Clinical trials: Hypoxic Brain Injury
Acute Kidney Injury, Heart Valve Diseases
Correlation of Brain and Thenar Muscle Oximetry During Cardiac Surgery With Parameters of Acute Kidney Injury
Identification of risk factors of acute kidney injury (AKI). It is hypothesized that there might be a correlation between brain oximetry, tissue saturation of thenar muscle and marker of AKI in blood - neutrophil…
- Trial name
- NCT02979275
- Testing
- Open heart surgery on cardiopulmonary bypass.
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
HIE, TBI (Traumatic Brain Injury)
Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)
This is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different…
- Conditions
- HIE, TBI (Traumatic Brain Injury), TBI, Hemodynamic Instability
- Trial name
- ICHOR 1 (NCT06195345)
- Testing
- MR Imaging
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Traumatic Coma
Brain Network Disruptions Related to Traumatic Coma
To provide a fine-grained description of the brain network dysfunctions induced by severe traumatic brain injury (TBI) or anoxic encephalopathy, that are responsible for the acute state of unarousable unawareness, named coma…
- Trial name
- Coma3D (NCT03482115)
- Testing
- PET examination with radiopharmaceutical drug [18F] DPA-714, MRI examination, Blood samples
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Trauma, Brain
The Role of Hypoxia on Subconcussive Head Impacts
The purpose of this study is to examine the combined effects of hypoxia and a short bout of subconcussive head impacts on neurocognitive and ocular-motor function and plasma expression of brain-derived blood biomarkers.
- Trial name
- NCT04624152
- Testing
- Soccer heading
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Indiana University
Hypoxic-Ischemic Encephalopathy, Hypoglycemia
Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk
The main goal of this study is to quantitatively assess the sucking and feeding activity of infants at high risk of neurological impairment (preterm infants and term infants at risk of abnormal neurodevelopment) during oral…
- Conditions
- Hypoxic-Ischemic Encephalopathy, Hypoglycemia, Neonatal Abstinence Syndrome
- Trial name
- NCT03246243
- Testing
- nfant feeding solution
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Brain Death, Anoxic Brain Injury
Rapid Reversal of CNS-Depressant Drug Effect Prior to Brain Death Determination
Current standard of care prior to determination of brain death in subjects with suspected anoxic brain injury is to exclude complicating medical conditions that may confound clinical assessment (such as severe electrolyte, acid…
- Conditions
- Brain Death, Anoxic Brain Injury, Cardiac Arrest, Sedative Intoxication
- Trial name
- NCT03743805
- Testing
- Flumazenil, Naloxone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Prisma Health-Midlands
Hypoxic Ischaemic Encephalopathy (HIE), Asphyxia
BiHiVE2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy.
Despite recent advances in the care of mothers and newborn infants, many infants (approximately 20 per 1000 live births) continue to need resuscitation at birth.
- Trial name
- BiHiVE2 (NCT02019147)
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University College Cork
Hypoxic-Ischemic Encephalopathy
A Study of a Blood Marker in Newborns With Brain Injury Caused by Lack of Oxygen at Birth
Perinatal asphyxia is a significant health problem with an incidence of 1 to 8 per 1,000 live births and can lead to serious morbidity and mortality during the neonatal period.
- Trial name
- NCT07292220
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mustafa Gürkan
Hypoxia-Ischemia, Brain
Transauricular Vagus Nerve Stimulation in Children
The goal of this clinical trial is to learn about brain waves during transauricular vagus nerve stimulation (taVNS) in healthy children.
- Trial name
- NCT06168071
- Testing
- taVNS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cerebral Hypoxia, Severe Traumatic Brain Injury
Prioritization of Cerebral Deoxygenation in Severe Traumatic Brain Injury and Mortality Benefit.
Severe traumatic brain injury with a decrease in cerebral oximetry is associated with multiple impaired systemic microcirculations, more morbidities, and a higher mortality rate.
- Trial name
- NCT06306950
- Testing
- Near infrared spectroscopy neuromonitor to prevent cerebral desaturation
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Perinatal Hypoxia
Serum Erythropoietin Level in Perinatal Asphyxia
This study is to evaluate brain and kidney injuries in full-term neonates with perinatal asphyxia by detecting specific biomarker in blood (Erythropoietin).
