Clinical trials: Hypoxemia
Aspiration, Respiratory, Hypoxia
Reverse Trendelenburg Positioning and Its Effect on Outcomes: a Retrospective Study of Consecutive Patients
The purpose of this study is to investigate whether intraoperative reverse Trendelenburg positioning decreases postoperative hypoxemia and perioperative pulmonary aspiration rates.
- Conditions
- Aspiration, Respiratory, Hypoxia, Perioperative Period, Supine Position
- Trial name
- NCT02984657
- Testing
- Surgical patients in 2012 with anesthesia and nursing staff less attuned to intraoperative RTP., Surgical patients in 2015 with enhanced anesthesia and nursing staff awareness and use of intraoperative RTP.
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- C. Michael Dunham
Pulmonary Rehabilitation
Improving Outcomes of Respiratory Patients With Exertional Hypoxemia
The primary aim of this pilot randomized controlled trial is to determine feasibility of the proposed pulmonary rehabilitation intervention.
- Trial name
- NCT05752370
- Testing
- High flow oxygen, Usual care
- Where
- Singapore
- Volunteers
- 56 people
- Sponsor
- Changi General Hospital
Lung Diseases
Comparison of Two Strategies of One-lung Ventilation in Patients Undergoing Carcinological Lung Resection Surgery.
During thoracic surgery, one-lung ventilation (OLV) is associated with hypoxemia, lung injury, and perioperative respiratory complications.
- Trial name
- I-PEEP-THO (NCT05525312)
- Testing
- "Open-lung" protective ventilation strategy, "Standard" protective ventilation strategy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Montpellier
Hypoxic Pulmonary Vasoconstriction, Hypoxemia
Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction in ARDS Secondary to SARS-CoV2
Summary Currently, the COVID-19 pandemic has overtaken health systems worldwide, exceeding the capacity of intensive care units.
- Conditions
- Hypoxic Pulmonary Vasoconstriction, Hypoxemia, Acute Respiratory Distress Syndrome, SARS-CoV-2 Acute Respiratory Disease
- Trial name
- COVID-19 (NCT04998253)
- Testing
- Effects in oxygenation and hypoxic pulmonary vasoconstriction
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unidad Temporal COVID-19 en Centro Citibanamex
Respiratory Failure, Hypoxemia
OxyGap : Comparison Between Different Pulse Oximeter and With the Arterial Blood Gase
The oximeter is used to monitor intensive care patients undergoing oxygen therapy. It indicates pulsed oxygen saturation (SpO2), a reflection of arterial oxygen saturation (SaO2) which enables detection of hypoxemia and…
- Conditions
- Respiratory Failure, Hypoxemia, Hyperoxemia
- Trial name
- OxyGap (NCT04772183)
- Testing
- SpO2 and SaO2 comparison
- Where
- 2 sites in Canada
- Volunteers
- 300 people
- Sponsor
- Laval University
COVID-19, Hypoxemia
Clinical Impact of Automated Oxygen Administration on Confirmed or Suspected COVID-19 in the Emergency Department.
The aim of this study is to evaluate the impact of the FreeO2 system on the quality of the oxygen therapy in confirmed or suspected SARS-CoV-2 patients in the emergency department.
- Conditions
- COVID-19, Hypoxemia, Hyperoxia, Hypoxia
- Trial name
- NCT05235386
- Testing
- Automated oxygen titration
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Laval University
Hypoxemia
Effect of Different Bed Head Angles on Intraoperative Hypoxemia in Patients Undergoing Painless Gastroenteroscopy: A Prospective Randomized Controlled Study
Abstract: Objective: This study aimed to investigate the effect of different bed angles (0° vs. 15°) on the incidence of intraoperative hypoxemia in patients undergoing gastroscopy and colonoscopy.
- Trial name
- NCT07594951
- Testing
- Elevating the head of the bed to 15 degrees
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xiangya Hospital of Central South University
Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome)
EFFICACY and SAFETY OF BEVACIZUMAB (ZIRABEV®) IN PATIENTS WITH SEVERE HYPOXEMIC COVID-19
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the most frequent complications of the COVID-19 pandemic.
- Conditions
- Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome), Virus Diseases, Coronaviridae Infections
- Trial name
- BEVA (NCT04822818)
- Testing
- BEVA+SOC, SOC
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypoxemia, ARDS
Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass
More than 2 million patients worldwide receive heart surgery every year, majority of these surgical patients will undergo cardiopulmonary bypass.
- Conditions
- Hypoxemia, ARDS, Lung Injury, Acute, Cardiopulmonary Bypass
- Trial name
- NCT05647382
- Testing
- blood cell analysis, blood gas surveillance, chest radiograph and echocardiography
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhuan Zhang
Hypoxemia
Does Capnography Prevent Hypoxemia During Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound?
