Clinical trials: ICU Acquired Muscle Weakness
Ventilator Weaning
Instrumental Respiratory Physiotherapy in Difficult-to-wean ICU Patients
Difficult ventilatory weaning is associated with a 20% mortality rate. 40% of these patients will develop intensive care unit (ICU)-acquired neuromyopathy, associated with reduced cough strength and a 4-fold increase in the risk…
- Trial name
- PHYSIO WEAN (NCT06499389)
- Testing
- Systematic and early intensive instrumental respiratory physiotherapy for patients undergoing difficult ventilatory weaning, Protocolized standard-of-care respiratory physiotherapy
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Critical Illness
Body Impedance Analysis to Detect ICUAW
The aim of the study is to detect a value of muscle and organ mass measured by body impedance analysis and its correlation with the Medical Research Council (MRC) score.
- Trial name
- BIAMI (NCT05572138)
- Testing
- Body Impedance Analysis
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Charite University, Berlin, Germany
Peripheral Muscle Strength
Study of Intensive Care Unit (ICU)-Acquired Weakness (Handgrip Strength Study)
To better understand ICU-acquired weakness in patients requiring mechanical ventilation in the Intensive Care Unit.
- Trial name
- NCT00702000
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Naeem Ali, MD
ICU Acquired Weakness
Safety and Efficacy of the MyokinE100 (CL-EMS Alpha) Device in Inducing Visible Muscle Contraction in Healthy Volunteers
Every patient admitted to the Intensive Care Unit (ICU) is at risk of developing "Intensive Care Unit Acquired Weakness" (ICUAW).
- Trial name
- NCT06023511
- Testing
- Electrical muscle stimulation
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Health Discovery Labs
Sepsis
Dysfunctions of Human Muscle Stem Cells in Sepsis
Severe critical illness is often complicated by Intensive Care Unit - Acquired Weakness (ICU-AW), which is associated with increased in and post-ICU mortality, with delayed weaning from mechanical ventilation and with long-term…
- Trial name
- DISCUSS (NCT02789995)
- Testing
- Human biological samples
- Where
- 7 sites in France
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
ICU Acquired Weakness
The Use of Musculoskeletal Ultrasound for the Detection of ICU-Acquired Weakness
Intensive Care Unit-Acquired Weakness (ICU-AW) is a clinical entity frequently encountered in critically ill patients that have both short term and long-term implications.
- Trial name
- NCT05048953
- Testing
- Muscle ultrasound measurements (the index test)
- Where
- Nepal
- Volunteers
- 114 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
ICU Acquired Weakness, Diaphragmatic Injury
Transcutaneous Electrical Diaphragmatic Stimulation in Critically Ill Elderly Patients
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- Trial name
- NCT04565002
- Testing
- Transcutaneous Electrical Diaphragmatic Stimulation
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Centro Universitário Augusto Motta
Intensive Care Unit Acquired Weakness
Muscle Effects Of Neuromuscular Electrostimulation In Mechanically Ventilated Patients In An Icu
To prevent the development of ICUAW, both early mobilization and neuromuscular electrical stimulation (NMES) have been shown to prevent muscle atrophy in critically ill patients by preserving muscle mass.
- Trial name
- NCT06409611
- Testing
- neuromuscular electrical stimulation
- Where
- 3 sites in Brazil
- Volunteers
- 22 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Muscle Weakness, Sepsis
Evaluating Muscle Weakness Improvement With Lorcaserin in ICU
ICU acquired muscle weakness is a significant problem in patients recovering from critical illness. This trial will evaluate the safety and efficacy of a drug in improving muscle weakness in critically ill patients.
- Trial name
- EMILI (NCT02523690)
- Testing
- Lorcaserin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Intensive Care Unit Acquired Weakness, Sepsis, Severe
Is NMES Treatment in Sepsis/ Septic Shock Patients Protective in Development of ICU-AW?
Background: Sarcopenia (muscle weakness) characterized by a decrease in muscle mass, strength and performance is a condition that increases with old age.
