Clinical trials: ICU-acquired Muscle Weakness
Septic Shock
Interest of Plasma microRNAs
ICU acquired muscle weakness (IAMW) is a common disease that is associated with high morbidity and mortality. Patients with septic shock are particularly at risk.
- Trial name
- µARN (NCT02464371)
- Testing
- kinetic of microRNAs
- Where
- 2 sites in France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sarcopenia, Covid19
Sarcopenia and Related Factors in Coronavirus Disease 2019 (COVID-19) Following Intensive Care
The primary aim of this study is to evaluate the patients who had pneumonia or severe acute respiratory distress syndrome (ARDS) due to COVID-19 in terms of sarcopenia and related factors following Intensive Care Unit (ICU).
- Conditions
- Sarcopenia, Covid19, Intensive Care Unit Acquired Weakness
- Trial name
- NCT05474157
- Testing
- Standard care treatment for COVID-19 in Intensive Care Unit
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Koç University
Joint Contracture, Mechanical Ventilation
Using Continuous Passive Motion to Prevent Ankle Problems in ICU Patients
The goal of this clinical trial is to learn if continuous passive motion (CPM) helps prevent ankle joint contracture and muscle loss in critically ill, mechanically ventilated ICU patients.
- Conditions
- Joint Contracture, Mechanical Ventilation, ICU-acquired Weakness, Critical Illness
- Trial name
- NCT06944431
- Testing
- Continuous Passive Motion (CPM)
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
ICU Acquired Weakness, Post Intensive Care Unit Syndrome
Muscle Recovery After Critical Illness
The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which…
- Conditions
- ICU Acquired Weakness, Post Intensive Care Unit Syndrome, Muscle Weakness, Critical Illness
- Trial name
- TRACER (NCT05537298)
- Where
- 3 sites in United States
- Volunteers
- 209 people
- Sponsor
- Esther Dupont-Versteegden
Intensive Care Unit Acquired Paresis, Muscle Wasting
Investigation of the Role of FHL-1 and Myostatin in Intensive Care Unit Acquired Paresis (ICUAP)
The primary hypothesis for this study is that Myostatin and FHL-1 are important in the development of ICUAP and that changes in activity levels of muscle will modify the levels of expression and activity of these proteins.
- Trial name
- NCT01321320
- Testing
- Active muscle stimulation
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Imperial College London
Neuromuscular Electrical Stimulation, ICU Acquired Muscle Weakness
Neuromuscular Electrical Stimulation in Mechanically Ventilated Patients
Intensive care unit-acquired muscle weakness (ICUAMW) is a common problem following an ICU admission and is associated with prolonged hospitalization, delayed weaning and increased mortality.
- Trial name
- NCT05465291
- Testing
- Exercise group, Neuromuscular Electrical Muscle Stimulation group, Neuromuscular Electrical Muscle Stimulation and Exercise group
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Damanhour University
Critical Illness, ICU-acquired Weakness
Beyond Voluntary Effort: Reliability and Validity of Magnetic Femoral Nerve Stimulation for Assessing Quadriceps Strength in Critically Ill Patient
Intensive care unit-acquired weakness (ICU-AW) is a common complication of critical illness and can negatively affect recovery and long-term physical functioning.
- Trial name
- TWITCH FORCE (NCT07891273)
- Testing
- Magnetic Femoral Nerve Stimulation
- Volunteers
- 33 people
- Sponsor
- Daniel Langer
Sepsis, Critical Illness
MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients
The goal of this clinical trial is to learn if a new medical device that sends electrical signals to the thigh muscles is safe and easy to use for people in the ICU (Intensive Care Unit) who are at risk of losing muscle strength.
- Conditions
- Sepsis, Critical Illness, ICU-acquired Muscle Weakness, ICU-acquired Weakness
- Trial name
- ICUAW (NCT07362862)
- Testing
- Electrical Muscle Stimulation System
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Health Discovery Labs
Muscle Weakness, ICU-acquired Weakness
Improving Muscle Function in Nutritionally at Risk, Elderly Patients
The investigators propose to conduct a randomized, control trial of β-hydroxy-β-methylbutyrate (HMB) supplementation in elderly patients (≥65 years of age) with acute respiratory failure, who are identified at high risk for…
- Trial name
- NCT03071354
- Testing
- HMB protein supplement (3g), Nutritional Supplement
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Mechanically Ventilated Patients
Early Directed Physical Therapy in the Management of Mechanically Ventilated Patients in a Medical Intensive Care Unit
To study all ICU patients with an independent baseline functional status, who experience a critical illness requiring intubation and mechanical ventilation, evaluating the role of protocol-directed, early physical and…
- Trial name
- NCT00322010
- Testing
- early PT OT
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Chicago
Intensive Care Unit Syndrome, Intensive Care Neuropathy
Recovery From ICUAW Following Severe Respiratory and Cardiac Failure
To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO).
