Clinical trials: IBD-Inflammatory Bowel Disease
Ulcerative Colitis
An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis
The purpose of this open-label extension (OLE) study is to evaluate the safety and efficacy of etrasimod in participants with moderately to severely active ulcerative colitis (UC) who previously received double-blind treatment…
- Trial name
- ELEVATE UC OLE (NCT03950232)
- Testing
- Etrasimod
- Where
- 472 sites in United States, Argentina and 37 more
- Volunteers
- 896 people
- Sponsor
- Pfizer
Ulcerative Colitis, Unspecified
Mesalazine With Hydrocortisone Sodium Succinate Enema for 4-Week Treatment in Patients With Ulcerative Colitis
The research aims to evaluate the efficacy and safety of that mesalazine with hydrocortisone sodium succinate for the induction of clinical remission during a 4-week double-blind treatment period in active UC (define as total…
- Trial name
- NCT03110198
- Testing
- Mesalazine, hydrocortisone sodium succinate, Mesalazine with hydrocortisone sodium succinate
- Where
- China
- Volunteers
- 528 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Ulcerative Colitis
Naturopathic Approaches to Ulcerative Colitis
Ulcerative colitis (UC) is a long-term condition that causes inflammation in the large intestine. People with UC often have symptoms such as diarrhea, abdominal pain, and fatigue.
- Trial name
- NCT07521904
- Testing
- Naturopathic medicine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National University of Natural Medicine
Inflammatory Bowel Diseases, Rheumatic Disorder
Impact of Adalimumab Withdrawal or Continuation on Severity of COVID-19 and Risk of IMID Relapse
This study is a retrospective pharmacological study, of a historical cohort. Collection of Retrospective data from February 2020 to 30 September 2021 The index date is the date of COVID-19 positive PCR test.
- Trial name
- COV-ADA (NCT05706038)
- Testing
- Adalimumab
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- IRCCS San Raffaele
Ulcerative Colitis
An Observational Study to Assess Change in Disease Activity and Adverse Events of Rinvoq in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Japan
Ulcerative colitis (UC) is an idiopathic, chronic, inflammatory disease affecting the colon. Participants with UC have mucosal inflammation starting in the rectum that can extend continuously to proximal segments of the colon.
- Trial name
- NCT05791526
- Where
- 114 sites in Japan
- Volunteers
- 308 people
- Sponsor
- AbbVie
Ulcerative Colitis
Safety and Efficacy Trial of RPC1063 for Moderate to Severe Ulcerative Colitis
The purpose of this study is to determine whether RPC1063 is effective in the treatment of Ulcerative Colitis (UC).
- Trial name
- NCT02435992
- Testing
- RPC1063
- Where
- 372 sites in United States, Argentina and 28 more
- Volunteers
- 1,012 people
- Sponsor
- Celgene
Crohn Disease (CD)
Prospective Risk Evaluation and Detection of Crohn's Disease in First-degree Relatives
The PREDICT-CD study aims to validate a risk score for the development of Crohn's disease, based on serological biomarkers and lifestyle-related factors.
- Trial name
- PREDICT-CD (NCT07316621)
- Where
- 10 sites in Italy, Netherlands and 4 more
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- GLSMED Learning Health S.A.
Crohn Disease
A Comparative Study of MRI, US and CE for Assessing Treatment Response in Known Crohn's Disease
The aim of this study is to evaluate non-invasive imaging techniques for assessing treatment response in known Crohn's disease. 1.
- Trial name
- NCT03435016
- Testing
- Diagnostic work-up
- Where
- Denmark
- Volunteers
- 62 people
- Sponsor
- Sygehus Lillebaelt
Ulcerative Colitis (UC)
The Role of CALLY and HAALP in Ulcerative Colitis
The aim of this study is to demonstrate the type and amount of retention in the colon during ulcerative colitis activation, as well as the relationship between C-reactive protein (CRP), albumin and the calculated CALLY index.
- Trial name
- NCT07236333
- Testing
- CALLY, HALP
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ataturk University
Inflammatory Bowel Disease (IBD)
Impact of Obesity on Response to Therapy and Clinical Outcom in Patients With Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic relapsing inflammatory disorders of the gastrointestinal tract.
