Clinical trials: Hypoventilation Syndrome
Hypoventilation Syndrome, Chronic Obstructive Pulmonary Disease
The Debated Role of Sleep Studies in Patients Under Established Home Mechanical Ventilation
Patients suffering chronic hypercapnic respiratory insufficiency (e.g. in chronic obstructive pulmonary disease, obesity hypoventilation syndrome) benefit from home mechanical ventilation.
- Conditions
- Hypoventilation Syndrome, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome, Restrictive Lung Disease
- Trial name
- NCT03506906
- Testing
- Sleep studies under noninvasive ventilation therapy, Routine tests
- Where
- Germany
- Volunteers
- 105 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Obesity, Obesity Hypoventilation Syndrome
Factors Associated With Chronic Respiratory Failure in Obesity
Some overweight individuals develop problems with their breathing such that they gradually breathe less and less. This leads to a lack of oxygen and a buildup of carbon dioxide in the blood, called ventilatory failure.
- Trial name
- NCT01380418
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- Oxford University Hospitals NHS Trust
Myotonic Dystrophy, Steinert
Factors Associated With Hypoventilation in the Myotonic Dystrophy, Progressive Profile Over 5 Years
The aim of this study is to determine the factors associated with alveolar hypoventilation in terms of cognitive impairment, daytime sleepiness, respiratory function, nocturnal respiratory events This evaluation will clarify the…
- Trial name
- Steinert (NCT03764150)
- Where
- 6 sites in France
- Volunteers
- 113 people
- Sponsor
- University Hospital, Lille
Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome
Patient -Ventilator Interaction in Chronic Respiratory Failure
To evaluate a novel advanced physiological monitoring system to improve nocturnal non-invasive ventilation (NIV) in Neuromuscular disease (NMD), Chest wall disease (CWD), Chronic Obstructive Pulmonary Disease (COPD) and Obesity…
- Conditions
- Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome, Neuromuscular Disease, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01371149
- Testing
- Surface parasternal electromyography (EMG) set up
- Where
- 2 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- Michelle Ramsay
Acute Respiratory Distress Syndrome, Shock
Non-Invasive Ventilation Via a Helmet Device for Patients Respiratory Failure
The objective of our study is to evaluate the efficacy of helmet ventilation as compared with Face mask in patients with respiratory failure.
- Conditions
- Acute Respiratory Distress Syndrome, Shock, Ventilatory Failure, Cardiogenic Pulmonary Edema
- Trial name
- NCT01680783
- Testing
- Non invasive ventilation using a helmet hyperbaric device, Noninvasive ventilation via facemask
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Chicago
Neuromuscular Diseases, Obesity Hypoventilation Syndrome
Effectiveness Monitoring of Home Non-invasive Mechanical Ventilation by Digital Diagnosis Platform
The main objective will be to determine the effectiveness of home non-invasive ventilation by flow-time and time-pressure curves analysis in a cohort of patients with this treatment by digital diagnosis platform.
- Conditions
- Neuromuscular Diseases, Obesity Hypoventilation Syndrome, Lung Disease, Restrictive
- Trial name
- PRE-HVNI (NCT03085537)
- Where
- 3 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Corporacion Parc Tauli
Obesity Hypoventilation Syndrome (OHS)
Functional Capacity, Sleep Quality, and Cognitive Function in Obesity Hypoventilation Syndrome
Introduction: Obesity Hypoventilation Syndrome (OHS) is defined as the coexistence of obesity (BMI ≥ 30 kg/m²), daytime hypercapnia (PaCO₂ > 45 mmHg) in the absence of other causes of hypoventilation, and sleep-disordered…
- Trial name
- NCT07147153
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Bezmialem Vakif University
ROHHAD Syndrome
Treatment of Rapid Onset Obesity, Hypoventilation, Hypothalamic Dysfunction, and Autonomic Dysregulation (ROHHAD )
ROHHAD (rapid onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation) syndrome is a rare pediatric disorder associated with a cancer called neuroblastoma and presumed to be driven by an attack of…
- Trial name
- NCT02441491
- Testing
- Cyclophosphamide
- Where
- United States
- Sponsor
- Johns Hopkins University
Obesity Hypoventilation Syndrome (OHS)
Respiratory Muscle Endurance in Obesity Hypoventilation Syndrome
Obesity hypoventilation syndrome (OHS) is defined as a combination of obesity [body mass index (BMI) ≥30 kg/m2], chronic daytime hypercapnia (PaCO2 >45 mm Hg), and sleep-apnea in the absence of other known causes of hypercapnia.
- Trial name
- NCT04835558
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Overlap Syndrome, Nocturnal Hypoventilation
Continuous Positive Pressure Versus Bi-level in Overlap Syndrome
Continuous positive airway pressure (CPAP) became the established treatment for overlap syndrome (OS). It has been showed that the survival benefits of CPAP favored hypercapnic patients.