- Trial name
- NCT04833621
- Testing
- NMES GROUP
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Ondokuz Mayıs University
Muscle Weakness
Safety Evaluation of Functional Electrical Stimulation (FES) Cycling in Intensive Care Unit Patients
Intensive care unit acquired muscle weakness (ICUAW), is a common disease which influence rehabilitation, extend mechanical ventilation and length of stay in intensive care unit, and affect quality of life at hospital discharge.
- Trial name
- FES Cycling (NCT03526211)
- Testing
- FES cycling
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
ICU Acquired Weakness
Diagnosing Intensive Care Unit (ICU) Acquired Weakness
The goal of this study is to develop a non-invasive test to diagnose intensive care unit (ICU) acquired weakness that can be administered to both responsive and non-responsive patients.
- Trial name
- NCT04166630
- Testing
- Clinical Electrical Stimulator
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Emory University
ICU Acquired Weakness, Muscle Atrophy
Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO )
Intensive Care Unit Acquired Weakness (ICUAW) describes muscle weakness that occurs in around 40% of patients during an intensive care stay.
- Conditions
- ICU Acquired Weakness, Muscle Atrophy, Energy Malnutrition Protein, Quality of Life
- Trial name
- NCT05919940
- Testing
- Dietary Supplement: additional substitution of protein, Neuromuscular electrical stimulation, Early Mobilization
- Where
- 4 sites in Austria, Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
Intensive Care (ICU) Myopathy, Intensive Care Unit Acquired Weakness
Effect of Neurophysiological Facilitation Techniques in Intensive Care Patients
The aim of this study was to investigate the effect of neurophysiological facilitation techniques on respiratory and functional levels in intensive care patients.
- Trial name
- NCT05282576
- Testing
- NPF Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Saglik Bilimleri Universitesi
Intensive Care Unit Acquired Paresis, Muscle Wasting
Investigation of the Role of FHL-1 and Myostatin in Intensive Care Unit Acquired Paresis (ICUAP)
The primary hypothesis for this study is that Myostatin and FHL-1 are important in the development of ICUAP and that changes in activity levels of muscle will modify the levels of expression and activity of these proteins.
- Trial name
- NCT01321320
- Testing
- Active muscle stimulation
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Imperial College London
Muscle Weakness
Muscle Wasting in the Critically Ill
Muscle wasting is a common consequence of critical illness, and has a profound impact upon the rehabilitation of those who survive admission to critical to care.
- Trial name
- NCT03770442
- Testing
- Cycling with FES, Routine physiotherapy
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Liverpool
Muscle Weakness | Patient, Intensive Care (ICU) Myopathy
Whole-Body Vibration Versus Neuro Muscular Electrical Stimulation on Patients With ICU Acquired Weakness
Purpose: to investigate the effect of Whole-body vibration versus neuro-muscular electrical stimulation on patients with intensive care-acquired weakness.
- Conditions
- Muscle Weakness | Patient, Intensive Care (ICU) Myopathy, Intensive Care (ICU)
- Trial name
- NCT07336810
- Testing
- whole body VIBRATION Viberation, Neuro muscular electrical stimulation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Intensive Care Unit Acquired Weakness
The Effect of Inspiratory Muscle Training on Diaphragmatic Function in Mechanically Ventilated Patients
In this study, the effect of inspiratory muscle training on diaphragmatic functions will be investigated radiologically in mechanically ventilated patients.
- Trial name
- NCT05303623
- Testing
- Conventional Physiotherapy, Conventional Physiotherapy+ inspiratory muscle training, inspiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Demiroglu Bilim University
Muscle Weakness
Growth Differentiation Factor 15 in ICU Acquired Muscle Weakness
Intensive care unit -acquired weakness (ICU- AW) is a common consequence linked to a worse outcome as evidenced by prolonged mechanical ventilation, longer ICU stays, greater mortality rates and a lower quality of life for…
- Trial name
- NCT06713746
- Testing
- growth differentiation factor 15
- Where
- Egypt
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Minia University
Intensive Care Unit (ICU) Acquired Weakness (ICU - AW), Muscle Weakness
Nutrient Pattern Analysis in Critically Ill Patients (NAChO)
Little is known about nutritional Parameters that potentially influence the course of intensive-care unit acquired weakness (ICU - AW).
- Trial name
- NAChO (NCT02839018)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern