Clinical trials: Hypovitaminosis D
Hypophosphatasia
Safety and Efficacy Study of ENB-0040 in Juvenile Patients With Hypophosphatasia (HPP)
This Clinical Trial is being conducted to study Hypophosphatasia (HPP), a bone disorder caused by gene mutations or changes. These gene mutations cause low levels of an enzyme needed to harden bone.
- Trial name
- NCT00894075
- Testing
- ENB-0040
- Sponsor
- Alexion Pharmaceuticals, Inc.
Diabetes Mellitus, Vitamin D Deficiency
Does Vitamin D Improve Glycemic Control in Type II DM?
Vitamin D status has been negatively associated with the presence of type II DM and glycemic control. However, a cause-effect relationship between vitamin D deficiency and glycemic control has not been established.
- Trial name
- NCT01170442
- Testing
- vitamin D3 2000 IU, vitamin D3 5000 IU
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Infertility
Vitamin D Deficiency and Ovarian Reserve Among Infertile Patients
The role of vitamin D deficiency in female reproduction remains controversial. Early retrospective studies were inconsistent regarding the effect of serum 25-OH vitamin D levels on pregnancy rates in women undergoing in vitro…
- Trial name
- NCT01999608
- Where
- Belgium
- Volunteers
- 283 people
- Sponsor
- Universitair Ziekenhuis Brussel
PCOS, Depression
Metformin, Vitamin D, and Depression in Polycystic Ovary Syndrome (PCOS) Trial
Open-label randomized clinical trial assessing the efficacy of Metformin versus Vitamin D in improving symptoms of depressed mood in polycystic ovary syndrome.
- Conditions
- PCOS, Depression, Vitamin D Deficiency, Insulin Resistance
- Trial name
- MINDD (NCT03380091)
- Testing
- Metformin, Vitamin D
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stroke, Oral Disease
Oral Health and Vitamin D in Stroke Patients
Stroke is a common, serious and restrictive global health problem. Restricting the activities of daily living of stroke patients impairs patients' ability to pay attention to oral hygiene.
- Conditions
- Stroke, Oral Disease, D Vitamin Deficiency
- Trial name
- NCT05418335
- Testing
- Clinical examination, functional status evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Vitamin D Deficiency
Prognostic Value of Vitamin D Levels in Egyptian Females With Breast Cancer
In our study; we aim to analyze the correlation between pre-treatment serum vitamin D (VD) levels and breast cancer prognostic features in newly diagnosed breast cancer patients presenting to our department.
- Trial name
- NCT03594214
- Testing
- serum vitamin d level measured by ELISA kit
- Where
- Egypt
- Volunteers
- 222 people
- Sponsor
- Assiut University
Vitamin D Deficiency, Vitamin; Excess Vitamin D (Nutritional)
Vitamin D Supplements on Markers for Cardiovascular Disease and Diabetes: an Individual Participant Data Meta-analysis
This meta-analysis will be conducted to study the effect on vitamin D supplements on markers for cardiovascular disease and diabetes using individual participant data from 12 RCTs.
- Trial name
- NCT02551835
- Volunteers
- 2,945 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Vitamin D Deficiency, Neuromuscular Block
D Vitamin Effects on Neuromuscular Blocker Reverse Time
Background/aim: Investigators aimed to investigate the effect of D vitamin levels on Sugammadex and Neostigmine reverse durations in the study.
- Conditions
- Vitamin D Deficiency, Neuromuscular Block, Neuromuscular Block Problem
- Trial name
- NCT03734250
- Volunteers
- 84 people
- Sponsor
- Duzce University
Renal Osteodystrophy
Zoledronic Acid to Prevent Bone Loss After Kidney Transplantation
The purpose of this study is to determine whether zolendronic acid, a third generation bisphosphonate, is effective in preventing bone loss in the first year after kidney transplantation.
- Trial name
- NCT01675089
- Testing
- Zoledronic acid
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo General Hospital
Vitamin D Deficiency
Effect of Vitamin D Oral Supplements on 25 OH Vitamin D Levels
Vitamin D deficiency is common world wide. 25 OH vitamin D level is the best indicator of vitamin D status. Vitamin D supplements are available as vitamin D2 or D3, in small daily or large weekly/monthly doses.
- Trial name
- NCT01170494
- Testing
- ergocalciferol 2000 IU orally, daily, ergocalciferol 25000 IU oraly every 2 weeks, ergocalciferol 50000 IU orally every 4 weeks
- Where
- Saudi Arabia
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- King Faisal Specialist Hospital & Research Center
Osteoporosis, Vitamin D Deficiency
A Study to Evaluate the Safety, Tolerability, and Efficacy of an Investigational Drug and Dietary Supplement in Men and Postmenopausal Women With Osteoporosis (0217A-227)
The purpose of this study is to test the safety, tolerability and effectiveness of an investigational drug and dietary supplement to reduce the risk of vitamin D insufficiency and deficiency during the treatment of osteoporosis…
- Trial name
- NCT00092066
- Testing
- MK0217A, alendronate sodium (+) cholecalciferol / Duration of Treatment: 15 weeks
- Volunteers
- 717 people
- Sponsor
- Organon and Co
Vitamin D Deficiency
Does Supplementing Vitamin D Deficiency Affect Fusion Healing Rates in Elective Foot and Ankle Surgery?
