Clinical trials: Hypoxemic Respiratory Failure
Hypoxemic Acute Respiratory Failure
Closed Loop Oxygen Control in INtubated Critically Ill Patients
The deleterious effects of alveolar hyperoxia and (severe) hyperoxaemia are well described. Achieving safe and efficient oxygenation may be challenging.
- Trial name
- CLOC-IN (NCT06829732)
- Testing
- closed-loop oxygen control (CLOC), 2. manual oxygen titration (MOT)
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Parc Taulí Hospital Universitari
Acute Hypoxemic Respiratory Failure, SARS-CoV-2 Virus
Intubation Prediction in COVID-19 Patients Treated With Awake Prone Positioning
Retrospective study in Sars-Cov 2 patients hospitalised in ICU. We aim to explore the effects of Awake prone positioning on oxygenation and intubation rate.
- Trial name
- Intub_prone (NCT05060926)
- Testing
- Awake prone positioning
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University of Lausanne Hospitals
Chronic Respiratory Failure, Acute Respiratory Failure
Automated Oxygen Titration With the EMILY.AI Device in a Respiratory Intermediate Care Unit
This study evaluates EMILY.AI, an investigational (non-CE-marked) smart oxygen valve that automatically adjusts the oxygen flow delivered to a patient, second by second, according to oxygen saturation (SpO2), heart rate and…
- Conditions
- Chronic Respiratory Failure, Acute Respiratory Failure, Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
- Trial name
- NCT06952816
- Testing
- Emily.AI, Manual oxygen titration
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Aether Tech S.L.
SARS-CoV 2
Efficacy of Tocilizumab on Patients With COVID-19
This is a randomized, double blind, multi-center study to evaluate the effects of tocilizumab compared to placebo on patient outcomes in participants with confirmed SARS-CoV-2 infection and evidence of systemic inflammation.
- Trial name
- NCT04356937
- Testing
- Tocilizumab
- Where
- 3 sites in United States
- Volunteers
- 243 people
- Sponsor
- Massachusetts General Hospital
Survival, Prosthesis, Oxygen Deficiency
Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure
The objective of our study is to evaluate the effectiveness of prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure.
- Trial name
- NCT05866289
- Testing
- Prone position
- Where
- Morocco
- Volunteers
- 1,069 people, healthy volunteers welcome
- Sponsor
- Mohammed VI University Hospital
Acute Hypoxemic Respiratory Failure
Tidal Volume in Patients With "de Novo" Acute Hypoxemic Respiratory Failure
Protective ventilation can be difficult to achieve during noninvasive ventilation for "de novo"acute hypoxemic respiratory failure (i.e., not due to exacerbation of chronic lung disease or cardiac failure).Recent data suggest…
- Trial name
- DENOVT (NCT04741659)
- Testing
- Ventimask, High Flow Nasal cannula (HFNC), Helmet CPAP
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna