Clinical trials: ICU
Sedation in the ICU
A Study of Remimazolam Tosilate for Prolonged Sedation in the ICU
The purpose of this study is to evaluate the efficacy and safety of Remimazolam Tosilate for Injection for prolonged sedation(≥72h) during mechanical ventilation in the ICU.
- Trial name
- NCT05913336
- Testing
- Remimazolam Tosilate
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Sepsis
Integration of NAVOY® Sepsis in an Electronic Health Record System
The study aims to evaluate the performance of NAVOY® Sepsis in predicting the sepsis risk in adult ICU patients. Data collection is performed via automatic retrieval from the electronic health record system to AlgoDx proprietary…
- Trial name
- GENIUS (NCT05095220)
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- AlgoDx
Ventilators, Mechanical, Stroke
Evaluation of VQm PHM on Pulmonary Health Parameters for ICU
The goal of this observational study is to compare pulmonary health parameter measurements from the VQm PHM™ to existing clinical measurements.
- Conditions
- Ventilators, Mechanical, Stroke, COPD, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT06147674
- Testing
- VQm Pulmonary Health Monitor™
- Where
- 4 sites in United States, Austria and 2 more
- Volunteers
- 150 people
- Sponsor
- Rostrum Medical Innovations Inc.
Invasive Candidiasis
Anidulafungin Candidemia/Invasive Candidiasis Intensive Care Study
To evaluate the efficacy and safety of anidulafungin in the treatment of systemic fungal infections in intensive care and critical care unit patients.
- Trial name
- ICE (NCT00689338)
- Testing
- Anidulafungin, Fluconazole, Voriconazole
- Where
- 61 sites in Austria, Belgium and 17 more
- Volunteers
- 216 people
- Sponsor
- Pfizer
COVID-19
Registry of CytoSorb Therapy in COVID-19 ICU Patients
The CTC Registry collects patient-level clinical data on CytoSorb hemoadsorption provided to COVID-19 ICU patients via integration of the CytoSorb device into ECMO, CRRT, or hemoperfusion extracorporeal circuits.
- Trial name
- CTC REGISTRY (NCT04391920)
- Testing
- CytoSorb 300 mL device
- Where
- 7 sites in United States
- Volunteers
- 138 people
- Sponsor
- CytoSorbents, Inc
Respiratory Failure
Holy Name Progressive Mobility in the ICU
Despite the known complications of immobility for ICU patients, compliance to mobility protocols is lacking in many institutions.
- Trial name
- NCT02533622
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Hill-Rom
Dysphagia
The PhINEST Study - Pharyngeal ICU Novel Electrical Stimulation Therapy
This is a prospective, multi-site, randomised, sham-controlled, single-blind (outcome assessor-blinded) study designed to assess the effects of Pharyngeal Electrical Stimulation (PES) (using Phagenyx®) for the treatment of…
- Trial name
- PhINEST (NCT03840395)
- Testing
- Pharyngeal Electrical Stimulation (PES)
- Where
- 5 sites in Austria, Germany and 1 more
- Volunteers
- 72 people
- Sponsor
- Phagenesis Ltd.
Pressure Incidence Prevention
Pressure Injury Prevention in the ICU With Multi-Layer Foam Dressings
A Multi-Centre, Open, Non-controlled, Clinical Investigation to Evaluate the User Friendliness and Wear Time of Multi-layer Foam Dressings With Safetac® for Pressure Injury Prevention in the Intensive Care Unit
- Trial name
- PUP16_01 (NCT02962882)
- Testing
- Mepilex Border
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Molnlycke Health Care AB
Continuous Sedation in Initially Sedated Adults in ICU
Dexmedetomidine Versus Propofol for Continuous Sedation in the Intensive Care Unit (ICU)
Patients in the ICU who need help with their breathing are put onto a machine called a ventilator and are also given a medicine, called a sedative, which helps them to sleep and makes them more comfortable.
- Trial name
- Prodex (NCT00479661)
- Testing
- Dexmedetomidine, Propofol
- Where
- 40 sites in Belgium, Finland and 5 more
- Volunteers
- 500 people
- Sponsor
- Orion Corporation, Orion Pharma
Immobility and Weakness Associated With Long Intensive Care Unit Stays
Early Progressive Mobility in the CVICU: Assessing Current Status
The current study is proposed to assess the frequency and type of progressive mobility procedures currently performed in the CVICU The study will evaluate the type and frequency of progressive mobility orders, whether or not…
- Trial name
- NCT01295541
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Hill-Rom
Surgery, Intensive Care Units
Study to Compare CAUTI Rates Following ERASE CAUTI Tray Non-Silver vs Silver Coated Foley Catheters
The Foley catheter is one component in a catheter insertion procedure that could contribute to a catheter associated urinary tract infection (CAUTI).
- Trial name
- NCT02101762
- Volunteers
- 756 people
- Sponsor
- Medline Industries
Sedation in Intensive Care
A Study Evaluating Sedation of Intravenous Administration of HSK3486 Injectable Emulsion in ICU Patients Undergoing Mechanical Ventilation
This is a multi-center, randomized, single-blind, propofol-controlled phase III clinical study. In this study, ICU patients undergoing mechanical ventilation are expected to be enrolled and will be randomly assigned to the…
- Trial name
- NCT04620031
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Acute on Chronic Liver Failure, Multiple Organ Failure
Feasibility Pilot Study to Evaluate the Safety and Performance of the MEX-CD1 Medical Device in ACLF
The goal of this clinical trial is to test the MEX-CD1 hemodialysis medical device in patients suffering from ACLF. The main questions it aims to answer are: Is the device safe when used according to the instructions for use?…
- Trial name
- MexACLF (NCT06340269)
- Testing
- MEX-CD1 Dialysis
- Where
- 2 sites in France
- Volunteers
- 11 people
- Sponsor
- Mexbrain
Fever
Fever Algorithm Development of a Non-invasive Wearable Core Body Temperature Sensor System in Intensive Care Unit Patients
Background and Rationale: The gold standard to assess fever, is to conduct invasive intravascular, esophageal or bladder thermistor core body temperature (CBT) measurements.
- Trial name
- NCT04182945
- Testing
- Data collection for algorithm development
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- greenTEG AG
ARDS (Moderate or Severe), AHRF
STimulation to Activate RespIration
Multi-center, randomized, controlled, open-label Phase 2 feasibility trial. Subjects on mechanical ventilation (MV) for acute hypoxemic respiratory failure (AHRF) with lung injury (including subjects who meet criteria for acute…
- Conditions
- ARDS (Moderate or Severe), AHRF, Mechanically Ventilated ICU Patients
- Trial name
- STARI (NCT06832306)
- Testing
- Phrenic Nerve Stimulation
- Where
- 7 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Lungpacer Medical Inc.
Infection, Bacterial Infection
Procalcitonin Level to Discontinue Antibiotics on ICU Patients With no Obvious Site of Infection
The purpose of this study is to test whether a U.S. Food and Drug Administration (FDA) approved laboratory test (PCT Kryptor) can help doctors make better decisions on the need for antibiotic therapy in ICU patients with…
- Conditions
- Infection, Bacterial Infection, Sepsis
- Trial name
- NCT00407147
- Testing
- Procalcitonin assay - B.R.A.H.M.S PCT sensitive Kryptor
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Brahms AG