To assess if vitamin D status in the elective foot and ankle fusion population affects fusion healing categorically (fused vs. un-fused).
- Trial name
- NCT04450199
- Testing
- Vitamin D2
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Vitamin D Deficiency, Diabetes Mellitus
Vitamin D Supplementation on Metabolic Syndrome Indicators Among Older Adults, Alborz Province, Iran
General objective: To assess the effect of vitamin D supplementation on metabolic syndrome among food insecure and vitamin D deficient older adults in Karaj city, Alborz province in Iran.
- Conditions
- Vitamin D Deficiency, Diabetes Mellitus, Hypertension, Lipid Metabolism Disorders
- Trial name
- NCT03193944
- Testing
- D-vitin, soft gelatin capsule (vitamin D3,50000 IU)
- Where
- Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Alborz Medical University
Kidney Diseases, Dialysis; Complications
PRevEnting FracturEs in REnal Disease - 1
PREFERRED-1 is a pilot study designed to determine the feasibility of a large randomized, pragmatic, open-label, comparative-effectiveness trial of denosumab for the prevention of fragility fractures in people receiving…
- Conditions
- Kidney Diseases, Dialysis; Complications, Fragility Fracture, Chronic Kidney Disease-Mineral and Bone Disorder
- Trial name
- PREFERRED-1 (NCT05096195)
- Testing
- Denosumab 60 mg/ml, Calcium and vitamin D prophylaxis, Monitoring of post-injection calcium and phosphate
- Where
- 6 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
Peri Implant Mucositis, Peri Implant Bone Loss
Local and Systemic Inflammatory Bone Alterations Related to Dental Implant Survival.
Introduction: Dental implants offer a durable, aesthetic, and functional option for tooth replacement. However, they are not immune to failure.
- Conditions
- Peri Implant Mucositis, Peri Implant Bone Loss, Peri Implantitis, Calcium Deficiency
- Trial name
- NCT07766707
- Where
- Spain
- Volunteers
- 192 people
- Sponsor
- University of Barcelona
Chronic Kidney Disease, End Stage Renal Disease
Klotho Gene Polymorphism in Dialyzed Patients With Hyperphosphatemia
Patients with chronic kidney disease (CKD) and those with end-stage renal disease (ESRD) undergoing renal replacement therapies show elevated serum phosphate levels which predispose them to cardiovascular calcifications and high…
- Conditions
- Chronic Kidney Disease, End Stage Renal Disease, Hyperphosphatemia, Renal Osteodystrophy
- Trial name
- NCT00374712
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammatory Bowel Diseases
Association Between Vitamin D Deficiency and Inflammatory Bowel Disease
Crohn's disease (CD) and ulcerative colitis (UC) are two major types of inflammatory bowel disease (IBD) that are identified by different clinical, endoscopic, pathological, and radiologic diagnostic methods.
- Trial name
- NCT07259603
- Testing
- Serum 25(OH)D (Vitamin D3), C- reactive protein, Erthrocyte sedimentation rate
- Volunteers
- 100 people
- Sponsor
- Assiut University
Diabetes (DM), Vitamin D Deficiency
Comparison of Different Doses of Vitamin D Supplementation on Glycated Haemoglobin and Blood Glucose Parameters With Type II Diabetes Mellitus Having Vitamin d Deficiency
COMPARISON OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON GLYCATED HEMOGLOBIN (HbA1c) and BLOOD GLUCOSE PARAMETRS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS HAVING VITAMIN D DEFICIENCY"
- Trial name
- NCT07321223
- Testing
- Vitamin D
- Where
- Pakistan
- Volunteers
- 108 people
- Sponsor
- University of Lahore
Vitamin D Deficiency
A Prospective, Multi-center Study to Evaluate the Efficacy and Safety of Vitamin D3 B.O.N. Intramuscular Injection in Adults With Vitamin D Deficiency
To compare the efficacy of Vitamin D3 B.O.N. Intramuscular Injection within 12 weeks with that of placebo in adults with Vitamin D Deficiency.
- Trial name
- NCT02443246
- Testing
- Vitamin D3 B.O.N. Injection (cholecalciferol 200,000IU)
- Volunteers
- 84 people
- Sponsor
- Kwang Dong Pharmaceutical co., ltd.
Tooth Loss, Vitamin D3 Deficiency
Dental Implants Rehabilitation in Patients With Vitamin D3 Imbalance
Interventional retrospective prospective randomized clinical trial (RCT) in parallel groups. The sample size is 384 patients with loss of teeth and vitamin D imbalance.
- Conditions
- Tooth Loss, Vitamin D3 Deficiency, Osteomalacia
- Trial name
- NCT04841213
- Testing
- Dental implantation
- Where
- 2 sites in Russia
- Volunteers
- 384 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
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