Clinical trials: ICP
Severe Traumatic Brain Injury, Intracranial Hypertension
External Lumbar Drainage to Reduce ICP in Severe TBI: a Phase 1 Clinical Trial
The goal of this phase 1 randomized controlled safety and feasibility clinical trial are to determine the safety of external lumbar drainage (ELD) in select patients with severe Traumatic Brain Injury (TBI).
- Trial name
- ELASTIC (NCT05889650)
- Testing
- External Lumbar drainage
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Brain Trauma Foundation
ICP (Intracranial Pressure) Increase, Optic Nerve Sheath Diameter
Optic Nerve Sheath Diameter: A Non-Invasive Indicator of Intracranial Pressure in the Intensive Care Unit Monitoring
Determination of high intracranial pressure (ICP) is necessary for the treatment of patients with raised ICP to improve long-term neurological outcomes.
- Conditions
- ICP (Intracranial Pressure) Increase, Optic Nerve Sheath Diameter, Intracranial Hypertension
- Trial name
- NCT06367868
- Testing
- After 5 ml CSF Drainage
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Istanbul University - Cerrahpasa
Traumatic Brain Injury
Evidence Based Diagnostics and Treatment Planning Solution for Traumatic Brain Injuries
Adult patients, age ≥ 18 years, with clinically diagnosed mild, moderate or severe brain trauma will be asked to participate in the study.
- Trial name
- NCT02021877
- Where
- 2 sites in Finland, United Kingdom
- Volunteers
- 396 people
- Sponsor
- Turku University Hospital
Advanced Solid Tumor
Evaluation of ICP-B208 in Patients With Advanced Solid Tumors
To evaluate the safety, tolerability, efficacy and pharmacokinetic characteristics of ICP-B208 in the trial participants of unresectable advanced or metastatic solid tumors
- Trial name
- NCT07617493
- Testing
- ICP-B208
- Where
- China
- Volunteers
- 539 people
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Traumatic Brain Injury
Intracranial Pressure (ICP) Monitoring Following Traumatic Brain Injury (TBI)
The aim of this retrospective cohort study is to evaluate complications rates, indications, and the utility of follow-up imaging studies of ICP measurement in severe TBI patients.
- Trial name
- NCT04428970
- Testing
- Invasive ICP monitoring
- Where
- Austria
- Volunteers
- 214 people
- Sponsor
- Medical University of Vienna
Pseudotumor Cerebri
Multifocal Chromatic Pupilloperimetry in Patients With Pseudotumor Cerebri and Healthy Subjects.
PTC(Pseudotumor cerebri) patients may develop increased Intracranial pressure (ICP) that can produces increased pressure around the distal optic nerve,which is likely followed by venule compression, ischemia, and loss of visual…
- Trial name
- NCT03304314
- Testing
- objective chromatic multifocal pupillometer
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Heart Failure
C-Pulse Implantable Counterpulsation Pump (ICP) - A Heart Assist Device
The C-Pulse Study is evaluating the safety and performance of a new product for the treatment of heart failure. The product is designed to help reduce the symptoms of heart failure and help patients function better with daily…
- Trial name
- NCT01176370
- Testing
- C-Pulse™ (Implantable Counterpulsation Therapy)
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Nuwellis, Inc.
Heart Failure
C-Pulse IDE Feasibility Study- A Heart Assist System
The C-Pulse Feasibility Study is evaluating the safety and performance of a new product for the treatment of heart failure. The product is designed to help reduce the symptoms of heart failure and help patients function better…
- Trial name
- NCT00815880
- Testing
- C-Pulse™ (Implantable Counterpulsation Therapy)
- Where
- 6 sites in United States
- Volunteers
- 21 people
- Sponsor
- Nuwellis, Inc.
Healthy Volunteers
iCP-NI - Safety, Tolerability, Pharmacokinetic, and Immunogenicity Study in Healthy Male and Female Subjects
This is a Phase 1, double-blind, randomized, placebo-controlled study to investigate single and multiple intravenous infusions of improved cell-permeable nuclear import inhibitor (iCP NI) in healthy subjects.
- Trial name
- NCT05740280
- Testing
- iCP-NI
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cellivery Therapeutics, Inc.
