Clinical trials: Hypoxia, Brain
Cardiac Arrest, Inflammation
Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)
This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after…
- Conditions
- Cardiac Arrest, Inflammation, Obesity, Hypoxic Ischemic Encephalopathy (HIE)
- Trial name
- PCAS (NCT02664831)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- MaineHealth
High Altitude Hypoxia, Exercise
Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral…
- Trial name
- NCT07063732
- Testing
- Ketone Monoester (KME)
- Where
- 2 sites in United States, Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Obstructive Pulmonary Disease (COPD), Sleep Apnea Obstructive (OSA)
Brain During Effort : Effects of Hypoxia With Respiratory Patients
Brain oxygenation is determined by the product of CaO2 and the cerebral blood flow (CBF), the modification of one or the other can affect the neuronal O2 availability.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Sleep Apnea Obstructive (OSA), Healthy Volunteers
- Trial name
- NEUROX (NCT02854280)
- Testing
- Pedalling exercise on a cycle ergometer, Isolated contractions of the quadriceps
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Brain Hypoxia
Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia
The primary objective of this research is to measure changes in neurochemical concentrations during stimulation of the primary visual cortex, in both conditions of normoxia (normal oxygen availability) and induced mild hypoxia…
- Trial name
- NCT02482571
- Testing
- Mild Hypoxia
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cryotherapy Effect, Oxygen Deficiency
The Effect of Cryotherapy on Cerebral Hemodynamics Within Healthy Subjects
Upon suffering a concussion, a neurometabolic cascade including an increase in glucose and oxygen demand occurs for up to 48 hours post-insult.5 This period of increased glucose and oxygen demand is coupled with a period of…
- Trial name
- NCT03185507
- Testing
- CryoHelmet
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Hyperoxia, Hypoxia, Brain
Neuroimaging During Pure Oxygen Breathing
The investigators will conduct a non-randomized clinical trial to examine the effect of pure oxygen breathing on the brain. The study will compare cerebral blood flow, cortical electrical activity, and cognitive performance in 32…
- Conditions
- Hyperoxia, Hypoxia, Brain, Neurobehavioral Manifestations
- Trial name
- NCT03268590
- Testing
- Oxygen
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Hypoxia, Altitude, Exercise Tolerance
Direct and Cross Effects of Adaptation to Systemic Hyperthermia: Impact on Quality of Life, Neurohormonal and Psychophysiological Human Status
Life expectancy and quality of human life are important indicator of the sustainable development of the society. At the same time, the physical, functional, emotional and psychological components of the of the quality of life…
- Conditions
- Hypoxia, Altitude, Exercise Tolerance, Metabolic Disturbance, Quality of Life
- Trial name
- NCT04089410
- Testing
- Hyperthermic Fitness Treatment (HFT), Physical Examination, Assessment of Cardiorespiratory Fitness
- Where
- Russia
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy
Healthy Little Eyes
The purpose of this research study is to gather more information on how eye injury is related to a baby's future development and see if eye function and brain test results can be used, along with current measures, to better…
- Conditions
- Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy, Encephalopathy
- Trial name
- NCT05971446
- Testing
- Visual Evoked Potential (VEP), Electroretinogram (ERG)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Brain Injuries, Traumatic
Brain Oximeter Calibration and Validation Study
The purpose of the study is to calibrate and to validate the accuracy of the oximeter with an estimate of brain oxygen levels assessed by measuring arterial and internal jugular vein blood oxygen saturations.