- Trial name
- NCT05018364
- Testing
- Serum erythropoietin level
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cerebral Palsy, Cerebral Palsy (CP)
Assessing Intellectual and Motor Outcomes in High-risk Infants
Cerebral palsy (CP) is a condition when a baby has a brain injury that affects their movement and muscle tone. Some people with CP can have other developmental issues, like learning impairments, but many do not and have isolated…
- Conditions
- Cerebral Palsy, Cerebral Palsy (CP), Cerebral Palsy Children, High-risk Infants
- Trial name
- AIM-High (NCT06857539)
- Where
- 4 sites in Ireland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University College Cork
Acquired Brain Injury, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic)
Regulating Emotions and Behaviors After Brain Injury
After acquired brain injury (ABI), persons can experience emotional and behavioral difficulties, that can be painful both for the person and his/her family.
- Conditions
- Acquired Brain Injury, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic), Brain Tumor (After Recovery), Encephalitis
- Trial name
- GREMO-LCA (NCT05393492)
- Testing
- Dialectical Behavior Therapy and Radically Open dialectical behavior therapy
- Where
- France
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
HIE - Hypoxic - Ischemic Encephalopathy, Perinatal Anoxic-ischemic Brain Injury
Biomarkers Study in Infants With Prior Neonatal Brain Injury
This research focuses on the long-term cognitive development of children, including healthy infants and those who had a perinatal brain injury.
- Conditions
- HIE - Hypoxic - Ischemic Encephalopathy, Perinatal Anoxic-ischemic Brain Injury, Premature Birth, Healthy Participants
- Trial name
- NCT07413900
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Neurological Outcome, Cardiac Arrest
Out-of-hospital Cardiac Arrest (OHCA) Biomarkers
Few early prognostic indicators are currently available for patients' families and clinicians following out of hospital cardiac arrest (OHCA), and blood biomarkers may be of prognostic value in these cases.
- Conditions
- Neurological Outcome, Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Brain Anoxia Ischemia
- Trial name
- NCT03112486
- Testing
- blood draw
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Florida
Craniocerebral Trauma, Traumatic Brain Injury
Effect of Passive Gait Training on the Cortical Activity in Patients With Severe Brain Injury.
The aim of this study is to determine effect of proprioceptive stimulation with passive gait training on the cortical activity in patients with severe brain injury, demonstrated as changes in EEG (electroencephalogram)and ERP…
- Conditions
- Craniocerebral Trauma, Traumatic Brain Injury, Subarachnoid Hemorrhage, Anoxic Brain Injury
- Trial name
- NCT00526500
- Testing
- Tilt Table With Integrated Stepping System
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Severe Traumatic Brain Injury, Subarachnoid Hemorrhage
Cortical Excitability in Patients With Severe Brain Injury
The aim of the study is to evaluate the cortical excitability in the severe brain injured patients. We hypothesize that: 1. There is a continuous decrease in intracortical inhibition from healthy subjects to awake patients with…
- Conditions
- Severe Traumatic Brain Injury, Subarachnoid Hemorrhage, Anoxic Brain Injury
- Trial name
- NCT00788723
- Testing
- Transcranial Magnetic Stimulation
- Where
- Denmark
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Brain Injuries, Traumatic
Brain Oximeter Calibration and Validation Study
The purpose of the study is to calibrate and to validate the accuracy of the oximeter with an estimate of brain oxygen levels assessed by measuring arterial and internal jugular vein blood oxygen saturations.
- Trial name
- TPOT (NCT05397704)
- Testing
- brain pulse oximeter
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cyban Pty Ltd
Perinatal Death, Respiratory Distress Syndrome, Newborn
Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities
Hyperoxygenation for resuscitation of abnormal fetal heart rate tracings has been routine obstetric practice. However, there have not been any studies to support this practice.
- Conditions
- Perinatal Death, Respiratory Distress Syndrome, Newborn, Hypoxic-Ischemic Encephalopathy, Neonatal Seizure
- Trial name
- NCT03996317
- Testing
- Room air
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University