- Trial name
- NCT03766542
- Testing
- Bi-level positive airway pressure with ventilatory support, continuous positive airway pressure without ventilatory support
- Volunteers
- 70 people
- Sponsor
- Hospital Sao Joao
Covid19, Acute Respiratory Distress Syndrome
Clinical Features of COVID-19 Patients
The data were retrospectively collected during the first and the second wave of epidemic in COVID-19 patients with Severe Acute Respiratory Syndrome Coronavirus 2, at the moment of intensive care unit admission and during the in…
- Conditions
- Covid19, Acute Respiratory Distress Syndrome, Ventilatory Failure
- Trial name
- NCT04815304
- Testing
- peripheral lymphocytes subsets
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United Kingdom
Chronic hypercapnic respiratory failure (CHRF) in the context of Chronic Obstructive Pulmonary Disease (COPD) and Obesity Hypoventilation Syndrome (OHS) is associated with increased mortality.
- Conditions
- Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome (OHS), Nasal High Flow
- Trial name
- NCT05167201
- Testing
- Nasal High Flow
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Respiratory Failure, Neuromuscular Disease
Ventilator Monitoring in Early Exacerbation Detection
The aim of this study is to determine whether respiratory disease exacerbations (a sudden worsening of symptoms) can be predicted by variables that are monitored by non-invasive ventilators (small machines that assist breathing)…
- Conditions
- Respiratory Failure, Neuromuscular Disease, Chest Wall Disorder, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01644162
- Testing
- iVAPS ventilation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- ResMed
Obesity Hypoventilation Syndrome
PAP Therapy in Patients With Obesity Hypoventilation Syndrome
The role of different levels of compliance and long-term effects of positive airway pressure (PAP) therapy on gas exchange, sleepiness, quality of life, depression and death rate in patients with obesity hypoventilation syndrome…
- Trial name
- NCT03449641
- Testing
- Positive airway pressure (PAP)
- Volunteers
- 252 people
- Sponsor
- University of Crete
Obstructive Sleep Apnoea (OSA), Hypoventilation Syndrome
Sleep-disordered Breathing Database
The goal of this study is to collect clinical data on patients who have had a sleep study and are given a diagnosis of a sleep related breathing disorder such as obstructive sleep apnoea.
- Trial name
- NCT07402603
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Euthyroid Sick Syndrome, Obesity Hypoventilation Syndrome (OHS)
Euthyroid Sick Syndrome in Obesity Hypoventilation Syndrome
The goal of this observational study is to learn about the frequency and clinical impact of Euthyroid Sick Syndrome (ESS) in patients with Obesity Hypoventilation Syndrome (OHS) who are admitted to the intensive care unit (ICU)…
- Trial name
- NCT06983418
- Where
- Egypt
- Volunteers
- 49 people
- Sponsor
- Mansoura University
Obesity Hypoventilation Syndrome, Obesity
The Effect of Obesity Hypoventilation Syndrome on Exercise Capacity, Peripheral Muscle Strength, and Quality of Life in Obese Individuals
Obesity Hypoventilation Syndrome(OHS) is a disease characterized by daytime hypercapnia and sleep-disordered breathing without other causes of hypoventilation in individuals with a body mass index above 30 kg/m2.
- Conditions
- Obesity Hypoventilation Syndrome, Obesity, Hypoventilation, Respiration Disorders
- Trial name
- NCT06142513
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istanbul University
Obesity-hypoventilation Syndrome, Resting Energy Expenditure
Resting Energy Expenditure in Patients With OHS Treated With Long-term NIV
This study aims to compare, in subjects with obesity-hypoventilation syndrome (OHS) treated by long-term non-invasive ventilation (NIV), resting energy expenditure (REE) in spontaneous breathing and under NIV.
- Conditions
- Obesity-hypoventilation Syndrome, Resting Energy Expenditure, Long-term Non-invasive Ventilation
- Trial name
- NCT04474587
- Testing
- Indirect calorimetry
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Pulmonary Disease, Chronic Obstructive, Amyotrophic Lateral Sclerosis
European Home Mechanical Ventilation Registry
The European Home Mechanical Ventilation Registry (EHMVR) will enable a thorough evaluation of HMV by documenting the characteristics of HMV patients and their treatment.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Amyotrophic Lateral Sclerosis, Spinal Cord Injury, Muscular Dystrophies
- Trial name
- EHMVR (NCT02315339)
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- ResMed
Obesity Hypoventilation Syndrome, Ketogenic Dieting
Ketogenic Diet for Obesity Hypoventilation Syndrome
Obesity hypoventilation syndrome (OHS) is a condition that occurs in small percentage of obese people that causes high carbon dioxide and low oxygen levels in the blood.
- Conditions
- Obesity Hypoventilation Syndrome, Ketogenic Dieting, Hypercapnic Respiratory Failure
- Trial name
- KETOHS (NCT04108819)
- Testing
- Ketogenic Diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University