Clinical trials: IBD
Safety Issues, Pharmacokinetic
Safety and Pharmacokinetics of Oral Controlled-ileocolonic-release Nicotinamide (CICR-NAM)
Double-blind, randomised, placebo-controlled phase I trial with single-ascending and multiple-ascending dose to evaluate safety and pharmacokinetics of oral controlled-ileocolonic-release nicotinamide (CICR-NAM) compared to…
- Trial name
- NCT05258474
- Testing
- controlled-ileocolonic-release nicotinamide (SAD/MAD/MD), Immediate-release nicotinamide (SAD)
- Where
- Germany
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Crohn Disease
PANenteric Crohn's Capsule Versus Ileo-Colonoscopy and Scan Study
Crohn's disease (CD) is a lifelong condition affecting the small and/or large bowel, causing diarrhoea, abdominal pain and weight loss.
- Trial name
- PAN-ICS (NCT04274010)
- Testing
- PillCamTM Crohn's capsule, Magnetic resonance enterography, Ileo-colonoscopy
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- South Tyneside and Sunderland NHS Foundation Trust
Diarrhea-predominant Irritable Bowel Syndrome
Study on the Effectiveness and Mechanism of Tong-Xie-Yao-Fang in Treating Diarrhea-predominant Irritable Bowel Syndrome
Traditional Chinese Medicine focuses on the main pathogenesis of liver depression and spleen deficiency, and treats them from the perspective of soothing the liver and strengthening the spleen to treat on Diarrhea-predominant…
- Trial name
- NCT06737666
- Testing
- Tong-Xie-Yao-Fang
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
ALPCO Calprotectin ELISA - Measurement of Calprotectin Levels in Human Stool
The ALPCO Calprotectin ELISA is an in vitro diagnostic test intended to quantitatively measure concentrations of fecal calprotectin in human stool samples. Calprotectin is a protein biomarker of mucosal inflammation.
- Trial name
- NCT03082287
- Testing
- Fecal Calprotectin Level
- Where
- United States
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- American Laboratory Products Company
Ulcerative Colitis, Ulcerative Colitis Exacerbation
Role of Intestinal Protozoa and Helminths in the Course of Ulcerative Colitis
Ulcerative colitis (UC) is a chronic inflammatory disorder of the gastrointestinal tract of unknown etiology. UC is characterized by recurring episodes of inflammation limited to mucosal and submucosal layers of the colon.
- Conditions
- Ulcerative Colitis, Ulcerative Colitis Exacerbation, Protozoan Infections, Helminth Infection
- Trial name
- NCT03441893
- Testing
- parasitological diagnostics (coproscopy), Nitazoxanide 500Mg Oral Tablet, Mesalazine 250Mg Tablet and nitazoxanide 500Mg Oral Tablet
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Fibromyalgia, Irritable Bowel Syndrome
Welfare Benefits in Functional Somatic Disorders
The objective of this observational study is to estimate the number of weeks of welfare benefits, i.e. sickness benefit, unemployment benefit and social assistance, for individuals with functional somatic disorders and compare…
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Chronic Fatigue Syndrome, Bodily Distress Syndrome
- Trial name
- NCT05611606
- Volunteers
- 9,656 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Crohn Disease, Pregnancy
Modulating Early Life Microbiome Through Dietary Intervention in Crohn's Disease
The MELODY Trial: Modulating Early Life Microbiome through Dietary Intervention in Crohn's Disease, will test whether a non-invasive dietary intervention during pregnancy can improve the gut microbiota composition in both…
- Trial name
- NCT03850600
- Testing
- Diet-CD
- Where
- 2 sites in United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Axial Spondyloarthritis, Crohn Disease
MRE as a Screening Tool for axSpA in IBD
This study aims to assess the effectiveness (specificity and sensitivity) of using magnetic resonance enterography (MRE) as a screening tool for axial spondyloarthritis (axSpA) in patients with Crohns disease.
- Trial name
- ProSpA-CD (NCT03817983)
- Testing
- MRE review for evidence of axSpA in SIJs, Clinical assessment and dedicated MRI of the spine and pelvis
- Where
- United Kingdom
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Colitis, Ulcerative, Sleep Quality
Clinical Characteristics of Sleep Disorders in Patients With Ulcerative Colitis
Ulcerative colitis(UC) is one of the two main forms of inflammatory bowel disease(IBD), which seriously affects the quality of life of patients.