Intracranial Pressure
Mitigating Cephalad Fluid Shifts: A NSBRI Study
This is a feasibility study to determine optimal thigh cuff design using a cephalad fluid shift protocol in patients who have an intraventricular catheter (such as Ommaya reservoir) placed for the delivery of central nervous…
- Trial name
- NSBRI (NCT03097523)
- Testing
- Custom Thigh Cuff
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Saint John's Cancer Institute
Diabetes in Children, Diabetes Type 1
Intelligent Care Platform - Quasi-Experimental Trial
This study will measure the implementation and effectiveness of an intervention, the use of a digital health tool, Haibu Diabetes, for the management of pediatric type 1 diabetes (T1D), on clinical outcomes.
- Trial name
- UBColumbia (NCT07712809)
- Testing
- Digital Diabetes Care Platform
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Traumatic Brain Injury, Mechanical Ventilation Complication
Effects of Positive End-expiratory Pressure on Intracranial Pressure in Patients With Severe Traumatic Brain Injury
The impact of PEEP on ICP was dependent on the difference between elevated CVP levels and baseline ICP levels. ICP would increase once elevated CVP through PEEP adjustment exceeds the baseline ICP.
- Trial name
- PEEP，ICP，CVP (NCT03296293)
- Testing
- PEEP at 5cmH2O, PEEP at 10cmH2O, PEEP at 15cmH2O
- Volunteers
- 38 people
- Sponsor
- Hongpeng Li
Eye Change, Idiopathic Intracranial Hypertension
ICP & Outflow Study
This study aims to investigate the relationship between intracranial pressure (ICP) and aqueous outflow (the flow of the eye's internal fluid out of the eye), in patients with increased intracranial pressure (idiopathic…
- Trial name
- NCT06436820
- Testing
- Lumbar puncture
- Volunteers
- 66 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
ICP Regulation Using a New Device for Automated Zero-calibration for a Ventricular Drainage System
A Prospective Clinical Trial to Evaluate an Automated Cerebral Ventricular Drainage System in Patients in the Neurointensive Care
This is a prospective, randomised trial to evaluate a new medical device for automated zero calibration of ventricular drainage systems in neurointensive care patients.
- Trial name
- NCT05177692
- Testing
- Vguard
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Skane University Hospital
Traumatic Brain Injury, Pediatric
Age Related Thresholds for Management of Severe Head Injury in Paediatrics: An Extension of STARSHIP
Traumatic brain injury in children can cause serious and long-lasting neuro-disability. However, there is still limited evidence about the best ways to treat children with severe brain injury in intensive care.
- Conditions
- Traumatic Brain Injury, Pediatric, Cerebral Perfusion Pressure, Cerebral Autoregulation
- Trial name
- ARTSHIP (NCT07834476)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Subarachnoid Hemorrhage
Ventriculostomies in SAH: ICP Open or Not?
The purpose of this study is explore how cerebrospinal fluid (CSF) drainage impacts outcomes for patients diagnosed with subarachnoid hemorrhage (SAH).
- Trial name
- VISION (NCT00787020)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Duke University
Relapsed/Refractory Marginal Zone Lymphoma (MZL)
Orelabrutinib Plus ICP 248 vs Orelabrutinib for Relapsed/Refractory Marginal Zone Lymphoma
To evaluate the efficacy of olubrutinib combined with ICP-248 compared with the olubrutinib in the treatment of r/r MZL
- Trial name
- NCT07896590
- Testing
- Orelabrutinib, ICP-248
- Where
- 46 sites in China
- Volunteers
- 292 people
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Brain Injuries, Intracranial Hypertension
Development and Evaluation of the ICP Waveform Tracing Capabilities and Safety of HS-1000 Device
Invasive intracranial pressure (ICP) monitoring, using modalities such as parenchymal pressure transducer or external ventricular drain (EVD), provides an ICP waveform that encapsulates valuable diagnostic and monitoring clinical…
- Trial name
- NCT02772471
- Testing
- HS-1000
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- HeadSense Medical
Intracranial Hypertension
Sonography of the Optic Nerve Sheath Diameter for Detection of Elevated Intracranial Pressure (ICP)
In this study the invistigators chose to measure the optic nerve sheath diameter by sonography for diagnosis of elevated intracranial pressure (ICP) in comparison to brain computed tomograhy (CT) as the reference gold standard…
- Trial name
- NCT03529370
- Testing
- optic nerve ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- National Heart Institute, Egypt
Subarachnoid Hemorrhage
Ventriculostomy in Subarachnoid Hemorrhage (SAH): Intracranial Pressure (ICP) Open or Not?
The purpose of this study is to explore two currently accepted methods of intracranial pressure (ICP) management through cerebral spinal fluid (CRF) drainage for patients diagnosed with subarachnoid hemorrhage (SAH).
- Trial name
- VISION 2 (NCT01169454)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University