Clinical trials: Hypotension, Orthostatic Hypotension
Parkinson Disease, Orthostatic Hypotension
Blood Pressure Effects on Cognition and Brain Blood Flow in PD
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Besides causing symptoms that impair movement, PD also causes non-motor symptoms, such as problems thinking and orthostatic hypotension…
- Conditions
- Parkinson Disease, Orthostatic Hypotension, Dysautonomia
- Trial name
- NCT05400174
- Testing
- Tilt table (upright position)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Benign Prostatic Hyperplasia
Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial)
After surgery for benign prostatic hyperplasia (BPH) that physically removes the prostatic transition zone (such as TURP or laser enucleation), many men are routinely sent home with a 2- to 4-week prescription of an alpha-blocker…
- Trial name
- CLEAR (NCT07846579)
- Testing
- Tamsulosin hydrochloride 0.2 mg
- Volunteers
- 400 people
- Sponsor
- Shanghai East Hospital
Neurogenic Orthostatic Hypotension, Non-Diabetic Autonomic Neuropathy
Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)
The purpose of this study is to assess the durability of effect of Droxidopa in treating symptoms of neurogenic orthostatic hypotension in patients with Primary Autonomic Failure (Pure Autonomic Failure, Multiple System Atrophy…
- Conditions
- Neurogenic Orthostatic Hypotension, Non-Diabetic Autonomic Neuropathy, Multiple System Atrophy, Dopamine Beta Hydroxylase Deficiency
- Trial name
- NOH303 (NCT00738062)
- Testing
- Droxidopa
- Where
- 54 sites in United States, Australia and 2 more
- Volunteers
- 103 people
- Sponsor
- Chelsea Therapeutics
Young Adults, Hypertension
Examining the Circadian Timing Effects of the Hypotensive Response to Exercise
The goal of this study is to learn how exercise timing affects blood pressure in adults with elevated or high blood pressure. Exercise can influence the body's natural 24-hour rhythms, including blood pressure patterns.
- Conditions
- Young Adults, Hypertension, Post-Exercise Hypotension, Circadian Rhythm
- Trial name
- XTIME (NCT07049783)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Freda Patterson
Hypotension, Orthostatic Hypotension
Orthostatic Hypotension Among Veterans
Orthostatic hypotension (OH) is defined as a fall in blood pressure when standing. Several different underlying diseases, conditions, or combinations of medicines may contribute to OH; therefore the cause of the condition varies…
- Trial name
- OH (NCT02123303)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Fever, Orthostatic Hypotension
Orthostatic Hypotension in Children With Acute Febrile Illness
Objective:to determent if children suffering from acute febrile illness has higher rate of orthostatic hypotension compared with children with no febrile illness. Design: a prospective cohort study.
- Trial name
- NCT00452712
- Testing
- All subjects will have their blood pressure measured in supine position (after 5 minute of rest) and after 3 minute of standing.
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Orthostatic Hypotension
Impedance Threshold Device Tilt Study
This study will see if a special piece of equipment can help burn patients who have been in bed for a long time to get out of bed without feeling dizzy or faint.
- Trial name
- NCT00137319
- Testing
- Impedance threshold device
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- United States Army Institute of Surgical Research
Orthostatic Hypotension
Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury
The goal of this interventional crossover study is to determine the effects of transcutaneous spinal cord stimulation (TSCS) on the ability to perform moderate exercise and regulate core body temperature in the chronic spinal…
- Trial name
- NCT05960448
- Testing
- Transcutaneous Spinal Cord Stimulation (TSCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury
The purpose of this study is to stimulate the circuits in the spinal cord that are directly responsible for hemodynamic control to restore hemodynamic stability in participants with chronic cervical or high-thoracic spinal cord…
- Trial name
- HEMO (NCT05044923)
- Testing
- Targeted Epidural Spinal Stimulation
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Aaron Phillips
Parkinson's Disease
The Effects of Supplementing Tyrosine on Blood Pressure in Parkinson's Disease
The objective of this experiment is: Primary: To determine the effects of tyrosine supplementation on orthostatic hypotension in people with PD.