Subjects undergoing elective ERCP and EUS will receive standard monitoring and sedation. In addition, capnography which measures carbon dioxide levels and can graphically assess respiratory activity will be used.
- Trial name
- NCT00675415
- Testing
- Capnography
- Where
- United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Respiratory Control in Premature Infants
Prematurity-Related Ventilatory Control
The purpose of this research study is to improve our understanding of unstable breathing and heart blood flow patterns seen in premature infants.
- Trial name
- PreVent (NCT03464396)
- Testing
- Bedside Physiology study, Carotid Body Function Test, Room Air Challenge
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Washington University School of Medicine
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE
We wish to prospectively assess the burden of, management and therapeutic approaches to, and outcomes from acute hypoxaemic respiratory failure requiring ventilatory support, during the winter months in both the northern and…
- Trial name
- LUNG-SAFE (NCT02010073)
- Where
- Belgium
- Volunteers
- 14,000 people
- Sponsor
- European Society of Intensive Care Medicine
Hypoxemia
The Effects of Wearing a Face Mask During Exercise in Youth Hockey Players During COVID-19
There is concern that wearing a face mask during COVID will affect oxygen uptake, especially during intense exercise. COVID transmission is especially prevalent in sports such as hockey, where there is close contact between…
- Trial name
- NCT04874766
- Testing
- Wingate exercise test and on-ice testing while wearing a face mask
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Covid19
Hyperbaric Oxygen as an Adjuvant Treatment for Patients With Covid-19 Severe Hypoxemia
The severity of COVID-19 is related to the level of hypoxemia, respiratory failure, how long it lasts and how refractory it is at increasing concentrations of inspired oxygen.
- Trial name
- NCT04477954
- Testing
- Hyperbaric Oxygen
- Where
- 3 sites in Argentina
- Volunteers
- 40 people
- Sponsor
- Asociación Argentina de Medicina Hiperbárica e Investigación
Hypoxemia
SpO2 Accuracy in Children
Evaluation of SpO2 Accuracy in Children with Various Skin Color
- Trial name
- NCT07168798
- Testing
- Pulse oximeter
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nihon Kohden
Chronic Obstructive Pulmonary Disease, Hypoxemia
Exercise Pulseoximetry for Pre-flight Evaluation of Chronic Obstructive Pulmonary Disease (COPD) Patients
Some patients with chronic obstructive pulmonary disease (COPD) need supplementary oxygen during air travel. Guidelines issued by The British Thoracic Society (BTS) for pre-flight evaluation do not discriminate sufficiently…
- Trial name
- NCT00896584
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- LHL Helse
Hypoxemia, Hypercapnia
Optimising Ventilatory Strategies by Using Positive Respiratory Integer Measurements
Background Intermittent Positive Pressure Ventilation is used during general anesthesia but can lead to serious complications. Respiratory parameter settings can be adjusted to minimize the detrimental effects of this…
- Conditions
- Hypoxemia, Hypercapnia, Ventilator Associated Pneumonia, Complication of Anesthesia
- Trial name
- OPTIMVSPRIME (NCT06298435)
- Testing
- Intermittent Positive pressure ventilation
- Where
- Netherlands
- Volunteers
- 20,000 people
- Sponsor
- University Medical Center Groningen
Hypoxemia
'Optiflow + Duet' Interface' vs 'Standard' High Flow Nasal Cannula
High-flow nasal cannula (HFNC) therapy is increasingly used in the management of acute respiratory failure. Its clinical application has been largely investigated in chronic obstructive pulmonary disease (COPD) patients but only…
- Trial name
- OPTIMARF (NCT05838326)
- Testing
- Symmetrical high flow nasal cannula (HFNO), Asymmetrical high flow nasal cannula (DUET HFNO)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Padova
Intraoperative Hypertension, Pain Threshold
Post SARS-Cov-2 Disease Anesthesia Events
Estimating and recording the rate of occurrence of pulmonary and cardiovascular complications during the perioperative period in patients with past covid infection
- Conditions
- Intraoperative Hypertension, Pain Threshold, Postoperative Pain, Postoperative Hypoxemia
- Trial name
- NCT05252234
- Testing
- Observation of hemodynamic status and post operative pain
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Respiratory Failure, Hypoxemia
NIV-FOB, HFNC-FOB- Comparison of Methods
The aim of the study is to asses safety and indications and contraindications for performing bronchofiberocopy (FB) with respiratory support methods, i.e. non-invasive ventilation (NIV) and high flow nasal oxygen therapy (HFNO).
- Conditions
- Respiratory Failure, Hypoxemia, Hypoxemic Respiratory Failure
- Trial name
- NIRA (NCT05655026)
- Testing
- NIV, HFNO
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Medical University of Silesia