Clinical trials: IDDM
Type 1 Diabetes, Overweight
Effect of Circadian Rhythm and Physical Exercise in Overweight Type 1 Diabetes Patients
Cardiometabolic risk in patients with abdominal obesity and type 1 diabetes can be moderated by life style modifications. There is an intimate link between gene regulation and circadian rhythm in mediating response to exercise in…
- Trial name
- NCT05277532
- Testing
- High intensity interval training (HIIT)
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Obesity, Overweight
The Effects of Type 1 Diabetes Mellitus and Increased Weight on Gut Microbiome and Urine Metabolome Profiles in Children
This study employs a cross-sectional design to profile the gut microbiome and urine metabolome in overweight/obese children with type 1 diabetes (T1D).
- Conditions
- Obesity, Overweight, Type 1 Diabetes Mellitus
- Trial name
- NCT02938806
- Testing
- No intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Type 1 Diabetes
M1no-Study - Early Identification of Infants With High Type 1 Diabetes Risk for Participation in Primary Prevention Trials
The goal of this observational study is to identify newborns at increased genetic risk of developing type 1 diabetes-specific beta-cell autoantibodies in order to determine eligibility for participation in primary prevention…
- Trial name
- M1N0 (NCT07670143)
- Where
- 5 sites in Italy
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Type 1 Diabetes Mellitus
Real-time Adaptation to Changes in Insulin Sensitivity
The purpose of this research study is to test an automated blood glucose control system that includes a new component designed to adapt to stress.
- Trial name
- NCT01261052
- Testing
- The Fading Memory Proportional Derivative/Adaptive Proportional Derivative Algorithm, The Adaptive Proportional Derivative Algorithm
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Legacy Health System
Type 1 Diabetes Mellitus
Mechanisms of Glucose Counterregulation in Pancreatic Islet Transplantation
Pancreatic islet transplantation improves glucose counterregulation and stabilizes glycemic control in patients with type 1 diabetes mellitus prone to severe hypoglycemia even if insulin independence is not achieved.
- Trial name
- NCT01668485
- Testing
- Hypoglycemic and euglycemic glucose clamp
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Type 1 Diabetes, Type 2 Diabetes
Ketone Monitoring Approaches for Diabetic Ketoacidosis Risk Mitigation in People With T1D on Adjunctive SGLT-2 Inhibitors
The purpose of this research is to see how well a special education plan using continuous ketone monitoring (DGK) works to lower the risk of a condition called diabetic ketoacidosis (DKA) in people with type 1 diabetes (T1D)…
- Trial name
- KARMA (NCT07421518)
- Testing
- SGLT-2 inhibitor (Sotagliflozin), Insulin withdrawal test (IWT)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Type 1 Diabetes
Effectiveness of a Multidisciplinary Treatment and Structured Education Programme
This trial compared an structured education programme and multidisciplinary treatment vs an standard treatment in type 1 diabetes patient, the Primary outcome is glycemic control at 6-month follow up and secondary outcome are…
- Trial name
- NCT06184815
- Testing
- Educational programme 12, Standard education and treatment
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Diabetes Mellitus, Type 1
Neurocognitive Performance During Hyperglycemia , and Brain Tissue Integrity in Youth With Type 1 Diabetes and in Healthy
Study population : 90 Participants. 60 with T1DM , and 30 healthy controls. T1DM patients will be recruited by research publication in diabetes mellitus forums. Baseline visit: informed consent signing.
- Trial name
- T1DM (NCT02923323)
- Testing
- MRI including DTI , EEG, CGMS, Neurocognitive tests
- Where
- Israel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Type 1 Diabetes Mellitus
Fast Track CSII Using a Novel Device in Young Children With Newly Diagnosed T1DM
This study evaluates early initiation of continuous subcutaneous insulin infusion (CSII) therapy in young children using a novel delivery method in the form of a self-contained, lightweight, and disposable insulin pump unit…
- Trial name
- NCT00476788
- Testing
- Omnipod Insulin Management System
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Type 1 Diabetes
Incretin Hormones in Type-1 Diabetes Mellitus Glycemic Response in Type-1 Diabetes Mellitus
The purpose of this study is to investigate whether secretion of incretin hormones is intact and to what extent endogenous as well as exogenous GLP-1 controls postprandial glucose excursions in patients with type-1 diabetes…
- Trial name
- NCT00832741
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Healthy, Diabetes
A Trial Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneous NNC0123-0338 in Healthy Subjects and in Subjects With Type 1 Diabetes Mellitus
This trial is conducted in Europe. The purpose is to evaluate safety and tolerability of a range of single doses of subcutaneous insulin 338.
- Conditions
- Healthy, Diabetes, Diabetes Mellitus, Type 1
- Trial name
- NCT02220296
- Testing
- Insulin 338, insulin glargine
- Where
- Germany
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Biomarkers of Acute Organ Injury in Pediatric Newly Diagnosed Type 1 Diabetes
Diabetic ketoacidosis (DKA) is a severe metabolic complication in children with newly diagnosed type 1 diabetes mellitus (T1DM) and may be associated with early injury of vital organs such as the kidneys and the heart.
- Trial name
- NCT07483879
- Testing
- Biomarker and Echocardiographic Assessment
- Where
- Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Type 1 Diabetes
Intranasal Insulin for Prevention of Type 1 Diabetes
Children born in Turku, Oulu and Tampere university cities in Finland are screened at birth for HLA alleles that carry increased risk to or protection from development of type 1 diabetes.
- Trial name
- NCT00223613
- Testing
- daily intranasal administration of insulin
- Where
- Finland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Turku
Diabetes Mellitus Type 1
Assessment of the Neurovascular Microcirculatory Response in Diabetes Type 1 Patients
This study aims to see whether or not the diabetes 1 patients have a neurovascular microcirculatory dysfunction using various microvascular tests which have been previously validated.
- Trial name
- NEURODIAB1 (NCT02538120)
- Testing
- Microvascular assessment
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Type 1 Diabetes
Exercise Detection Study
The risk of hypoglycemia in individuals with type 1 diabetes increases considerably during exercise. As a result, many patients with type 1 diabetes experience fear of and reluctance to pursue physical activity, in order to avoid…
- Trial name
- NCT02688218
- Testing
- Aerobic Exercise, Resistance Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University