- Trial name
- NCT01676103
- Testing
- Tyrosine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- New York Institute of Technology
Orthostatic Hypotension
State of Knowledge Among Nurses Regarding the Screening for Orthostatic Hypotension in Elderly Individuals in Acute Geriatric Medicine and Medical and Rehabilitation Services
Orthostatic hypotension is a common geriatric syndrome associated with an increased risk of falls, syncope, functional decline and mortality in older adults.
- Trial name
- HTO-IDE (NCT07738666)
- Testing
- Administration of questionnaires on nurses' knowledge of orthostatic hypotension, its measurement, diagnosis and management
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hôpital NOVO
Hypertension, Autonomic Dysfunction
Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals
The goal of this observational study is to assess arterial stiffness and autonomic regulation of blood pressure and heart rate in healthy adults and people with arterial hypertension during orthostatic stress and graded physical…
- Conditions
- Hypertension, Autonomic Dysfunction, Orthostatic Hypotension
- Trial name
- NCT07482462
- Where
- Slovenia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Autonomic Nervous System Diseases, Orthostatic Hypotension
The Pathophysiology of Orthostatic Hypotension
The purpose of this study is to determine the cause of low blood pressure in selective patients who have problems with their involuntary (autonomic) nervous system.
- Conditions
- Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency, Orthostatic Intolerance
- Trial name
- NCT00748059
- Testing
- Standing or upright tilt, Microneurography, QSweat
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Autonomic Failure, Orthostatic Hypotension
Abdominal Compression in Orthostatic Hypotension
The purpose of this study is to assess if abdominal binders that use pull strings to adjust compression (non-elastic) are more effective than standard elastic abdominal binders in attenuating neurogenic orthostatic hypotension.
- Trial name
- NCT01223391
- Testing
- Abdominal binder, No abdominal binder
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency
Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304)
Symptomatic NOH in patients with primary autonomic failure is thought to be a consequence of norepinephrine depletion leading to a diminished capacity to effect an appropriate cardiovascular response to an orthostatic challenge…
- Conditions
- Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency, Non-Diabetic Neuropathy, Neurogenic Orthostatic Hypotension
- Trial name
- NOH304 (NCT01132326)
- Testing
- Droxidopa
- Volunteers
- 350 people
- Sponsor
- Chelsea Therapeutics
Hypertension, Frailty
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
Rationale: Systolic hypertension represents the leading risk for burden of disease among older adults (age >70 years), with an increasing prevalence due to the increase in lifespan.
- Conditions
- Hypertension, Frailty, Old Age; Dementia, Orthostatic Intolerance
- Trial name
- BLUEBERRY (NCT05529147)
- Testing
- Antihypertensive Agents
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Spinal Cord Injury, Orthostatic Hypotension
Prevention of Orthostatic Hypotension With Electric Stimulation in Persons With Acute SCI
Background: The presence of orthostatic hypotension (OH) as a consequence of blood volume redistribution during verticalisation in persons with spinal cord injury (SCI) is a common condition.
- Trial name
- NCT01891110
- Testing
- ES of the abdominal muscles, ES of the limb muscles, ES of limbs & abdomen
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction
RaGuS Trial by Postoperative Patients
Vasoplegic syndrome is characterized clinically by reduced systemic vascular resistance and normal or increased cardiac output. It is principally observed in cardiovascular and orthopedic interventions and is characterized by a…
- Conditions
- Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction, Orthostatic Hypotension
- Trial name
- RaGuS (NCT04440085)
- Testing
- Midodrine Hydrochloride
- Volunteers
- 50 people
- Sponsor
- Bürgerspital Solothurn
Post-Exercise Hypotension
Resistance Exercise Modify Cardiovascular Responses of Professors During Teaching and Sleep
Both work activity and reduced nocturnal dipping of blood pressure are related to increased cardiovascular risk. The aim of the present study was to assess the hemodynamic and autonomic responses of university professors during…
- Trial name
- NCT02650089
- Testing
- Resistance Exercise Low intensity, Resistance Exercise High intensity, Control
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do vale do São Francisco
Orthostatic Hypotension, Idiopathic Parkinson Disease
Lundbeck TOMs Orthostatic Hypotension
Orthostatic hypotension (OH), which consists in a significant reduction in blood pressure levels upon standing from a seated position, may affect approximately one in three patients with Parkinson's disease (PD).
- Trial name
- NCT04510922
- Testing
- Droxidopa 100 MG [Northera]
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Alberto Espay, MD, MSc