatic Hypotension
OBJECTIVES: I. Study further the safety and efficacy of the alpha-receptor agonist midodrine in patients with neurogenic orthostatic hypotension. II. Assess the quality of life in these patients with this treatment regimen.
- Trial name
- NCT00004268
- Testing
- midodrine
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Center for Research Resources (NCRR)