- Trial name
- NCT07343726
- Volunteers
- 120 people
- Sponsor
- Assiut University
IBD (Inflammatory Bowel Disease), Hemorrhoid
HEmorrhoidAl Disease in Inflammatory Bowel Disease: a Multicenter Prospective Cohort Study
Patients who will undergo surgery for HD after the diagnosis of IBD over a 12-month period will be enrolled across Europe. Primary objective of this study is to determine the safety and effectiveness of surgical treatments for HD…
- Conditions
- IBD (Inflammatory Bowel Disease), Hemorrhoid, Safety, Sugery
- Trial name
- HEAD-IBD-II (NCT06638814)
- Volunteers
- 50 people
- Sponsor
- Treviso Regional Hospital
Crohn's Disease
MRE Predictors of Disease Relapse After Stopping Biologics
This study aims to investigate if MR Enterography (MRE) improves the ability to predict which Crohn's disease patients will relapse quickly (disease comes back) after stopping biologic medication.
- Trial name
- METEOR (NCT06124287)
- Testing
- MR Enterography (MRE)
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University College, London
Autism Spectrum Disorder, Gastrointestinal Dysfunction
ASC - Autism Study
The ASC - Autism Pilot Study is a single center randomized open dose titrating phase I clinical intervention pilot trial with the aim of investigating safety and treatment effect of an allogeneic adipose tissue derived…
- Conditions
- Autism Spectrum Disorder, Gastrointestinal Dysfunction, Leaky Gut Syndrome, Mesenchymal Stromal Cells
- Trial name
- NCT05602116
- Testing
- Adipose tissue derived mesenchymal stromal/stem cells (Cell2Cure®)
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Cell to Cure ApS
Inflammatory Bowel Diseases, Crohn's Disease
Efficacy and Safety Study of Tripterygium Glycoside in the Treatment of Crohn's Disease for Induction Remission
The purpose of this study is to assess the effect and safety of Tripterygium Glycosides in the treatment of Crohn's disease for induction remission and compare the therapeutic effect with patients who received mesalazine.
- Conditions
- Inflammatory Bowel Diseases, Crohn's Disease, Gastrointestinal Diseases, Digestive System Diseases
- Trial name
- NCT02044952
- Testing
- Mesalazine, Tripterygium glycosides
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhu Weiming
Ulcerative Colitis
Pilot Study of a New Medical Food in the Management of Ulcerative Colitis
The goal of this clinical trial is to determine at how well a new medical food works in managing inflammation associated with ulcerative colitis in children.
- Trial name
- NCT06116643
- Testing
- Soluble protein hydrolysate (SPHi)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Inflammatory Bowel Diseases, Coronavirus Infection
PREPARE-IBD: Physician Responses to Disease Flares and Patient Adaptation in Relation to Events in Inflammatory Bowel Disease During COVID-19 Pandemic
To find out what adaptations have been made by Inflammatory bowel disease physicians and patients in relation to therapies in flaring IBD patients during severe acute respiratory syndrome 2-COV and what the impact of these is on…
- Trial name
- PREPARE IBD (NCT04410484)
- Where
- United Kingdom
- Volunteers
- 3,728 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Inflammatory Bowel Diseases, Colitis, Ulcerative
Protein and Magnesium in Ulcerative Colitis
The aim of the study is to improve the quality of nutritional therapy for patients admitted with Acute Severe Ulcerative Colitis (ASUC) treated with high-dose steroids.
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Magnesium Deficiency, Nutritional Deficiency
- Trial name
- PAMUC (NCT05271838)
- Testing
- Magnesium acetate mixture (30 mmol/ml), High-protein diet (2 g/kg/day)
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- University of Aarhus
Crohn's Disease
Human Anti-TNF Monoclonal Antibody Adalimumab in Canadian Subjects With Moderate to Severe Crohn's Disease (ACCESS)
To make adalimumab available to subjects suffering from moderately to severely active Crohn's Disease (CD) and to expand the safety information on adalimumab.
- Trial name
- ACCESS (NCT00427921)
- Testing
- adalimumab
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- Abbott
Crohn Disease
Fecal Microbiota Transplantation in Crohn's Disease as Relay After Anti-TNF Withdrawal
Crohn's disease (CD) is a chronic inflammatory bowel disease. CD pathogenesis remains poorly understood but involves an inappropriate immune response toward an unbalanced gut microbiota in predisposed hosts.
- Trial name
- MIRACLE (NCT04997733)
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ulcerative Colitis
A Study Evaluating the Effect of Filgotinib Dose De-escalation in Participants With Ulcerative Colitis (UC) in Remission
Participants who were in clinical remission on 200 milligram (mg) filgotinib once daily for at least 2 consecutive quarterly visits in the ongoing SELECTION-LTE study (GS-US-418-3899, NCT02914535), were planned to be rolled over…
- Trial name
- CAPYBARA (NCT05479058)
- Testing
- Filgotinib
- Where
- 50 sites in United States, Belgium and 11 more
- Volunteers
- 22 people
- Sponsor
- Lakefront Biotherapeutics NV
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