Clinical trials: Hypotension
Orthostatic Hypotension
Breathing Device for Orthostatic Hypotension (OH)
The investigators will test whether breathing through an inspiratory resistance device will improve the ability to be upright and decrease blood pressure drops on standing in patients with orthostatic hypotension.
- Trial name
- NCT00962884
- Testing
- Inspiratory Threshold Device (Res-Q-Gard ITD)
- Where
- United States
- Sponsor
- Alfredo Gamboa
Preeclampsia, Spinal Anesthesia-Induced Hypotension
Dexamethasone Versus Ondansetron for Preventing Post-Spinal Hypotension in Preeclampsia
This study compares the efficacy and safety of intravenous dexamethasone versus intravenous ondansetron in preventing low blood pressure (hypotension) following spinal anesthesia in pregnant women with preeclampsia undergoing…
- Conditions
- Preeclampsia, Spinal Anesthesia-Induced Hypotension, Cesarean Section
- Trial name
- NCT07793760
- Testing
- Dexamethasone, Ondansetron
- Volunteers
- 110 people
- Sponsor
- Assiut University
Anesthesia
A Study of Changes in Heart Function and Blood Flow in People Receiving Anesthesia
The purpose of this study is to understand changes in heart function (how the heart pumps blood) and blood flow in people who receive general anesthesia during surgery.
- Trial name
- NCT05954832
- Testing
- Echocardiography
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Neurogenic Orthostatic Hypotension
Efficacy and Tolerance of Flucortac in Patients With Orthostatic Neurogenic Hypotension
To evaluate the efficacy of a 4-week fludrocortisone (FLU) treatment on systolic blood pressure depression after 5 minutes of active orthostatism in patients with neurogenic orthostatic hypotension (HON) symptomatic, despite…
- Trial name
- NCT04128137
- Testing
- Fludrocortisone
- Where
- France
- Volunteers
- 90 people
- Sponsor
- H.A.C. PHARMA
Remimazolam, Spinal Anesthesia
The Effect of Remimazolam and Dexmedetomidine on the Incidence of Hypotension During Spinal Anesthesia
The goal of this clinical trial is to compare the effect of remimazolam and dexmedetomidine on the incidence of hypotension during spinal anesthesia in adult patients.
- Trial name
- NCT05935657
- Testing
- Remimazolam, Dexmedetomidine
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Head and Neck Surgery, Maxillofacial Surgery
Impact of Nociception Level (NOL)-Guided Remifentanil Infusion on Intraoperative Arterial Pressure and Vasopressor Necessity
The aim of this study is to determine if Nociception Level (NOL)-guided Remifentanil analgesia, combined with Entropy-guided Propofol anesthesia, has a significant beneficial effect on the incidence of intraoperative hypotension…
- Trial name
- NCT04963036
- Testing
- Entropy and NOL-Guided Goal Directed Anesthesia, Standard of Care Group (Entropy and blinded NOL)
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Severe Sepsis, Persistent Hypotension
Epidemiology of Septic Shock in Medical or Polyvalent ICU in the North-East Region of France
The epidemiology of this study aims and outcome of patients with septic shock in the intensive care unit (or versatile) of the North-East region in france as well as the modalities of care.
- Trial name
- NCT01903746
- Volunteers
- 1,495 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Hypotension
Manual vs Closed-loop Control of Mean Arterial Pressure
Intraoperative hypotension can impact patient outcome. Vasopressors are usually used to correct hypotension and ensure adequate organ perfusion.
- Trial name
- NCT04089644
- Testing
- closed-loop system, Manual adjustment
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Erasme University Hospital
Hypotension
Early Prediction of ICU Hypotension Using Machine Learning
This prospective observational study aims to develop and internally validate a machine learning model for the early prediction of hypotension in adult intensive care unit patients.
- Trial name
- ICU-HypoAI (NCT07627607)
- Testing
- Routine ICU Data Collection
- Where
- Turkey (Türkiye)
- Volunteers
- 107 people
- Sponsor
- Kutahya Health Sciences University
Acute Cerebrovascular Accident
Effect of Individualized Versus Standard Bp Management During MT for Anterior Ischemic Stroke
DETERMINE is a multicenter, prospective, randomised, open, blinded end-point assessed (PROBE) trial, to evaluate two approaches of blood pressure (BP) management during mechanical thrombectomy for acute ischemic stroke due to an…
- Trial name
- DETERMINE (NCT04352296)
- Testing
- Individualized blood pressure, Standard blood pressure
- Where
- France
- Volunteers
- 433 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Shock, Surgical, Shock
Angiotensin II in the Perioperative Management of Hypotension in Kidney Transplant Recipients
The current standard of catecholamine vasopressor management of perioperative hypotension in kidney transplant patients carries significant risks and falls short in many ways.