- Conditions
- Colitis, Ulcerative, Sleep Quality, Gastrointestinal Microbiome, Autonomic Nervous System Imbalance
- Trial name
- NCT06359808
- Where
- China
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Intestinal Diseases, Irritable Bowel Syndrome
Biomarkers for Intestinal Permeability in Patients With Constipation
Our overall objective with this study is firstly to provide a comprehensive assessment of intestinal permeability, mucosal barrier function using existing biomarkers and secondly to explore novel biomarkers for measuring…
- Conditions
- Intestinal Diseases, Irritable Bowel Syndrome, Constipation
- Trial name
- NCT02246647
- Testing
- Permeability measurement, Esophagogastroduodenoscopy, Flexible sigmoidoscopy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Crohn's Disease, Ulcerative Colitis
Assessing the Drug Exposure Risk of Infants Breastfed by Women With Inflammatory Bowel Disease
Breastfeeding is beneficial to both mother and baby. However, many breastfeeding women are affected by long-term health conditions and need to take medications.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Healthy Controls
- Trial name
- NCT03397108
- Testing
- The IBD group was divided into 2 subgroups: with or without anti-TNF antibody use
- Where
- 2 sites in Canada
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
The Comparison Between the Biomarkers in Inflammatory Bowel Disease Patients and General Control Group
The aims of this study is to investigate a blood-based biomarker that can replace endoscopy in patients with inflammatory bowel disease.
- Trial name
- NCT03778918
- Testing
- inflammatory bowel disease, IBS or Normal Control
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bo-In Lee
Gluten Sensitivity
Gluten Free Diet in IBS
Patients with irritable bowel syndrome (IBS) often benefit from dietary changes. The effect of a gluten-free diet (GFD) on clinical symptom improvement and psychological well-being will be checked in patients with IBS.
- Trial name
- NCT04247737
- Testing
- gluten free diet
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Crohn's Disease, Genetic Predisposition
Abnormal Fecal Microbiota in Healthy Subjects at High Risk for Crohn's Disease
Transversal multicentric French study on the microbiota in patients with Crohn's disease and their first degree healthy relatives The primary objective is the comparison of microbiota between patients with CD, healthy controls…
- Trial name
- MAGIC (NCT02826330)
- Testing
- biomarkers
- Where
- 10 sites in France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Irritable Bowel Syndrome
Randomised Double-blind Active vs. Placebo Clinical Trial on the Effect of a Food Supplement on IBS in Children
The goal of this clinical trial is to test a food supplement in children of 3-17 years with IBS. The main questions it aims to answer are: Is the tested supplement able to improve and/or reduce IBS-related symptoms? After…
- Trial name
- NCT06123234
- Testing
- Verum
- Where
- Italy
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Irritable Bowel Syndrome
Fructose and Fructans in Irritabla Bowel Syndrome
The purpose of the study is to investigate if patients with Irritable Bowel Syndrome (IBS) who also report bloating are more likely to report clinically important gastrointestinal symptoms after consuming fructose or fructans…
- Trial name
- FABS (NCT01776853)
- Testing
- Glucose, Fructose, Fructans
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
The Effect of Zespri Green Kiwifruit on Digestive and Gut Health Functions
The proposed study will primarily demonstrate the efficacy of kiwifruit as a food intervention for the relief of constipation and associated symptoms in functionally constipated adults, and those with IBS-C.
- Trial name
- NCT02888392
- Testing
- Kiwifruit, Psyllium
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zespri International Limited
Insulin Resistance, Inflammatory Bowel Diseases
Nutraceutical Composition Containing Natural Products Derivatives on the Modulation of the Endocrine Neuroimmune Axis
The use of natural products in the prevention or treatment of chronic diseases is an emerging field in current medicine. And studying the mechanisms of actions by which natural products act in our bodies contributes to the…
- Conditions
- Insulin Resistance, Inflammatory Bowel Diseases, Overweight and Obesity, Healthy
- Trial name
- NCCNPDMENA (NCT04810572)
- Testing
- Composition with Silymarin, Low-mineral composition without Silymarin
- Where
- Brazil
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
IBD (Inflammatory Bowel Disease), Colonoscopy
Analysis of Factors Influencing the Quality of Bowel Preparation Before Colonoscopy in IBD Patients
The primary objectives of this project are twofold. On the one hand, it aims to investigate the current status of bowel preparation protocols and their quality in IBD patients undergoing colonoscopy, particularly focusing on the…
- Conditions
- IBD (Inflammatory Bowel Disease), Colonoscopy, Colonoscopy: Bowel Preparation
- Trial name
- NCT07335705
- Testing
- Standard Pre-colonoscopy Bowel Preparation Protocol
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Dietary Fiber, Gastrointestinal Microbiome
Luxembourgish Fiber Cohort
Many human populations across the world are deficient in the intake of dietary fiber. This decline in fiber consumption parallels an increase in prevalence of a multitude of diseases (e.g. colorectal cancer, multiple sclerosis).
- Conditions
- Dietary Fiber, Gastrointestinal Microbiome, Healthy Volunteers
- Trial name
- Lux-FiCo (NCT04352231)
- Testing
- High Fiber Diet Intervention, Low Fiber Diet Intervention
- Where
- 2 sites in Luxembourg
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health