Clinical trials: ICU Mortality
Critical Illness, Infection Complication
A Trial of Enteral Colostrum on Clinical Outcomes in Critically Ill Patients
Enteral administration of immune-modulating nutrients such as glutamine, omega-3 fatty acids, selenium, and antioxidants has been suggested to reduce infections and improve recovery from critical illness.
- Conditions
- Critical Illness, Infection Complication, Multiple Organ Dysfunction Syndrome
- Trial name
- NCT03019250
- Testing
- Colostrum, Maltodextrin
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- National Nutrition and Food Technology Institute
Critical Illness
European Mortality & Length Of Intensive Care Unit (ICU) Stay Evaluation (ELOISE)
The starting point of ELOISE is the significant number of Intensive Care Unit (ICU) survivors who die after the transfer to ward.
- Trial name
- ELOISE (NCT01422070)
- Where
- Italy
- Volunteers
- 6,433 people
- Sponsor
- Università degli Studi di Ferrara
Chronic Obstructive Lung Disease (COLD)
ANTEAB: a Study of Early Antibiotherapy in the ICU Management of Acute Exacerbations of COPD
Intensive Care Unit (ICU) admission for acute exacerbation of chronic obstructive lung disease (COLD) is a major cause of morbidity and mortality in such patients. Although bacterial of mortality in such patients.
- Trial name
- NCT00190437
- Testing
- Amoxicillin-clavulanic
- Where
- 2 sites in France
- Volunteers
- 520 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19
Predictive Value of SOFA and APACHE Scores for In-hospital Mortality in COVID-19 ICU Patients
The aim of this study is to evaluate the predictive value for in-hospital mortality of respectively the SOFA and Apache scores in a COVID-19 ICU cohort and to develop a new prediction model for COVID-19 patients admitted to the…
- Trial name
- NCT04713852
- Where
- Belgium
- Volunteers
- 116 people
- Sponsor
- Jessa Hospital
Protein-Energy Malnutrition
Reducing In-Hospital and 60-Day Mortality in ICU Patients After Surgery With Strict Nutritional Supplementation
Malnutrition in critically ill patients is a global concern due to its association with increased infectious complications, prolonged hospital stays, and higher morbidity rates.
- Trial name
- NCT06058247
- Testing
- Active nutritional supplementation, Conventional nutritional supplementation
- Where
- South Korea
- Volunteers
- 368 people
- Sponsor
- Seoul St. Mary's Hospital
Postoperative Mortality, Frailty at Older Adults
Predictive Value of Frailty Scores and Admission Laboratory Markers for Postoperative ICU Mortality
This prospective observational study aims to evaluate the predictive value of the Clinical Frailty Scale (CFS), the Katz Activities of Daily Living (ADL) scale, and admission laboratory markers for postoperative mortality among…
- Conditions
- Postoperative Mortality, Frailty at Older Adults, Activities of Daily Living, Postoperative Complications
- Trial name
- GERI-MORTAL (NCT07279519)
- Where
- Turkey (Türkiye)
- Volunteers
- 393 people
- Sponsor
- Malatya Egitim Ve Arastirma Hastanesi
Hyperdynamic, Left Ventricular Ejection Fraction
Hyperdynamic Left Ventricular Ejection Fraction as a Predictor of Mortality in Intensive Care Unit Patients With Septic Shock
The study aimed to evaluate the cause and prognosis of hyperdynamic left ventricular ejection fraction in critically ill patients with sepsis.
- Conditions
- Hyperdynamic, Left Ventricular Ejection Fraction, Mortality, Intensive Care Unit
- Trial name
- NCT06993948
- Testing
- Transthoracic echocardiography
- Where
- Egypt
- Volunteers
- 235 people
- Sponsor
- Ain Shams University
Critical Illness, Post Intensive Care Syndrome (PICS)
Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS)
This two-arm, parallel-group randomized clinical trial investigates the effectiveness of an additional telerehabilitation program compared with standard care in patients with Post-Intensive Care Syndrome (PICS).
- Conditions
- Critical Illness, Post Intensive Care Syndrome (PICS), Cardiopathy
- Trial name
- CARDIO-PICS (NCT07599306)
- Testing
- Tele-rehabilitation, Standard of Care
- Where
- Italy
- Volunteers
- 326 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Septic Shock, Acute Renal Failure (as Defined by the "Failure" Stage of the RIFLE Classification)
I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit)
The purpose of this multicentric, randomized controlled trial is to assess whether the timing of renal replacement therapy initiation (early vs delayed) has an impact on mortality at 90 days in patients with severe acute kidney…
- Trial name
- IDEAL-ICU (NCT01682590)
- Testing
- Renal Remplacement Therapy
- Where
- 27 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Multiple Trauma/Injuries
Predictors of Mortality in Multiple Trauma Patients
Trauma is a public health concern that causes serious financial and medical burdens worldwide. According to the World Health Organization, 4.4 million people die from traumatic injuries each year which account for about 8% of…
- Trial name
- NCT07185529
- Testing
- Data of the patients were obtained from patient observation files and hospital information system database.
