Clinical trials: Hypoxia
Sensitivity
Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults
Exposure to acute intermittent hypoxia (AIH) can facilitate of motor output but no studies of sensory effects has been reported.
- Trial name
- SensoryFLO (NCT03283072)
- Testing
- Intervention 1, Intervention 2, Intervention 3
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Perinatal Hypoxia, Dopamine
Measuring Brain Activity of School Age Children
This observational study will investigate whether differences in birth events and oxygen levels during the newborn period affects the brain activity of children during the middle childhood years.
- Conditions
- Perinatal Hypoxia, Dopamine, Neurobehavioral Manifestations
- Trial name
- NCT03407729
- Testing
- Magnetic Resonance Imaging, Cognitive Performance Testing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Aging
Dietary Nitrate and Physiological Aging
The main purpose/s of this study is to examine the effects of 4 weeks of dietary nitrate supplementation on peripheral chemoreceptor sensitivity, spontaneous baroreflex sensitivity, and blood pressure responsiveness to a variety…
- Trial name
- NCT02593305
- Testing
- Super Beets
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Darren P Casey
Oxygen Deficiency, Desaturation of Blood
THRIVE Use in Pediatric Populations- Multi Site
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia.
- Conditions
- Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
- Trial name
- NCT04322994
- Testing
- Transnasal Humidified Rapid-Insufflation Ventilatory Echange
- Where
- 5 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Volunteers
Study of GSK2586881 on Acute Hypoxia and Exercise
This study is conducted to examine how GSK2586881, a recombinant human ACE2 peptide, modulates the acute hypoxic pulmonary vasoconstriction (HPV) response in healthy volunteers.
- Trial name
- NCT03000686
- Testing
- GSK2586881
- Where
- Germany
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hypoxia
The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia
The study will aim to describe and evaluate the effect of chronic beetroot juice supplementation on acute mountain sickness symptoms and exercise in a hypoxic environment.
- Trial name
- NCT03101904
- Testing
- Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Bangor University
Hypoxia
Evaluation of the Attenuation by Aes-103 of Hypoxia Mediated Decrements in Endurance Exercise Performance
In low oxygen environments, such as high-altitude, some adults may become ill and suffer from acute mountain sickness. Further, all adults will find that exercising becomes much more difficult when compared with exercise at lower…
- Trial name
- NCT01871142
- Testing
- Aes-103
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Hypoxia
Accuracy of Pulse Oximeters With Profound Hypoxia During Motion
The aim of this study is to determine the accuracy of devices called pulse oximeters, which measure blood oxygen by shining light through fingers, ears or other skin, without requiring blood sampling.
- Trial name
- NIHO12 (NCT04814342)
- Testing
- Pulse oximeter
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Nihon Kohden
Healthy Brain Perfusion
Improving Human Cerebrovascular Function Using Acute Intermittent Hypoxia
This study uses magnetic resonance imaging to determine whether 3 weeks of repeated exposure to Acute Intermittent Hypoxia can improve brain blood flow or blood flow regulation in healthy adults.
- Trial name
- NCT05164705
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Hypoxia, Altitude
Effects of Nebivolol Versus Carvedilol on Cardiopulmonary Function at High Altitude in Healthy Subjects.
Exposure of healthy subjects to high altitude hypoxia elicits changes in cardiovascular, respiratory and metabolic features as weel as in exercise performance similar, for some aspects, to those observed in chronic heart failure.
- Conditions
- Hypoxia, Altitude, Heart Failure
- Trial name
- NCT00924833
- Testing
- Carvedilol, Nebivolol
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Hypoxemia
Does Capnography Prevent Hypoxemia During Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound?
Subjects undergoing elective ERCP and EUS will receive standard monitoring and sedation. In addition, capnography which measures carbon dioxide levels and can graphically assess respiratory activity will be used.
- Trial name
- NCT00675415
- Testing
- Capnography
- Where
- United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Major Depressive Disorder
Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females
The investigators propose to determine if 8 weeks of dietary augmentation with oral 5g creatine monohydrate daily and 100 mg of 5-hydroxytryptophan (5-HTP) twice daily reduces hypoxia-related depressive symptoms measured by the…
- Trial name
- NCT02922725
- Testing
- 5-hydroxytryptophan and Creatine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brent Michael Kious, MD, PhD
Healthy
Validation of Brain Oxygenation Monitor
A cerebral oximeter is a device that uses light to measure the amount of oxygen within the brain. It is similar to the device that measures the level of oxygen in the tip of the finger, known as a pulse oximeter.
- Trial name
- NCT00815490
- Testing
- Desaturation
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Duke University
Emphysema
Hypoxic Pulmonary Vasoconstriction Pilot Study
The purpose of this study is to determine if the events leading to smoking-associated centrilobular and paraseptal emphysema are caused by a failure of the lungs' inherent mechanisms to block hypoxic pulmonary vasoconstriction…
- Trial name
- NCT03733470
- Testing
- Sildenafil study group
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Eric A. Hoffman
Oximetry
Accuracy of ScanWatch Pulse Oximeter With Profound Hypoxia
Performance testing of pulse oximeters. The protocol involves brief stable arterial oxygen desaturation in healthy volunteers and sampling arterial blood when a stable level of hypoxia has been attained.
- Trial name
- NCT04380389
- Testing
- hypoxia
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Withings
Severe Obesity, Hypoxia
Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures
The study evaluated the effect of non-invasive positive pressure ventilation (NIPPV) to decrease the incidence of desaturation events in patients with severe obesity undergoing upper endoscopy.
- Trial name
- NCT03529461
- Testing
- Non-invasive positive pressure ventilation through nasal mask, Rescue non-invasive positive pressure ventilation through nasal mask, Secondary rescue maneuvers
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bristol Hospital
Healthy
Nonin 4 Wavelength Cerebral Oximeter Study
A cerebral oximeter is a device that uses light to measure the amount of oxygen within the brain. It is similar to the device that measures the level of oxygen in the tip of the finger, known as a pulse oximeter.
- Trial name
- Nonin4 (NCT01762722)
- Testing
- Reduction of inspired oxygen
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Duke University
Fetal Hypoxia, Fetal Distress
Trans-abdominal Fetal Pulse Oximetry
The Raydiant Oximetry Sensing System (Lumerah) is a non-invasive fetal pulse oximeter that measures fetal arterial oxygen saturation using safe, non-invasive, transabdominal near-infrared spectroscopy.
- Conditions
- Fetal Hypoxia, Fetal Distress, Fetal Acidemia, Fetal or Neonatal Effect of Complication of Labor
- Trial name
- NCT05147584
- Testing
- Dual fetal oxygen sensors
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Raydiant Oximetry, Inc.
Hypoxia, Altitude
Effect of an H1 Receptor Antagonist on Exercise Performance in Hypoxia
This study seeks to determine whether a simple, single intervention of Cetirizine / Zyrtec® use can improve exercise performance of active individuals when acutely exposed to altitude.
- Trial name
- NCT03192488
- Testing
- Cetirizine, Hypoxia
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy, Hypoxia
SpO2 Accuracy of Noninvasive Disposable Pulse Oximeter Sensor With Motion Conditions
The purpose of this clinical study is to validate the SpO2 accuracy of the Stryker Sustainability Solutions pulse oximetry sensors during motion conditions over the range of 70-100% SaO2 as compared to arterial blood samples…
- Trial name
- NCT05264116
- Testing
- STRYKER SUSTAINABILITY SOLUTIONS PULSE OXIMETERS
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Stryker Sustainability Solutions