Clinical trials: ICSI
Infertility
Automation of Gamete Preparation, Intracytoplasmic Sperm Injection (ICSI), Embryo Culture, and Vitrification
Patients suffering from infertility may seek assisted conception treatment. In a full treatment cycle, the sperm and eggs (gametes) from the intended parents will be looked after by skilled laboratory staff (embryologists) who…
- Trial name
- NCT06074835
- Testing
- Gamete preparation, ICSI, embryo culture and vitrification robot assistant, Routine Manual ICSI Workflow
- Where
- Mexico
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Conceivable Life Sciences
Infertility
Study of Free DNA Content of Embryo Culture Medium as a Non-Invasive Tool for Embryo Assessment
Study of Cell Free DNA Content of Human Embryo Culture Medium as a Non-Invasive Tool for Embryo Assessment in intra cytoplasmic sperm injection Treatment Cycles.
- Trial name
- NCT02480491
- Testing
- measuring cell freeDNA
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sadat City University
Sub Fertility, Female, Fertility Disorders
Effects of Fasting on Success Rates of Assisted Reproductive Techologies
This exploratory study investigates fasting as a potential supportive therapy for infertility treatment in women undergoing in-vitro-fertilization (IVF) / intracystoplamsatic sperm injection (ICSI)
- Conditions
- Sub Fertility, Female, Fertility Disorders, Fertility Issues, Sub-fertility
- Trial name
- KiWuC (NCT04998591)
- Testing
- Fasting
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- Charite University, Berlin, Germany
the Application of Time-lapes System in IVF/ICSI
The Application of Time-lapse System in IVF/ICSI
Nowadays, the rapid development of human assisted reproductive technology (ART) has provided many help for couples with fertility issues.
- Trial name
- NCT02974517
- Testing
- EmbryoScope®
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Infertility
Half-Dose Depot Triptorelin Versus Reduced-Dose Daily Buserelin
The purpose of this study is to determine whether half-dose depot triptorelin are as effective as reduced-dose daily buserelin in the controlled ovarian stimulation for intracytoplasmic sperm injection and embryo transfer
- Trial name
- NCT00461916
- Testing
- Half-Dose Depot Triptorelin, Reduced-Dose Daily Buserelin
- Where
- Iran
- Volunteers
- 182 people
- Sponsor
- Tehran University of Medical Sciences
Subfertility, Assisted Reproduction
Role of Follicular Output Rate in the Prediction of in Vitro Fertilization and Intracytoplasmic Sperm Injection in Women With Unexplained Infertility
300 women with unexplained infertility who are already decided to be treated with ICSI will be recruited from Cairo university hospitals and Dar Al-Teb subfertility centre.
- Trial name
- NCT02154958
- Where
- 2 sites in Egypt
- Volunteers
- 300 people
- Sponsor
- Cairo University
Infertility
Humidified Culture and Live Birth After ICSI
Humidity for human embryo culture has been raised as essential with advantageous effect on clinical pregnancy and ongoing pregnancy after ICSI compared with a dry incubator.
- Trial name
- NCT03823235
- Testing
- Human embryo culture
- Where
- 3 sites in Egypt
- Volunteers
- 1,837 people
- Sponsor
- Ibn Sina Hospital
Infertility, Oocyte
Improvement of Live Babies Rates After ICSI, Using cpFT
Demonstrate the improvement of the live births rate after ICSI by supplementing the pre-ICSI incubation medium of oocytes and that of preimplantation embryos with cpFT at the 1st embryo transfer for women under 37 years old.
- Conditions
- Infertility, Oocyte, Pregnancy
- Trial name
- FERTICSI (NCT04954274)
- Testing
- Cyclic peptide Fertiline
- Where
- France
- Volunteers
- 366 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oxidative Stress
What is the Best Sperm Source and Way of Sperm Selection in Cases With Abnormal sORP Levels on the Day of ICSI?
Does the level of statistic oxidation reduction potential (sORP) affects the choice of sperm source or sperm selection method used during ICSI.
- Trial name
- NCT03360526
- Testing
- PICSI, TESA
- Where
- Egypt
- Volunteers
- 820 people
- Sponsor
- Ganin Fertility Center
Fertility Disorders
Use of Gcsf in Patients With Recurrent Ivf/Icsi Failure
Evaluate the effectiveness of granulocyte colony-stimulating factor (GCSF) in the treatment of thin endometrium or in women with recurrent implantation failure in ICSI cycles
- Trial name
- NCT03023774
- Testing
- Neupogen
- Volunteers
- 20 people
- Sponsor
- Ain Shams Maternity Hospital
Infertility, Female
Efficacy of Growth Hormone Supplementation With Gonadotrophins in IVF/ICSI for Poor Responders
The objective of this study is to assess the effectiveness of adjuvant growth hormone injection during controlled ovarian stimulation, in poor responder women undergoing intracytoplasmic sperm injection (ICSI) procedures.