- Conditions
- Shock, Surgical, Shock, Hypotension and Shock, Kidney Transplant; Complications
- Trial name
- NCT04529005
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois at Chicago
Autonomic Failure, Pure Autonomic Failure
CPAP for the Treatment of Supine Hypertension
This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their…
- Conditions
- Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy, Parkinson Disease
- Trial name
- NCT05489575
- Testing
- Active CPAP, Sleeping in a head-up tilt (HUT) position
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Vanderbilt University Medical Center
Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension
Intraoperative Hypotension and Acute Kidney Injury After Off-pump Coronary Artery Bypass Grafting Surgery
Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. Hypotension is an important risk factor for the development of AKI after noncardiac surgery.
- Conditions
- Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension, Acute Kidney Injury
- Trial name
- NCT03889730
- Where
- China
- Volunteers
- 821 people
- Sponsor
- Peking University First Hospital
Vomiting, Nausea
Exteriorized Versus In Situ Uterine Repair at Cesarean Delivery
This study was undertaken to compare the two techniques (exteriorized vs in situ) of uterine repair with respect to patient comfort, hemodynamic changes, surgical time and blood loss, in patients undergoing elective CD under a…
- Conditions
- Vomiting, Nausea, Pain, Hypotension
- Trial name
- NCT00452972
- Testing
- Spinal Anesthesia
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Cesarean Section Complications, Spinal Anesthesia
Three Protocols for Phenylephrine Administration in Cesarean Delivery
The investigators will compare variable infusion of phenylephrine (at a starting rate of 0.75 mcg/Kg/min) with fixed rate (0.75 mcg/Kg/min which will stop of reactive hypertension occurred) and single shot (1.5 mcg/Kg)…
- Trial name
- NCT03302039
- Testing
- Single shot phenylephrine, Fixed infusion phenylephrine., Variable infusion phenylephrine.
- Where
- Egypt
- Volunteers
- 217 people
- Sponsor
- Cairo University
Spontaneous Intracranial Hypotension
Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension
Spontaneous intracranial hypotension (SIH) is a condition characterized by refractory orthostatic headache, mostly due to leaks of cerebrospinal fluid (CSF).
- Trial name
- NCT07602556
- Testing
- PRP Patch group, Whole Blood Patch Group
- Volunteers
- 218 people
- Sponsor
- Beijing Tiantan Hospital
Post-spinal Hypotension
Ultrasonographic Assessment of Neck Vessels as Predictors of Spinal Anesthesia Induced Hypotension in Elderly
Spinal anesthesia induces sympathetic blockade and venodilation, thus reducing venous return and the cardiac output. Therefore, assessment of intravascular volume deficit before anesthesia might predict a critical decrease in…
- Trial name
- NCT05078606
- Testing
- IJV Ultrasonography, Carotid Intima Media Thickness, Spinal anesthesia
- Where
- Egypt
- Volunteers
- 71 people
- Sponsor
- Cairo University
Propofol Induced Hypotension
Comparison of Leg Elevation and Leg Wrapping in the Prevention of Propofol Induced Hypotension
Propofol is an intravenous anaesthetic agent used for both induction and maintenance of anaesthesia. An important adverse effect is the significant fall in blood pressure.
- Trial name
- NCT02845921
- Testing
- leg elevation, leg wrapping, control
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Nitte University
Orthostatic Hypotension
Evaluation of the Effect of Hydration About Orthostatic Hypotension in the Elderly. Difference With Venous Compression
Primary objective: To compare the decrease in systolic blood pressure between hydration and venous contention when switching to a standing position. Hypothesis in that hydration is better than venous contention.
- Trial name
- CHHO (NCT02179216)
- Testing
- Hydration, Venous contention
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Central Hospital, Nancy, France
Adverse Effect
Intensive Versus Standard Treatment for Hypotension on Maternal Hemodynamics in Preeclamptic Patients
The objective of this study is to investigate the impact of varying maternal blood pressure maintenance targets on maternal hemodynamics in preeclamptic patients following cesarean section.
- Trial name
- NCT06151444
- Testing
- Alpha-Agonist, α-adrenergic receptor agonist
- Volunteers
- 160 people
- Sponsor
- General Hospital of Ningxia Medical University