- Conditions
- Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy, Acute Respiratory Distress Syndrome
- Trial name
- CLEVERER (NCT03753412)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Barts & The London NHS Trust
Critical Illness
Body Impedance Analysis to Detect ICUAW
The aim of the study is to detect a value of muscle and organ mass measured by body impedance analysis and its correlation with the Medical Research Council (MRC) score.
- Trial name
- BIAMI (NCT05572138)
- Testing
- Body Impedance Analysis
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Charite University, Berlin, Germany
Muscle Weakness
Muscle Wasting in the Critically Ill
Muscle wasting is a common consequence of critical illness, and has a profound impact upon the rehabilitation of those who survive admission to critical to care.
- Trial name
- NCT03770442
- Testing
- Cycling with FES, Routine physiotherapy
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Liverpool
ICU Acquired Weakness, Muscle Atrophy
Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO )
Intensive Care Unit Acquired Weakness (ICUAW) describes muscle weakness that occurs in around 40% of patients during an intensive care stay.
- Conditions
- ICU Acquired Weakness, Muscle Atrophy, Energy Malnutrition Protein, Quality of Life
- Trial name
- NCT05919940
- Testing
- Dietary Supplement: additional substitution of protein, Neuromuscular electrical stimulation, Early Mobilization
- Where
- 4 sites in Austria, Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
ICU-acquired Muscle Weakness
Electrical Muscle Stimulation and Bicycling Combined to Early Standard Rehabilitation in the ICU
Early mobilization (from the first day if possible), first passive and then passive and active, is recommended for critically ill patients in whom it reduces the duration of mechanical ventilation, the length of hospital stay…
- Trial name
- PROMOREA1 (NCT02185989)
- Testing
- Early electrical stimulation and early leg bicycling added to early standard rehabilitation
- Where
- France
- Volunteers
- 314 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Aortic Diseases, Intensive Care Unit Syndrome
Muscle Recovery Following Aortic Surgery Induced ICUAW.
To identify determinants of 'good and bad recovery' from ICUAW and build knowledge around the timing of these processes. Also, the investigators want to discover the effects of ICUAW on physical function and HRQoL following…
- Conditions
- Aortic Diseases, Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy
- Trial name
- VARIANCE (NCT03714399)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Barts & The London NHS Trust
Muscle Weakness | Patient, Intensive Care (ICU) Myopathy
Whole-Body Vibration Versus Neuro Muscular Electrical Stimulation on Patients With ICU Acquired Weakness
Purpose: to investigate the effect of Whole-body vibration versus neuro-muscular electrical stimulation on patients with intensive care-acquired weakness.
- Conditions
- Muscle Weakness | Patient, Intensive Care (ICU) Myopathy, Intensive Care (ICU)
- Trial name
- NCT07336810
- Testing
- whole body VIBRATION Viberation, Neuro muscular electrical stimulation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
ICU Acquired Weakness, Quadriceps Muscle Atrophy
Ultrasound Measurement of Quadriceps Shortening During Neuromuscular Electrical Stimulation in Critically Ill Patients
ICU-Aw is highly prevalent (50%) among critically ill patients. Its diagnosis is usually delayed as it requires patients' awakening and collaboration to provide accurate measurement.
- Trial name
- DETECT (NCT04722445)
- Testing
- Early ultrasound measurement of quadriceps shortening during neuromuscular electrical stimulation (NMES)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Groupe Hospitalier du Havre
SARS-CoV-2 Acute Respiratory Disease, Sarcopenia
How COVID-19 Effects to Muscle Mass Change ın ICU?
Critical illness myopathy and neuropathy are associated with prolonged mechanical ventilation, resulting in increased morbidity and mortality in intensive care units, .the investigators aimed to determine the decrease in muscle…
- Conditions
- SARS-CoV-2 Acute Respiratory Disease, Sarcopenia, ICU Acquired Weakness, Critical Illness Myopathy
- Trial name
- NCT05008562
- Testing
- COVID-19 RELATED MUSCLE MASS CHANGE IN THE INTENSIVE CARE UNIT
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Ondokuz Mayıs University
Polyneuropathies, Septic Shock
Electrical Muscle Stimulation in the Development of Acquired Weakness in Patients With Severe Sepsis and Septic Shock
The aim of this study is to compare the effect of EMS and conventional physical therapy on strength and muscle mass and development in adult patients with severe sepsis and septic shock.
- Conditions
- Polyneuropathies, Septic Shock, Muscle Weakness
- Trial name
- NCT03765489
- Testing
- electrical muscle stimulation, conventional physical therapy
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Chile