- Trial name
- NCT03759301
- Testing
- Growth Hormones Somatropin Recombinant
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- ClinAmygate
ICSI, IVF
Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Responders
To compare the embryological and reproductive outcomes of dual trigger versus conventional hCG trigger for final oocyte maturation in normal responder patients undergoing ICSI cycles.
- Conditions
- ICSI, IVF, Normal Responders, Infertility Assisted Reproductive Technology
- Trial name
- DT-HCG-IVF (NCT07861399)
- Testing
- Dual trigger (human chorionic gonadotropin plus GnRH-agonist), hCG trigger
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Infertility
Adding Insulin to IVF Culture Media Significantly Improve Outcome
Add insulin to a single step culture media for IVF embryo culture from day 0 to day 5/6 of In Vitro culture and detect the the effect upon embryo quality and implantation potential.
- Trial name
- NCT02420171
- Testing
- Adding insulin to In Vitro culture media
- Where
- 2 sites in Egypt
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Infertility
Magnetic Nanoparticle Sperm Separation for Teratozoospermia Male and Women Older Than 35 Years
Women over 35 years old are likely to suffer from impaired oocyte repair capacity. Teratozoospermia is a condition reflects morphological affection of sperm. These spermatozoa would add an extra burden on the oocyte after ICSI.
- Trial name
- NCT03666364
- Testing
- Sperm preparation for ICSI
- Where
- 3 sites in Egypt
- Volunteers
- 1,400 people
- Sponsor
- Ibn Sina Hospital
Poor Ovarian Response
Ovarian PRP Injection in Women With POR
Patients with poor ovarian response (POR）is considered one of most challenging tasks in artificial reproductive treatment (ART).
- Trial name
- NCT05601193
- Testing
- autologous platelet-rich plasma
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Infertility, Male
Varicocele Repair for Men Undergoing IVF/ICSI
For infertile men undergoing intracytoplasmic sperm injection (ICSI), data from retrospective studies suggested that varicocele repair may be beneficial and associated with improved livebirth and pregnancy rates, however, its…
- Trial name
- Varicocele (NCT04608864)
- Testing
- varicocelectomy
- Volunteers
- 2,000 people
- Sponsor
- Al-Yasmeen Fertility and Gynecology Center
Ovarian Hyperstimulation Syndrome
Double GnRH Antagonist Daily Dose in Hyperresponding IVF/ICSI Cycles May Prevent the OHSS
The possibility to prevent the early ovarian hyperstimulation syndrome (OHSS) by doubling the daily dose of GnRH-antagonist in women stimulated with the antagonist protocol who are at risk for OHSS was evaluated.
- Trial name
- NCT01477970
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Iakentro Fertility Centre
Women Conceiving by: 1- ICSI-PGS 2- ICSI-non-PGS 3- Spontaneously Conceiving Women
Comparison Between Biopsied and Non-biopsied Intracytoplasmatic Sperm Injection (ICSI) Embryos and Natural Pregnancy Embryos
As Pre Implantation Genetic Screening (PGS) becomes now a replacement modality and trend gaining popularity among physicians and patients on claiming its ability to settle on the simplest genetically normal embryo, so it had been…
- Trial name
- BNB-ICSI (NCT04280757)
- Testing
- Biopsied ICSI embryos (PGS)
- Where
- Egypt
- Volunteers
- 420 people
- Sponsor
- Wael Elbanna Clinic
Infertility
Laser-assisted ICSI Versus Conventional ICSI
Degeneration rate after ICSI is expectable but decreasing it is a goal. Laser-assisted ICSI can serve to decrease this degeneration rate.
- Trial name
- NCT03665103
- Testing
- Laser-assisted ICSI
- Where
- Egypt
- Volunteers
- 966 people
- Sponsor
- Ibn Sina Hospital
Controlled Ovarian Stimulation
A Study to Assess the Efficacy and Safety of Ganirelix (Orgalutran®) Treatment in Chinese Women Undergoing Controlled Ovarian Stimulation for in Vitro Fertilization (IVF) or Intra Cytoplasmatic Sperm Injection (ICSI) (Study 38651)(P05703)
The primary purpose of this study is to assess that ganirelix is safe and well-tolerated in Chinese women and that a controlled ovarian stimulation (COS) protocol combining recombinant follicle stimulating hormone (recFSH) with…
- Trial name
- NCT00725491
- Testing
- ganirelix, triptorelin
- Volunteers
- 259 people
- Sponsor
- Organon and Co