- Where
- Turkey (Türkiye)
- Volunteers
- 269 people
- Sponsor
- Melike Cengiz
Invasive Ventilation
Harmonized and Pooled Database, Named PRIME.
We merged the dataset of three large observational studies of invasive ventilation in critically ill patients.
- Trial name
- PRIME (NCT06592937)
- Testing
- Invasive ventilation
- Where
- Netherlands
- Volunteers
- 3,270 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Disease
Is a Positive NECPAL in ICU Patients Associated With Higher Mortality
The aim of the present study is to evaluate the usefulness of the NECPAL scale in identifying Intensive Care Unit (ICU)-admitted patients at higher risk of dying within 90 days of ICU admission
- Trial name
- NCT07007156
- Testing
- NECPAL positive
- Where
- Spain
- Volunteers
- 199 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Sepsis, Respiratory Failure
Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Patients
This observational study aims to determine whether three blood test ratios - lactate-to-albumin, CRP-to-albumin, and procalcitonin-to-albumin - can predict in-hospital mortality among critically ill adults.
- Conditions
- Sepsis, Respiratory Failure, Cardiac Arrest, Circulatory Failure
- Trial name
- LAR-CAR-PAR (NCT07242027)
- Where
- Poland
- Volunteers
- 212 people
- Sponsor
- Medical University of Silesia
Covid19
Glutamine Supplementation and Short-term Mortality in Covid-19
The aim of this study is to investigate the effect of parenteral L-Glutamine supplementation added to enteral nutrition on short-term ICU mortality (7 days) in Covid-19 diseased patients.
- Trial name
- NCT04909905
- Testing
- Standard enteral nutrition, Glutamine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Sepsis
Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial
Background: Dexmedetomidine, a highly selective arfa2-adrenergic agonist, is known to be a unique sedative agent which causes less acute tolerance, drug addiction and withdrawal compared with gamma-aminobutyrate (GABA) agonists.
- Trial name
- DESIRE (NCT01760967)
- Testing
- Dexmedetomidine
- Where
- Japan
- Volunteers
- 203 people
- Sponsor
- Wakayama Medical University
ARDS, Acute Respiratory Distress Syndrome
Effect of Prone Positioning on Mortality in Patients With Mild to Moderate Acute Respiratory Distress Syndrome.
Acute respiratory distress syndrome (ARDS) accounts for almost 10% of intensive care units (ICU) admissions. Three ARDS stages have been defined, based on the PaO2/FIO2 ratio measured with positive end-expiratory pressure (PEEP)…
- Conditions
- ARDS, Acute Respiratory Distress Syndrome, Intensive Care Unit, Mechanical Ventilation
- Trial name
- PROMILD (NCT05056090)
- Testing
- Patients will receive MV in PP
- Where
- France
- Volunteers
- 656 people
- Sponsor
- University Hospital, Grenoble
Hyperglycemia
Pre-admission Hyperglycemia and Its Effect on Morbidity and Mortality
It is currently standard of care in many Medical and Surgical ICU's to institute a nurse driven insulin protocol in maintaining tight glucose control in the critical patient. Many articles have been written to address this topic.
- Trial name
- NCT00871832
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Northwell Health
Cardiac Surgery
Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery.
To date, no pharmacological agents are proven efficacious in treating perioperative AKI. There is a strong biological rationale for the administration of amino acid in the management of patients at risk of AKI with increases in…
- Trial name
- PROTection (NCT03709264)
- Testing
- Amino Acids
- Where
- 22 sites in Croatia, Italy and 1 more
- Volunteers
- 3,511 people
- Sponsor
- Università Vita-Salute San Raffaele
ICU
External Validation of the FedHist Dynamic Early Warning Model for Mortality Risk in Critically Ill Patients: A Prospective Multicenter Study
The purpose of this study is to assess how accurately FedHist, an artificial intelligence model, predicts the risk of death in critically ill patients. Patients in intensive care units (ICUs) can become worse quickly.
- Trial name
- NCT07825012
- Testing
- Risk of mortality
- Volunteers
- 23,579 people
- Sponsor
- Southeast University, China
Major Trauma, Traumatic Brain Injury
Severe Trauma Registry in Tarragona
Severe trauma is one of the leading causes of morbidity, mortality, and disability worldwide. Currently, it is the primary cause of death among individuals under 45 years of age.
- Trial name
- IcuTrauma (NCT06007807)
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.