- Trial name
- TPOT (NCT05397704)
- Testing
- brain pulse oximeter
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cyban Pty Ltd
Headache, Migraine
Migraine With Aura Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow by Hypoxia
In this study the investigators will investigate the following hypothesis that hypoxia induce migraine headache and migraine aura the aura phase is associated with a spreading reduction in cerebral blood flow the migraine…
- Conditions
- Headache, Migraine, Aura
- Trial name
- NCT01896167
- Testing
- Hypoxia
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Stroke, Problem of Aging
Modulation of Cerebral Blood Flow Using Iron Chelators
The purpose of this study is determine if the iron chelator, desferrioxamine can increase blood levels of hypoxia-inducible transcription factor 1 (HIF-1 protein) and to see if there is a corresponding increase in blood flow to…
- Trial name
- DFO (NCT01365104)
- Testing
- desferrioxamine
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sexual Behavior, Hypoxia, Brain
Uncovering the Acute Neurobiological Significance of Emerging Sexual Behaviors
The purpose of this study is to examine the acute effect of being choked during partnered sex on neurological measures. The study is designed to identify the effects being choked during partnered sex on the brain through the use…
- Trial name
- NCT06602362
- Testing
- Partnered sex involving choking, Partnered sex not involving choking
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Indiana University
Perinatal Death, Respiratory Distress Syndrome, Newborn
Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities
Hyperoxygenation for resuscitation of abnormal fetal heart rate tracings has been routine obstetric practice. However, there have not been any studies to support this practice.
- Conditions
- Perinatal Death, Respiratory Distress Syndrome, Newborn, Hypoxic-Ischemic Encephalopathy, Neonatal Seizure
- Trial name
- NCT03996317
- Testing
- Room air
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
HIE - Hypoxic - Ischemic Encephalopathy, Perinatal Anoxic-ischemic Brain Injury
Biomarkers Study in Infants With Prior Neonatal Brain Injury
This research focuses on the long-term cognitive development of children, including healthy infants and those who had a perinatal brain injury.
- Conditions
- HIE - Hypoxic - Ischemic Encephalopathy, Perinatal Anoxic-ischemic Brain Injury, Premature Birth, Healthy Participants
- Trial name
- NCT07413900
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
High Grade Gliomas, Hypoxia Brain
Brain Radiotherapy Imaging for High-grade Glioma Using Hypoxia Targeting Through Oxygen-Enhanced Response
High-grade gliomas (HGGs) are the most common type of brain cancer in adults. Life expectancy for patients with HGGs is low. Radiotherapy aims to cure the tumour, but this is hard because HGGs are resistant to treatment.
- Conditions
- High Grade Gliomas, Hypoxia Brain, Glioblastoma (GBM), Brain Neoplasms, Adult
- Trial name
- BRIGHTER (NCT07670455)
- Testing
- Oxygen-Enhanced MRI (OE-MRI)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
HIE, TBI (Traumatic Brain Injury)
Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)
This is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different…
- Conditions
- HIE, TBI (Traumatic Brain Injury), TBI, Hemodynamic Instability
- Trial name
- ICHOR 1 (NCT06195345)
- Testing
- MR Imaging
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Premature Baby, Pulmonary Hypertension of Newborn
Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography
This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle…
- Conditions
- Premature Baby, Pulmonary Hypertension of Newborn, Hypoxic Ischaemic Encephalopathy (HIE), Congenital Diaphragmatic Hernia
- Trial name
- NCT07364682
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Cerebral Hypoxia, Severe Traumatic Brain Injury
Prioritization of Cerebral Deoxygenation in Severe Traumatic Brain Injury and Mortality Benefit.
Severe traumatic brain injury with a decrease in cerebral oximetry is associated with multiple impaired systemic microcirculations, more morbidities, and a higher mortality rate.
- Trial name
- NCT06306950
- Testing
- Near infrared spectroscopy neuromonitor to prevent cerebral desaturation
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Type 2 Diabetes, Aging
IH, Brain Health, and T2D
The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without…
- Trial name
- NCT07173543
- Testing
- Intermittent Hypoxia 1 (IH1), Intermittent Hypoxia 2 (IH2)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Darren P Casey
Mental Fatigue, Near Infrared Spectroscopy
A Potential Role for Oxygen in the Development of Mental Fatigue and the Subsequent Decline in Cognitive Performance
Introduction Both Mental Fatigue (MF) and hypoxia impair multiple aspects of cognitive functioning. The decline in cognitive functioning in hypoxic conditions is associated with alterations in brain oxygenation and hemodynamic…
- Conditions
- Mental Fatigue, Near Infrared Spectroscopy, NIRS, Hypoxia
- Trial name
- NCT05100667
- Testing
- Hypoxia, Normoxia
- Where
- 2 sites in Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel